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The map label for this gene is uppS [H]

Identifier: 110834008

GI number: 110834008

Start: 1303990

End: 1304772

Strand: Direct

Name: uppS [H]

Synonym: ABO_1147

Alternate gene names: 110834008

Gene position: 1303990-1304772 (Clockwise)

Preceding gene: 110834007

Following gene: 110834009

Centisome position: 41.79

GC content: 54.92

Gene sequence:

>783_bases
ATGGCCGACAATCAGCCTCATTCCAGTGCCCCAGATATCGATTCCTATCAAGGTGTTGTGCCCCGTCATGTAGCCATCAT
CATGGACGGCAATAACCGCTGGGCACGCAAGCATGGTGTTCCGGGTGAGGAGGGGCATCGAGCGGGAGAAGCTACGGTTC
AGGCGATTATTCGTCAGGCAGCGCAGCGCGGTCTCGAGGCACTAACACTGTTTGCTTTTAGCTCGGAAAACTGGCGTCGA
CCGCAGGCGGAAGTGGACCACCTGATGGCGCTGTTCTTGAAGGCGCTGGCTGGCCGTGTTGAAGAGCTTCACAGTCACGA
GGTTCGTATTCGCTTTATTGGCGATCGCGGTGCGTTTTCGCAAGGTCTTCAGGATGGCATGACACAAGCGGAAGTCCTGA
CCGGCAATAACACCAGGATGACGGTGGTTATTGCTGTGAATTACGGCGGGCAGTGGGACATTGCCCATGCGGCCCGCCAG
TTGGCTGCAAAAGTGGCAGAAGGTGAGATGGAGGTAGACCAGATAGATGCCGGGGCGATGGCACCCTATCTGTCCATGGC
CGACCTGCCACCCCCGGATTTGCTCATTCGCACCGGTGGCGACCAAAGAATAAGTAACTTTTTGTTATGGCAATTGGCCT
ACAGCGAGCTGTTTTTTTCGCCGTTGCTATGGCCTGATTTTGATGCTGATGCCTTTGATGCAGCGCTACAGGATTATGCT
GGTCGCCAACGGCGTTTTGGTCGTTCTGGTGAAGAAGTGGCCAGCTTGAATGGAGAACAATAA

Upstream 100 bases:

>100_bases
AGAAGAAGAATTGATGACCGTTTGATCGCTTCGCGCGAGCGGTGATCGAAAGACATCTCGGGCTGCAGGTCAGCCCGTTT
CTATTCTTGGCGGATGCAGT

Downstream 100 bases:

>100_bases
TGCTAAAACTGCGCGTGATTACCGCGCTGGTGCTGTTGCCGATTGTGTTGGGCGCAGTATTTGGATTAGACCGTCAGATG
TTTGCCATTGTGGCTGGCGT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MADNQPHSSAPDIDSYQGVVPRHVAIIMDGNNRWARKHGVPGEEGHRAGEATVQAIIRQAAQRGLEALTLFAFSSENWRR
PQAEVDHLMALFLKALAGRVEELHSHEVRIRFIGDRGAFSQGLQDGMTQAEVLTGNNTRMTVVIAVNYGGQWDIAHAARQ
LAAKVAEGEMEVDQIDAGAMAPYLSMADLPPPDLLIRTGGDQRISNFLLWQLAYSELFFSPLLWPDFDADAFDAALQDYA
GRQRRFGRSGEEVASLNGEQ

Sequences:

>Translated_260_residues
MADNQPHSSAPDIDSYQGVVPRHVAIIMDGNNRWARKHGVPGEEGHRAGEATVQAIIRQAAQRGLEALTLFAFSSENWRR
PQAEVDHLMALFLKALAGRVEELHSHEVRIRFIGDRGAFSQGLQDGMTQAEVLTGNNTRMTVVIAVNYGGQWDIAHAARQ
LAAKVAEGEMEVDQIDAGAMAPYLSMADLPPPDLLIRTGGDQRISNFLLWQLAYSELFFSPLLWPDFDADAFDAALQDYA
GRQRRFGRSGEEVASLNGEQ
>Mature_259_residues
ADNQPHSSAPDIDSYQGVVPRHVAIIMDGNNRWARKHGVPGEEGHRAGEATVQAIIRQAAQRGLEALTLFAFSSENWRRP
QAEVDHLMALFLKALAGRVEELHSHEVRIRFIGDRGAFSQGLQDGMTQAEVLTGNNTRMTVVIAVNYGGQWDIAHAARQL
AAKVAEGEMEVDQIDAGAMAPYLSMADLPPPDLLIRTGGDQRISNFLLWQLAYSELFFSPLLWPDFDADAFDAALQDYAG
RQRRFGRSGEEVASLNGEQ

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=36.6071428571429, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=36.6071428571429, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI1786371, Length=235, Percent_Identity=53.6170212765957, Blast_Score=257, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=33.0396475770925, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=37.2093023255814, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=255, Percent_Identity=30.1960784313725, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28666; Mature: 28535

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNQPHSSAPDIDSYQGVVPRHVAIIMDGNNRWARKHGVPGEEGHRAGEATVQAIIRQA
CCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
AQRGLEALTLFAFSSENWRRPQAEVDHLMALFLKALAGRVEELHSHEVRIRFIGDRGAFS
HHCCHHHEEHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHH
QGLQDGMTQAEVLTGNNTRMTVVIAVNYGGQWDIAHAARQLAAKVAEGEMEVDQIDAGAM
HHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCHH
APYLSMADLPPPDLLIRTGGDQRISNFLLWQLAYSELFFSPLLWPDFDADAFDAALQDYA
HHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
GRQRRFGRSGEEVASLNGEQ
HHHHHCCCCCHHHHHCCCCC
>Mature Secondary Structure 
ADNQPHSSAPDIDSYQGVVPRHVAIIMDGNNRWARKHGVPGEEGHRAGEATVQAIIRQA
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
AQRGLEALTLFAFSSENWRRPQAEVDHLMALFLKALAGRVEELHSHEVRIRFIGDRGAFS
HHCCHHHEEHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHH
QGLQDGMTQAEVLTGNNTRMTVVIAVNYGGQWDIAHAARQLAAKVAEGEMEVDQIDAGAM
HHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCHH
APYLSMADLPPPDLLIRTGGDQRISNFLLWQLAYSELFFSPLLWPDFDADAFDAALQDYA
HHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
GRQRRFGRSGEEVASLNGEQ
HHHHHCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]