Click here to switch to the map view.

The map label for this gene is clpA [H]

Identifier: 110834146

GI number: 110834146

Start: 1458777

End: 1461044

Strand: Direct

Name: clpA [H]

Synonym: ABO_1285

Alternate gene names: 110834146

Gene position: 1458777-1461044 (Clockwise)

Preceding gene: 110834145

Following gene: 110834151

Centisome position: 46.75

GC content: 54.81

Gene sequence:

>2268_bases
ATGCTCAGCAAAGAACTGGAAATGACGCTTAACGAGGCGTTTCGTCACGCACGTGGCCATCGTCATGAATTTATGACAGT
GGAGCATTTGCTGCTGGCGCTGCTGGATAACGAGGCGGCCGTCGAGGTCTTGCGCGCCTGCGCCGCAGACCTGGATGAAT
TGCGTGATGCGTTATCCCAATTTATCGAAGACTCCACACCGTTACTGCCGGATACCGATCCTGAGCGCGACACCCAGCCC
ACGCTTGGTTTTCAGCGGGTCCTGCAGCGTGCGGTATTCAGTGTGCAGTCGTCAGGCAAGAAAGAAGTGACCGGCGCCAA
TGTGCTGGTGGCAATCTTCAATGAACAGGAAAGCCAAGCCGTCTATTTCCTCAATTGCCAAGATATTCACCGCTTGGATA
TCGTCAATTTTATCGCCCATGGCATTTCCCAGATTGAAGATGCGGATCCCTCTGTTGAAACCGAAAAGGAAATGGAGGCT
GGCCAAGAAAGTGCGGCTTCGGCCAGAGCGCTGGATAACTACGCCACCAATTTGAATGAGCTGGCCCGAGAGGACCGCAT
TGACCCGCTGGTGGGCCGCGCGTTTGAGATTGAGCGAGCGGCGCAGATTCTTTGTCGTCGCCGCAAGAATAACCCCTTGC
TGGTAGGCGAGCCCGGGGTGGGCAAAACCGCCATCGCGGAAGGCCTGGCGCGGATGATCGTGGAAGAGCAGGTGCCTGAG
CCGCTGCTGGATGCAGTCGTCTACTCGCTGGATCTGGGAGCTCTGCTGGCTGGCACCAAGTACCGTGGGGATTTCGAAAA
ACGCTTGAAAACCCTGTTGGGCGAGCTGAAGAAAGAGCCTAATTCGATCCTGTTTATCGATGAGATTCACACCATTATTG
GTGCCGGTGCCGCCTCCGGTGGGGTCATGGATGCCTCCAACCTATTGAAGCCGCTGTTAGCCTCCGGTGAACTGAAATGC
ATGGGTTCAACCACCTTCCAGGAATACCGCGGTGTATTCGAGAAGGATCGGGCGCTGTCTCGTCGTTTCCAGAAGATTGA
TGTGGTTGAGCCGTCTGTTGAAGACACGGTTGGCATCCTAAAAGGGCTGAAGAGCCGTTTTGAAGCCCATCATGATGTCA
GCTACACGGACGGAGCCTTGAAAGCGGCGGCGGAGCTGAGCGCCCGTTATATCAATGATCGCTATTTGCCGGATAAGGCC
ATCGACGTGATCGATGAAGTGGGCGCTTGGCAGAGGCTGCGCCCACAGGACGTGCGCAAACACACTATCGAAGAAACCGA
TGTGGAAGATATGGTGGCTAAAATTGCCCGTATTCCTCCCAAGCAAGTGTCGTCATCCGACAAGGAGTTGCTGCGCAATC
TGGAGCGTGACCTGAAGATGACCGTCTTTGGTCAGGATGAGGCCATTGATACCATTTCGGCAGCCATCAAACTGTCCCGC
GCTGGCTTGAAGGGTGAACATAAACCTATCGGTAGCTTCATGTTTGCCGGTCCCACAGGGGTGGGTAAAACGGAAGTAAG
CCGGCAACTGGCCCGTGCCTTGGGTGTGGAGCTGGTACGCTTTGATATGTCCGAATATATGGAACGCCATACGGTGAGCC
GCCTGATTGGCGCGCCTCCCGGCTACGTGGGCTTTGATCAGGGCGGTTTGCTGACCGAGGCGATCACCAAAACGCCACAC
TGTGTGTTGCTATTGGATGAAATCGAGAAAGCCCACCCGGAAGTGTTCAATATCCTGCTGCAGGTGATGGACAATGCCAC
GCTGACCGACAATAACGGCCGTAAGGCGGACTTCCGTAACGTGATCTTGATTATGACCACCAATGCGGGCGCGGAGGTGC
TCAACAAGCGCTCTATCGGCTTTACTGAGCAGGACAACAGCACCGATGGCATGGAAATGCTCAAGAAGGTTTTCACACCG
GAGTTCCGCAATCGTCTTGATGGCACCATTCAGTTCTTGCCGTTGACCAGCACGGTTATCTTGGGTGTGGTCGATAAGTT
CCTGGTGGAATTACAGGCCCAGCTGGATGAGCGCGCAGTGGTATTGAATGTGGATGATGCAGCCCGCACCTGGTTAGCTG
AAAAGGGTTACGACAAAGATATGGGGGCACGCCCCATGGCGCGTTTGTTACAGGAAAAAATCAAGAAACCGTTGGCAGAG
AAACTGCTGTTCGGTGAATTGGCCGGTGCCGGTGGGCAGGTCAATGTCACTGAGAAAGACGGGGACCTGGTGCTTTCTGT
GGAAGCGACCACGGCCGAACCTGCTTAA

Upstream 100 bases:

>100_bases
CGCAAGTGGTGGAATACGCCCGGGAGAATCAGCATCCGTTGATGTGTCAGGTGGAACAGGCCTGACACTCTCCTTGCGGG
CCCTGCAGTGAGGTAGCCTT

Downstream 100 bases:

>100_bases
ATAGGAGGGAGCAGGGCGTTTTCTTTGTTAGAGTGCGCGCCCTGTTGCTCTTTATTATCAAACACCAACAAAAAAACCCG
GCTATACCGGGTTTTTTTGT

Product: ATP-dependent Clp protease, ATP-binding subunitclpa

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MLSKELEMTLNEAFRHARGHRHEFMTVEHLLLALLDNEAAVEVLRACAADLDELRDALSQFIEDSTPLLPDTDPERDTQP
TLGFQRVLQRAVFSVQSSGKKEVTGANVLVAIFNEQESQAVYFLNCQDIHRLDIVNFIAHGISQIEDADPSVETEKEMEA
GQESAASARALDNYATNLNELAREDRIDPLVGRAFEIERAAQILCRRRKNNPLLVGEPGVGKTAIAEGLARMIVEEQVPE
PLLDAVVYSLDLGALLAGTKYRGDFEKRLKTLLGELKKEPNSILFIDEIHTIIGAGAASGGVMDASNLLKPLLASGELKC
MGSTTFQEYRGVFEKDRALSRRFQKIDVVEPSVEDTVGILKGLKSRFEAHHDVSYTDGALKAAAELSARYINDRYLPDKA
IDVIDEVGAWQRLRPQDVRKHTIEETDVEDMVAKIARIPPKQVSSSDKELLRNLERDLKMTVFGQDEAIDTISAAIKLSR
AGLKGEHKPIGSFMFAGPTGVGKTEVSRQLARALGVELVRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITKTPH
CVLLLDEIEKAHPEVFNILLQVMDNATLTDNNGRKADFRNVILIMTTNAGAEVLNKRSIGFTEQDNSTDGMEMLKKVFTP
EFRNRLDGTIQFLPLTSTVILGVVDKFLVELQAQLDERAVVLNVDDAARTWLAEKGYDKDMGARPMARLLQEKIKKPLAE
KLLFGELAGAGGQVNVTEKDGDLVLSVEATTAEPA

Sequences:

>Translated_755_residues
MLSKELEMTLNEAFRHARGHRHEFMTVEHLLLALLDNEAAVEVLRACAADLDELRDALSQFIEDSTPLLPDTDPERDTQP
TLGFQRVLQRAVFSVQSSGKKEVTGANVLVAIFNEQESQAVYFLNCQDIHRLDIVNFIAHGISQIEDADPSVETEKEMEA
GQESAASARALDNYATNLNELAREDRIDPLVGRAFEIERAAQILCRRRKNNPLLVGEPGVGKTAIAEGLARMIVEEQVPE
PLLDAVVYSLDLGALLAGTKYRGDFEKRLKTLLGELKKEPNSILFIDEIHTIIGAGAASGGVMDASNLLKPLLASGELKC
MGSTTFQEYRGVFEKDRALSRRFQKIDVVEPSVEDTVGILKGLKSRFEAHHDVSYTDGALKAAAELSARYINDRYLPDKA
IDVIDEVGAWQRLRPQDVRKHTIEETDVEDMVAKIARIPPKQVSSSDKELLRNLERDLKMTVFGQDEAIDTISAAIKLSR
AGLKGEHKPIGSFMFAGPTGVGKTEVSRQLARALGVELVRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITKTPH
CVLLLDEIEKAHPEVFNILLQVMDNATLTDNNGRKADFRNVILIMTTNAGAEVLNKRSIGFTEQDNSTDGMEMLKKVFTP
EFRNRLDGTIQFLPLTSTVILGVVDKFLVELQAQLDERAVVLNVDDAARTWLAEKGYDKDMGARPMARLLQEKIKKPLAE
KLLFGELAGAGGQVNVTEKDGDLVLSVEATTAEPA
>Mature_755_residues
MLSKELEMTLNEAFRHARGHRHEFMTVEHLLLALLDNEAAVEVLRACAADLDELRDALSQFIEDSTPLLPDTDPERDTQP
TLGFQRVLQRAVFSVQSSGKKEVTGANVLVAIFNEQESQAVYFLNCQDIHRLDIVNFIAHGISQIEDADPSVETEKEMEA
GQESAASARALDNYATNLNELAREDRIDPLVGRAFEIERAAQILCRRRKNNPLLVGEPGVGKTAIAEGLARMIVEEQVPE
PLLDAVVYSLDLGALLAGTKYRGDFEKRLKTLLGELKKEPNSILFIDEIHTIIGAGAASGGVMDASNLLKPLLASGELKC
MGSTTFQEYRGVFEKDRALSRRFQKIDVVEPSVEDTVGILKGLKSRFEAHHDVSYTDGALKAAAELSARYINDRYLPDKA
IDVIDEVGAWQRLRPQDVRKHTIEETDVEDMVAKIARIPPKQVSSSDKELLRNLERDLKMTVFGQDEAIDTISAAIKLSR
AGLKGEHKPIGSFMFAGPTGVGKTEVSRQLARALGVELVRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITKTPH
CVLLLDEIEKAHPEVFNILLQVMDNATLTDNNGRKADFRNVILIMTTNAGAEVLNKRSIGFTEQDNSTDGMEMLKKVFTP
EFRNRLDGTIQFLPLTSTVILGVVDKFLVELQAQLDERAVVLNVDDAARTWLAEKGYDKDMGARPMARLLQEKIKKPLAE
KLLFGELAGAGGQVNVTEKDGDLVLSVEATTAEPA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=331, Percent_Identity=30.5135951661631, Blast_Score=160, Evalue=4e-39,
Organism=Escherichia coli, GI1787109, Length=739, Percent_Identity=66.9824086603518, Blast_Score=1017, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=418, Percent_Identity=43.7799043062201, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6320464, Length=331, Percent_Identity=45.3172205438066, Blast_Score=277, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6323002, Length=400, Percent_Identity=37, Blast_Score=249, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83352; Mature: 83352

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKELEMTLNEAFRHARGHRHEFMTVEHLLLALLDNEAAVEVLRACAADLDELRDALSQ
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FIEDSTPLLPDTDPERDTQPTLGFQRVLQRAVFSVQSSGKKEVTGANVLVAIFNEQESQA
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCE
VYFLNCQDIHRLDIVNFIAHGISQIEDADPSVETEKEMEAGQESAASARALDNYATNLNE
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
LAREDRIDPLVGRAFEIERAAQILCRRRKNNPLLVGEPGVGKTAIAEGLARMIVEEQVPE
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCH
PLLDAVVYSLDLGALLAGTKYRGDFEKRLKTLLGELKKEPNSILFIDEIHTIIGAGAASG
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCC
GVMDASNLLKPLLASGELKCMGSTTFQEYRGVFEKDRALSRRFQKIDVVEPSVEDTVGIL
CCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
KGLKSRFEAHHDVSYTDGALKAAAELSARYINDRYLPDKAIDVIDEVGAWQRLRPQDVRK
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHCCCHHHHHH
HTIEETDVEDMVAKIARIPPKQVSSSDKELLRNLERDLKMTVFGQDEAIDTISAAIKLSR
HHCCCCCHHHHHHHHHCCCCHHCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHH
AGLKGEHKPIGSFMFAGPTGVGKTEVSRQLARALGVELVRFDMSEYMERHTVSRLIGAPP
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GYVGFDQGGLLTEAITKTPHCVLLLDEIEKAHPEVFNILLQVMDNATLTDNNGRKADFRN
CCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCEEECCCCCCCCCCC
VILIMTTNAGAEVLNKRSIGFTEQDNSTDGMEMLKKVFTPEFRNRLDGTIQFLPLTSTVI
EEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCCEEEEEEHHHHHH
LGVVDKFLVELQAQLDERAVVLNVDDAARTWLAEKGYDKDMGARPMARLLQEKIKKPLAE
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
KLLFGELAGAGGQVNVTEKDGDLVLSVEATTAEPA
HHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCC
>Mature Secondary Structure
MLSKELEMTLNEAFRHARGHRHEFMTVEHLLLALLDNEAAVEVLRACAADLDELRDALSQ
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
FIEDSTPLLPDTDPERDTQPTLGFQRVLQRAVFSVQSSGKKEVTGANVLVAIFNEQESQA
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCE
VYFLNCQDIHRLDIVNFIAHGISQIEDADPSVETEKEMEAGQESAASARALDNYATNLNE
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
LAREDRIDPLVGRAFEIERAAQILCRRRKNNPLLVGEPGVGKTAIAEGLARMIVEEQVPE
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCH
PLLDAVVYSLDLGALLAGTKYRGDFEKRLKTLLGELKKEPNSILFIDEIHTIIGAGAASG
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCC
GVMDASNLLKPLLASGELKCMGSTTFQEYRGVFEKDRALSRRFQKIDVVEPSVEDTVGIL
CCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
KGLKSRFEAHHDVSYTDGALKAAAELSARYINDRYLPDKAIDVIDEVGAWQRLRPQDVRK
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHCCCHHHHHH
HTIEETDVEDMVAKIARIPPKQVSSSDKELLRNLERDLKMTVFGQDEAIDTISAAIKLSR
HHCCCCCHHHHHHHHHCCCCHHCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHH
AGLKGEHKPIGSFMFAGPTGVGKTEVSRQLARALGVELVRFDMSEYMERHTVSRLIGAPP
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GYVGFDQGGLLTEAITKTPHCVLLLDEIEKAHPEVFNILLQVMDNATLTDNNGRKADFRN
CCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCEEECCCCCCCCCCC
VILIMTTNAGAEVLNKRSIGFTEQDNSTDGMEMLKKVFTPEFRNRLDGTIQFLPLTSTVI
EEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHCCCCEEEEEEHHHHHH
LGVVDKFLVELQAQLDERAVVLNVDDAARTWLAEKGYDKDMGARPMARLLQEKIKKPLAE
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
KLLFGELAGAGGQVNVTEKDGDLVLSVEATTAEPA
HHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]