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The map label for this gene is vllY [H]

Identifier: 110635218

GI number: 110635218

Start: 3139067

End: 3140176

Strand: Reverse

Name: vllY [H]

Synonym: Meso_2885

Alternate gene names: 110635218

Gene position: 3140176-3139067 (Counterclockwise)

Preceding gene: 110635222

Following gene: 110635217

Centisome position: 71.17

GC content: 57.3

Gene sequence:

>1110_bases
ATGGGACCCTTTCCACATGATGCGCCGCCCGCCACCATCAGCCCGGAAAATCCGGCTGGTACTGACGGTTTCGAGTTTGT
GGAATTTGCCCATCCGGAGCCGGAAAAGCTCGCTGAGTTGTTCGGTCGTATGGGCTTTGTCGCGGTCGCCAAGCACCGGA
CCAAGAATGTCACCGTTTGGCGGCAGGGCGATATCAACTATATCGTAAATGCAGAGCCCGGCTCCCACGCTTCTCGCTTC
GTGGAAGAGCATGGGCCTTGTGCGTCCTCCATGGCATGGCGCGTGGTGGATGCCAGGCACGCTTTTGACCACGCCGTTTC
AAAGGGCGCTCAGCCCTATGAAGGCAAAGACAAGGTGCTGGATGTGCCGGCCATCGTCGGCATTGGCGGATCGCTTCTCT
ATTTCATCGAGCGGTATGGCGCTAAGGGCTCCGCCTATGAGGACGAGTTCGAGTGGCTGGGCGAGCGCAACCCGAAGCCG
GAAGGCGTCGGCTTCTACTATCTCGACCACCTGACCCACAATGTCTATCGCGGCAATATGGACAAGTGGTGGGCCTTCTA
CCGGGATCTGTTCGGGTTCAAGCAAATCCACTATTTCGATATCGACGGTCGCATTACCGGCCTTGTAAGCCGCGCTATCA
CCAGCCCCTGCGGCAAGATCCGTATTCCGCTGAACGAATCCAAGGACGAGACAAGCCAGATCGTCGAATATTTGAAGAAG
TACAAGGGCGAGGGCATCCAGCATATCGCGGTGGGAACGGAACACATCTACGATGCCACCGATCGGCTGGCCGATAATGG
GCTGAAATTCATGCCCGGCCCCCCGGATGTCTATTACGAGAGATCGTTCCAGCGCGTGGCCGGTCATTCGGAGCCGATCG
AGCGCATGAAGAAATACGGCATTCTGATCGATGGCGAAGGCGTGGTGAATGGCGGCATGACGAAGATCCTGCTGCAGATA
TTCTCCAAAACCGTTATCGGCCCGATCTTCTTCGAGTTCATCCAGAGGAAGGGTGACGAGGGCTTCGGAGAAGGCAACTT
CCGCGCCCTTTTCGAATCCATCGAAGAAGACCAGATCCGCCGCGGCGTGCTCAAGGAGGCCGCTGTATAG

Upstream 100 bases:

>100_bases
TACCGTGCAAAATAGAGCCTTTTTGCTTGATGAATGCAAGCCCACTGCATGCCGGATTTGGTATAGTCCCGACAAATGAA
GGCTCTAACAGGAGGAAATT

Downstream 100 bases:

>100_bases
CCCAATTTGTGGTCGACTGAGCGGGCGAGCGGACCCTAAGCTCGCCCGCTTCCACTGTCCCCGAGCCCAACTCCGGCGCC
TATTGCCGCCGGAGATCTCG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MGPFPHDAPPATISPENPAGTDGFEFVEFAHPEPEKLAELFGRMGFVAVAKHRTKNVTVWRQGDINYIVNAEPGSHASRF
VEEHGPCASSMAWRVVDARHAFDHAVSKGAQPYEGKDKVLDVPAIVGIGGSLLYFIERYGAKGSAYEDEFEWLGERNPKP
EGVGFYYLDHLTHNVYRGNMDKWWAFYRDLFGFKQIHYFDIDGRITGLVSRAITSPCGKIRIPLNESKDETSQIVEYLKK
YKGEGIQHIAVGTEHIYDATDRLADNGLKFMPGPPDVYYERSFQRVAGHSEPIERMKKYGILIDGEGVVNGGMTKILLQI
FSKTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEEDQIRRGVLKEAAV

Sequences:

>Translated_369_residues
MGPFPHDAPPATISPENPAGTDGFEFVEFAHPEPEKLAELFGRMGFVAVAKHRTKNVTVWRQGDINYIVNAEPGSHASRF
VEEHGPCASSMAWRVVDARHAFDHAVSKGAQPYEGKDKVLDVPAIVGIGGSLLYFIERYGAKGSAYEDEFEWLGERNPKP
EGVGFYYLDHLTHNVYRGNMDKWWAFYRDLFGFKQIHYFDIDGRITGLVSRAITSPCGKIRIPLNESKDETSQIVEYLKK
YKGEGIQHIAVGTEHIYDATDRLADNGLKFMPGPPDVYYERSFQRVAGHSEPIERMKKYGILIDGEGVVNGGMTKILLQI
FSKTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEEDQIRRGVLKEAAV
>Mature_368_residues
GPFPHDAPPATISPENPAGTDGFEFVEFAHPEPEKLAELFGRMGFVAVAKHRTKNVTVWRQGDINYIVNAEPGSHASRFV
EEHGPCASSMAWRVVDARHAFDHAVSKGAQPYEGKDKVLDVPAIVGIGGSLLYFIERYGAKGSAYEDEFEWLGERNPKPE
GVGFYYLDHLTHNVYRGNMDKWWAFYRDLFGFKQIHYFDIDGRITGLVSRAITSPCGKIRIPLNESKDETSQIVEYLKKY
KGEGIQHIAVGTEHIYDATDRLADNGLKFMPGPPDVYYERSFQRVAGHSEPIERMKKYGILIDGEGVVNGGMTKILLQIF
SKTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEEDQIRRGVLKEAAV

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI14249394, Length=377, Percent_Identity=28.3819628647215, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI285002264, Length=341, Percent_Identity=26.6862170087977, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4504477, Length=341, Percent_Identity=26.6862170087977, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17555220, Length=322, Percent_Identity=32.6086956521739, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550752, Length=211, Percent_Identity=27.9620853080569, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24667510, Length=319, Percent_Identity=31.6614420062696, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356105, Length=305, Percent_Identity=31.8032786885246, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 41474; Mature: 41343

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPFPHDAPPATISPENPAGTDGFEFVEFAHPEPEKLAELFGRMGFVAVAKHRTKNVTVW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
RQGDINYIVNAEPGSHASRFVEEHGPCASSMAWRVVDARHAFDHAVSKGAQPYEGKDKVL
EECCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
DVPAIVGIGGSLLYFIERYGAKGSAYEDEFEWLGERNPKPEGVGFYYLDHLTHNVYRGNM
ECCHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHCCCH
DKWWAFYRDLFGFKQIHYFDIDGRITGLVSRAITSPCGKIRIPLNESKDETSQIVEYLKK
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHH
YKGEGIQHIAVGTEHIYDATDRLADNGLKFMPGPPDVYYERSFQRVAGHSEPIERMKKYG
HCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCC
ILIDGEGVVNGGMTKILLQIFSKTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEEDQIR
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RGVLKEAAV
HHHHHHHCC
>Mature Secondary Structure 
GPFPHDAPPATISPENPAGTDGFEFVEFAHPEPEKLAELFGRMGFVAVAKHRTKNVTVW
CCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
RQGDINYIVNAEPGSHASRFVEEHGPCASSMAWRVVDARHAFDHAVSKGAQPYEGKDKVL
EECCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
DVPAIVGIGGSLLYFIERYGAKGSAYEDEFEWLGERNPKPEGVGFYYLDHLTHNVYRGNM
ECCHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHCCCH
DKWWAFYRDLFGFKQIHYFDIDGRITGLVSRAITSPCGKIRIPLNESKDETSQIVEYLKK
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHH
YKGEGIQHIAVGTEHIYDATDRLADNGLKFMPGPPDVYYERSFQRVAGHSEPIERMKKYG
HCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCC
ILIDGEGVVNGGMTKILLQIFSKTVIGPIFFEFIQRKGDEGFGEGNFRALFESIEEDQIR
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RGVLKEAAV
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA