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The map label for this gene is pcaR [H]

Identifier: 110635971

GI number: 110635971

Start: 3938122

End: 3938919

Strand: Reverse

Name: pcaR [H]

Synonym: Meso_3645

Alternate gene names: 110635971

Gene position: 3938919-3938122 (Counterclockwise)

Preceding gene: 110635974

Following gene: 110635970

Centisome position: 89.27

GC content: 62.91

Gene sequence:

>798_bases
TTGAGCGCTCGCGATCCATTGATGGTGAAGTCGGTCGAGAAAGCGGTGCGCATTCTCGGCGCCTTCAGCAACGGACAACC
GACAATGAGCCTGGCCGATGTGGCTGCGCTGACGGGGTTAGACAAGAGCGGATCTCAGCGCTTTACGCACACGCTGGTGC
AGCTTGGCTTGCTGCGCAAGGATCCGGACACGAAGCGGTTCGAGCTGACCGCTCGCGTGCTTGAGTTCGGCGCCAACTTC
ACGCGCAGCAACGAACTCGTGCGCGCGGCGGCCCCCCACCTGCTGAACCTGTCCAAGACGACGGAAGAGGCCGTCAGCTT
GACCGTCCTGGACGATACCGACATCGTGTACATCCAGCGGCTTGTGAGCCGCAACATGCTTACAACCGACGTCATCACTG
GCACGCGCCTGCCGGCTTACTGCACGGCGCCGGGGTTGGCCCTGCTTTCCGGCATGCCGCGCGCCGAAGCACTGGCGATC
ATCCAACGCTCCGACCGCAAGCCGATCACGCCGAAGACGAAATGGGCGATGGACGAGATCGTCGAACAGCTGGAGCTGAC
GGCGGAGCACGGCTATGCGCTGGTCGTCGATCAGATCTACCTCAACGACATTTCCGTCGCGGCGCCCGTATATGGTGTGA
ATGGCCGGTCGATCGCGGCGGTGAGCATCGGCGTGAGCAAGCTTCGCTGTACACCTGAGGAAGCCCGCAAGCGCTTCGCG
CCGCTGCTGATCACGGTTGCGGAGGCACTTTCCCACGGCCGACCGCAACCGCGAGACTTAAAAAGGCCGCAGGCATAG

Upstream 100 bases:

>100_bases
ATATTAGTCCGATGGATTTTCCATCTGTCAACTCGAAATCAGCCGGTCCTCAGCCCTGCCTTATGGCATTTCCGCACCGT
CAACCCAATCGGGGGGCGTC

Downstream 100 bases:

>100_bases
GAACATCGATGACCAGCCAGGTTGACATCGCCGTCTTCGGCGCGGGCCAGTTTGCCGAGCGGATCGTCACCGATCTCGGC
GCGATAGCGCCCGGTCCGAT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSARDPLMVKSVEKAVRILGAFSNGQPTMSLADVAALTGLDKSGSQRFTHTLVQLGLLRKDPDTKRFELTARVLEFGANF
TRSNELVRAAAPHLLNLSKTTEEAVSLTVLDDTDIVYIQRLVSRNMLTTDVITGTRLPAYCTAPGLALLSGMPRAEALAI
IQRSDRKPITPKTKWAMDEIVEQLELTAEHGYALVVDQIYLNDISVAAPVYGVNGRSIAAVSIGVSKLRCTPEEARKRFA
PLLITVAEALSHGRPQPRDLKRPQA

Sequences:

>Translated_265_residues
MSARDPLMVKSVEKAVRILGAFSNGQPTMSLADVAALTGLDKSGSQRFTHTLVQLGLLRKDPDTKRFELTARVLEFGANF
TRSNELVRAAAPHLLNLSKTTEEAVSLTVLDDTDIVYIQRLVSRNMLTTDVITGTRLPAYCTAPGLALLSGMPRAEALAI
IQRSDRKPITPKTKWAMDEIVEQLELTAEHGYALVVDQIYLNDISVAAPVYGVNGRSIAAVSIGVSKLRCTPEEARKRFA
PLLITVAEALSHGRPQPRDLKRPQA
>Mature_264_residues
SARDPLMVKSVEKAVRILGAFSNGQPTMSLADVAALTGLDKSGSQRFTHTLVQLGLLRKDPDTKRFELTARVLEFGANFT
RSNELVRAAAPHLLNLSKTTEEAVSLTVLDDTDIVYIQRLVSRNMLTTDVITGTRLPAYCTAPGLALLSGMPRAEALAII
QRSDRKPITPKTKWAMDEIVEQLELTAEHGYALVVDQIYLNDISVAAPVYGVNGRSIAAVSIGVSKLRCTPEEARKRFAP
LLITVAEALSHGRPQPRDLKRPQA

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=216, Percent_Identity=28.7037037037037, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788131, Length=248, Percent_Identity=28.6290322580645, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1789999, Length=240, Percent_Identity=27.9166666666667, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082359, Length=245, Percent_Identity=22.4489795918367, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786715, Length=224, Percent_Identity=22.7678571428571, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28913; Mature: 28782

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARDPLMVKSVEKAVRILGAFSNGQPTMSLADVAALTGLDKSGSQRFTHTLVQLGLLRK
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
DPDTKRFELTARVLEFGANFTRSNELVRAAAPHLLNLSKTTEEAVSLTVLDDTDIVYIQR
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHCCCHHHHHHEEEEEECCCCHHHHHH
LVSRNMLTTDVITGTRLPAYCTAPGLALLSGMPRAEALAIIQRSDRKPITPKTKWAMDEI
HHHCCCHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
VEQLELTAEHGYALVVDQIYLNDISVAAPVYGVNGRSIAAVSIGVSKLRCTPEEARKRFA
HHHHHHHHCCCEEEEEEEHHHCCCHHHCCEECCCCCEEEEEEECHHHHCCCHHHHHHHHH
PLLITVAEALSHGRPQPRDLKRPQA
HHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SARDPLMVKSVEKAVRILGAFSNGQPTMSLADVAALTGLDKSGSQRFTHTLVQLGLLRK
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
DPDTKRFELTARVLEFGANFTRSNELVRAAAPHLLNLSKTTEEAVSLTVLDDTDIVYIQR
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHCCCHHHHHHEEEEEECCCCHHHHHH
LVSRNMLTTDVITGTRLPAYCTAPGLALLSGMPRAEALAIIQRSDRKPITPKTKWAMDEI
HHHCCCHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
VEQLELTAEHGYALVVDQIYLNDISVAAPVYGVNGRSIAAVSIGVSKLRCTPEEARKRFA
HHHHHHHHCCCEEEEEEEHHHCCCHHHCCEECCCCCEEEEEEECHHHHCCCHHHHHHHHH
PLLITVAEALSHGRPQPRDLKRPQA
HHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]