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The map label for this gene is murC

Identifier: 110833460

GI number: 110833460

Start: 657047

End: 658471

Strand: Direct

Name: murC

Synonym: ABO_0599

Alternate gene names: 110833460

Gene position: 657047-658471 (Clockwise)

Preceding gene: 110833459

Following gene: 110833461

Centisome position: 21.06

GC content: 59.51

Gene sequence:

>1425_bases
ATGGCCGATAACGACATTATTCATACGGTGCCGGAGATGCGCCGCATTCGCGGTATCCACTTTGTGGGTATCGGCGGTGT
GGGCATGTGCGGCATTGCGGAAGTGCTGGCCAACCAGGGTTATGCCATCAGCGGCAGCGACATTAAGGAATCGCCGGTGC
TAGAGCGTCTGCGCAGCCTGGGTGTGAGAGTGGACATTGGCCACCGTGCCGAGAATATCGATGGTGCAGATGTGGTGGTG
ACCTCCACCGCGGTGAATACCGAGAACCTGGAAGTGGCGGCGGCCCACGAGCGCCGTATTCCGGTGGTGCCACGGGCTCA
GATGTTGGCGGAGTTAATGCGCTTTCGTCACGGTATCGCGGTGGCCGGCACCCACGGCAAGACCACCACTACGTCATTAA
CCGCAGCGATCATGGCGGAGGCAGGGCTGGACCCGACCTTTGTGATTGGTGGCCGTTTGAATAGCGCGGGCACCAATGCG
CGCCTGGGACAGAGCCGTTATCTGGTGGCGGAAGCGGATGAGTCCGATGCCAGTTTCCTGCACTTGCAGCCCATGAGCGC
CATCGTCACTAATGTTGATGCGGATCACATGCACACCTACGGCGGCGATTTCGCTCAGCTGGAGAATACCTTTATCGAGT
TTCTTCACAACCTGCCGTTCTACGGTGTGGCGGTGATGTGTGTGGATGATCCGGTGGTGCGCAAGCTGCTGCCCCGGGTC
AATCGTCAGGTGATTCGATATGGCTTCAGCGAGGATGCAGACCTACGTGCGGAGAACGTGCGTCAGGACGGCATGGTGAC
TCATTTCCGGGTGGTGCGCGCGGAAGGCGAGCCCCTGGACGTGTCGCTAAATATGCCCGGACGCCATAACGTGCTTAATG
CGCTGGCCGCTATTGCGGTGTCGGCGGATGAGGGTGCGGGCGACGAGGCCATTATCCGTGGCCTGAACAACTTTACCGGA
GTGGGACGTCGCTTTGACGTGCAAGGCGATTATCACTTTGACGGCGGCAGCGCGACGCTGGTGGATGACTACGGTCACCA
TCCCCGTGAGGTGGCTGCCACCATTGATGCCATTCGTGAAGGCTGGCCGGGCCGTCGCCTAGCCATGCTGTTTCAGCCTC
ACCGTTATACCCGTACCCAAGACCTTTACGAGGACTTCGTGGAAGTATTGTCCGGTGTGGATGTATTGCTGATGTTAGAA
GTGTATGCCGCTGGGGAAGAACCGATTCCCGGTGCTGACGCCCGTGCTTTGTGTCGCAGTCTGCGCAAGCGCGGGCTGGA
GCCTGTGTTTGTGGATGACCCGGACAAGCTGCAAGGCTTGTTGGCCAGCCAGCTTCAGAATGGCGATCTGCTCGTCACCC
AAGGCGCGGGTAATGTCGGTGCCATCGCCAAGCAGTTGGTTGCTCAGGGAGGCGGCCATGGATAA

Upstream 100 bases:

>100_bases
GCAGAGCGTGGCCTGTTGGCGCAAATCGCCGAGCGGGCCCGTGAGCAGGCGATGGCGGATAGTGCAGAGCGCGCCGCCAC
GCTGTGTGAGGAGGTGGCCA

Downstream 100 bases:

>100_bases
GCGTGCATTGAAAGAACGATTGAGCCGAGTAGGCCGCGTGGCAGTGCTGGCTGGTGGTCGATCTGCAGAACGCGCTGTGT
CGCTGAAGAGCGGTGCTGCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MADNDIIHTVPEMRRIRGIHFVGIGGVGMCGIAEVLANQGYAISGSDIKESPVLERLRSLGVRVDIGHRAENIDGADVVV
TSTAVNTENLEVAAAHERRIPVVPRAQMLAELMRFRHGIAVAGTHGKTTTTSLTAAIMAEAGLDPTFVIGGRLNSAGTNA
RLGQSRYLVAEADESDASFLHLQPMSAIVTNVDADHMHTYGGDFAQLENTFIEFLHNLPFYGVAVMCVDDPVVRKLLPRV
NRQVIRYGFSEDADLRAENVRQDGMVTHFRVVRAEGEPLDVSLNMPGRHNVLNALAAIAVSADEGAGDEAIIRGLNNFTG
VGRRFDVQGDYHFDGGSATLVDDYGHHPREVAATIDAIREGWPGRRLAMLFQPHRYTRTQDLYEDFVEVLSGVDVLLMLE
VYAAGEEPIPGADARALCRSLRKRGLEPVFVDDPDKLQGLLASQLQNGDLLVTQGAGNVGAIAKQLVAQGGGHG

Sequences:

>Translated_474_residues
MADNDIIHTVPEMRRIRGIHFVGIGGVGMCGIAEVLANQGYAISGSDIKESPVLERLRSLGVRVDIGHRAENIDGADVVV
TSTAVNTENLEVAAAHERRIPVVPRAQMLAELMRFRHGIAVAGTHGKTTTTSLTAAIMAEAGLDPTFVIGGRLNSAGTNA
RLGQSRYLVAEADESDASFLHLQPMSAIVTNVDADHMHTYGGDFAQLENTFIEFLHNLPFYGVAVMCVDDPVVRKLLPRV
NRQVIRYGFSEDADLRAENVRQDGMVTHFRVVRAEGEPLDVSLNMPGRHNVLNALAAIAVSADEGAGDEAIIRGLNNFTG
VGRRFDVQGDYHFDGGSATLVDDYGHHPREVAATIDAIREGWPGRRLAMLFQPHRYTRTQDLYEDFVEVLSGVDVLLMLE
VYAAGEEPIPGADARALCRSLRKRGLEPVFVDDPDKLQGLLASQLQNGDLLVTQGAGNVGAIAKQLVAQGGGHG
>Mature_473_residues
ADNDIIHTVPEMRRIRGIHFVGIGGVGMCGIAEVLANQGYAISGSDIKESPVLERLRSLGVRVDIGHRAENIDGADVVVT
STAVNTENLEVAAAHERRIPVVPRAQMLAELMRFRHGIAVAGTHGKTTTTSLTAAIMAEAGLDPTFVIGGRLNSAGTNAR
LGQSRYLVAEADESDASFLHLQPMSAIVTNVDADHMHTYGGDFAQLENTFIEFLHNLPFYGVAVMCVDDPVVRKLLPRVN
RQVIRYGFSEDADLRAENVRQDGMVTHFRVVRAEGEPLDVSLNMPGRHNVLNALAAIAVSADEGAGDEAIIRGLNNFTGV
GRRFDVQGDYHFDGGSATLVDDYGHHPREVAATIDAIREGWPGRRLAMLFQPHRYTRTQDLYEDFVEVLSGVDVLLMLEV
YAAGEEPIPGADARALCRSLRKRGLEPVFVDDPDKLQGLLASQLQNGDLLVTQGAGNVGAIAKQLVAQGGGHG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=463, Percent_Identity=63.4989200863931, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=26.8817204301075, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_ALCBS (Q0VS01)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692319.1
- ProteinModelPortal:   Q0VS01
- SMR:   Q0VS01
- STRING:   Q0VS01
- GeneID:   4211241
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0599
- NMPDR:   fig|393595.12.peg.597
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q0VS01
- BioCyc:   ABOR393595:ABO_0599-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51162; Mature: 51030

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNDIIHTVPEMRRIRGIHFVGIGGVGMCGIAEVLANQGYAISGSDIKESPVLERLRSL
CCCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHC
GVRVDIGHRAENIDGADVVVTSTAVNTENLEVAAAHERRIPVVPRAQMLAELMRFRHGIA
CCEEEECCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCEE
VAGTHGKTTTTSLTAAIMAEAGLDPTFVIGGRLNSAGTNARLGQSRYLVAEADESDASFL
EEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEE
HLQPMSAIVTNVDADHMHTYGGDFAQLENTFIEFLHNLPFYGVAVMCVDDPVVRKLLPRV
EECHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHH
NRQVIRYGFSEDADLRAENVRQDGMVTHFRVVRAEGEPLDVSLNMPGRHNVLNALAAIAV
HHHHHHCCCCCCCCCCHHHHCCCCCEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHEE
SADEGAGDEAIIRGLNNFTGVGRRFDVQGDYHFDGGSATLVDDYGHHPREVAATIDAIRE
ECCCCCCHHHHHHHCHHHCCCCCEEECCCCEEECCCCEEEECCCCCCHHHHHHHHHHHHC
GWPGRRLAMLFQPHRYTRTQDLYEDFVEVLSGVDVLLMLEVYAAGEEPIPGADARALCRS
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
LRKRGLEPVFVDDPDKLQGLLASQLQNGDLLVTQGAGNVGAIAKQLVAQGGGHG
HHHCCCCEEECCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ADNDIIHTVPEMRRIRGIHFVGIGGVGMCGIAEVLANQGYAISGSDIKESPVLERLRSL
CCCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHC
GVRVDIGHRAENIDGADVVVTSTAVNTENLEVAAAHERRIPVVPRAQMLAELMRFRHGIA
CCEEEECCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCEE
VAGTHGKTTTTSLTAAIMAEAGLDPTFVIGGRLNSAGTNARLGQSRYLVAEADESDASFL
EEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEE
HLQPMSAIVTNVDADHMHTYGGDFAQLENTFIEFLHNLPFYGVAVMCVDDPVVRKLLPRV
EECHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHH
NRQVIRYGFSEDADLRAENVRQDGMVTHFRVVRAEGEPLDVSLNMPGRHNVLNALAAIAV
HHHHHHCCCCCCCCCCHHHHCCCCCEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHEE
SADEGAGDEAIIRGLNNFTGVGRRFDVQGDYHFDGGSATLVDDYGHHPREVAATIDAIRE
ECCCCCCHHHHHHHCHHHCCCCCEEECCCCEEECCCCEEEECCCCCCHHHHHHHHHHHHC
GWPGRRLAMLFQPHRYTRTQDLYEDFVEVLSGVDVLLMLEVYAAGEEPIPGADARALCRS
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
LRKRGLEPVFVDDPDKLQGLLASQLQNGDLLVTQGAGNVGAIAKQLVAQGGGHG
HHHCCCCEEECCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA