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The map label for this gene is prpD2 [H]

Identifier: 110634853

GI number: 110634853

Start: 2691106

End: 2692629

Strand: Direct

Name: prpD2 [H]

Synonym: Meso_2512

Alternate gene names: 110634853

Gene position: 2691106-2692629 (Clockwise)

Preceding gene: 110634852

Following gene: 110634854

Centisome position: 60.99

GC content: 66.4

Gene sequence:

>1524_bases
ATGAAAAAACACACTGTGAAGGTCCACCCCTCGGCAGCAAAGCTTCCGCGCGAGGAGCAACTTGCCTGGCACATTGCGGA
TTTTGCCGCCCATTGCGGCCCGCTCGATGCCGACGTGCAGGACATGATCGCCTGCCGCATCGTCGACAATGCCGCCGTGG
CACTCGCCGCGATCAACCGCAAGCCGGTGGCGGCGGCCCGCGCGATGGCGCTGGCCCACCCGCGCAAGCGCGGCGCAACC
CTCTTCGGCCTGCCTGCCGCGACGCGCGTCGATGCCGAATGGGCGGCCTGGGCCAACGCGACGGCCGTGCGCGAGCTCGA
TTTCCACGACACGTTCCTTGCCGCCGACTATTCGCACCCGGGCGACTCCATTTCGCCGCTGGTCGCAGTGGCGCAGCAGA
TGGGGCTGGACGGGGCCGCTCTTGCCCGCGGCATTGCGGTCGCCTACGAGATCCACGTGGCGCTGGTGAAGGCGATCTCG
CTGCACAAGTACAAGAAGGATCATGTGGCCCATTTGGCCCCCGCCACCACGGCCGGCATTGGCGCCATGCTCGGCCTGCC
GACGGACGTCATCTTCCAGGCGGTAAACCAGGCCGTCCACCTCGCCTTCTCCACGCGGCAATCGCGCAAGGGCGAGATCA
GCTCCTGGAAAGCCTACGTGCCGGGCTTCTCCGGCAAACTCGCCATCGAATGCATCGACCGCGCCATGCGCGGCGAGGCG
GCCCCCTCCCCCATCTATGAGGGCGAGGATTCCGTCATCGCCTGGATGCTCGGCGGGCCTGAGACCGCCTACGAGGTCTT
CCTGCCCGCCCCTGGCGAGAGCCCGCGCGGCATTATGGAGACCTACACCAAGGCGCATTCCGCCGAATACCAGGCGCAGG
CGCTGATCGACCTCGCCATCGAGCTTTCCGGCCAGATTGGCGATCTTTCTGAGGTGCGCGACATCCTTTTGGAGACGAGC
CACCACACGCATTATGTGATCGGCACCGGCGCCAATGACCCGCAGAAGATGGACCCGGAGGCGAGCCGCGAGACGCTCGA
CCATTCCATCATGTACATCCTGGCCGTGGCGCTGGAAGACCGCAAATGGCACCATGTGGATTCCTACACGCGCGAGCGTT
CACGCCGCGCCTCCACGGTGGAGCTCTGGCACAAGATCAGAACGGTGGAGGACCAGGTCTGGACCACGCGCTATCACGAG
CCAGACCCTGCCAAACGCGCCTTCGGCGGCAGGCTCATCGTCACCATGAAAGACGGCCGTGTGATCTCCGGCGAGCGGGC
GGTGGCCGATGCCCACCCCAACGGTGCTCGCCCCTGGACCTGGCCGGATTATGTCGGCAAGTTCGATGGACTCACACGCG
AGATGCTGGGCGCGCCGGAGCGCGAGGCGTTCCTGTCCGCGGCCAAGGGATTTGCAAAGCTTGCCCCCGGCGCGCTCGAC
GCGCTGGTGCCCGCGCTCACCGCCGGAAGCGTGAACCCGTCACGCCCAACCGGCGAAGGCATTTTCGACCGCGGTCTGGA
GTAG

Upstream 100 bases:

>100_bases
CTGCGGGCCAACGCTTAACAAGAGCATGATTCCGAAGAGTTGCACACTCTCGGCAAGATCATGCGGCTGAAGAACCAAAA
ACAATAGGCAACGTCAAACA

Downstream 100 bases:

>100_bases
GCCGATGCTCAATCACGAGATCAACAGGGCGTTCCGCGCGCGGCTGGAGAAGGGCGGCGCGCTCCTGCTGCCGGGTGCGG
CCAACGCGCTTGCCGCGCGC

Product: MmgE/PrpD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MKKHTVKVHPSAAKLPREEQLAWHIADFAAHCGPLDADVQDMIACRIVDNAAVALAAINRKPVAAARAMALAHPRKRGAT
LFGLPAATRVDAEWAAWANATAVRELDFHDTFLAADYSHPGDSISPLVAVAQQMGLDGAALARGIAVAYEIHVALVKAIS
LHKYKKDHVAHLAPATTAGIGAMLGLPTDVIFQAVNQAVHLAFSTRQSRKGEISSWKAYVPGFSGKLAIECIDRAMRGEA
APSPIYEGEDSVIAWMLGGPETAYEVFLPAPGESPRGIMETYTKAHSAEYQAQALIDLAIELSGQIGDLSEVRDILLETS
HHTHYVIGTGANDPQKMDPEASRETLDHSIMYILAVALEDRKWHHVDSYTRERSRRASTVELWHKIRTVEDQVWTTRYHE
PDPAKRAFGGRLIVTMKDGRVISGERAVADAHPNGARPWTWPDYVGKFDGLTREMLGAPEREAFLSAAKGFAKLAPGALD
ALVPALTAGSVNPSRPTGEGIFDRGLE

Sequences:

>Translated_507_residues
MKKHTVKVHPSAAKLPREEQLAWHIADFAAHCGPLDADVQDMIACRIVDNAAVALAAINRKPVAAARAMALAHPRKRGAT
LFGLPAATRVDAEWAAWANATAVRELDFHDTFLAADYSHPGDSISPLVAVAQQMGLDGAALARGIAVAYEIHVALVKAIS
LHKYKKDHVAHLAPATTAGIGAMLGLPTDVIFQAVNQAVHLAFSTRQSRKGEISSWKAYVPGFSGKLAIECIDRAMRGEA
APSPIYEGEDSVIAWMLGGPETAYEVFLPAPGESPRGIMETYTKAHSAEYQAQALIDLAIELSGQIGDLSEVRDILLETS
HHTHYVIGTGANDPQKMDPEASRETLDHSIMYILAVALEDRKWHHVDSYTRERSRRASTVELWHKIRTVEDQVWTTRYHE
PDPAKRAFGGRLIVTMKDGRVISGERAVADAHPNGARPWTWPDYVGKFDGLTREMLGAPEREAFLSAAKGFAKLAPGALD
ALVPALTAGSVNPSRPTGEGIFDRGLE
>Mature_507_residues
MKKHTVKVHPSAAKLPREEQLAWHIADFAAHCGPLDADVQDMIACRIVDNAAVALAAINRKPVAAARAMALAHPRKRGAT
LFGLPAATRVDAEWAAWANATAVRELDFHDTFLAADYSHPGDSISPLVAVAQQMGLDGAALARGIAVAYEIHVALVKAIS
LHKYKKDHVAHLAPATTAGIGAMLGLPTDVIFQAVNQAVHLAFSTRQSRKGEISSWKAYVPGFSGKLAIECIDRAMRGEA
APSPIYEGEDSVIAWMLGGPETAYEVFLPAPGESPRGIMETYTKAHSAEYQAQALIDLAIELSGQIGDLSEVRDILLETS
HHTHYVIGTGANDPQKMDPEASRETLDHSIMYILAVALEDRKWHHVDSYTRERSRRASTVELWHKIRTVEDQVWTTRYHE
PDPAKRAFGGRLIVTMKDGRVISGERAVADAHPNGARPWTWPDYVGKFDGLTREMLGAPEREAFLSAAKGFAKLAPGALD
ALVPALTAGSVNPSRPTGEGIFDRGLE

Specific function: Catalyzes the dehydration of 2-methylcitrate to 2- methyl-cis-aconitate [H]

COG id: COG2079

COG function: function code R; Uncharacterized protein involved in propionate catabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prpD family [H]

Homologues:

Organism=Escherichia coli, GI1786528, Length=346, Percent_Identity=24.8554913294798, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005656 [H]

Pfam domain/function: PF03972 MmgE_PrpD [H]

EC number: =4.2.1.79 [H]

Molecular weight: Translated: 54971; Mature: 54971

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHTVKVHPSAAKLPREEQLAWHIADFAAHCGPLDADVQDMIACRIVDNAAVALAAINR
CCCCEEEECCHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEECCHHEEEEECCC
KPVAAARAMALAHPRKRGATLFGLPAATRVDAEWAAWANATAVRELDFHDTFLAADYSHP
CCHHHHHHHHHHCCHHCCCEEEECCCCCCCCCHHHHHCCCCEEEECCCCCCEEEECCCCC
GDSISPLVAVAQQMGLDGAALARGIAVAYEIHVALVKAISLHKYKKDHVAHLAPATTAGI
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GAMLGLPTDVIFQAVNQAVHLAFSTRQSRKGEISSWKAYVPGFSGKLAIECIDRAMRGEA
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCC
APSPIYEGEDSVIAWMLGGPETAYEVFLPAPGESPRGIMETYTKAHSAEYQAQALIDLAI
CCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHH
ELSGQIGDLSEVRDILLETSHHTHYVIGTGANDPQKMDPEASRETLDHSIMYILAVALED
HHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
RKWHHVDSYTRERSRRASTVELWHKIRTVEDQVWTTRYHEPDPAKRAFGGRLIVTMKDGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCE
VISGERAVADAHPNGARPWTWPDYVGKFDGLTREMLGAPEREAFLSAAKGFAKLAPGALD
EECCCCEEECCCCCCCCCCCCHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHH
ALVPALTAGSVNPSRPTGEGIFDRGLE
HHHHHHHCCCCCCCCCCCCCHHHCCCC
>Mature Secondary Structure
MKKHTVKVHPSAAKLPREEQLAWHIADFAAHCGPLDADVQDMIACRIVDNAAVALAAINR
CCCCEEEECCHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEECCHHEEEEECCC
KPVAAARAMALAHPRKRGATLFGLPAATRVDAEWAAWANATAVRELDFHDTFLAADYSHP
CCHHHHHHHHHHCCHHCCCEEEECCCCCCCCCHHHHHCCCCEEEECCCCCCEEEECCCCC
GDSISPLVAVAQQMGLDGAALARGIAVAYEIHVALVKAISLHKYKKDHVAHLAPATTAGI
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GAMLGLPTDVIFQAVNQAVHLAFSTRQSRKGEISSWKAYVPGFSGKLAIECIDRAMRGEA
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCC
APSPIYEGEDSVIAWMLGGPETAYEVFLPAPGESPRGIMETYTKAHSAEYQAQALIDLAI
CCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHH
ELSGQIGDLSEVRDILLETSHHTHYVIGTGANDPQKMDPEASRETLDHSIMYILAVALED
HHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
RKWHHVDSYTRERSRRASTVELWHKIRTVEDQVWTTRYHEPDPAKRAFGGRLIVTMKDGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCE
VISGERAVADAHPNGARPWTWPDYVGKFDGLTREMLGAPEREAFLSAAKGFAKLAPGALD
EECCCCEEECCCCCCCCCCCCHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHH
ALVPALTAGSVNPSRPTGEGIFDRGLE
HHHHHHHCCCCCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11976302; 12948626 [H]