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The map label for this gene is lpxK

Identifier: 110833917

GI number: 110833917

Start: 1197846

End: 1198829

Strand: Direct

Name: lpxK

Synonym: ABO_1056

Alternate gene names: 110833917

Gene position: 1197846-1198829 (Clockwise)

Preceding gene: 110833916

Following gene: 110833918

Centisome position: 38.39

GC content: 56.91

Gene sequence:

>984_bases
ATGGGGTCACTGAGCGAATGGGTTCAACAGGGTTGGTATAAGGGCAGTCCCTGGCTGGTTCCACTACGGCCTTTGTCGGC
ACTGGTGTCGTTTGAAGCTAGGCGCCGGCTACAACGGTTCAGAAAACAGCGACCGCGTCCTCCTGTGCCGGTATTGGTGG
TGGGTAATATCACTGTGGGGGGGACAGGCAAAACCCCGTTGGTAATCGCTCTGGTAGAGGCTGCCCGCTCCAGGGGATTA
AAGGTAGCAGTCGTATCGCGCGGGTTTGCGGGTAAAACTAACCATTACCCTCAGCATGTAACCGCTAGCAGCGATGCCTT
GGATATGGGCGATGAACCTGTGTTGATTGCTCGCCGTACGGGCGTTCCGGTGGTGCTGGATCCTGATCGTCGTAATGCCC
TGGATGTGGCTATCCGTGAATACGCCCCGGATTTGGTGATCAGCGATGATGGCTTGCAGCATTATGCCCTGCCGCGCAGC
GCCGAAGTGGTGGTCGTGGATGCTCAACGCGGTCTGGGTAATGGGCGTTGTTTGCCGGAGGGGCCATTAAGAGAGCCTGC
CACCAGGCTCAAGGAAGTGGATTTCGTTATCAGCACTGGCGGTGGCTGGGCCGGGGCTTATCCGATGATTATGCGCCCTT
CAGGGGTCACCTGTCTGGCCGATAACCGTACCCTGACGCCTGATGATTTTCTGCGTCTTCATCCCCAGGTTCATGCGGTC
GCCGGTATCGGTAATCCCAAGCGGTTTTTTAACCTGCTCAGTATTCTCGGTCTAAGTGCCACGCCTCACGTTTTCCCTGA
TCATCATGCCTACCAGCCGGCGGATCTGGCATTTACTGATGGGTTGCCGGTTTTGATGACGGAAAAGGATGCGGTGAAGT
GCGCACCTTTCGCCGAGCCCCACTGGTGGTTTGTTCCGGTCACTGCGAGTTTGCCGGAAGGCTTGCTGGACCAGATGCTC
GACCGAGCGCTAGGAAAAGAATAG

Upstream 100 bases:

>100_bases
CCAGTTGATTGAGCAGGGTTCCCACCAGCAATTACTGGAAAAAAACGGGCTGTATACGCAAATGTACCGGATGAACTTTT
CCGAGGAGTAATCGGGCGAC

Downstream 100 bases:

>100_bases
CGACAAGCTTCATGCTGCAATGGGCCTTAGCTTTTGTTTTTAATTTGAAGTACGCAGTCCGTGCTCAATCCTTGGGCGAG
ACCCACGAAGCTTAAGAAAC

Product: tetraacyldisaccharide 4`-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MGSLSEWVQQGWYKGSPWLVPLRPLSALVSFEARRRLQRFRKQRPRPPVPVLVVGNITVGGTGKTPLVIALVEAARSRGL
KVAVVSRGFAGKTNHYPQHVTASSDALDMGDEPVLIARRTGVPVVLDPDRRNALDVAIREYAPDLVISDDGLQHYALPRS
AEVVVVDAQRGLGNGRCLPEGPLREPATRLKEVDFVISTGGGWAGAYPMIMRPSGVTCLADNRTLTPDDFLRLHPQVHAV
AGIGNPKRFFNLLSILGLSATPHVFPDHHAYQPADLAFTDGLPVLMTEKDAVKCAPFAEPHWWFVPVTASLPEGLLDQML
DRALGKE

Sequences:

>Translated_327_residues
MGSLSEWVQQGWYKGSPWLVPLRPLSALVSFEARRRLQRFRKQRPRPPVPVLVVGNITVGGTGKTPLVIALVEAARSRGL
KVAVVSRGFAGKTNHYPQHVTASSDALDMGDEPVLIARRTGVPVVLDPDRRNALDVAIREYAPDLVISDDGLQHYALPRS
AEVVVVDAQRGLGNGRCLPEGPLREPATRLKEVDFVISTGGGWAGAYPMIMRPSGVTCLADNRTLTPDDFLRLHPQVHAV
AGIGNPKRFFNLLSILGLSATPHVFPDHHAYQPADLAFTDGLPVLMTEKDAVKCAPFAEPHWWFVPVTASLPEGLLDQML
DRALGKE
>Mature_326_residues
GSLSEWVQQGWYKGSPWLVPLRPLSALVSFEARRRLQRFRKQRPRPPVPVLVVGNITVGGTGKTPLVIALVEAARSRGLK
VAVVSRGFAGKTNHYPQHVTASSDALDMGDEPVLIARRTGVPVVLDPDRRNALDVAIREYAPDLVISDDGLQHYALPRSA
EVVVVDAQRGLGNGRCLPEGPLREPATRLKEVDFVISTGGGWAGAYPMIMRPSGVTCLADNRTLTPDDFLRLHPQVHAVA
GIGNPKRFFNLLSILGLSATPHVFPDHHAYQPADLAFTDGLPVLMTEKDAVKCAPFAEPHWWFVPVTASLPEGLLDQMLD
RALGKE

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=332, Percent_Identity=44.2771084337349, Blast_Score=229, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_ALCBS (Q0VQP4)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692776.1
- STRING:   Q0VQP4
- GeneID:   4211464
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1056
- NMPDR:   fig|393595.12.peg.1064
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- PhylomeDB:   Q0VQP4
- BioCyc:   ABOR393595:ABO_1056-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 35668; Mature: 35536

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSLSEWVQQGWYKGSPWLVPLRPLSALVSFEARRRLQRFRKQRPRPPVPVLVVGNITVG
CCCHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEC
GTGKTPLVIALVEAARSRGLKVAVVSRGFAGKTNHYPQHVTASSDALDMGDEPVLIARRT
CCCCCCHHHHEEHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCEEEEECC
GVPVVLDPDRRNALDVAIREYAPDLVISDDGLQHYALPRSAEVVVVDAQRGLGNGRCLPE
CCCEEECCCCCCHHHHHHHHHCCCEEEECCCCEEEECCCCCEEEEEECCCCCCCCCCCCC
GPLREPATRLKEVDFVISTGGGWAGAYPMIMRPSGVTCLADNRTLTPDDFLRLHPQVHAV
CCCCCHHHHHHHEEEEEECCCCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHCCCEEEE
AGIGNPKRFFNLLSILGLSATPHVFPDHHAYQPADLAFTDGLPVLMTEKDAVKCAPFAEP
ECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCEEECCCCCC
HWWFVPVTASLPEGLLDQMLDRALGKE
CEEEEEECCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GSLSEWVQQGWYKGSPWLVPLRPLSALVSFEARRRLQRFRKQRPRPPVPVLVVGNITVG
CCHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEC
GTGKTPLVIALVEAARSRGLKVAVVSRGFAGKTNHYPQHVTASSDALDMGDEPVLIARRT
CCCCCCHHHHEEHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCEEEEECC
GVPVVLDPDRRNALDVAIREYAPDLVISDDGLQHYALPRSAEVVVVDAQRGLGNGRCLPE
CCCEEECCCCCCHHHHHHHHHCCCEEEECCCCEEEECCCCCEEEEEECCCCCCCCCCCCC
GPLREPATRLKEVDFVISTGGGWAGAYPMIMRPSGVTCLADNRTLTPDDFLRLHPQVHAV
CCCCCHHHHHHHEEEEEECCCCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHCCCEEEE
AGIGNPKRFFNLLSILGLSATPHVFPDHHAYQPADLAFTDGLPVLMTEKDAVKCAPFAEP
ECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCEEECCCCCC
HWWFVPVTASLPEGLLDQMLDRALGKE
CEEEEEECCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA