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The map label for this gene is cysK [H]

Identifier: 110833884

GI number: 110833884

Start: 1160497

End: 1161465

Strand: Direct

Name: cysK [H]

Synonym: ABO_1023

Alternate gene names: 110833884

Gene position: 1160497-1161465 (Clockwise)

Preceding gene: 110833883

Following gene: 110833885

Centisome position: 37.19

GC content: 56.35

Gene sequence:

>969_bases
ATGACCCGCATCTACCAAGACAATAGCGAAACCATCGGCAACACTCCTTTGGTAAAGATCAATCGTATCAGCCAGGGTAA
TATTCTCGCCAAGATCGAATCCCGTAACCCGGCTGGTAGCGTTAAGTGCCGCATCGGGGCATCCATGGTTCAGGATGCGG
AAAAGAGCGGTAAGCTCAAGCCGGGCATGACCCTGGTTGAACCAACCAGTGGTAATACCGGTATTGCGCTGGCCTATGTG
GCGGCCGCCCGAGGGTATGACCTGGTGCTCACCATGCCGGATTCCATGAGCTTAGAGCGTCGCAAGATCCTCAAGGCGCT
GGGCGCCAAACTGGTACTTACCCCGGGCCCTAAAGGCATGCCCGGTGCCATCGCCAAGGCCGAAGAGCTGGTGCAGGAAA
GCCCGGATACCCACTTGATGCTGCAACAGTTCGACAACCCGGCGAACCCGGCTATTCATGAAAAAACCACCGGCCCGGAA
ATCTGGGAAGATACTGGTGGGGATATTGATGTACTGGTATGTGGGGTGGGCACCGGCGGTACCATCACCGGTGTCGCCCG
CTATCTTAAGAATACTCAGGGTAAAGCCATCACCGCTGTTGCCGTGGAGCCAGATTCTTCCACGATGATCTCTGCTGCTT
TAAAAGGCGAAGAGCCGACCCACGGGCCCCATAAAATTCAGGGAATCGGCGCAGGTTTCGTGCCCCAGAATTTAGATATC
TCGGTTGTGGACCGGGCGGAGCAGGTCAACAACGAAGACGCCATGGCGTGGGCGCACAAGCTAATGCAGGAAGAAGGTAT
TCTGGCGGGTATTTCCTGTGGCGCTGCCATGTGCGTGGCAGATCGCCTTAGCCAGCAGCCCGAATTTGCCGGCAAGACCA
TTGTGGTGGTGCTGCCAGATTCCGGCGAACGTTACCTCAGTTCACCTCTGTTTGCGGATACCTTCACCGCACAAGAGCTT
GGGCAGTAG

Upstream 100 bases:

>100_bases
TGCGTTTGTATGCGCGCCAGCGTTGGAACCGGCGGCTGAAAAAGCAGGATAAACCGCAGTAAGCCATTGTGCGCCATGCG
CCAAGAACGGAGAGATCAAT

Downstream 100 bases:

>100_bases
CGGCAAAGCGAGCCTTGGGAGAATGTGAGATTGCGCCGGATTCGTTGTAACCGGCCATGCTCTGGCGGTTGAAGGTTGAA
GGTTGAAGGCGCCGCCGCTC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine sulfhydrylase A; Sulfate starvation-induced protein 5; SSI5 [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTRIYQDNSETIGNTPLVKINRISQGNILAKIESRNPAGSVKCRIGASMVQDAEKSGKLKPGMTLVEPTSGNTGIALAYV
AAARGYDLVLTMPDSMSLERRKILKALGAKLVLTPGPKGMPGAIAKAEELVQESPDTHLMLQQFDNPANPAIHEKTTGPE
IWEDTGGDIDVLVCGVGTGGTITGVARYLKNTQGKAITAVAVEPDSSTMISAALKGEEPTHGPHKIQGIGAGFVPQNLDI
SVVDRAEQVNNEDAMAWAHKLMQEEGILAGISCGAAMCVADRLSQQPEFAGKTIVVVLPDSGERYLSSPLFADTFTAQEL
GQ

Sequences:

>Translated_322_residues
MTRIYQDNSETIGNTPLVKINRISQGNILAKIESRNPAGSVKCRIGASMVQDAEKSGKLKPGMTLVEPTSGNTGIALAYV
AAARGYDLVLTMPDSMSLERRKILKALGAKLVLTPGPKGMPGAIAKAEELVQESPDTHLMLQQFDNPANPAIHEKTTGPE
IWEDTGGDIDVLVCGVGTGGTITGVARYLKNTQGKAITAVAVEPDSSTMISAALKGEEPTHGPHKIQGIGAGFVPQNLDI
SVVDRAEQVNNEDAMAWAHKLMQEEGILAGISCGAAMCVADRLSQQPEFAGKTIVVVLPDSGERYLSSPLFADTFTAQEL
GQ
>Mature_321_residues
TRIYQDNSETIGNTPLVKINRISQGNILAKIESRNPAGSVKCRIGASMVQDAEKSGKLKPGMTLVEPTSGNTGIALAYVA
AARGYDLVLTMPDSMSLERRKILKALGAKLVLTPGPKGMPGAIAKAEELVQESPDTHLMLQQFDNPANPAIHEKTTGPEI
WEDTGGDIDVLVCGVGTGGTITGVARYLKNTQGKAITAVAVEPDSSTMISAALKGEEPTHGPHKIQGIGAGFVPQNLDIS
VVDRAEQVNNEDAMAWAHKLMQEEGILAGISCGAAMCVADRLSQQPEFAGKTIVVVLPDSGERYLSSPLFADTFTAQELG
Q

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=329, Percent_Identity=40.7294832826748, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI295821200, Length=329, Percent_Identity=40.7294832826748, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI4557415, Length=329, Percent_Identity=40.7294832826748, Blast_Score=220, Evalue=1e-57,
Organism=Escherichia coli, GI1788754, Length=323, Percent_Identity=66.5634674922601, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI2367138, Length=315, Percent_Identity=41.2698412698413, Blast_Score=221, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17535051, Length=308, Percent_Identity=49.3506493506493, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI115535073, Length=314, Percent_Identity=52.2292993630573, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17562970, Length=321, Percent_Identity=47.9750778816199, Blast_Score=281, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI32566674, Length=312, Percent_Identity=49.0384615384615, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17561720, Length=315, Percent_Identity=47.3015873015873, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI32566672, Length=225, Percent_Identity=45.7777777777778, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17534315, Length=329, Percent_Identity=38.9057750759878, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25147552, Length=324, Percent_Identity=36.4197530864198, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17561716, Length=126, Percent_Identity=41.2698412698413, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321594, Length=321, Percent_Identity=37.6947040498442, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=35.9756097560976, Blast_Score=139, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=38.8349514563107, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=38.8349514563107, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33989; Mature: 33858

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIYQDNSETIGNTPLVKINRISQGNILAKIESRNPAGSVKCRIGASMVQDAEKSGKLK
CCEEECCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCEEEEECHHHHHHHHHCCCCC
PGMTLVEPTSGNTGIALAYVAAARGYDLVLTMPDSMSLERRKILKALGAKLVLTPGPKGM
CCCEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCC
PGAIAKAEELVQESPDTHLMLQQFDNPANPAIHEKTTGPEIWEDTGGDIDVLVCGVGTGG
CCHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCC
TITGVARYLKNTQGKAITAVAVEPDSSTMISAALKGEEPTHGPHKIQGIGAGFVPQNLDI
HHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCE
SVVDRAEQVNNEDAMAWAHKLMQEEGILAGISCGAAMCVADRLSQQPEFAGKTIVVVLPD
EEECHHHHCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEEEECC
SGERYLSSPLFADTFTAQELGQ
CCCHHHCCCCCCCCCCHHHHCC
>Mature Secondary Structure 
TRIYQDNSETIGNTPLVKINRISQGNILAKIESRNPAGSVKCRIGASMVQDAEKSGKLK
CEEECCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCEEEEECHHHHHHHHHCCCCC
PGMTLVEPTSGNTGIALAYVAAARGYDLVLTMPDSMSLERRKILKALGAKLVLTPGPKGM
CCCEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCC
PGAIAKAEELVQESPDTHLMLQQFDNPANPAIHEKTTGPEIWEDTGGDIDVLVCGVGTGG
CCHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCC
TITGVARYLKNTQGKAITAVAVEPDSSTMISAALKGEEPTHGPHKIQGIGAGFVPQNLDI
HHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCE
SVVDRAEQVNNEDAMAWAHKLMQEEGILAGISCGAAMCVADRLSQQPEFAGKTIVVVLPD
EEECHHHHCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEEEECC
SGERYLSSPLFADTFTAQELGQ
CCCHHHCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]