Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 110833806

GI number: 110833806

Start: 1059637

End: 1061652

Strand: Direct

Name: uvrB [H]

Synonym: ABO_0945

Alternate gene names: 110833806

Gene position: 1059637-1061652 (Clockwise)

Preceding gene: 110833801

Following gene: 110833808

Centisome position: 33.96

GC content: 56.3

Gene sequence:

>2016_bases
ATGTCTGAAAGCCTCTTCAAACTCCATTCCGACTACCAGCCCGCCGGTGATCAGCCCACCGCCATTGCGCAGCTGATTGA
GGGTATTGATGATGGCCTAGGCCACCAGACGCTGCTGGGGGTGACCGGTTCGGGTAAGACGTTCACCATGGCAAATGTGA
TTGCGCAAACGGGCCGGCCCACCATCATCATGGCGCCGAACAAGACGCTGGCTGCTCAGTTGTACGGGGAGTTTCGAGAG
TTTTTCCCCGAAAACGCGGTGGAGTATTTTGTTTCTTACTACGATTACTATCAGCCGGAAGCCTATGTGCCCAGCTCCGA
TACGTTTATCGAGAAAGATGCCTCGGTGAATGAGCAGATCGAGCAAATGCGACTGTCTGCCACCAAGGCGATATTGGAAC
GACCGGACACCATTATCGTGGCCACCGTGTCGGCCATTTACGGGCTGGGTGATCCCGCCAGTTACCACGCCATGGTGCTG
CATTTAGTGCGCGGCGATCATATCGATCAGCGTGAGCTGTTGCGACGGTTGGCGGAGCTGCAGTACACCCGTAACGAGAT
GGATTTTCGCCGCGCCACTTACCGAGTGCGTGGGGATGTGATTGATATCTTCCCGGCGGAAGAGGAAAAGGAAGCGGTTC
GTATTGAGCTGTTCGATGATGAGGTGGAATCCATCAGCATCTTTGATCCTCTTACCGGTGAGGTGATTCGTCGTATTAGC
CGCACCACCATCTACCCCAAGAGCCATTACGTGACGCCAAGGGAAACCGTGCTCAAGGCGGTGGAGATGATTAAGGAAGA
GTTGGCCGAGCGGCTGGCCGAACTTAAGGAGCAGAACAAGCTGGTGGAAGCCCAGCGGTTGGAGCAGCGCACCCGCTTTG
ACATTGAAATGCTGCAGGAGCTGGGTTATTGCAATGGAGTAGAAAACTACTCCCGGTTGTTTTCTGGTCGTGCCCCCGGC
GATGCTCCGCCCACCCTGTTTGATTACCTGCCGGACAATGCGCTGCTGATTGCCGATGAGTCCCACGTCACCATTCCCCA
GTTGGGCGCCATGTATAAGGGCGACCGCTCGCGTAAAGAAACCCTGGTAAGTTTCGGGTTCCGGTTGCCCTCTGCCATGG
ATAACCGGCCACTGAAGTTTGAGGAATGGGAGCTGCTGGCGCCACAAATGGTCTTTGTGTCTGCTACTCCAGGGCCCTAT
GAGAAGAAATACGCTGGGCAGGTGGTGGAGCAGGTGGTGCGCCCCACCGGCCTGGTGGACCCGAAAATCGAGATCCGTCC
GGCGACCACTCAGGTGGATGATCTGCTCGGCGAAGCCAAGGAATGCATTGCCAAAGAGCAGCGGGTGTTGGTGACCACGC
TGACCAAGCGCATGGCAGAGGATCTCACTGAATACCTGAATGAGCATGGTATTCGGGTGCGTTATCTGCATTCCGATATT
GATACAGTGGAGCGAGTGGAAATTATTCGCGATCTGCGCTTGGGCAAGTTCGATGTGCTGGTGGGGATTAACTTGCTGCG
TGAAGGGCTGGACATGCCAGAAGTGGCGCTGGTGGCGATTCTGGATGCGGACAAGGAGGGCTTTCTGCGCTCCGACCGGT
CACTGATCCAGACCATCGGCCGGGCTGCCCGGAATGTGGATGGCCGCGCGATTCTCTATGCGGACAAGATGACCGGCTCC
ATGGAGCGGGCTATCGACGAGACGGATCGTCGTCGCGAGAAGCAGGAGGCCTTCAATGAGGCCAATGGCATCACCCCGCA
AGGGCTGAATAAGAAGATTCGTGACATTATGGATGACAGCGGTGGCAGCCGTTTTGATCGCAAGTACAAGGGCGAAAAGA
AAGTGGCCGAGTCTCCGTCGGATTATCTGGGTGCCCGCTCACCGGCGCAAGTGGCCAAGGAAATCAAAGCGCTGGAAGCG
AAGATGATGGAACATGCCAAGAACCTGGAGTTCGAGGATGCCGCCGCCACCCGTGACAAGATTCACCAGCTCAGAGAGCT
GGGTTTTATGCGCTAG

Upstream 100 bases:

>100_bases
ATTTGATCTGCTGGCTCTGGTACACTACCCGGTGATTTTGCACGCATGACTTTTGCTGTTTTCCCGTCGTCGGGAGGGCA
GTAGCCATCAGGAAGCCCAA

Downstream 100 bases:

>100_bases
AGATACCCGTTGTGGGTAGCCGCCAACCCTTTGTGTATTGACACCTTCACTGTTACACAATCGCCCATCTTCCCACGGTG
CGAACCCGAGCCTTGGTCAG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MSESLFKLHSDYQPAGDQPTAIAQLIEGIDDGLGHQTLLGVTGSGKTFTMANVIAQTGRPTIIMAPNKTLAAQLYGEFRE
FFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEQIEQMRLSATKAILERPDTIIVATVSAIYGLGDPASYHAMVL
HLVRGDHIDQRELLRRLAELQYTRNEMDFRRATYRVRGDVIDIFPAEEEKEAVRIELFDDEVESISIFDPLTGEVIRRIS
RTTIYPKSHYVTPRETVLKAVEMIKEELAERLAELKEQNKLVEAQRLEQRTRFDIEMLQELGYCNGVENYSRLFSGRAPG
DAPPTLFDYLPDNALLIADESHVTIPQLGAMYKGDRSRKETLVSFGFRLPSAMDNRPLKFEEWELLAPQMVFVSATPGPY
EKKYAGQVVEQVVRPTGLVDPKIEIRPATTQVDDLLGEAKECIAKEQRVLVTTLTKRMAEDLTEYLNEHGIRVRYLHSDI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSDRSLIQTIGRAARNVDGRAILYADKMTGS
MERAIDETDRRREKQEAFNEANGITPQGLNKKIRDIMDDSGGSRFDRKYKGEKKVAESPSDYLGARSPAQVAKEIKALEA
KMMEHAKNLEFEDAAATRDKIHQLRELGFMR

Sequences:

>Translated_671_residues
MSESLFKLHSDYQPAGDQPTAIAQLIEGIDDGLGHQTLLGVTGSGKTFTMANVIAQTGRPTIIMAPNKTLAAQLYGEFRE
FFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEQIEQMRLSATKAILERPDTIIVATVSAIYGLGDPASYHAMVL
HLVRGDHIDQRELLRRLAELQYTRNEMDFRRATYRVRGDVIDIFPAEEEKEAVRIELFDDEVESISIFDPLTGEVIRRIS
RTTIYPKSHYVTPRETVLKAVEMIKEELAERLAELKEQNKLVEAQRLEQRTRFDIEMLQELGYCNGVENYSRLFSGRAPG
DAPPTLFDYLPDNALLIADESHVTIPQLGAMYKGDRSRKETLVSFGFRLPSAMDNRPLKFEEWELLAPQMVFVSATPGPY
EKKYAGQVVEQVVRPTGLVDPKIEIRPATTQVDDLLGEAKECIAKEQRVLVTTLTKRMAEDLTEYLNEHGIRVRYLHSDI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSDRSLIQTIGRAARNVDGRAILYADKMTGS
MERAIDETDRRREKQEAFNEANGITPQGLNKKIRDIMDDSGGSRFDRKYKGEKKVAESPSDYLGARSPAQVAKEIKALEA
KMMEHAKNLEFEDAAATRDKIHQLRELGFMR
>Mature_670_residues
SESLFKLHSDYQPAGDQPTAIAQLIEGIDDGLGHQTLLGVTGSGKTFTMANVIAQTGRPTIIMAPNKTLAAQLYGEFREF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEQIEQMRLSATKAILERPDTIIVATVSAIYGLGDPASYHAMVLH
LVRGDHIDQRELLRRLAELQYTRNEMDFRRATYRVRGDVIDIFPAEEEKEAVRIELFDDEVESISIFDPLTGEVIRRISR
TTIYPKSHYVTPRETVLKAVEMIKEELAERLAELKEQNKLVEAQRLEQRTRFDIEMLQELGYCNGVENYSRLFSGRAPGD
APPTLFDYLPDNALLIADESHVTIPQLGAMYKGDRSRKETLVSFGFRLPSAMDNRPLKFEEWELLAPQMVFVSATPGPYE
KKYAGQVVEQVVRPTGLVDPKIEIRPATTQVDDLLGEAKECIAKEQRVLVTTLTKRMAEDLTEYLNEHGIRVRYLHSDID
TVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSDRSLIQTIGRAARNVDGRAILYADKMTGSM
ERAIDETDRRREKQEAFNEANGITPQGLNKKIRDIMDDSGGSRFDRKYKGEKKVAESPSDYLGARSPAQVAKEIKALEAK
MMEHAKNLEFEDAAATRDKIHQLRELGFMR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=70.4819277108434, Blast_Score=945, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=309, Percent_Identity=21.6828478964401, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76063; Mature: 75932

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESLFKLHSDYQPAGDQPTAIAQLIEGIDDGLGHQTLLGVTGSGKTFTMANVIAQTGRP
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHHHHHHHCCCC
TIIMAPNKTLAAQLYGEFREFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEQI
EEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
EQMRLSATKAILERPDTIIVATVSAIYGLGDPASYHAMVLHLVRGDHIDQRELLRRLAEL
HHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QYTRNEMDFRRATYRVRGDVIDIFPAEEEKEAVRIELFDDEVESISIFDPLTGEVIRRIS
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCCCEEEECCCHHHHHHHHHH
RTTIYPKSHYVTPRETVLKAVEMIKEELAERLAELKEQNKLVEAQRLEQRTRFDIEMLQE
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGYCNGVENYSRLFSGRAPGDAPPTLFDYLPDNALLIADESHVTIPQLGAMYKGDRSRKE
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCHHHH
TLVSFGFRLPSAMDNRPLKFEEWELLAPQMVFVSATPGPYEKKYAGQVVEQVVRPTGLVD
HHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
PKIEIRPATTQVDDLLGEAKECIAKEQRVLVTTLTKRMAEDLTEYLNEHGIRVRYLHSDI
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCH
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSDRSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHH
RAARNVDGRAILYADKMTGSMERAIDETDRRREKQEAFNEANGITPQGLNKKIRDIMDDS
HHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
GGSRFDRKYKGEKKVAESPSDYLGARSPAQVAKEIKALEAKMMEHAKNLEFEDAAATRDK
CCCCHHHHHCCCHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
IHQLRELGFMR
HHHHHHHCCCC
>Mature Secondary Structure 
SESLFKLHSDYQPAGDQPTAIAQLIEGIDDGLGHQTLLGVTGSGKTFTMANVIAQTGRP
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHHHHHHHCCCC
TIIMAPNKTLAAQLYGEFREFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEQI
EEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
EQMRLSATKAILERPDTIIVATVSAIYGLGDPASYHAMVLHLVRGDHIDQRELLRRLAEL
HHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QYTRNEMDFRRATYRVRGDVIDIFPAEEEKEAVRIELFDDEVESISIFDPLTGEVIRRIS
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCCCEEEECCCHHHHHHHHHH
RTTIYPKSHYVTPRETVLKAVEMIKEELAERLAELKEQNKLVEAQRLEQRTRFDIEMLQE
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGYCNGVENYSRLFSGRAPGDAPPTLFDYLPDNALLIADESHVTIPQLGAMYKGDRSRKE
CCCCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCHHHH
TLVSFGFRLPSAMDNRPLKFEEWELLAPQMVFVSATPGPYEKKYAGQVVEQVVRPTGLVD
HHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
PKIEIRPATTQVDDLLGEAKECIAKEQRVLVTTLTKRMAEDLTEYLNEHGIRVRYLHSDI
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCH
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSDRSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHH
RAARNVDGRAILYADKMTGSMERAIDETDRRREKQEAFNEANGITPQGLNKKIRDIMDDS
HHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
GGSRFDRKYKGEKKVAESPSDYLGARSPAQVAKEIKALEAKMMEHAKNLEFEDAAATRDK
CCCCHHHHHCCCHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
IHQLRELGFMR
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8808952; 10984043; 8939432 [H]