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The map label for this gene is prsA [H]

Identifier: 110635342

GI number: 110635342

Start: 3279324

End: 3280379

Strand: Reverse

Name: prsA [H]

Synonym: Meso_3013

Alternate gene names: 110635342

Gene position: 3280379-3279324 (Counterclockwise)

Preceding gene: 110635349

Following gene: 110635341

Centisome position: 74.34

GC content: 61.74

Gene sequence:

>1056_bases
ATGTCAACTTTGCCGGGAAGGTCCTTTTCGACCGCACAAATCCGCCACATCCAGCACTTATTGGATTATCAGCGGCCCTC
ATTGTTGGCCATATCCCGATATCGTCCCCACGGAGAACGACTGATGCAAGAAACCCTACGCCGCAATCTGATCGCGCGGG
CCGGCGCGGCCGCGATTCTCGCAGTCCTCAGCGCTGCCCCGGCCATTGCCCAGGAAAGCCCCGTGGTGGCCACGATCAAC
GGCCAGCAGATCACGGAAGCCGATCTTGCGCTTGCGCAGGAAGAGCTGGGACCGCAGTTCGGTCAGATGCCGGAGGACCA
GCGCCGCGCGGCCGCTCTGTCCGCCGTCATCGATGTGCGGCTCTTTGCCTCCGAAGCGCAAAAGGAGGGGATCGACAAGA
CCGATGAGTTCCAGCGCCGGACGGAGTTCCTGCGCCAGCGCGCTCTGCACAGCGCCTATATCGATGCGAATGTCGTGAAG
CCGATCACCGACGAGGAGCTTAACGCACGCTACGAGGAAGAGGTCGCGAAGATTCCTCAGCAGGAGGAAGTCCACGCCCG
CCACATACTTGTGGATTCCGAAGAGGAAGCGAAGAATATCATCACGCAGCTTGACGAGGGCGGCGACTTTGCCGAGATCG
CCAAGGAGAAGTCGAAGGACGGGGCGGCCGCCAATGGCGGCGACCTCGGCTACTTCACCGAGGGTGCGATGGTACCGGAG
TTCAGCAAGGCGGCGTTTGCCATGGAACCGGGAGCTCATTCCGAGGAGCCCGTGAAGACGCAGTTCGGCTGGCATGTCAT
CAAGGTTGAGGACAAGCGCATGCAGCCTCCGCCGGCTCTCGAACAGGTGAAGGATCAGATCCGCTCCATGGTCATCCGAG
ACAAATATATGGAGACGCTCGTTTCCTTGCGGGAGAATGCCGAGCTCGACATCCCCAATGCCGACCTCAAGAGTGCGGTG
GACGGGCTGCTGCGCCAGCAACTCGGGCAGGGCGAGCCGGCTGAAGGCGGCGAGACGCCGGCGGAAGGCGCGCAACAAGA
GACTCCTGCGCAGTAA

Upstream 100 bases:

>100_bases
GTCAACCGATGCGGCAGCCAGCAGTTCCGATGCATCCCAATGCTTCCGGCGAATGCTTCTGGACGCTGGATCGAAGGAGA
GATAAGAGGGGGCAACTCTT

Downstream 100 bases:

>100_bases
GAATTCAAGCAGTCGTTCGAAAGGCCGCGGATCATGCTCCGCGGCCTTTTGCTGTCGTAGCGCATCGCGACGGGGTGTTT
CCGCTGTTTCGGCTTGCGTC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSTLPGRSFSTAQIRHIQHLLDYQRPSLLAISRYRPHGERLMQETLRRNLIARAGAAAILAVLSAAPAIAQESPVVATIN
GQQITEADLALAQEELGPQFGQMPEDQRRAAALSAVIDVRLFASEAQKEGIDKTDEFQRRTEFLRQRALHSAYIDANVVK
PITDEELNARYEEEVAKIPQQEEVHARHILVDSEEEAKNIITQLDEGGDFAEIAKEKSKDGAAANGGDLGYFTEGAMVPE
FSKAAFAMEPGAHSEEPVKTQFGWHVIKVEDKRMQPPPALEQVKDQIRSMVIRDKYMETLVSLRENAELDIPNADLKSAV
DGLLRQQLGQGEPAEGGETPAEGAQQETPAQ

Sequences:

>Translated_351_residues
MSTLPGRSFSTAQIRHIQHLLDYQRPSLLAISRYRPHGERLMQETLRRNLIARAGAAAILAVLSAAPAIAQESPVVATIN
GQQITEADLALAQEELGPQFGQMPEDQRRAAALSAVIDVRLFASEAQKEGIDKTDEFQRRTEFLRQRALHSAYIDANVVK
PITDEELNARYEEEVAKIPQQEEVHARHILVDSEEEAKNIITQLDEGGDFAEIAKEKSKDGAAANGGDLGYFTEGAMVPE
FSKAAFAMEPGAHSEEPVKTQFGWHVIKVEDKRMQPPPALEQVKDQIRSMVIRDKYMETLVSLRENAELDIPNADLKSAV
DGLLRQQLGQGEPAEGGETPAEGAQQETPAQ
>Mature_350_residues
STLPGRSFSTAQIRHIQHLLDYQRPSLLAISRYRPHGERLMQETLRRNLIARAGAAAILAVLSAAPAIAQESPVVATING
QQITEADLALAQEELGPQFGQMPEDQRRAAALSAVIDVRLFASEAQKEGIDKTDEFQRRTEFLRQRALHSAYIDANVVKP
ITDEELNARYEEEVAKIPQQEEVHARHILVDSEEEAKNIITQLDEGGDFAEIAKEKSKDGAAANGGDLGYFTEGAMVPEF
SKAAFAMEPGAHSEEPVKTQFGWHVIKVEDKRMQPPPALEQVKDQIRSMVIRDKYMETLVSLRENAELDIPNADLKSAVD
GLLRQQLGQGEPAEGGETPAEGAQQETPAQ

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=95, Percent_Identity=40, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786645, Length=172, Percent_Identity=29.0697674418605, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790211, Length=84, Percent_Identity=44.047619047619, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17537235, Length=95, Percent_Identity=43.1578947368421, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21356303, Length=96, Percent_Identity=39.5833333333333, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 38691; Mature: 38560

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLPGRSFSTAQIRHIQHLLDYQRPSLLAISRYRPHGERLMQETLRRNLIARAGAAAIL
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AVLSAAPAIAQESPVVATINGQQITEADLALAQEELGPQFGQMPEDQRRAAALSAVIDVR
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHH
LFASEAQKEGIDKTDEFQRRTEFLRQRALHSAYIDANVVKPITDEELNARYEEEVAKIPQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
QEEVHARHILVDSEEEAKNIITQLDEGGDFAEIAKEKSKDGAAANGGDLGYFTEGAMVPE
HHHHHHHHEEECCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCEECCCCCCCC
FSKAAFAMEPGAHSEEPVKTQFGWHVIKVEDKRMQPPPALEQVKDQIRSMVIRDKYMETL
HHHHHEEECCCCCCCCCCHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VSLRENAELDIPNADLKSAVDGLLRQQLGQGEPAEGGETPAEGAQQETPAQ
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STLPGRSFSTAQIRHIQHLLDYQRPSLLAISRYRPHGERLMQETLRRNLIARAGAAAIL
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AVLSAAPAIAQESPVVATINGQQITEADLALAQEELGPQFGQMPEDQRRAAALSAVIDVR
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHH
LFASEAQKEGIDKTDEFQRRTEFLRQRALHSAYIDANVVKPITDEELNARYEEEVAKIPQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
QEEVHARHILVDSEEEAKNIITQLDEGGDFAEIAKEKSKDGAAANGGDLGYFTEGAMVPE
HHHHHHHHEEECCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCEECCCCCCCC
FSKAAFAMEPGAHSEEPVKTQFGWHVIKVEDKRMQPPPALEQVKDQIRSMVIRDKYMETL
HHHHHEEECCCCCCCCCCHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VSLRENAELDIPNADLKSAVDGLLRQQLGQGEPAEGGETPAEGAQQETPAQ
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA