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The map label for this gene is hutU [H]

Identifier: 110634972

GI number: 110634972

Start: 2848003

End: 2849667

Strand: Reverse

Name: hutU [H]

Synonym: Meso_2638

Alternate gene names: 110634972

Gene position: 2849667-2848003 (Counterclockwise)

Preceding gene: 110634973

Following gene: 110634971

Centisome position: 64.58

GC content: 61.08

Gene sequence:

>1665_bases
ATGTCGACGCCAAACGCCCGTCACCCGAATTTTCCCATCCCCGGTGGGCCGGAGTTGCGCGCCAAGGGATGGCGCCAAGA
AGCTTTGTTGCGCCTCCTCGAAAATGTGCTGAGCGTTGGCGAGAATCCCGATGACTTGGTCGTCTATGCCGCTCTGGGCA
AGGCCGCCCGCAACTGGGCCGCACATAAGGGCATCGTGCAATCCCTGCTGAGCATGGATGAGGACCAGACCCTTGTCATC
CAGTCCGGCAAGCCCATCGGCCTCCTGAAAACCCACTCCAGGGCGCCGCTGGTGATAATGGCCAATTGTAACCTCGTCGG
CCAGTGGGCCAAGTCGGAAGTCTTTTATGAACTGGAGCGAAAGGGGCTGATCTGCTGGGGAGGACTTACGGCCGGCGCCT
GGCAATATATCGGCTCGCAGGGGGTGATTCAGGGCACCTACGAAATCTTCATGCGGATTGCCGAAAGCCGTTTTGGCGGT
TCGCTCGCCGGACGCTTTATTCTCACCGCGGGCCTTGGTGGTATGGGTGGCGCCCAGCCTCTGGCGGGGCGCATGGCCGG
TGCCGCTATTCTCTGCGTCGATGTAGATGCCGAGCGCTGCAGGAAGCGCCAGCAAATCGGCTATCTCGAAGAGATTGCTC
CTGACCTGGATACGGCTTTGTCCATGATCGACCGGGCGGTGAAGGAGCGGCGCGCTACCTCCATCGGGCTTGTCGGCAAC
GCGGCCGAAATTTATCCGGAGATCGCGCGCCGTGCTATCGTGCCGGACATCGTCACCGACCAGACGGCCGCCCATGATCT
TGTCTATGGATACGTACCCAGGGGTATGTCGCTTGACGACGTAAAGCGCTTGCGCGTGGACGGACAAGCCCAACTGATGG
CCGCAAGCCGCGCATCCATGGTCGATCAGGTGCGGGCCATGCTCGATTTCCAGAAAGCCGGCGCCGAAGTATTCGATAAC
GGCAATCTCATCCGCACCCATGCCAGGGATGGCGGCGTGGAAAACGCGTTCGACATCAAAATCTTCACCGAGGCCTATCT
GCGGCCGCTTTTCGCACGGGGAATTGGTCCGTTTCGCTGGGTGGCGCTGTCGGGCGATCCTGAGGACATCCGCAAGATCG
ACGACAAATTGCTGGAGATGTTTGCGGATAACAAGATCATCACCAACTGGATCGGCCTGGCGCGCCGGTATGTGCCCTTT
GAAGGGCTGCCGGCGCGCATCGCCTGGCTTGGCCATGGCGAGCGCACCGCGCTGGGACGGGCCGTCAATGCCATGGTGGC
TGAGGGTGTGCTCGCTGGGCCGGTGGCCTTCAGTCGCGATCACCTCGATGCCGGCGCCATGGCCCATCCCAATATTATGA
CCGAGCGGATGAAGGATGGCTCCGACGCCGTCGCCGATTGGCCGCTGCTGAATGCCATGCTGCTCTGTTCCTCCATGGCG
GATCTGGTCGTCGTCCATTCGGGCGGGGGCGGCTATGCCGGTTACATGACCTCGGCCGGCGTGACGATCGTCGCTGATGG
AACGCCGGAGGCCGATGAACGGCTGGAGCATGCGTTGACCAACGATACCGCATTGGGCGTGATGCGGTATGCCGATGCGG
GATATGACGAAAGCCACGAAGAAATAGTGGCCAAAGGAATCCACCATATCGCCCTATCGGAATAG

Upstream 100 bases:

>100_bases
TTGCAGGCCTAGGCGCCCAGCCGCGCCAACGGTCATCTGCGCAGGGACGAGGCCTCATCCCTCGGCAGTATGAGAACGAG
GTCTATGGAGATTTTCCATC

Downstream 100 bases:

>100_bases
CTGACGGCATATAGCCGCAGGCGGACGCCGCGCCCGGATTATTTTCCTCAATCCGGCAATTTCGAGAGCACTGTGGAAAT
CGGCGGGCGCGGTCGGGTGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSTPNARHPNFPIPGGPELRAKGWRQEALLRLLENVLSVGENPDDLVVYAALGKAARNWAAHKGIVQSLLSMDEDQTLVI
QSGKPIGLLKTHSRAPLVIMANCNLVGQWAKSEVFYELERKGLICWGGLTAGAWQYIGSQGVIQGTYEIFMRIAESRFGG
SLAGRFILTAGLGGMGGAQPLAGRMAGAAILCVDVDAERCRKRQQIGYLEEIAPDLDTALSMIDRAVKERRATSIGLVGN
AAEIYPEIARRAIVPDIVTDQTAAHDLVYGYVPRGMSLDDVKRLRVDGQAQLMAASRASMVDQVRAMLDFQKAGAEVFDN
GNLIRTHARDGGVENAFDIKIFTEAYLRPLFARGIGPFRWVALSGDPEDIRKIDDKLLEMFADNKIITNWIGLARRYVPF
EGLPARIAWLGHGERTALGRAVNAMVAEGVLAGPVAFSRDHLDAGAMAHPNIMTERMKDGSDAVADWPLLNAMLLCSSMA
DLVVVHSGGGGYAGYMTSAGVTIVADGTPEADERLEHALTNDTALGVMRYADAGYDESHEEIVAKGIHHIALSE

Sequences:

>Translated_554_residues
MSTPNARHPNFPIPGGPELRAKGWRQEALLRLLENVLSVGENPDDLVVYAALGKAARNWAAHKGIVQSLLSMDEDQTLVI
QSGKPIGLLKTHSRAPLVIMANCNLVGQWAKSEVFYELERKGLICWGGLTAGAWQYIGSQGVIQGTYEIFMRIAESRFGG
SLAGRFILTAGLGGMGGAQPLAGRMAGAAILCVDVDAERCRKRQQIGYLEEIAPDLDTALSMIDRAVKERRATSIGLVGN
AAEIYPEIARRAIVPDIVTDQTAAHDLVYGYVPRGMSLDDVKRLRVDGQAQLMAASRASMVDQVRAMLDFQKAGAEVFDN
GNLIRTHARDGGVENAFDIKIFTEAYLRPLFARGIGPFRWVALSGDPEDIRKIDDKLLEMFADNKIITNWIGLARRYVPF
EGLPARIAWLGHGERTALGRAVNAMVAEGVLAGPVAFSRDHLDAGAMAHPNIMTERMKDGSDAVADWPLLNAMLLCSSMA
DLVVVHSGGGGYAGYMTSAGVTIVADGTPEADERLEHALTNDTALGVMRYADAGYDESHEEIVAKGIHHIALSE
>Mature_553_residues
STPNARHPNFPIPGGPELRAKGWRQEALLRLLENVLSVGENPDDLVVYAALGKAARNWAAHKGIVQSLLSMDEDQTLVIQ
SGKPIGLLKTHSRAPLVIMANCNLVGQWAKSEVFYELERKGLICWGGLTAGAWQYIGSQGVIQGTYEIFMRIAESRFGGS
LAGRFILTAGLGGMGGAQPLAGRMAGAAILCVDVDAERCRKRQQIGYLEEIAPDLDTALSMIDRAVKERRATSIGLVGNA
AEIYPEIARRAIVPDIVTDQTAAHDLVYGYVPRGMSLDDVKRLRVDGQAQLMAASRASMVDQVRAMLDFQKAGAEVFDNG
NLIRTHARDGGVENAFDIKIFTEAYLRPLFARGIGPFRWVALSGDPEDIRKIDDKLLEMFADNKIITNWIGLARRYVPFE
GLPARIAWLGHGERTALGRAVNAMVAEGVLAGPVAFSRDHLDAGAMAHPNIMTERMKDGSDAVADWPLLNAMLLCSSMAD
LVVVHSGGGGYAGYMTSAGVTIVADGTPEADERLEHALTNDTALGVMRYADAGYDESHEEIVAKGIHHIALSE

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=546, Percent_Identity=29.6703296703297, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI260306182, Length=345, Percent_Identity=28.1159420289855, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71997891, Length=569, Percent_Identity=29.8769771528998, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 59897; Mature: 59766

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPNARHPNFPIPGGPELRAKGWRQEALLRLLENVLSVGENPDDLVVYAALGKAARNWA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHH
AHKGIVQSLLSMDEDQTLVIQSGKPIGLLKTHSRAPLVIMANCNLVGQWAKSEVFYELER
HHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCEEECHHHHHHHHHHHC
KGLICWGGLTAGAWQYIGSQGVIQGTYEIFMRIAESRFGGSLAGRFILTAGLGGMGGAQP
CCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHEEECCCCCCCCCC
LAGRMAGAAILCVDVDAERCRKRQQIGYLEEIAPDLDTALSMIDRAVKERRATSIGLVGN
HHHHHCCCEEEEEECCHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCC
AAEIYPEIARRAIVPDIVTDQTAAHDLVYGYVPRGMSLDDVKRLRVDGQAQLMAASRASM
HHHHHHHHHHHHCCCCHHCCCHHHHHHHEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
VDQVRAMLDFQKAGAEVFDNGNLIRTHARDGGVENAFDIKIFTEAYLRPLFARGIGPFRW
HHHHHHHHHHHHCCHHEECCCCEEEEECCCCCCCCEEEEEEHHHHHHHHHHHCCCCCEEE
VALSGDPEDIRKIDDKLLEMFADNKIITNWIGLARRYVPFEGLPARIAWLGHGERTALGR
EEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHH
AVNAMVAEGVLAGPVAFSRDHLDAGAMAHPNIMTERMKDGSDAVADWPLLNAMLLCSSMA
HHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
DLVVVHSGGGGYAGYMTSAGVTIVADGTPEADERLEHALTNDTALGVMRYADAGYDESHE
CEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCHHH
EIVAKGIHHIALSE
HHHHHHHHHHHCCC
>Mature Secondary Structure 
STPNARHPNFPIPGGPELRAKGWRQEALLRLLENVLSVGENPDDLVVYAALGKAARNWA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHH
AHKGIVQSLLSMDEDQTLVIQSGKPIGLLKTHSRAPLVIMANCNLVGQWAKSEVFYELER
HHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCEEECHHHHHHHHHHHC
KGLICWGGLTAGAWQYIGSQGVIQGTYEIFMRIAESRFGGSLAGRFILTAGLGGMGGAQP
CCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHEEECCCCCCCCCC
LAGRMAGAAILCVDVDAERCRKRQQIGYLEEIAPDLDTALSMIDRAVKERRATSIGLVGN
HHHHHCCCEEEEEECCHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCC
AAEIYPEIARRAIVPDIVTDQTAAHDLVYGYVPRGMSLDDVKRLRVDGQAQLMAASRASM
HHHHHHHHHHHHCCCCHHCCCHHHHHHHEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
VDQVRAMLDFQKAGAEVFDNGNLIRTHARDGGVENAFDIKIFTEAYLRPLFARGIGPFRW
HHHHHHHHHHHHCCHHEECCCCEEEEECCCCCCCCEEEEEEHHHHHHHHHHHCCCCCEEE
VALSGDPEDIRKIDDKLLEMFADNKIITNWIGLARRYVPFEGLPARIAWLGHGERTALGR
EEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHH
AVNAMVAEGVLAGPVAFSRDHLDAGAMAHPNIMTERMKDGSDAVADWPLLNAMLLCSSMA
HHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
DLVVVHSGGGGYAGYMTSAGVTIVADGTPEADERLEHALTNDTALGVMRYADAGYDESHE
CEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCHHH
EIVAKGIHHIALSE
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]