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The map label for this gene is lutR [H]

Identifier: 110635879

GI number: 110635879

Start: 3826285

End: 3826995

Strand: Reverse

Name: lutR [H]

Synonym: Meso_3552

Alternate gene names: 110635879

Gene position: 3826995-3826285 (Counterclockwise)

Preceding gene: 110635881

Following gene: 110635878

Centisome position: 86.73

GC content: 63.29

Gene sequence:

>711_bases
GTGATCCGCAAACCCGTTTTGGCGCGCGTCGTGCTCGTCGACCAAGTCACCGCCGTTCTGATGGAACGCATTCTCGACCG
CGACTACACCCCGGGCGAGAAGCTTAACATCGATGCGCTCTCGCGTGAGTTCGAGGTGAGTTCCTCTCCCATTCGCGAGG
CGTTGACGCGGCTGTCCACGCTGGGCCTGGTCGCATTCGCCTCCTTCACCGGATTTTCGGTCGCGCCTGAGCCATCGCGC
GAGTGGTTCGAGCAGTTGCGCGACTTCCGCATCCTTAACGAGGGGTGGGCGGCTCGGCGTCTGGCGCGCAGCCGCGAACC
CGCGGCGATCGCGCGAATGCGTGAGAGCATCGAGGCGATGGAGGCCAATCCGCCGCGCGGGCAGGACCGGGACTATGTCG
GCATTAGCCGTGCCGACGAGAACTTCCACAACGCCATGCTGGAGGCCGCCGGCAACGAGATTTTGTCCCAGGCGGTAAAG
GGACTGCATCCTCATCTGCATCATGCGCGGCTGTTCAGCCGCATCCCCCACGACATTGCGCCGATGCTCGACGAGCACCG
CGCCATCTACGACGCGATCATCCGGGGCGACGAAGATGGGGCTCAAGCCGCGGTCGAAGTGCATCTTCAGATGTCATGGC
GTCGCTACGGCGGCTGGCATTCGGACCTGCCAGGAAAATCGCAAGAAGAACTTTCGGGCGTGAAAGGTTAG

Upstream 100 bases:

>100_bases
GCTCATCCAATCGCTCATAGAATCATGCACGATTTATGATTTATGATCGATCCTTGACGATCGATAATTTATCGTAGATT
ATGAGATCAGGAGGACAATC

Downstream 100 bases:

>100_bases
ATTCTTGCTTTGTGCCTGCTGCCTGATTGCGATCTTTGGCATCTATGCCGCGTTGCCGGTCTTCTGGCCGCCCCCGCCGA
TATTCCTGGCGGGGGCGGCC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: L-lactate utilization operon repressor [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MIRKPVLARVVLVDQVTAVLMERILDRDYTPGEKLNIDALSREFEVSSSPIREALTRLSTLGLVAFASFTGFSVAPEPSR
EWFEQLRDFRILNEGWAARRLARSREPAAIARMRESIEAMEANPPRGQDRDYVGISRADENFHNAMLEAAGNEILSQAVK
GLHPHLHHARLFSRIPHDIAPMLDEHRAIYDAIIRGDEDGAQAAVEVHLQMSWRRYGGWHSDLPGKSQEELSGVKG

Sequences:

>Translated_236_residues
MIRKPVLARVVLVDQVTAVLMERILDRDYTPGEKLNIDALSREFEVSSSPIREALTRLSTLGLVAFASFTGFSVAPEPSR
EWFEQLRDFRILNEGWAARRLARSREPAAIARMRESIEAMEANPPRGQDRDYVGISRADENFHNAMLEAAGNEILSQAVK
GLHPHLHHARLFSRIPHDIAPMLDEHRAIYDAIIRGDEDGAQAAVEVHLQMSWRRYGGWHSDLPGKSQEELSGVKG
>Mature_236_residues
MIRKPVLARVVLVDQVTAVLMERILDRDYTPGEKLNIDALSREFEVSSSPIREALTRLSTLGLVAFASFTGFSVAPEPSR
EWFEQLRDFRILNEGWAARRLARSREPAAIARMRESIEAMEANPPRGQDRDYVGISRADENFHNAMLEAAGNEILSQAVK
GLHPHLHHARLFSRIPHDIAPMLDEHRAIYDAIIRGDEDGAQAAVEVHLQMSWRRYGGWHSDLPGKSQEELSGVKG

Specific function: Negatively regulates the transcription of the lutABC operon, which is required for L-lactate utilization. LutR activity is regulated by lactate, since presence of L-lactate, that probably binds to lutR, leads to derepression of the operon. Also appears to

COG id: COG1802

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26583; Mature: 26583

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKPVLARVVLVDQVTAVLMERILDRDYTPGEKLNIDALSREFEVSSSPIREALTRLST
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
LGLVAFASFTGFSVAPEPSREWFEQLRDFRILNEGWAARRLARSREPAAIARMRESIEAM
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHH
EANPPRGQDRDYVGISRADENFHNAMLEAAGNEILSQAVKGLHPHLHHARLFSRIPHDIA
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHH
PMLDEHRAIYDAIIRGDEDGAQAAVEVHLQMSWRRYGGWHSDLPGKSQEELSGVKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MIRKPVLARVVLVDQVTAVLMERILDRDYTPGEKLNIDALSREFEVSSSPIREALTRLST
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
LGLVAFASFTGFSVAPEPSREWFEQLRDFRILNEGWAARRLARSREPAAIARMRESIEAM
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHH
EANPPRGQDRDYVGISRADENFHNAMLEAAGNEILSQAVKGLHPHLHHARLFSRIPHDIA
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHH
PMLDEHRAIYDAIIRGDEDGAQAAVEVHLQMSWRRYGGWHSDLPGKSQEELSGVKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]