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The map label for this gene is Dml [H]

Identifier: 110634854

GI number: 110634854

Start: 2692634

End: 2693515

Strand: Direct

Name: Dml [H]

Synonym: Meso_2513

Alternate gene names: 110634854

Gene position: 2692634-2693515 (Clockwise)

Preceding gene: 110634853

Following gene: 110634855

Centisome position: 61.02

GC content: 65.65

Gene sequence:

>882_bases
ATGCTCAATCACGAGATCAACAGGGCGTTCCGCGCGCGGCTGGAGAAGGGCGGCGCGCTCCTGCTGCCGGGTGCGGCCAA
CGCGCTTGCCGCGCGCATCATCGCCGATCTGGGCTTCGAGGCGATCTATCTTTCCGGCGCGGGCCTGACCAACACCTATC
TCGGCATGCCGGACTTGGGCTTCGTCAGCCTGCCGGAGATCGCGCAACATACGGCCACCATCCGCGACGCGACGGACCTG
CCCATCGTCGTCGATGCCGACACCGGCTTCGGCAATGCGCTCAACGTGCGCCACACGGTTCGCACCCTGGAGCGTGCCGG
CGCCAGCGCCATCCAGATTGAGGACCAGGTGAGCCCGAAGCGCTGCGGCCATTTTTCCGGCAAGGACGTTGTGGACCTTG
CCGAAGCCCGCAGCCGCATCAAGGCCGCCGCCGACGCCCGCCAGGACGAAAACCTGCTGATCGTCGCCCGCACCGATGCG
CGGGCCACACTGGGCTTTGACGCGGCCATCGAGCGGGCGCAGGCTTTCATCGAGGACGGCGCGGACATTACCTTTGTCGA
AGCGCCGGAAAGCACGGACGAGATCCGCGCCATTCCTGCCCGCCTGAAGGGCACGCCGCAGCTCGTGAACCTCGTCGTCG
GCGGGCGCACGCCGATCATGGATTTCGACGAGCTGAACGCAATGGGTTTTTCGCTCGTGCTTTATGCCAACGTGGCGTTG
CAGGGCGCGGTCTACGGCATGCAGGCCGCGCTCGGAAAGCTCAAGGCGGACGGAAAGCTGGATGAATCCGGGCCGGTCGC
GGGTTTCAAGGAGCGCCAACGGCTTGTGGCAAAGCCTTTCTTCGACGAGTTGGAACGGCGCTATTCCACCGAGAAGGCGT
GA

Upstream 100 bases:

>100_bases
GGCGCGCTCGACGCGCTGGTGCCCGCGCTCACCGCCGGAAGCGTGAACCCGTCACGCCCAACCGGCGAAGGCATTTTCGA
CCGCGGTCTGGAGTAGGCCG

Downstream 100 bases:

>100_bases
ACTCGTGGTGGAGACGGAAGAGATCGGAGCGGAGGCTGAACAGGACTTTCAGTCGCTGTCGGATTCGCTATTCGAGAAGC
TGAGCGAGGCCATCGTTCGA

Product: 2,3-dimethylmalate lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLNHEINRAFRARLEKGGALLLPGAANALAARIIADLGFEAIYLSGAGLTNTYLGMPDLGFVSLPEIAQHTATIRDATDL
PIVVDADTGFGNALNVRHTVRTLERAGASAIQIEDQVSPKRCGHFSGKDVVDLAEARSRIKAAADARQDENLLIVARTDA
RATLGFDAAIERAQAFIEDGADITFVEAPESTDEIRAIPARLKGTPQLVNLVVGGRTPIMDFDELNAMGFSLVLYANVAL
QGAVYGMQAALGKLKADGKLDESGPVAGFKERQRLVAKPFFDELERRYSTEKA

Sequences:

>Translated_293_residues
MLNHEINRAFRARLEKGGALLLPGAANALAARIIADLGFEAIYLSGAGLTNTYLGMPDLGFVSLPEIAQHTATIRDATDL
PIVVDADTGFGNALNVRHTVRTLERAGASAIQIEDQVSPKRCGHFSGKDVVDLAEARSRIKAAADARQDENLLIVARTDA
RATLGFDAAIERAQAFIEDGADITFVEAPESTDEIRAIPARLKGTPQLVNLVVGGRTPIMDFDELNAMGFSLVLYANVAL
QGAVYGMQAALGKLKADGKLDESGPVAGFKERQRLVAKPFFDELERRYSTEKA
>Mature_293_residues
MLNHEINRAFRARLEKGGALLLPGAANALAARIIADLGFEAIYLSGAGLTNTYLGMPDLGFVSLPEIAQHTATIRDATDL
PIVVDADTGFGNALNVRHTVRTLERAGASAIQIEDQVSPKRCGHFSGKDVVDLAEARSRIKAAADARQDENLLIVARTDA
RATLGFDAAIERAQAFIEDGADITFVEAPESTDEIRAIPARLKGTPQLVNLVVGGRTPIMDFDELNAMGFSLVLYANVAL
QGAVYGMQAALGKLKADGKLDESGPVAGFKERQRLVAKPFFDELERRYSTEKA

Specific function: Catalyzes the formation of proponate and pyruvate from (2R,3S)-2,3-dimethylmalate. Has no activity toward dimethylmaleate, malate, citramalate, isocitrate and citrate [H]

COG id: COG2513

COG function: function code G; PEP phosphonomutase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786525, Length=233, Percent_Identity=43.3476394849785, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1790445, Length=87, Percent_Identity=47.1264367816092, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.32 [H]

Molecular weight: Translated: 31433; Mature: 31433

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNHEINRAFRARLEKGGALLLPGAANALAARIIADLGFEAIYLSGAGLTNTYLGMPDLG
CCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCC
FVSLPEIAQHTATIRDATDLPIVVDADTGFGNALNVRHTVRTLERAGASAIQIEDQVSPK
CCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCHH
RCGHFSGKDVVDLAEARSRIKAAADARQDENLLIVARTDARATLGFDAAIERAQAFIEDG
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCHHHHHHHHHHHHHCC
ADITFVEAPESTDEIRAIPARLKGTPQLVNLVVGGRTPIMDFDELNAMGFSLVLYANVAL
CCEEEEECCCCHHHHHHHHHHCCCCHHHEEEEECCCCCCCCHHHHHHHHHEEEEHHHHHH
QGAVYGMQAALGKLKADGKLDESGPVAGFKERQRLVAKPFFDELERRYSTEKA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLNHEINRAFRARLEKGGALLLPGAANALAARIIADLGFEAIYLSGAGLTNTYLGMPDLG
CCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCC
FVSLPEIAQHTATIRDATDLPIVVDADTGFGNALNVRHTVRTLERAGASAIQIEDQVSPK
CCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCHH
RCGHFSGKDVVDLAEARSRIKAAADARQDENLLIVARTDARATLGFDAAIERAQAFIEDG
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCHHHHHHHHHHHHHCC
ADITFVEAPESTDEIRAIPARLKGTPQLVNLVVGGRTPIMDFDELNAMGFSLVLYANVAL
CCEEEEECCCCHHHHHHHHHHCCCCHHHEEEEECCCCCCCCHHHHHHHHHEEEEHHHHHH
QGAVYGMQAALGKLKADGKLDESGPVAGFKERQRLVAKPFFDELERRYSTEKA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA