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The map label for this gene is groEL

Identifier: 110635424

GI number: 110635424

Start: 3364498

End: 3366126

Strand: Reverse

Name: groEL

Synonym: Meso_3095

Alternate gene names: 110635424

Gene position: 3366126-3364498 (Counterclockwise)

Preceding gene: 110635425

Following gene: 110635420

Centisome position: 76.29

GC content: 62.19

Gene sequence:

>1629_bases
ATGGCTGCCAAGGACGTAAAATTTCATTCGGATGCCCGCGAGCGCATGCTGCGCGGTGTCGATGTCCTCGCCAATGCTGT
GAAGGTCACTCTTGGTCCCAAGGGCCGCAACGTCGTCATCGACAAATCGTTCGGCGCCCCCCGCATCACCAAGGACGGTG
TCACCGTCGCCAAGGAGATCGAGCTTGAGGACAAGTTCGAAAATATGGGCGCTCAGATGGTGCGCGAGGTGGCCTCGAAA
ACCAACGATGCCGCCGGCGACGGCACTACCACGGCGACGGTTCTTACTCAGGCCATCGTGAAGGAAGGCGCAAAGGCAGT
CGCCTCCGGCATGAACCCGATGGATCTGAAGCGCGGCATCGACAAGGCCGTCGAGGCTATCGTCGAGGAGCTCAAGAAGA
ACGCCCGTAAGGTCACCAAGAACGACGAGATCGCGCAGGTCGGCACGATTTCTGCCAATGGCGATCAGGAGATTGGCCGT
TTCCTGGCCCAGGCGATGGAGAAGGTCGGCAATGAAGGCGTGATTACGGTCGAGGAAGCCAAAACCGCCGAGACCGAGCT
CGAAGTGGTCGAAGGCATGCAGTTCGACCGTGGCTATCTCTCCCCGTATTTCATCACCAATCAGGAGAAGATGCGGGTGG
AGCTCGATGAGCCCTATCTGCTCATTCACGAGAAGAAGCTTGCCAGCCTTCAGCCGCTGCTTCCCGTTCTTGAGGCGGTG
GTGCAGTCCGGCAAGCCGCTTCTCATCATCGCGGAGGATGTGGAGGGCGAGGCCCTTGCAACGCTGGTGGTCAACAAGCT
GCGCGGCGGCTTGAAAGTCGCAGCCGTGAAGGCTCCTGGCTTCGGCGATCGCCGCAAGGCCATGCTGCAGGACATCGCCA
TTCTCACCGGCGGCACCGCCATCTCCGAGGATCTCGGCATCAAGCTTGAGAACGTCACGCTCGAGATGCTTGGCCGCGCC
AAGAAAGTGGTCATCGAAAAGGAGAACACCACCATTGTCGACGGGGCTGGCTCCAAGGACGAGATCCAGGGCCGCGTCAA
TCAGATCAAGGCGCAGATCGAGGAGACGACCTCCGACTACGACCGCGAGAAGCTGCAGGAGCGGCTGGCCAAGCTCGCTG
GGGGCGTTGCCGTGATCCGCGTCGGCGGTGCCACCGAAGTCGAGGTGAAGGAGCGCAAGGACCGGGTGGACGATGCGATG
CATGCGACGCGCGCGGCGGTCGAGGAAGGCTTGCTGCCCGGCGGCGGCGTGGCGCTCCTGCGTGCGGCCAAGGCGCTGGA
CAATGTCACGGGCGAGAACGAGGACCAGAAGGTCGGCATCAGTATCGTCCGCCGCGCCATCGAAGCTCCGATCCGGCAGA
TCGCCGAGAACGCGGGCGCTGAAGGCTCAATCATCGTCGGGAGAGTGCGCGAAAAGCCGGACTTCGGTTATGGCTGGAAC
GCCCAGACCGGTGAATATGGAGACCTCTATCAGATGGGCGTGATCGATCCGGTGAAAGTGGTGCGCGCTGCACTGCAGGA
TGCCGCTTCCGTTGCCGGGCTGCTGATCACCACCGAAGCGATGGTGGCCGACCGGCCGAAGAAGGAAACCGCTCCCGCCA
TGCCCGCGGGCGCCGGGATGGACTTCTAA

Upstream 100 bases:

>100_bases
AGGAAAGCGACGTCCTCGGCATTCTCGACAAGGAAGCCGAGGTCAAGAAGGCTGCTTGAGCGCGGCCATCAGTCGAATCC
GCCAATGAAGGAGTATTAAA

Downstream 100 bases:

>100_bases
ACAGCCTTCTCAAGGCTTTAAGGGCGCGGCCGGCCTCCGGCCGCGCTCTCGCGCGGGAATGGTCAAGCTGCCAGCGCTTT
GCCGACCCGGTCGCGGATCT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MAAKDVKFHSDARERMLRGVDVLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASK
TNDAAGDGTTTATVLTQAIVKEGAKAVASGMNPMDLKRGIDKAVEAIVEELKKNARKVTKNDEIAQVGTISANGDQEIGR
FLAQAMEKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNQEKMRVELDEPYLLIHEKKLASLQPLLPVLEAV
VQSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGTAISEDLGIKLENVTLEMLGRA
KKVVIEKENTTIVDGAGSKDEIQGRVNQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDAM
HATRAAVEEGLLPGGGVALLRAAKALDNVTGENEDQKVGISIVRRAIEAPIRQIAENAGAEGSIIVGRVREKPDFGYGWN
AQTGEYGDLYQMGVIDPVKVVRAALQDAASVAGLLITTEAMVADRPKKETAPAMPAGAGMDF

Sequences:

>Translated_542_residues
MAAKDVKFHSDARERMLRGVDVLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASK
TNDAAGDGTTTATVLTQAIVKEGAKAVASGMNPMDLKRGIDKAVEAIVEELKKNARKVTKNDEIAQVGTISANGDQEIGR
FLAQAMEKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNQEKMRVELDEPYLLIHEKKLASLQPLLPVLEAV
VQSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGTAISEDLGIKLENVTLEMLGRA
KKVVIEKENTTIVDGAGSKDEIQGRVNQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDAM
HATRAAVEEGLLPGGGVALLRAAKALDNVTGENEDQKVGISIVRRAIEAPIRQIAENAGAEGSIIVGRVREKPDFGYGWN
AQTGEYGDLYQMGVIDPVKVVRAALQDAASVAGLLITTEAMVADRPKKETAPAMPAGAGMDF
>Mature_541_residues
AAKDVKFHSDARERMLRGVDVLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKT
NDAAGDGTTTATVLTQAIVKEGAKAVASGMNPMDLKRGIDKAVEAIVEELKKNARKVTKNDEIAQVGTISANGDQEIGRF
LAQAMEKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNQEKMRVELDEPYLLIHEKKLASLQPLLPVLEAVV
QSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGTAISEDLGIKLENVTLEMLGRAK
KVVIEKENTTIVDGAGSKDEIQGRVNQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDAMH
ATRAAVEEGLLPGGGVALLRAAKALDNVTGENEDQKVGISIVRRAIEAPIRQIAENAGAEGSIIVGRVREKPDFGYGWNA
QTGEYGDLYQMGVIDPVKVVRAALQDAASVAGLLITTEAMVADRPKKETAPAMPAGAGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=53.8606403013183, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=53.8606403013183, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI5453607, Length=550, Percent_Identity=22.5454545454545, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=69.4915254237288, Blast_Score=728, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=53.7878787878788, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI193210679, Length=239, Percent_Identity=50.2092050209205, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=58.745247148289, Blast_Score=622, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6322524, Length=176, Percent_Identity=26.1363636363636, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=57.0075757575758, Blast_Score=599, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=57.0075757575758, Blast_Score=599, Evalue=1e-171,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=52.8409090909091, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=52.8409090909091, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=52.8409090909091, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI17864606, Length=544, Percent_Identity=44.4852941176471, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=36.9606003752345, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=36.9606003752345, Blast_Score=347, Evalue=1e-95,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_MESSB (Q11DQ8)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675632.1
- ProteinModelPortal:   Q11DQ8
- SMR:   Q11DQ8
- STRING:   Q11DQ8
- GeneID:   4183282
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3095
- NMPDR:   fig|266779.1.peg.189
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   DVKFHDS
- PhylomeDB:   Q11DQ8
- ProtClustDB:   PRK12849
- BioCyc:   MSP266779:MESO_3095-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58024; Mature: 57893

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFHSDARERMLRGVDVLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHC
ELEDKFENMGAQMVREVASKTNDAAGDGTTTATVLTQAIVKEGAKAVASGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVEAIVEELKKNARKVTKNDEIAQVGTISANGDQEIGRFLAQAMEKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFITNQEKMRVELDEPYLLIHEKKLASLQPLLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHH
VQSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGTA
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
ISEDLGIKLENVTLEMLGRAKKVVIEKENTTIVDGAGSKDEIQGRVNQIKAQIEETTSDY
EHHHHCCEEEHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDAMHATRAAVEEGLLPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAAKALDNVTGENEDQKVGISIVRRAIEAPIRQIAENAGAEGSIIVGRVREKPDFGYGWN
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
AQTGEYGDLYQMGVIDPVKVVRAALQDAASVAGLLITTEAMVADRPKKETAPAMPAGAGM
CCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DF
CC
>Mature Secondary Structure 
AAKDVKFHSDARERMLRGVDVLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHC
ELEDKFENMGAQMVREVASKTNDAAGDGTTTATVLTQAIVKEGAKAVASGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVEAIVEELKKNARKVTKNDEIAQVGTISANGDQEIGRFLAQAMEKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFITNQEKMRVELDEPYLLIHEKKLASLQPLLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHH
VQSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGTA
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
ISEDLGIKLENVTLEMLGRAKKVVIEKENTTIVDGAGSKDEIQGRVNQIKAQIEETTSDY
EHHHHCCEEEHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGATEVEVKERKDRVDDAMHATRAAVEEGLLPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAAKALDNVTGENEDQKVGISIVRRAIEAPIRQIAENAGAEGSIIVGRVREKPDFGYGWN
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
AQTGEYGDLYQMGVIDPVKVVRAALQDAASVAGLLITTEAMVADRPKKETAPAMPAGAGM
CCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DF
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA