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The map label for this gene is macA [H]

Identifier: 110635661

GI number: 110635661

Start: 3605453

End: 3606586

Strand: Reverse

Name: macA [H]

Synonym: Meso_3333

Alternate gene names: 110635661

Gene position: 3606586-3605453 (Counterclockwise)

Preceding gene: 110635663

Following gene: 110635660

Centisome position: 81.74

GC content: 63.84

Gene sequence:

>1134_bases
ATGGCTAAGCTGAAATTCCACAAGATCGCAGCAATAGTGGTGCTCGTCGCAACGGCAGGCTGGATTGCCACCGGCCAATT
TTCCTCAGTGGGCAGCGCCAGAGAGGAGGCGAAGCCCGCAGGCGCCGAGCCGGATCGCCCTGTCGTTTTGAAGACGGTGC
AGGTCGCAGTGCCGCCGCGGGTTGAGCACGCGCGCACCATCCATGTCTCGGGACGGACAGAGGCGGACAAGAACGTAAAT
CTAGCGGCGCGCGTCGCCGGAATCGTGGAAGAATTGCCTGTCGAGGAAGGCTCCCGTGTGAAGGAGGGGGACCTGATCCT
GCGCCTCGAAAACGAAGGCAAGGAGGCGGCTGTGACATCGGCGCAGCAGACGCTTGCCCACAGAGAGGCTGAATTTGCCG
CGGCGGAACGGCTTTCCAAGAGTGGCAATCTCGCCAGCCTGCAGCTCGATGTCGCGCGCGCCAATCTGGCCGCCGCCCGC
TCGGCCCTGGAGCAGGCGAAGGCCGAACTCGACCGCGTCTCGGTGCGCGCGCCATTCGATGCGGTGGTGGACAAAATTCA
AGTCGAAAAGGGCACCGCCGCCATGCAGGGCGCGGAAGTGGCCACTCTCCTGAAGCTCGATCCCATCGTGGCCGCGGGCG
AGGTGAGCGAGCGCGATCTCGGCACGATCAGGCCGGGTGACAAGGCCGAGGTGCGCCTGGTCAATGGCGAGACGCTTTCC
GGCACGATTCGCCATGTGAGCCGCGCCGCTTCCCCGCAGACGCGTACCTATCGGATCGAAGTCGTTGCTCCCAATCCGGA
CAACGGCATCCCCGCAGGAATGACGGCGGAAATCAGCATCAAGACGGAGATGGTGGAAACCGTAGCGCTGCCGCGGTCCG
TCATCACGCTCAGCAACAACGGAGAACTTGGCGTCCGCGCCGTGGATGAGGCCGCCCAGGTGCATTTCTACCCGATCGAT
ATCGTGGATGATACGCCCGAAGCGCTCTATCTGGCCGGCATACCGCAGGAAATGCGCATCATTGTCGCCGGCCAGGACCT
CGTGACCGACGGAGAGAAGGTGAAGGCGGAAGAGGCAGACGCCGCTACCATCCGTGAGCTCGCCAGCGCGGCGCGGCCAC
AGCAAGAGCAATGA

Upstream 100 bases:

>100_bases
CAATGCGCTTTCTAGGCCTGATTGAAATAGCCCGCTGCCCTGCCCATATCGGCGCGGTCCTAGCCGTCTAAGTGGCGCAA
CTGTTCACTGGAAAATATCC

Downstream 100 bases:

>100_bases
TCCCATGGATATTGTCCGACTTGCCATACGCAATGCCCGCCTGACGCTGTCGATCCTTCTTTTCTTCATCGTCGCGGGCA
GCCTGGCTTACATCAACATT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAKLKFHKIAAIVVLVATAGWIATGQFSSVGSAREEAKPAGAEPDRPVVLKTVQVAVPPRVEHARTIHVSGRTEADKNVN
LAARVAGIVEELPVEEGSRVKEGDLILRLENEGKEAAVTSAQQTLAHREAEFAAAERLSKSGNLASLQLDVARANLAAAR
SALEQAKAELDRVSVRAPFDAVVDKIQVEKGTAAMQGAEVATLLKLDPIVAAGEVSERDLGTIRPGDKAEVRLVNGETLS
GTIRHVSRAASPQTRTYRIEVVAPNPDNGIPAGMTAEISIKTEMVETVALPRSVITLSNNGELGVRAVDEAAQVHFYPID
IVDDTPEALYLAGIPQEMRIIVAGQDLVTDGEKVKAEEADAATIRELASAARPQQEQ

Sequences:

>Translated_377_residues
MAKLKFHKIAAIVVLVATAGWIATGQFSSVGSAREEAKPAGAEPDRPVVLKTVQVAVPPRVEHARTIHVSGRTEADKNVN
LAARVAGIVEELPVEEGSRVKEGDLILRLENEGKEAAVTSAQQTLAHREAEFAAAERLSKSGNLASLQLDVARANLAAAR
SALEQAKAELDRVSVRAPFDAVVDKIQVEKGTAAMQGAEVATLLKLDPIVAAGEVSERDLGTIRPGDKAEVRLVNGETLS
GTIRHVSRAASPQTRTYRIEVVAPNPDNGIPAGMTAEISIKTEMVETVALPRSVITLSNNGELGVRAVDEAAQVHFYPID
IVDDTPEALYLAGIPQEMRIIVAGQDLVTDGEKVKAEEADAATIRELASAARPQQEQ
>Mature_376_residues
AKLKFHKIAAIVVLVATAGWIATGQFSSVGSAREEAKPAGAEPDRPVVLKTVQVAVPPRVEHARTIHVSGRTEADKNVNL
AARVAGIVEELPVEEGSRVKEGDLILRLENEGKEAAVTSAQQTLAHREAEFAAAERLSKSGNLASLQLDVARANLAAARS
ALEQAKAELDRVSVRAPFDAVVDKIQVEKGTAAMQGAEVATLLKLDPIVAAGEVSERDLGTIRPGDKAEVRLVNGETLSG
TIRHVSRAASPQTRTYRIEVVAPNPDNGIPAGMTAEISIKTEMVETVALPRSVITLSNNGELGVRAVDEAAQVHFYPIDI
VDDTPEALYLAGIPQEMRIIVAGQDLVTDGEKVKAEEADAATIRELASAARPQQEQ

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=391, Percent_Identity=25.5754475703325, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081951, Length=198, Percent_Identity=26.7676767676768, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40014; Mature: 39883

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLKFHKIAAIVVLVATAGWIATGQFSSVGSAREEAKPAGAEPDRPVVLKTVQVAVPPR
CCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHCCCCCCCCCCCEEEEEEEEECCCC
VEHARTIHVSGRTEADKNVNLAARVAGIVEELPVEEGSRVKEGDLILRLENEGKEAAVTS
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCEEEEECCCCCHHHHHH
AQQTLAHREAEFAAAERLSKSGNLASLQLDVARANLAAARSALEQAKAELDRVSVRAPFD
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHEEECCCHH
AVVDKIQVEKGTAAMQGAEVATLLKLDPIVAAGEVSERDLGTIRPGDKAEVRLVNGETLS
HHHHHHEECCCCHHHCCCCEEEEEEECCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCH
GTIRHVSRAASPQTRTYRIEVVAPNPDNGIPAGMTAEISIKTEMVETVALPRSVITLSNN
HHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHCCCEEEEECCC
GELGVRAVDEAAQVHFYPIDIVDDTPEALYLAGIPQEMRIIVAGQDLVTDGEKVKAEEAD
CCCCEEEECCCCEEEEEEEEEECCCCCEEEEECCCCCEEEEEECCHHCCCCCHHCCCCCH
AATIRELASAARPQQEQ
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AKLKFHKIAAIVVLVATAGWIATGQFSSVGSAREEAKPAGAEPDRPVVLKTVQVAVPPR
CCCHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHCCCCCCCCCCCEEEEEEEEECCCC
VEHARTIHVSGRTEADKNVNLAARVAGIVEELPVEEGSRVKEGDLILRLENEGKEAAVTS
CCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCEEEEECCCCCHHHHHH
AQQTLAHREAEFAAAERLSKSGNLASLQLDVARANLAAARSALEQAKAELDRVSVRAPFD
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHEEECCCHH
AVVDKIQVEKGTAAMQGAEVATLLKLDPIVAAGEVSERDLGTIRPGDKAEVRLVNGETLS
HHHHHHEECCCCHHHCCCCEEEEEEECCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCH
GTIRHVSRAASPQTRTYRIEVVAPNPDNGIPAGMTAEISIKTEMVETVALPRSVITLSNN
HHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHCCCEEEEECCC
GELGVRAVDEAAQVHFYPIDIVDDTPEALYLAGIPQEMRIIVAGQDLVTDGEKVKAEEAD
CCCCEEEECCCCEEEEEEEEEECCCCCEEEEECCCCCEEEEEECCHHCCCCCHHCCCCCH
AATIRELASAARPQQEQ
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]