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The map label for this gene is csdA [H]

Identifier: 110834729

GI number: 110834729

Start: 2144292

End: 2145500

Strand: Direct

Name: csdA [H]

Synonym: ABO_1868

Alternate gene names: 110834729

Gene position: 2144292-2145500 (Clockwise)

Preceding gene: 110834728

Following gene: 110834730

Centisome position: 68.72

GC content: 59.31

Gene sequence:

>1209_bases
ATGGATATTCAGGCCCTGCGTGCGCAATTTCCGATTCTGGATCAGCAAGTCAACGGCAAACCGCTGGTGTACTTGGATAA
CGGCGCCACCACCCAAAAACCGGTAGCAGTGCTCAACGCACTGGACAACTATTACCGCACGGTGAACTCCAACGTACATC
GCGGCGCCCACTATCTGAGCGACGAGGCCACCGGCCAGTTTGAAGGCGCCCGCCAAACCGTGGCGGATTTCCTCAACGCC
AGCCGCGAAGAAATTTTGTGGACCAAGGGCACCACCGAGTCCATCAACATGGTGGCCCAGTGCGTTGCCCGTGAGCGCCT
GCAGCCGGGCGACGAAGTACTGATTGGCACCAGTGAGCACCACGCCAATATCGTGCCTTGGCAACAGGCCTGCGCCGCCA
CCGGCGCCACCCTGAAAGTGATCCCGCTGCACGATGATTGCAGCCTAAATCAGGCCGCCTTTGAGCAGTTACTCAGCAGC
AAAACAAAGATTTTCGCCATCGGCCATGCCAGCAATGCGCTGGGCACCCTGAATCCGGTAAAAGCGATGGTCGCCAAGGC
GAAAGCCGCCGGCGCCATTACCCTGGTCGACGGCGCTCAAGCGGTGGCGCACTTCCCGGTGGACGTGCAGGACCTGGACG
TGGATTTCTACGCCTTTTCCGGCCACAAGTTATTTGGCCCCACTGGCATAGGCGTACTCTACGGTCGCCGCGAACAGCTC
GAGGCCATGCCGCCCTACCAGACCGGCGGCGAAATGATTGAAACGGTGAGCTTCGAAAAAAGCACCTGGAACCAGCTGCC
CTACAAATTCGAAGCCGGCACCCCAAACATTGCCGGCGCCATCGGCCTGGCCGCCGCCATTGCGTGGCTGCGACAACAGG
ACCGCCCGGCACTGGCGGCCCACGAAGACGCCCTGCTGGCCCATGCCACAGAGCGGGCCCAAGCCTGCGACGGCTTGAAA
ATCATCGGTACCGCCGCCAATAAAGTCAGTGTGCTGTCCTTTCTGTTGGATGGCGGCCACCCAGCCGATGTGGGCATGCT
GCTGGACAAACAAGGCATTGCCGTACGCACCGGCCACCACTGCACCATGCCCCTGATGGATACCCTAGGCATACCCGGCA
CTGTTAGGGCCTCATTCTCGATTTATAATACTCTGGAAGAGGTAGATCGCTTGTTCGAAGGACTAGAGAAAGTGAAAACA
TTTCTCTGA

Upstream 100 bases:

>100_bases
TGCTGATGACCCTGCCCCACGAAAAAGTGGCACAGTGGGCCACCCCCTGGCTGGAAGCCGAACTGACCCACGCCTCGCCG
GCGCAAGAGTCTGCCGCGTG

Downstream 100 bases:

>100_bases
AAATTAGGGCGCTACTGATTGCCCCACTGACTGAAATATTCATGCAGCGGACGTTGAAAGCTCAAAGTTTAAGCGTAGTC
GCGTATTGACGCTAAACTAA

Product: cysteine sulfinate desulfinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MDIQALRAQFPILDQQVNGKPLVYLDNGATTQKPVAVLNALDNYYRTVNSNVHRGAHYLSDEATGQFEGARQTVADFLNA
SREEILWTKGTTESINMVAQCVARERLQPGDEVLIGTSEHHANIVPWQQACAATGATLKVIPLHDDCSLNQAAFEQLLSS
KTKIFAIGHASNALGTLNPVKAMVAKAKAAGAITLVDGAQAVAHFPVDVQDLDVDFYAFSGHKLFGPTGIGVLYGRREQL
EAMPPYQTGGEMIETVSFEKSTWNQLPYKFEAGTPNIAGAIGLAAAIAWLRQQDRPALAAHEDALLAHATERAQACDGLK
IIGTAANKVSVLSFLLDGGHPADVGMLLDKQGIAVRTGHHCTMPLMDTLGIPGTVRASFSIYNTLEEVDRLFEGLEKVKT
FL

Sequences:

>Translated_402_residues
MDIQALRAQFPILDQQVNGKPLVYLDNGATTQKPVAVLNALDNYYRTVNSNVHRGAHYLSDEATGQFEGARQTVADFLNA
SREEILWTKGTTESINMVAQCVARERLQPGDEVLIGTSEHHANIVPWQQACAATGATLKVIPLHDDCSLNQAAFEQLLSS
KTKIFAIGHASNALGTLNPVKAMVAKAKAAGAITLVDGAQAVAHFPVDVQDLDVDFYAFSGHKLFGPTGIGVLYGRREQL
EAMPPYQTGGEMIETVSFEKSTWNQLPYKFEAGTPNIAGAIGLAAAIAWLRQQDRPALAAHEDALLAHATERAQACDGLK
IIGTAANKVSVLSFLLDGGHPADVGMLLDKQGIAVRTGHHCTMPLMDTLGIPGTVRASFSIYNTLEEVDRLFEGLEKVKT
FL
>Mature_402_residues
MDIQALRAQFPILDQQVNGKPLVYLDNGATTQKPVAVLNALDNYYRTVNSNVHRGAHYLSDEATGQFEGARQTVADFLNA
SREEILWTKGTTESINMVAQCVARERLQPGDEVLIGTSEHHANIVPWQQACAATGATLKVIPLHDDCSLNQAAFEQLLSS
KTKIFAIGHASNALGTLNPVKAMVAKAKAAGAITLVDGAQAVAHFPVDVQDLDVDFYAFSGHKLFGPTGIGVLYGRREQL
EAMPPYQTGGEMIETVSFEKSTWNQLPYKFEAGTPNIAGAIGLAAAIAWLRQQDRPALAAHEDALLAHATERAQACDGLK
IIGTAANKVSVLSFLLDGGHPADVGMLLDKQGIAVRTGHHCTMPLMDTLGIPGTVRASFSIYNTLEEVDRLFEGLEKVKT
FL

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=231, Percent_Identity=29.8701298701299, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=48.019801980198, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1789175, Length=406, Percent_Identity=45.0738916256158, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI48994898, Length=222, Percent_Identity=29.2792792792793, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=228, Percent_Identity=27.6315789473684, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193211090, Length=443, Percent_Identity=22.3476297968397, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319831, Length=228, Percent_Identity=28.5087719298246, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI20129463, Length=249, Percent_Identity=30.5220883534137, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43300; Mature: 43300

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQALRAQFPILDQQVNGKPLVYLDNGATTQKPVAVLNALDNYYRTVNSNVHRGAHYLS
CCHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHCHHHHC
DEATGQFEGARQTVADFLNASREEILWTKGTTESINMVAQCVARERLQPGDEVLIGTSEH
CCCCCCCCHHHHHHHHHHCCCCHHEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCC
HANIVPWQQACAATGATLKVIPLHDDCSLNQAAFEQLLSSKTKIFAIGHASNALGTLNPV
CCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHH
KAMVAKAKAAGAITLVDGAQAVAHFPVDVQDLDVDFYAFSGHKLFGPTGIGVLYGRREQL
HHHHHHHHCCCEEEEECCCHHHEECCCCCEECCEEEEEECCCEEECCCCCEEEECCHHHH
EAMPPYQTGGEMIETVSFEKSTWNQLPYKFEAGTPNIAGAIGLAAAIAWLRQQDRPALAA
CCCCCCCCCCHHHHHEECCCHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHH
HEDALLAHATERAQACDGLKIIGTAANKVSVLSFLLDGGHPADVGMLLDKQGIAVRTGHH
CHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCC
CTMPLMDTLGIPGTVRASFSIYNTLEEVDRLFEGLEKVKTFL
CCCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIQALRAQFPILDQQVNGKPLVYLDNGATTQKPVAVLNALDNYYRTVNSNVHRGAHYLS
CCHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHCHHHHC
DEATGQFEGARQTVADFLNASREEILWTKGTTESINMVAQCVARERLQPGDEVLIGTSEH
CCCCCCCCHHHHHHHHHHCCCCHHEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCC
HANIVPWQQACAATGATLKVIPLHDDCSLNQAAFEQLLSSKTKIFAIGHASNALGTLNPV
CCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHH
KAMVAKAKAAGAITLVDGAQAVAHFPVDVQDLDVDFYAFSGHKLFGPTGIGVLYGRREQL
HHHHHHHHCCCEEEEECCCHHHEECCCCCEECCEEEEEECCCEEECCCCCEEEECCHHHH
EAMPPYQTGGEMIETVSFEKSTWNQLPYKFEAGTPNIAGAIGLAAAIAWLRQQDRPALAA
CCCCCCCCCCHHHHHEECCCHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHH
HEDALLAHATERAQACDGLKIIGTAANKVSVLSFLLDGGHPADVGMLLDKQGIAVRTGHH
CHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCC
CTMPLMDTLGIPGTVRASFSIYNTLEEVDRLFEGLEKVKTFL
CCCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]