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The map label for this gene is iscA [H]

Identifier: 110834730

GI number: 110834730

Start: 2145736

End: 2146095

Strand: Direct

Name: iscA [H]

Synonym: ABO_1869

Alternate gene names: 110834730

Gene position: 2145736-2146095 (Clockwise)

Preceding gene: 110834729

Following gene: 110834731

Centisome position: 68.77

GC content: 58.06

Gene sequence:

>360_bases
ATGACAGTTCAGACATTCCACCCCGGCCAGGTCACACTGCACCTGACCGAGGCCGCCAACCAACAAGCCCTGCGCGAGAT
CCAGCGGGCCGGTGCCGCCGGTATTCGTCTGGATCTGGACGAGTCCGGCTGCTCCGGCTTCATGTACACCCTGGACTTCG
TGGAAAGCGCCAAAGACGGTGACAAACTGTTCAAAATCGACGGCGTAAACCTCTACGTGCCGGAAAAATGGCTGCCCATG
CTGAATGGTCTGGTTATCGACTACGTCACCGAAGGGGTCAACAGCCTGTTCAAGTTTCGCAATCCCAACGCCACCGGCGA
ATGCGGTTGCGGCGAAAGCTTTACCGTCGACGACGTCTAA

Upstream 100 bases:

>100_bases
CACGCATGATGGAAAGGTTTTCTGCCCATGCCTGCGCCTTTTCAACGTTAAACTTTGAACGTGCAACTCACTCCTCGCAA
GCTCGCAAGGAAGGTACAAC

Downstream 100 bases:

>100_bases
CCCGTAGCCCGGATAAATAATGGCAGACCAACGCACGGTAGTGGTTCAACGCGACGTTCCGGCCCGCAAGGTACCGGACG
GCACCCGTATAACCATTCCC

Product: iron-binding protein IscA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MTVQTFHPGQVTLHLTEAANQQALREIQRAGAAGIRLDLDESGCSGFMYTLDFVESAKDGDKLFKIDGVNLYVPEKWLPM
LNGLVIDYVTEGVNSLFKFRNPNATGECGCGESFTVDDV

Sequences:

>Translated_119_residues
MTVQTFHPGQVTLHLTEAANQQALREIQRAGAAGIRLDLDESGCSGFMYTLDFVESAKDGDKLFKIDGVNLYVPEKWLPM
LNGLVIDYVTEGVNSLFKFRNPNATGECGCGESFTVDDV
>Mature_118_residues
TVQTFHPGQVTLHLTEAANQQALREIQRAGAAGIRLDLDESGCSGFMYTLDFVESAKDGDKLFKIDGVNLYVPEKWLPML
NGLVIDYVTEGVNSLFKFRNPNATGECGCGESFTVDDV

Specific function: Unknown

COG id: COG0316

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesB/iscA family [H]

Homologues:

Organism=Homo sapiens, GI52426768, Length=114, Percent_Identity=32.4561403508772, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787974, Length=121, Percent_Identity=43.801652892562, Blast_Score=99, Evalue=6e-23,
Organism=Escherichia coli, GI1788877, Length=107, Percent_Identity=42.9906542056075, Blast_Score=83, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI193209025, Length=113, Percent_Identity=34.5132743362832, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25146411, Length=108, Percent_Identity=35.1851851851852, Blast_Score=75, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323001, Length=82, Percent_Identity=37.8048780487805, Blast_Score=67, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24642263, Length=110, Percent_Identity=34.5454545454545, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000361
- InterPro:   IPR016092
- InterPro:   IPR017870
- InterPro:   IPR011298 [H]

Pfam domain/function: PF01521 Fe-S_biosyn [H]

EC number: NA

Molecular weight: Translated: 13049; Mature: 12918

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS01152 HESB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQTFHPGQVTLHLTEAANQQALREIQRAGAAGIRLDLDESGCSGFMYTLDFVESAKDG
CCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEHHHHHHHCCCCC
DKLFKIDGVNLYVPEKWLPMLNGLVIDYVTEGVNSLFKFRNPNATGECGCGESFTVDDV
CEEEEECCCEEEECHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCC
>Mature Secondary Structure 
TVQTFHPGQVTLHLTEAANQQALREIQRAGAAGIRLDLDESGCSGFMYTLDFVESAKDG
CCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCEEEHHHHHHHCCCCC
DKLFKIDGVNLYVPEKWLPMLNGLVIDYVTEGVNSLFKFRNPNATGECGCGESFTVDDV
CEEEEECCCEEEECHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 10322040 [H]