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The map label for this gene is ilvD1 [H]

Identifier: 110635000

GI number: 110635000

Start: 2886908

End: 2888743

Strand: Reverse

Name: ilvD1 [H]

Synonym: Meso_2666

Alternate gene names: 110635000

Gene position: 2888743-2886908 (Counterclockwise)

Preceding gene: 110635001

Following gene: 110634998

Centisome position: 65.47

GC content: 63.73

Gene sequence:

>1836_bases
ATGCCCGCTTATCGCTCCCGCACGACAACCCATGGCCGCAATATGGCCGGTGCACGCGGCCTCTGGCGCGCTACCGGCAT
GAAGGATTCCGATTTCGGCAAGCCGATCATCGCCGTGGTCAATTCCTTCACGCAGTTCGTACCGGGGCACGTGCACCTGA
AAGATCTCGGTCAGCTCGTGGCGCACGAGATTGAGGCGGCCGGCGGTGTGGCCAAGGAGTTCAACACGATTGCCGTGGAT
GATGGCATCGCCATGGGCCATGACGGCATGCTCTATTCGCTGCCCTCGCGCGAACTCATCGCGGACTCGGTCGAATACAT
GGTGAACGCCCATTGTGCGGACGCCATGGTCTGCATCTCCAATTGCGACAAGATTACGCCGGGCATGCTGATGGCGGCCC
TGCGGCTCAATATCCCGGCGGTATTCGTGTCCGGCGGGCCGATGGAGGCGGGCAAGGTTGTCCTTTCCGGTCAGAAACGG
GCGCTCGATCTCGTTGACGCCATGGTTGCCGCGGCAGACGACCGCGTGAGCGACGAGGATGTGCAGGTGATCGAACGGTC
CGCCTGCCCGACCTGCGGCTCCTGCTCGGGCATGTTCACCGCCAACTCCATGAATTGCCTTACGGAGGCGCTGGGGCTCT
CGTTGCCCGGCAACGGCTCGACGCTTGCCACCCATGCCGACCGCCGGCGGCTCTTCGTCGAGGCTGGGCATCTCATCGTC
GACCTCGCTCGCCGCTATTACGAACAGGATGACGACAGCGTGCTGCCGCGCAGCATCGCAAGCTTTTCGGCTTTCCAAAA
TGCGATGACACTCGACATCGCCATGGGCGGCTCCACCAACACCGTGCTTCACCTGCTCGCCGCCGCGCATGAGGCGGAGG
TGGACTTCACCATGGAGGAGATAGACCGGCTGTCACGGCGCGTGCCCGTGCTCTGCAAGGTGGCGCCCGCGAAGTCGGAC
GTGCATATGGAGGACGTGCACCGCGCCGGCGGCATCATGGCGATCCTGGGCGAACTTGACCGGGGAGGCCTCATCAATCG
GGACGTGCCGACGGTTCACACGGCAACCCTTGGTCAGGCAATCGAGCATTGGGACATCACACTGACCAAAAGCCAGAAGG
TGCGCGACTTCTTCCTTGCTGCGCCGGGCGGCGTGCCCACCCAAGTGGCATTCAGCCAGGATCGGCGGTGGGACGATCTC
GACCTCGACCGCCAGAGTGGCGTGATCCGCAGCGCCGAACATCCCTTCTCCAAGGATGGCGGGCTCGCGGTGCTGAAGGG
CAATCTCGCCGAGGACGGCTGCATCGTGAAGACGGCCGGGGTTGACGAGTCGATCCTGAAATTTTCCGGTCCGGCGCGCG
TGTTCGAGAGCCAGGATTCGGCCGTGCAGGCGATCCTCGCAAACAAGATCAATGCCGGCGACGTGGTCGTGATCCGCTAC
GAAGGACCGCGTGGTGGGCCGGGCATGCAGGAGATGCTCTATCCCACCAGCTACCTGAAGGCGAAGAGCCTGGGCAAGGA
TTGCGCGCTGATTACGGACGGGCGTTTCTCGGGCGGCACGTCCGGCCTTTCCATCGGGCACGTCTCTCCTGAGGCCGCCA
ACGGTGGATTGATCGGGCTGGTGCGTGAGGGCGACCGGATAGAGATCGATATCCCGAACCGGAAGATCCATCTCGCCGTG
GACGACGCGGAAATCGCGCGTCGCCGCGCCGCACAGGATGCCAAGGGCTGGAAGCCTGCGGAAAACCGGAAGCGACAGGT
CAGCACCGCGCTTAAGGCCTATGCTGCTTTTGCCACAAGCGCGGACAAGGGCGCTGTGCGCAAGCTGCCGGATTGA

Upstream 100 bases:

>100_bases
TGCCTTTCCAGAGCGTGAAGTAGTATCACCGCTTTTCCGGCGGCAGATTACTCCGCCGGTGCCGCACCAGTCCGTTCCCG
ACCTCAGCTTTGGAAGTACA

Downstream 100 bases:

>100_bases
TGAAGGCGCGCCCTGCCAGGGCTACGCCCTGACGGTCTCAGGCCAGCTCCGGATGGAGCTGGCGGCGCGGTAAGTCGCTT
TTTGGCGTATGTTCGGTTCA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1 [H]

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAHEIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLSGQKR
ALDLVDAMVAAADDRVSDEDVQVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRRRLFVEAGHLIV
DLARRYYEQDDDSVLPRSIASFSAFQNAMTLDIAMGGSTNTVLHLLAAAHEAEVDFTMEEIDRLSRRVPVLCKVAPAKSD
VHMEDVHRAGGIMAILGELDRGGLINRDVPTVHTATLGQAIEHWDITLTKSQKVRDFFLAAPGGVPTQVAFSQDRRWDDL
DLDRQSGVIRSAEHPFSKDGGLAVLKGNLAEDGCIVKTAGVDESILKFSGPARVFESQDSAVQAILANKINAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKAKSLGKDCALITDGRFSGGTSGLSIGHVSPEAANGGLIGLVREGDRIEIDIPNRKIHLAV
DDAEIARRRAAQDAKGWKPAENRKRQVSTALKAYAAFATSADKGAVRKLPD

Sequences:

>Translated_611_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAHEIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLSGQKR
ALDLVDAMVAAADDRVSDEDVQVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRRRLFVEAGHLIV
DLARRYYEQDDDSVLPRSIASFSAFQNAMTLDIAMGGSTNTVLHLLAAAHEAEVDFTMEEIDRLSRRVPVLCKVAPAKSD
VHMEDVHRAGGIMAILGELDRGGLINRDVPTVHTATLGQAIEHWDITLTKSQKVRDFFLAAPGGVPTQVAFSQDRRWDDL
DLDRQSGVIRSAEHPFSKDGGLAVLKGNLAEDGCIVKTAGVDESILKFSGPARVFESQDSAVQAILANKINAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKAKSLGKDCALITDGRFSGGTSGLSIGHVSPEAANGGLIGLVREGDRIEIDIPNRKIHLAV
DDAEIARRRAAQDAKGWKPAENRKRQVSTALKAYAAFATSADKGAVRKLPD
>Mature_610_residues
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAHEIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLSGQKRA
LDLVDAMVAAADDRVSDEDVQVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRRRLFVEAGHLIVD
LARRYYEQDDDSVLPRSIASFSAFQNAMTLDIAMGGSTNTVLHLLAAAHEAEVDFTMEEIDRLSRRVPVLCKVAPAKSDV
HMEDVHRAGGIMAILGELDRGGLINRDVPTVHTATLGQAIEHWDITLTKSQKVRDFFLAAPGGVPTQVAFSQDRRWDDLD
LDRQSGVIRSAEHPFSKDGGLAVLKGNLAEDGCIVKTAGVDESILKFSGPARVFESQDSAVQAILANKINAGDVVVIRYE
GPRGGPGMQEMLYPTSYLKAKSLGKDCALITDGRFSGGTSGLSIGHVSPEAANGGLIGLVREGDRIEIDIPNRKIHLAVD
DAEIARRRAAQDAKGWKPAENRKRQVSTALKAYAAFATSADKGAVRKLPD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=76.2295081967213, Blast_Score=959, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=540, Percent_Identity=30.9259259259259, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI2367371, Length=557, Percent_Identity=30.1615798922801, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1786464, Length=523, Percent_Identity=31.3575525812619, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=608, Percent_Identity=36.8421052631579, Blast_Score=347, Evalue=5e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65312; Mature: 65181

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AHEIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLSGQKRALDLVDAMVAAADDRVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCHH
VQVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRRRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECHHHHEEEHHHHHHHH
DLARRYYEQDDDSVLPRSIASFSAFQNAMTLDIAMGGSTNTVLHLLAAAHEAEVDFTMEE
HHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHH
IDRLSRRVPVLCKVAPAKSDVHMEDVHRAGGIMAILGELDRGGLINRDVPTVHTATLGQA
HHHHHCCCCEEEEECCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEHHHHHHH
IEHWDITLTKSQKVRDFFLAAPGGVPTQVAFSQDRRWDDLDLDRQSGVIRSAEHPFSKDG
HHHCEEEEECCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCHHCCCEECCCCCCCCCC
GLAVLKGNLAEDGCIVKTAGVDESILKFSGPARVFESQDSAVQAILANKINAGDVVVIRY
CEEEEECCCCCCCEEEEECCCCHHHHHCCCCHHHHCCCHHHHHHHHHCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKAKSLGKDCALITDGRFSGGTSGLSIGHVSPEAANGGLIGL
CCCCCCCCHHHHHCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VREGDRIEIDIPNRKIHLAVDDAEIARRRAAQDAKGWKPAENRKRQVSTALKAYAAFATS
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
ADKGAVRKLPD
CCCCCCCCCCC
>Mature Secondary Structure 
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AHEIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLSGQKRALDLVDAMVAAADDRVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCHH
VQVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRRRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECHHHHEEEHHHHHHHH
DLARRYYEQDDDSVLPRSIASFSAFQNAMTLDIAMGGSTNTVLHLLAAAHEAEVDFTMEE
HHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHH
IDRLSRRVPVLCKVAPAKSDVHMEDVHRAGGIMAILGELDRGGLINRDVPTVHTATLGQA
HHHHHCCCCEEEEECCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEHHHHHHH
IEHWDITLTKSQKVRDFFLAAPGGVPTQVAFSQDRRWDDLDLDRQSGVIRSAEHPFSKDG
HHHCEEEEECCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCHHCCCEECCCCCCCCCC
GLAVLKGNLAEDGCIVKTAGVDESILKFSGPARVFESQDSAVQAILANKINAGDVVVIRY
CEEEEECCCCCCCEEEEECCCCHHHHHCCCCHHHHCCCHHHHHHHHHCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKAKSLGKDCALITDGRFSGGTSGLSIGHVSPEAANGGLIGL
CCCCCCCCHHHHHCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VREGDRIEIDIPNRKIHLAVDDAEIARRRAAQDAKGWKPAENRKRQVSTALKAYAAFATS
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
ADKGAVRKLPD
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]