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The map label for this gene is rmlA [H]

Identifier: 110833774

GI number: 110833774

Start: 1021035

End: 1021919

Strand: Direct

Name: rmlA [H]

Synonym: ABO_0913

Alternate gene names: 110833774

Gene position: 1021035-1021919 (Clockwise)

Preceding gene: 110833773

Following gene: 110833775

Centisome position: 32.72

GC content: 55.37

Gene sequence:

>885_bases
ATGACTGCAACCAACCGTAAAGGCATCATTCTGGCCGGAGGCTCCGGCACACGCCTGTATCCACTCACCATTGGTGTGTC
CAAGCAGCTACTGCCCATCTACGACAAGCCCATGATCTATTACCCGCTGTCAGTATTGATGCTGGCGGGTATCCGCGAAG
TGCTGATCATCACCACCCCGGAAGATCAGGCCGGCTTCCAGCGCCTGCTGGGCGATGGCAGTCAGTTCGGTATCGAGCTC
ACCTATGCCATCCAGCCAAGCCCGGATGGCCTGGCCCAGGCCTTTATCATTGGCGAAGAGTTCATCGGCGATGCGCCGGT
GTGCTTGGTGTTGGGCGACAACATCTATCACGGCCCAGGTTTGTCGCAACTACTCAAGAACGCAAATGCCCAGCAAAGCG
GCGCCACCGTCTTTGGCTATCACGTCTCCGATCCGGAGCGTTTTGGGGTAGTGGAGTTCGATGAAAACAAGCGCGCGGTG
TCCATCGAAGAGAAGCCTGCAAAGCCCAAATCCAATTACGCCGTTACTGGTCTCTATTTCTACGACAACGATGTGGTCGA
GATCGCCAAGCAGGTAAAACCATCAAACAGAGGTGAGCTGGAAATCACCACCGTAAACCAGATGTACCTCGATCGTGGCG
ACCTCAACGTAGAACTGCTCGGTCGTGGCTACGCCTGGCTGGATACCGGCACTTTCGATTCCCTGCATGAAGCCGCGGGC
TATATCGAAACCCTGGAAAAGCGCCAGGGCCTGAAAGTGGCCTGCCTGGAAGAAATTGCCTACCGCATGGGCTTTATCAG
CAAGGCGCAGCTAAAGGAGCAGGCCGAACTGCTCAAGAAGAACAGTTACGGTGCCTATCTGGTGAAGTTAGTGGAGCAGG
AATAA

Upstream 100 bases:

>100_bases
GTGCTGTAATCGCTTCTATCTTGGCTGGCGCTATTTACTACAAACTTTGGGAAAAGCCGGTTCTGGCCCTCTCCCGAAAA
TGGATCAAAAAGGGTTAGTT

Downstream 100 bases:

>100_bases
TCATGGAAGTGATTGAAACCCGTATTCCAGAGGTAAAGCTCATCAAGCCGAAAGTGTTTGGCGATGAGCGTGGCTTCTTC
ATGGAAACCTGGAATGCACG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTATNRKGIILAGGSGTRLYPLTIGVSKQLLPIYDKPMIYYPLSVLMLAGIREVLIITTPEDQAGFQRLLGDGSQFGIEL
TYAIQPSPDGLAQAFIIGEEFIGDAPVCLVLGDNIYHGPGLSQLLKNANAQQSGATVFGYHVSDPERFGVVEFDENKRAV
SIEEKPAKPKSNYAVTGLYFYDNDVVEIAKQVKPSNRGELEITTVNQMYLDRGDLNVELLGRGYAWLDTGTFDSLHEAAG
YIETLEKRQGLKVACLEEIAYRMGFISKAQLKEQAELLKKNSYGAYLVKLVEQE

Sequences:

>Translated_294_residues
MTATNRKGIILAGGSGTRLYPLTIGVSKQLLPIYDKPMIYYPLSVLMLAGIREVLIITTPEDQAGFQRLLGDGSQFGIEL
TYAIQPSPDGLAQAFIIGEEFIGDAPVCLVLGDNIYHGPGLSQLLKNANAQQSGATVFGYHVSDPERFGVVEFDENKRAV
SIEEKPAKPKSNYAVTGLYFYDNDVVEIAKQVKPSNRGELEITTVNQMYLDRGDLNVELLGRGYAWLDTGTFDSLHEAAG
YIETLEKRQGLKVACLEEIAYRMGFISKAQLKEQAELLKKNSYGAYLVKLVEQE
>Mature_293_residues
TATNRKGIILAGGSGTRLYPLTIGVSKQLLPIYDKPMIYYPLSVLMLAGIREVLIITTPEDQAGFQRLLGDGSQFGIELT
YAIQPSPDGLAQAFIIGEEFIGDAPVCLVLGDNIYHGPGLSQLLKNANAQQSGATVFGYHVSDPERFGVVEFDENKRAVS
IEEKPAKPKSNYAVTGLYFYDNDVVEIAKQVKPSNRGELEITTVNQMYLDRGDLNVELLGRGYAWLDTGTFDSLHEAAGY
IETLEKRQGLKVACLEEIAYRMGFISKAQLKEQAELLKKNSYGAYLVKLVEQE

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=71.9298245614035, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1788351, Length=287, Percent_Identity=68.2926829268293, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1787488, Length=252, Percent_Identity=23.8095238095238, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788355, Length=238, Percent_Identity=23.9495798319328, Blast_Score=67, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=183, Percent_Identity=27.3224043715847, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=276, Percent_Identity=25.7246376811594, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=250, Percent_Identity=26.8, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24644084, Length=250, Percent_Identity=26.8, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32396; Mature: 32265

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATNRKGIILAGGSGTRLYPLTIGVSKQLLPIYDKPMIYYPLSVLMLAGIREVLIITTP
CCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECC
EDQAGFQRLLGDGSQFGIELTYAIQPSPDGLAQAFIIGEEFIGDAPVCLVLGDNIYHGPG
CCHHHHHHHHCCCCEEEEEEEEEECCCCCCHHEEEEECHHHCCCCCEEEEECCCCCCCCC
LSQLLKNANAQQSGATVFGYHVSDPERFGVVEFDENKRAVSIEEKPAKPKSNYAVTGLYF
HHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEE
YDNDVVEIAKQVKPSNRGELEITTVNQMYLDRGDLNVELLGRGYAWLDTGTFDSLHEAAG
ECCHHHHHHHHCCCCCCCEEEEEEEHEEEECCCCCEEEEEECCEEEEECCCHHHHHHHHH
YIETLEKRQGLKVACLEEIAYRMGFISKAQLKEQAELLKKNSYGAYLVKLVEQE
HHHHHHHHCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEECCC
>Mature Secondary Structure 
TATNRKGIILAGGSGTRLYPLTIGVSKQLLPIYDKPMIYYPLSVLMLAGIREVLIITTP
CCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECC
EDQAGFQRLLGDGSQFGIELTYAIQPSPDGLAQAFIIGEEFIGDAPVCLVLGDNIYHGPG
CCHHHHHHHHCCCCEEEEEEEEEECCCCCCHHEEEEECHHHCCCCCEEEEECCCCCCCCC
LSQLLKNANAQQSGATVFGYHVSDPERFGVVEFDENKRAVSIEEKPAKPKSNYAVTGLYF
HHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEE
YDNDVVEIAKQVKPSNRGELEITTVNQMYLDRGDLNVELLGRGYAWLDTGTFDSLHEAAG
ECCHHHHHHHHCCCCCCCEEEEEEEHEEEECCCCCEEEEEECCEEEEECCCHHHHHHHHH
YIETLEKRQGLKVACLEEIAYRMGFISKAQLKEQAELLKKNSYGAYLVKLVEQE
HHHHHHHHCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]