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The map label for this gene is nth [H]

Identifier: 110635893

GI number: 110635893

Start: 3840335

End: 3841141

Strand: Reverse

Name: nth [H]

Synonym: Meso_3567

Alternate gene names: 110635893

Gene position: 3841141-3840335 (Counterclockwise)

Preceding gene: 110635909

Following gene: 110635887

Centisome position: 87.05

GC content: 60.22

Gene sequence:

>807_bases
ATGCAAAAGCCCAAGTCCCCACGTGCCATTGCGGGAACGCCCGTTCGTTCACCCGCCAAGCCCGTCCGCAACAAAGTCTC
CGGTAAGGCACTCACCGCCTATGATGCGGGTGAAGTGGAAGAAATCTTTCGCCGCTTCAGCGTGCAGCGGCCCGAGCCCA
AGGGTGAGCTCGAATCAGTGAATGCGTTCACGCTGCTCGTTGCGGTGGTGCTCTCAGCTCAGGCGACCGATGTTGGTGTG
AACAAGGCGACGCGGCCGCTCTTCAAAATCGCCGACACGCCCGAAAAGATGCTGGCGCTGGGAGAAGAAAAGCTTGGCGA
ATACATCCGCACTATCGGCTTATGGCGCAATAAGGCCAAGAACGTTATCGCTCTATGCGAGGCGCTGATCCGCGACCACG
GCGGCCAGGTGCCGGAAGACCGCGAAGCCCTGACGAAGCTGCCGGGGGTCGGGCGCAAAACGGCAAATGTCGTGCTTAAC
GTCGCCTTCGGCCATCCGACGATGGCGGTCGACACGCATATATTCCGGATTTCGAACCGGATTTTGCTCGCTCCCGGCAA
GACACCCGAAGAGGTGGAGCAGGCGTTGCTGAAAGTCATACCGCAGCACTACCTTCTTCACGCCCATCATTGGCTGATCC
TGCATGGCCGCTATGTTTGCAAGGCGAGGAAGCCCGATTGCCCGGCCTGCGTTATCGCCGATCTGTGCAAGGCACCGGAG
AAGACGACAAATGTGCCGGCGCCCCTCGTTCCGTGGCGCGATCTGACCGATACGCCGAGGCCAGACGTGGAGGCAGCTGA
AGGATAG

Upstream 100 bases:

>100_bases
ACCCCGTGCGCCCCAATGATCGGTGGGGAACGAGAAGAGCCTTGAATAAAGGCGTTTCGCTGGCATTCTTTTCATCCATA
AGACAGATTATAGAGGCTGA

Downstream 100 bases:

>100_bases
CCCGGTTGGCAATTCGGTCTCGAATGCGCCGGATGGACCCGCCGTACCTGCGGGATTAGGCCCCGCTCGCTGCGGAACCC
CGCAAGTCAGCGATGTCCGA

Product: endonuclease III / DNA-(apurinic or apyrimidinic site) lyase

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MQKPKSPRAIAGTPVRSPAKPVRNKVSGKALTAYDAGEVEEIFRRFSVQRPEPKGELESVNAFTLLVAVVLSAQATDVGV
NKATRPLFKIADTPEKMLALGEEKLGEYIRTIGLWRNKAKNVIALCEALIRDHGGQVPEDREALTKLPGVGRKTANVVLN
VAFGHPTMAVDTHIFRISNRILLAPGKTPEEVEQALLKVIPQHYLLHAHHWLILHGRYVCKARKPDCPACVIADLCKAPE
KTTNVPAPLVPWRDLTDTPRPDVEAAEG

Sequences:

>Translated_268_residues
MQKPKSPRAIAGTPVRSPAKPVRNKVSGKALTAYDAGEVEEIFRRFSVQRPEPKGELESVNAFTLLVAVVLSAQATDVGV
NKATRPLFKIADTPEKMLALGEEKLGEYIRTIGLWRNKAKNVIALCEALIRDHGGQVPEDREALTKLPGVGRKTANVVLN
VAFGHPTMAVDTHIFRISNRILLAPGKTPEEVEQALLKVIPQHYLLHAHHWLILHGRYVCKARKPDCPACVIADLCKAPE
KTTNVPAPLVPWRDLTDTPRPDVEAAEG
>Mature_268_residues
MQKPKSPRAIAGTPVRSPAKPVRNKVSGKALTAYDAGEVEEIFRRFSVQRPEPKGELESVNAFTLLVAVVLSAQATDVGV
NKATRPLFKIADTPEKMLALGEEKLGEYIRTIGLWRNKAKNVIALCEALIRDHGGQVPEDREALTKLPGVGRKTANVVLN
VAFGHPTMAVDTHIFRISNRILLAPGKTPEEVEQALLKVIPQHYLLHAHHWLILHGRYVCKARKPDCPACVIADLCKAPE
KTTNVPAPLVPWRDLTDTPRPDVEAAEG

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=184, Percent_Identity=32.0652173913043, Blast_Score=95, Evalue=5e-20,
Organism=Escherichia coli, GI1787920, Length=201, Percent_Identity=59.2039800995025, Blast_Score=248, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17554540, Length=178, Percent_Identity=32.0224719101124, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324530, Length=189, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550361, Length=177, Percent_Identity=32.2033898305085, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 29407; Mature: 29407

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKPKSPRAIAGTPVRSPAKPVRNKVSGKALTAYDAGEVEEIFRRFSVQRPEPKGELESV
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCCCCCCHHHHH
NAFTLLVAVVLSAQATDVGVNKATRPLFKIADTPEKMLALGEEKLGEYIRTIGLWRNKAK
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHH
NVIALCEALIRDHGGQVPEDREALTKLPGVGRKTANVVLNVAFGHPTMAVDTHIFRISNR
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEEEEEECCCCHHHHHHHEEECCE
ILLAPGKTPEEVEQALLKVIPQHYLLHAHHWLILHGRYVCKARKPDCPACVIADLCKAPE
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECEEEEECCCCCCCHHHHHHHHCCCC
KTTNVPAPLVPWRDLTDTPRPDVEAAEG
CCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKPKSPRAIAGTPVRSPAKPVRNKVSGKALTAYDAGEVEEIFRRFSVQRPEPKGELESV
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCCCCCCHHHHH
NAFTLLVAVVLSAQATDVGVNKATRPLFKIADTPEKMLALGEEKLGEYIRTIGLWRNKAK
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHH
NVIALCEALIRDHGGQVPEDREALTKLPGVGRKTANVVLNVAFGHPTMAVDTHIFRISNR
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEEEEEEECCCCHHHHHHHEEECCE
ILLAPGKTPEEVEQALLKVIPQHYLLHAHHWLILHGRYVCKARKPDCPACVIADLCKAPE
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECEEEEECCCCCCCHHHHHHHHCCCC
KTTNVPAPLVPWRDLTDTPRPDVEAAEG
CCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA