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The map label for this gene is dxr [H]

Identifier: 110834010

GI number: 110834010

Start: 1305593

End: 1306807

Strand: Direct

Name: dxr [H]

Synonym: ABO_1149

Alternate gene names: 110834010

Gene position: 1305593-1306807 (Clockwise)

Preceding gene: 110834009

Following gene: 110834011

Centisome position: 41.84

GC content: 57.28

Gene sequence:

>1215_bases
GTGACACCCTCTGAGAAACCTTCCATTTCGGCCGTTGCTACTGGCAGACAGCGCCTCACCTTGCTGGGCGCCACGGGAAG
TATTGGGCAACAAACTCTGGATGTGCTGGTTCGCCACCCGGAGCGTTATGAGGTTTTTGCGGTTACCGCGGGCACGCAAT
GGCAGGCTATGGCACGGCTTTGCGAAACGGTGCAGCCTCGCTATGCAGCCATGGCTGATGCCACCTCGGCAACGTCCCTT
CGGAACCATCTTGCTGGCCTTGGGTCACAAGTAGAGGTTTTATCAGGCCCAGAGGCCTTGGCTGAGCTGGCGGCTCATCC
GGATGTTGATACCGTGGTGGCGGGTATTGTGGGTGCCGCGGGTGTGCGTCCCACTTTGGCGGCTGTGGAGGCAGGGAAGC
GAGTACTGCTGGCCAACAAAGAAGCTCTGGTGGTCACCGGTTCCCTGTTTATGGATGCAGTGAAGCGCTATGGTGCAACA
TTGTTGCCACTGGATTCCGAACACAACGCGATTTTCCAGTGCCTGCCCACGGAAGGGGTAAATGCAGGAGTTGAACGTTT
ATTGTTGACGGCATCAGGTGGCCCGTTCCGCGAGTTCAGCGCTGAGCAGCTGAAAGCGGTTACGCCGGAGCAGGCAATAA
AACACCCCAACTGGGATATGGGCCCCAAGATTTCGGTGGACTCCGCCACGCTGATGAATAAGGGGCTGGAGTTTATTGAG
GCTTGCTGGCTGTTTGATGTTCCCCCTGCCATGGTGGATGTGGTGGTGCATCCACAGAGTGTGATCCACTCTATGGTCGC
TTACCGGGATGGCTCGGTATTGGCCCAGATGGGGACACCTGATATGCGTACTCCCATTGCCTGTGGCTTGTCTTGGCCCG
AGCGAGTGGAGTCCGGTGCCCAGCGGTTGGACTTTTCAACGCTGATCGGGCTGAATTTTGAATTGCCGGATCTTGAGAGG
TTTCCATGCTTGGGCTTGGCCCGTGATGCCATGGCCGCAGGTGGAACGGCCACGGCGGTGTTAAACGCAGCGAATGAAGA
AGCGGTTGCGGCTTTTCTTGACGGCCGGCTCGATTTTATGGGCATTGCGGATGTGGTAGCGCGAACTCTTGATAAACAGG
ATGCGCCAGCCTGCTGTGATGTGGATGCGGTTATGGAAATTGACCGCCAGGCGCGACAGCTTGCCTGTCACTGGATTAAG
GAGCGTGGATGCTGA

Upstream 100 bases:

>100_bases
CAGGTCATGGCGGCATGCTCGACCGCATTGACAGTGTCACTGCAGCCATGCCGATTGCTTTGGCTGGGTTTAACTGGTTC
GCCCTGCCTGGAGGGAGTTT

Downstream 100 bases:

>100_bases
CGTTATTGGCATTCGTCGTCACCATCGTGATCATTGTGGCCTTCCACGAGTGGGGCCACTTTCTTGCCATGCGCGCTTTC
GGTGTTCGTGTTCTGACCTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTPSEKPSISAVATGRQRLTLLGATGSIGQQTLDVLVRHPERYEVFAVTAGTQWQAMARLCETVQPRYAAMADATSATSL
RNHLAGLGSQVEVLSGPEALAELAAHPDVDTVVAGIVGAAGVRPTLAAVEAGKRVLLANKEALVVTGSLFMDAVKRYGAT
LLPLDSEHNAIFQCLPTEGVNAGVERLLLTASGGPFREFSAEQLKAVTPEQAIKHPNWDMGPKISVDSATLMNKGLEFIE
ACWLFDVPPAMVDVVVHPQSVIHSMVAYRDGSVLAQMGTPDMRTPIACGLSWPERVESGAQRLDFSTLIGLNFELPDLER
FPCLGLARDAMAAGGTATAVLNAANEEAVAAFLDGRLDFMGIADVVARTLDKQDAPACCDVDAVMEIDRQARQLACHWIK
ERGC

Sequences:

>Translated_404_residues
MTPSEKPSISAVATGRQRLTLLGATGSIGQQTLDVLVRHPERYEVFAVTAGTQWQAMARLCETVQPRYAAMADATSATSL
RNHLAGLGSQVEVLSGPEALAELAAHPDVDTVVAGIVGAAGVRPTLAAVEAGKRVLLANKEALVVTGSLFMDAVKRYGAT
LLPLDSEHNAIFQCLPTEGVNAGVERLLLTASGGPFREFSAEQLKAVTPEQAIKHPNWDMGPKISVDSATLMNKGLEFIE
ACWLFDVPPAMVDVVVHPQSVIHSMVAYRDGSVLAQMGTPDMRTPIACGLSWPERVESGAQRLDFSTLIGLNFELPDLER
FPCLGLARDAMAAGGTATAVLNAANEEAVAAFLDGRLDFMGIADVVARTLDKQDAPACCDVDAVMEIDRQARQLACHWIK
ERGC
>Mature_403_residues
TPSEKPSISAVATGRQRLTLLGATGSIGQQTLDVLVRHPERYEVFAVTAGTQWQAMARLCETVQPRYAAMADATSATSLR
NHLAGLGSQVEVLSGPEALAELAAHPDVDTVVAGIVGAAGVRPTLAAVEAGKRVLLANKEALVVTGSLFMDAVKRYGATL
LPLDSEHNAIFQCLPTEGVNAGVERLLLTASGGPFREFSAEQLKAVTPEQAIKHPNWDMGPKISVDSATLMNKGLEFIEA
CWLFDVPPAMVDVVVHPQSVIHSMVAYRDGSVLAQMGTPDMRTPIACGLSWPERVESGAQRLDFSTLIGLNFELPDLERF
PCLGLARDAMAAGGTATAVLNAANEEAVAAFLDGRLDFMGIADVVARTLDKQDAPACCDVDAVMEIDRQARQLACHWIKE
RGC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=390, Percent_Identity=54.3589743589744, Blast_Score=385, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43013; Mature: 42882

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSEKPSISAVATGRQRLTLLGATGSIGQQTLDVLVRHPERYEVFAVTAGTQWQAMARL
CCCCCCCCCCCEECCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHH
CETVQPRYAAMADATSATSLRNHLAGLGSQVEVLSGPEALAELAAHPDVDTVVAGIVGAA
HHHHCCHHHHHHCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCHHHHHHHHHHCC
GVRPTLAAVEAGKRVLLANKEALVVTGSLFMDAVKRYGATLLPLDSEHNAIFQCLPTEGV
CCCHHHHHHHCCCEEEEECCCEEEEEHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCC
NAGVERLLLTASGGPFREFSAEQLKAVTPEQAIKHPNWDMGPKISVDSATLMNKGLEFIE
CHHHHHEEEECCCCCCHHCCHHHHHHCCHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHH
ACWLFDVPPAMVDVVVHPQSVIHSMVAYRDGSVLAQMGTPDMRTPIACGLSWPERVESGA
HHHHCCCCHHHHEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCCEEECCCCHHHHHHHH
QRLDFSTLIGLNFELPDLERFPCLGLARDAMAAGGTATAVLNAANEEAVAAFLDGRLDFM
HHCCHHHEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHEEEECCCHHHHHHHHCCCCHHH
GIADVVARTLDKQDAPACCDVDAVMEIDRQARQLACHWIKERGC
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPSEKPSISAVATGRQRLTLLGATGSIGQQTLDVLVRHPERYEVFAVTAGTQWQAMARL
CCCCCCCCCCEECCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHH
CETVQPRYAAMADATSATSLRNHLAGLGSQVEVLSGPEALAELAAHPDVDTVVAGIVGAA
HHHHCCHHHHHHCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCHHHHHHHHHHCC
GVRPTLAAVEAGKRVLLANKEALVVTGSLFMDAVKRYGATLLPLDSEHNAIFQCLPTEGV
CCCHHHHHHHCCCEEEEECCCEEEEEHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCC
NAGVERLLLTASGGPFREFSAEQLKAVTPEQAIKHPNWDMGPKISVDSATLMNKGLEFIE
CHHHHHEEEECCCCCCHHCCHHHHHHCCHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHH
ACWLFDVPPAMVDVVVHPQSVIHSMVAYRDGSVLAQMGTPDMRTPIACGLSWPERVESGA
HHHHCCCCHHHHEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCCEEECCCCHHHHHHHH
QRLDFSTLIGLNFELPDLERFPCLGLARDAMAAGGTATAVLNAANEEAVAAFLDGRLDFM
HHCCHHHEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHEEEECCCHHHHHHHHCCCCHHH
GIADVVARTLDKQDAPACCDVDAVMEIDRQARQLACHWIKERGC
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA