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The map label for this gene is dht [H]

Identifier: 110634998

GI number: 110634998

Start: 2884929

End: 2886386

Strand: Reverse

Name: dht [H]

Synonym: Meso_2664

Alternate gene names: 110634998

Gene position: 2886386-2884929 (Counterclockwise)

Preceding gene: 110635000

Following gene: 110634995

Centisome position: 65.41

GC content: 62.28

Gene sequence:

>1458_bases
ATGTCGATCGTCATCAAAGGTGGAACAATTGTTGCGGCAGATCGCAGCTACGAAGCGGATATCCTCATTGAAGGGGAGAC
GATAGCCGCAATCGGCAAGGACCTGAAAGGCGACAAGGTGGTTGACGCCGAAGGCGCCTATGTGATGCCGGGCGGCATCG
ACCCGCACACGCATCTGGAAATGCCGTTCATGGGCACTACCGCCGCCGAGACGTGGGAATCCGGCACCTATGCGGCCATC
TCCGGCGGCACGACCATGGTGGTGGACTTTGTCATTCCCGGGCCGGCGGGCATGCTCGCGGCCCTTGATGAGTGGCAGGA
GAGGGCGGCGCGCCAGGCCTCGTCCGATTACTCGCTGCATATGTGCGTGACCGGCTGGTCGAAGCAGATTTTCGACGAAA
TGCCGCTCGTCGTCGAGCGCGGCATCAACACCTTCAAGCACTTCATGGCCTATAAGGGCGCGCTGATGGTGAATGATGAC
GAGATGTTCGCCTCCTTCCAGCGCTGCGCTGCGCTTGGCGCGCTGCCGCTGGTGCACGCGGAAAACGGCGACATCGTTGC
CGCACTCCAGCAGAAGTATCTGCAGGAGGGTATGTCCGGGCCCGAAGCGCACGCCTATTCGCGCCCGCCCGAGGTTGAAG
GCGAGGCTACCAACCGCGCCATCATGATCGCGGATGCGGCGGGGGTTCCCGTCTATATCGTGCACACCTCCTGCGAGCAG
TCGCACGAGGCGATCCGCCGCGCCCGGCAGAAGGGCATGCGTGTCTATGGCGAGCCTTTGATCCAGCATCTCCTGCTTGA
TGAATCCGAATACCGCAATCCTGACTGGGAAGAGGCGGCGCGCCGGGTGATGTCGCCGCCCTTCCGTGACAAGCGGCATC
AGGACAGCCTTTGGGCTGGACTTGCGGCCGGCTCGCTCCAGGTCGTGGCAACCGATCACGCAGCTTTCACTACGGAGCAG
AAGCGTCTGGGTCTCAACGACTTCACCAAGATTCCCAACGGCACCGGCGGGTTGGAGGATCGCATGCCGCTCCTGTGGAC
GTATGGGGTGAAGACCGGGCGGCTTACGCCCAACGAGTTCGTGGCGGTCACCTCCACCAATATCGCGCAGATTCTCAACA
TCTATCCGCAGAAGGGCGCGATCCTGCCGGGCTCGGATGCCGACCTCGTGGTGTGGGATCCTTCGAAGTCGAAGACGATC
AGCGCTTCGGCGCAGCGTTCGATCATTGACTACAACGTCTTCGAAGGCTTCGAGGTGAACGGTTTGCCGCGCTATACTCT
GTCGCGCGGCGAGGTGGTCTATGGCAAGGAGGGCAGCAACGAGCCGCGCCCGGGACGCGGGCGCTATGTTCCCCGCCCTG
CTTTCCCGGCCGTCAATAAGGCGCTTTCAACCTGGAAGGAGCTTGTGGCCCCGCGCGCTGTGGAGCGCTCGGCAAAGCAT
ATGCCAATCGGTGTGTAA

Upstream 100 bases:

>100_bases
ATCAATTCTTCGTTGAGTGTATCCTTCCGCCGGATCTATGATCATCGGTAGCGCCAGAGGGATACCGGCCGGCAGGAACC
GGCAAGAAAGAGGAGCGGCC

Downstream 100 bases:

>100_bases
GCAGTCCTGTTTGCAAGCTGTGCATCCTTGAGAATGCTCTGAGAAGGGCGCGGTTCACCACGATGCGGGGAGGGCCTGGA
CGGCTTTGACGCGCTCGCCT

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSIVIKGGTIVAADRSYEADILIEGETIAAIGKDLKGDKVVDAEGAYVMPGGIDPHTHLEMPFMGTTAAETWESGTYAAI
SGGTTMVVDFVIPGPAGMLAALDEWQERAARQASSDYSLHMCVTGWSKQIFDEMPLVVERGINTFKHFMAYKGALMVNDD
EMFASFQRCAALGALPLVHAENGDIVAALQQKYLQEGMSGPEAHAYSRPPEVEGEATNRAIMIADAAGVPVYIVHTSCEQ
SHEAIRRARQKGMRVYGEPLIQHLLLDESEYRNPDWEEAARRVMSPPFRDKRHQDSLWAGLAAGSLQVVATDHAAFTTEQ
KRLGLNDFTKIPNGTGGLEDRMPLLWTYGVKTGRLTPNEFVAVTSTNIAQILNIYPQKGAILPGSDADLVVWDPSKSKTI
SASAQRSIIDYNVFEGFEVNGLPRYTLSRGEVVYGKEGSNEPRPGRGRYVPRPAFPAVNKALSTWKELVAPRAVERSAKH
MPIGV

Sequences:

>Translated_485_residues
MSIVIKGGTIVAADRSYEADILIEGETIAAIGKDLKGDKVVDAEGAYVMPGGIDPHTHLEMPFMGTTAAETWESGTYAAI
SGGTTMVVDFVIPGPAGMLAALDEWQERAARQASSDYSLHMCVTGWSKQIFDEMPLVVERGINTFKHFMAYKGALMVNDD
EMFASFQRCAALGALPLVHAENGDIVAALQQKYLQEGMSGPEAHAYSRPPEVEGEATNRAIMIADAAGVPVYIVHTSCEQ
SHEAIRRARQKGMRVYGEPLIQHLLLDESEYRNPDWEEAARRVMSPPFRDKRHQDSLWAGLAAGSLQVVATDHAAFTTEQ
KRLGLNDFTKIPNGTGGLEDRMPLLWTYGVKTGRLTPNEFVAVTSTNIAQILNIYPQKGAILPGSDADLVVWDPSKSKTI
SASAQRSIIDYNVFEGFEVNGLPRYTLSRGEVVYGKEGSNEPRPGRGRYVPRPAFPAVNKALSTWKELVAPRAVERSAKH
MPIGV
>Mature_484_residues
SIVIKGGTIVAADRSYEADILIEGETIAAIGKDLKGDKVVDAEGAYVMPGGIDPHTHLEMPFMGTTAAETWESGTYAAIS
GGTTMVVDFVIPGPAGMLAALDEWQERAARQASSDYSLHMCVTGWSKQIFDEMPLVVERGINTFKHFMAYKGALMVNDDE
MFASFQRCAALGALPLVHAENGDIVAALQQKYLQEGMSGPEAHAYSRPPEVEGEATNRAIMIADAAGVPVYIVHTSCEQS
HEAIRRARQKGMRVYGEPLIQHLLLDESEYRNPDWEEAARRVMSPPFRDKRHQDSLWAGLAAGSLQVVATDHAAFTTEQK
RLGLNDFTKIPNGTGGLEDRMPLLWTYGVKTGRLTPNEFVAVTSTNIAQILNIYPQKGAILPGSDADLVVWDPSKSKTIS
ASAQRSIIDYNVFEGFEVNGLPRYTLSRGEVVYGKEGSNEPRPGRGRYVPRPAFPAVNKALSTWKELVAPRAVERSAKHM
PIGV

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=486, Percent_Identity=45.2674897119342, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI4503377, Length=488, Percent_Identity=44.4672131147541, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI190194363, Length=460, Percent_Identity=44.7826086956522, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI4503051, Length=460, Percent_Identity=43.4782608695652, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI62422571, Length=460, Percent_Identity=43.4782608695652, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI4503379, Length=488, Percent_Identity=40.7786885245902, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI19923821, Length=482, Percent_Identity=41.701244813278, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI18105007, Length=459, Percent_Identity=25.9259259259259, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87082175, Length=462, Percent_Identity=38.961038961039, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI1786722, Length=460, Percent_Identity=29.3478260869565, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17539558, Length=484, Percent_Identity=45.0413223140496, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71989490, Length=484, Percent_Identity=41.7355371900826, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI86575075, Length=440, Percent_Identity=31.1363636363636, Blast_Score=202, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6322218, Length=401, Percent_Identity=28.428927680798, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI221377917, Length=464, Percent_Identity=43.1034482758621, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI17137462, Length=462, Percent_Identity=42.6406926406926, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24644287, Length=310, Percent_Identity=40.6451612903226, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24644289, Length=260, Percent_Identity=41.9230769230769, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24642586, Length=410, Percent_Identity=27.8048780487805, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18859883, Length=459, Percent_Identity=22.4400871459695, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 52950; Mature: 52818

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVIKGGTIVAADRSYEADILIEGETIAAIGKDLKGDKVVDAEGAYVMPGGIDPHTHLE
CEEEEECCEEEEECCCCCCEEEEECCEEEECCCCCCCCEEEECCCCEEECCCCCCCCEEE
MPFMGTTAAETWESGTYAAISGGTTMVVDFVIPGPAGMLAALDEWQERAARQASSDYSLH
CCCCCCCHHHHCCCCCEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEE
MCVTGWSKQIFDEMPLVVERGINTFKHFMAYKGALMVNDDEMFASFQRCAALGALPLVHA
EEEECCHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCCEEEEC
ENGDIVAALQQKYLQEGMSGPEAHAYSRPPEVEGEATNRAIMIADAAGVPVYIVHTSCEQ
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHH
SHEAIRRARQKGMRVYGEPLIQHLLLDESEYRNPDWEEAARRVMSPPFRDKRHQDSLWAG
HHHHHHHHHHCCCEEHHHHHHHHHHCCCHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHH
LAAGSLQVVATDHAAFTTEQKRLGLNDFTKIPNGTGGLEDRMPLLWTYGVKTGRLTPNEF
HCCCCEEEEEECCHHCCCHHHHCCCHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCE
VAVTSTNIAQILNIYPQKGAILPGSDADLVVWDPSKSKTISASAQRSIIDYNVFEGFEVN
EEEECCCHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCEEECHHHHCEEEEECCCCEECC
GLPRYTLSRGEVVYGKEGSNEPRPGRGRYVPRPAFPAVNKALSTWKELVAPRAVERSAKH
CCCCEEECCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCC
MPIGV
CCCCC
>Mature Secondary Structure 
SIVIKGGTIVAADRSYEADILIEGETIAAIGKDLKGDKVVDAEGAYVMPGGIDPHTHLE
EEEEECCEEEEECCCCCCEEEEECCEEEECCCCCCCCEEEECCCCEEECCCCCCCCEEE
MPFMGTTAAETWESGTYAAISGGTTMVVDFVIPGPAGMLAALDEWQERAARQASSDYSLH
CCCCCCCHHHHCCCCCEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEE
MCVTGWSKQIFDEMPLVVERGINTFKHFMAYKGALMVNDDEMFASFQRCAALGALPLVHA
EEEECCHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCCEEEEC
ENGDIVAALQQKYLQEGMSGPEAHAYSRPPEVEGEATNRAIMIADAAGVPVYIVHTSCEQ
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHH
SHEAIRRARQKGMRVYGEPLIQHLLLDESEYRNPDWEEAARRVMSPPFRDKRHQDSLWAG
HHHHHHHHHHCCCEEHHHHHHHHHHCCCHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHH
LAAGSLQVVATDHAAFTTEQKRLGLNDFTKIPNGTGGLEDRMPLLWTYGVKTGRLTPNEF
HCCCCEEEEEECCHHCCCHHHHCCCHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCE
VAVTSTNIAQILNIYPQKGAILPGSDADLVVWDPSKSKTISASAQRSIIDYNVFEGFEVN
EEEECCCHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCEEECHHHHCEEEEECCCCEECC
GLPRYTLSRGEVVYGKEGSNEPRPGRGRYVPRPAFPAVNKALSTWKELVAPRAVERSAKH
CCCCEEECCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCC
MPIGV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]