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The map label for this gene is obgE

Identifier: 110635786

GI number: 110635786

Start: 3735873

End: 3736922

Strand: Reverse

Name: obgE

Synonym: Meso_3458

Alternate gene names: 110635786

Gene position: 3736922-3735873 (Counterclockwise)

Preceding gene: 110635787

Following gene: 110635785

Centisome position: 84.69

GC content: 60.86

Gene sequence:

>1050_bases
ATGAAGTTTCTCGACCAAGCCAAGGTTTACATCCGCGCCGGCGATGGCGGTGCCGGCGCGGTTTCGTTTCGCCGCGAGAA
ATTCATCGAGTTCGGCGGGCCCGACGGTGGTGACGGCGGCCGCGGCGGCGATGTCTGGATCGAAGCGGTGGAGGGGCTCA
ACACGCTTATCGATTATCGCTACCAGCAGCACTTCAAGGCAAAACCCGGCATACATGGGATGGGGCGAAATCGCACGGGC
GCCAAGGGCGACGATGTGGTCCTGAAAGTACCGGTGGGTACGCAGGTCTATGAGGAAGACAACGAAACGCTGATCTGTGA
CCTGACCGAAGTCGGCCAGCGCTTTCTCCTTCTTAAAGGCGGAAACGGCGGATTCGGAAACCAGCACTTCAAAAGTTCGA
CCAACCAGGCGCCGCGCCGTGCCAATCCCGGCCTACCAGGCGAGGAGCTGTGGATATGGCTCCGGCTTAAGCTGATTGCC
GACGCCGGTCTGATCGGTCTTCCCAATGCGGGAAAGTCGACCTTCCTTGCAACTGTTACGGCCGCGAAACCGAAGATCGC
CGATTATCCCTTCACGACGCTGCACCCCAACCTGGGCGTGGTGCGGATTGACGCGCGGGAGTTCGTTCTTGCGGACATTC
CAGGTTTGATCGAGGGGGCGCATATGGGGGTGGGCATTGGAGATCGGTTCCTGGGCCATGTGGAACGCACCGGCGTGCTT
CTGCACCTGATATCCGCCCGGGAAGAAGATGTCGCGGCCACCTACAAGACCGTGCGCCGGGAGCTCAAGGCTTATGGCCA
TGGCCTTTCGGAGAAGCCGGAAGTGGTTGCGTTGAGCCAGATTGACCTGCTGGACGAGGAAGAGCGCAGGGAAAAACTCG
CTGCCCTCAAAAAGGCAGCGCGCCGCGCTGCCCTTCCCCTTTCCTCTGCAACCGGAGAAGGAGTTCAGGACGTGCTTCGG
GCGCTGATGCGTGTGGTGCAAGCGGCCCGTGAAGAAGAGCGCGCCGCTGAGACCGCAAACGAACGCTGGCAGAAACAGGC
CGACTCATGA

Upstream 100 bases:

>100_bases
GAGACGCGCGGGTTGCTTCAAAACCCGCGCGTTTTCGTCAGCACTCTCGCTCTTGGGCGCGCTATGCGCTAGATGAGGCT
CGCAAAGAAAGAGCTGTACG

Downstream 100 bases:

>100_bases
GTGGAATTTCGCTTTCCTCTTATCGCCGCGTGACCGTGAAGATCGGCTCTGCCCTGCTGGTCGATCGCGCGGCAGGGTTG
AAGCGTGAGTGGCTCGCCGC

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKFLDQAKVYIRAGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWIEAVEGLNTLIDYRYQQHFKAKPGIHGMGRNRTG
AKGDDVVLKVPVGTQVYEEDNETLICDLTEVGQRFLLLKGGNGGFGNQHFKSSTNQAPRRANPGLPGEELWIWLRLKLIA
DAGLIGLPNAGKSTFLATVTAAKPKIADYPFTTLHPNLGVVRIDAREFVLADIPGLIEGAHMGVGIGDRFLGHVERTGVL
LHLISAREEDVAATYKTVRRELKAYGHGLSEKPEVVALSQIDLLDEEERREKLAALKKAARRAALPLSSATGEGVQDVLR
ALMRVVQAAREEERAAETANERWQKQADS

Sequences:

>Translated_349_residues
MKFLDQAKVYIRAGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWIEAVEGLNTLIDYRYQQHFKAKPGIHGMGRNRTG
AKGDDVVLKVPVGTQVYEEDNETLICDLTEVGQRFLLLKGGNGGFGNQHFKSSTNQAPRRANPGLPGEELWIWLRLKLIA
DAGLIGLPNAGKSTFLATVTAAKPKIADYPFTTLHPNLGVVRIDAREFVLADIPGLIEGAHMGVGIGDRFLGHVERTGVL
LHLISAREEDVAATYKTVRRELKAYGHGLSEKPEVVALSQIDLLDEEERREKLAALKKAARRAALPLSSATGEGVQDVLR
ALMRVVQAAREEERAAETANERWQKQADS
>Mature_349_residues
MKFLDQAKVYIRAGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWIEAVEGLNTLIDYRYQQHFKAKPGIHGMGRNRTG
AKGDDVVLKVPVGTQVYEEDNETLICDLTEVGQRFLLLKGGNGGFGNQHFKSSTNQAPRRANPGLPGEELWIWLRLKLIA
DAGLIGLPNAGKSTFLATVTAAKPKIADYPFTTLHPNLGVVRIDAREFVLADIPGLIEGAHMGVGIGDRFLGHVERTGVL
LHLISAREEDVAATYKTVRRELKAYGHGLSEKPEVVALSQIDLLDEEERREKLAALKKAARRAALPLSSATGEGVQDVLR
ALMRVVQAAREEERAAETANERWQKQADS

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=345, Percent_Identity=37.3913043478261, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI111955139, Length=364, Percent_Identity=34.0659340659341, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI111955063, Length=264, Percent_Identity=30.6818181818182, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI58761500, Length=105, Percent_Identity=34.2857142857143, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789574, Length=355, Percent_Identity=50.1408450704225, Blast_Score=285, Evalue=2e-78,
Organism=Escherichia coli, GI1787454, Length=108, Percent_Identity=37.037037037037, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=323, Percent_Identity=38.0804953560372, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17552324, Length=309, Percent_Identity=29.7734627831715, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17509631, Length=106, Percent_Identity=33.9622641509434, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71981008, Length=121, Percent_Identity=33.0578512396694, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=114, Percent_Identity=48.2456140350877, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6319281, Length=115, Percent_Identity=33.9130434782609, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24585318, Length=292, Percent_Identity=35.958904109589, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI20129375, Length=327, Percent_Identity=35.474006116208, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI21356473, Length=117, Percent_Identity=35.042735042735, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_MESSB (Q11CP6)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675994.1
- ProteinModelPortal:   Q11CP6
- SMR:   Q11CP6
- STRING:   Q11CP6
- GeneID:   4181699
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3458
- NMPDR:   fig|266779.1.peg.1072
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   RNRTGAK
- PhylomeDB:   Q11CP6
- ProtClustDB:   PRK12299
- BioCyc:   MSP266779:MESO_3458-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 37984; Mature: 37984

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLDQAKVYIRAGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWIEAVEGLNTLIDYR
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YQQHFKAKPGIHGMGRNRTGAKGDDVVLKVPVGTQVYEEDNETLICDLTEVGQRFLLLKG
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCEEEEEHHHCCCEEEEEEC
GNGGFGNQHFKSSTNQAPRRANPGLPGEELWIWLRLKLIADAGLIGLPNAGKSTFLATVT
CCCCCCCCHHCCCCCCCCCCCCCCCCHHHEEEEEEEEEHHCCCEEECCCCCCCEEEEEEE
AAKPKIADYPFTTLHPNLGVVRIDAREFVLADIPGLIEGAHMGVGIGDRFLGHVERTGVL
CCCCCCCCCCCEEECCCCCEEEECHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHH
LHLISAREEDVAATYKTVRRELKAYGHGLSEKPEVVALSQIDLLDEEERREKLAALKKAA
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHH
RRAALPLSSATGEGVQDVLRALMRVVQAAREEERAAETANERWQKQADS
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKFLDQAKVYIRAGDGGAGAVSFRREKFIEFGGPDGGDGGRGGDVWIEAVEGLNTLIDYR
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YQQHFKAKPGIHGMGRNRTGAKGDDVVLKVPVGTQVYEEDNETLICDLTEVGQRFLLLKG
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCEEEEEHHHCCCEEEEEEC
GNGGFGNQHFKSSTNQAPRRANPGLPGEELWIWLRLKLIADAGLIGLPNAGKSTFLATVT
CCCCCCCCHHCCCCCCCCCCCCCCCCHHHEEEEEEEEEHHCCCEEECCCCCCCEEEEEEE
AAKPKIADYPFTTLHPNLGVVRIDAREFVLADIPGLIEGAHMGVGIGDRFLGHVERTGVL
CCCCCCCCCCCEEECCCCCEEEECHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHH
LHLISAREEDVAATYKTVRRELKAYGHGLSEKPEVVALSQIDLLDEEERREKLAALKKAA
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHH
RRAALPLSSATGEGVQDVLRALMRVVQAAREEERAAETANERWQKQADS
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA