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The map label for this gene is mtaD [H]

Identifier: 110634746

GI number: 110634746

Start: 2562201

End: 2563499

Strand: Reverse

Name: mtaD [H]

Synonym: Meso_2404

Alternate gene names: 110634746

Gene position: 2563499-2562201 (Counterclockwise)

Preceding gene: 110634747

Following gene: 110634745

Centisome position: 58.1

GC content: 65.05

Gene sequence:

>1299_bases
ATGGCGACGCTGCTCCATAATGCCTTCATCTGCACCGGCCGCCCCGACGGTTTCTTCCAGGATGGCGCTATTCTGATCCG
CGACGGCAGGGTCGACTGGATTGGCGATCGCGCCGACCTGCCGGAGCAGGACGGCTCCGTCCAGCGCGAAGATCTCGGCG
GCCGCGTCGTGATTCCCGGCCTGATCAACACCCATGCGCATGGCGGACTTTCCACCCACCGCTGCAGTTGCGATGACGGC
GACCTGTTTCAGTGGGCGGCAGCCCTCGCGCCGCATACCTCGCACCTGACCGTCGAGGACAACCGGCGCGGTTGCTATCT
CGCCATCATGGACATGGTGCGTAACGGCATCACCACCGCCTGCGACTGCACGCGCTATGGAGCGGGCGTTTTTGCCGACG
TCGCCAGCGAAATAGGCATGCGCTCGCTAAGCGGCGCGCTGGCGAACTCGCCGGAGTTGCGCAAGACCGGACGGCCGAAT
TGGCCGCTGGCGCTGGAGGAGACCGTGGCCGCCATGGCAAAGCATGCGGGCAACGGACTCGCGCGCTTCTATCTCGGCGG
TCATTCACCCTATAGCTGCACGCCGGAGCTGCTGCGCGAGGTGAAGCACGAAGCCGACCGGCTCGATCTGCCCTTCGTCA
TCCATCTTGCCGAGAACAGGCGCGAGAACGAGATGATCCAGGAGCGCTACGGGCTGACGCCGACCGCCTGGCTTCATGAT
CTCGGGGCGCTCGACCGGCGGGCCATCCTCGCCCACTGCGTATGGCTGGACGAGGCCGACATGGACATTCTCGCGCGGAC
CGGCGCGGGTGTCGCGCACAACCCGGCAAGCAACGCAAAGCTTGCCAGCGGGATCGCGCCCGTGCCGGCGCTCCGCCGGC
GAGGCGTGCCCGTTGGGCTGGGCACGGACAGCACCCTCAGCAACAATTGCCTCGATCTCTTTCAGGAGATGAAACTTTCG
GTGCTGCTGCAGCGCGCGGCCTCGCTCGACGGTTTCATCATGAACGCCGAGGACGCCTTCACCATGGCGACGATCGAAGG
CGCGCGCGTGCTGAACTGGGACAACGAGATCGGCAGCCTTGAACCCGGCAAGCAGGCAGACCTCGTCATTCTCGACATCG
AACATCCGCTTGGCCTCACGGCCCAGCGCGTGCTTTCCGACGTCGTCTATCATGCCGGACCGCAGCATGTGTCGGGGGTG
ATGGTCGCCGGACGCATGATCTTCCGAAACGGCAGGCTGCTGCTCGTCGATGAGCCGGCCATTCGCGCGCAAATCCACCA
ACACTACGCACAACATTGA

Upstream 100 bases:

>100_bases
GGTCCCATCACCGTTGAAAATGGCGAATACATCGCCTCCGGCGTCTCTGCCGAGATTTCGCTCACCTTGCGCGAGAAGCG
CTTTCCGCTGGAGGCCTGAG

Downstream 100 bases:

>100_bases
CCCAGGGACTGGAAACAAGCATGACACAAGCGCCTGTCGGCCTCATTACGAGCGCAGCATCCGAAAACCTTCTCCAGGAC
CGCCGCACGGAGATCGTCTC

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MATLLHNAFICTGRPDGFFQDGAILIRDGRVDWIGDRADLPEQDGSVQREDLGGRVVIPGLINTHAHGGLSTHRCSCDDG
DLFQWAAALAPHTSHLTVEDNRRGCYLAIMDMVRNGITTACDCTRYGAGVFADVASEIGMRSLSGALANSPELRKTGRPN
WPLALEETVAAMAKHAGNGLARFYLGGHSPYSCTPELLREVKHEADRLDLPFVIHLAENRRENEMIQERYGLTPTAWLHD
LGALDRRAILAHCVWLDEADMDILARTGAGVAHNPASNAKLASGIAPVPALRRRGVPVGLGTDSTLSNNCLDLFQEMKLS
VLLQRAASLDGFIMNAEDAFTMATIEGARVLNWDNEIGSLEPGKQADLVILDIEHPLGLTAQRVLSDVVYHAGPQHVSGV
MVAGRMIFRNGRLLLVDEPAIRAQIHQHYAQH

Sequences:

>Translated_432_residues
MATLLHNAFICTGRPDGFFQDGAILIRDGRVDWIGDRADLPEQDGSVQREDLGGRVVIPGLINTHAHGGLSTHRCSCDDG
DLFQWAAALAPHTSHLTVEDNRRGCYLAIMDMVRNGITTACDCTRYGAGVFADVASEIGMRSLSGALANSPELRKTGRPN
WPLALEETVAAMAKHAGNGLARFYLGGHSPYSCTPELLREVKHEADRLDLPFVIHLAENRRENEMIQERYGLTPTAWLHD
LGALDRRAILAHCVWLDEADMDILARTGAGVAHNPASNAKLASGIAPVPALRRRGVPVGLGTDSTLSNNCLDLFQEMKLS
VLLQRAASLDGFIMNAEDAFTMATIEGARVLNWDNEIGSLEPGKQADLVILDIEHPLGLTAQRVLSDVVYHAGPQHVSGV
MVAGRMIFRNGRLLLVDEPAIRAQIHQHYAQH
>Mature_431_residues
ATLLHNAFICTGRPDGFFQDGAILIRDGRVDWIGDRADLPEQDGSVQREDLGGRVVIPGLINTHAHGGLSTHRCSCDDGD
LFQWAAALAPHTSHLTVEDNRRGCYLAIMDMVRNGITTACDCTRYGAGVFADVASEIGMRSLSGALANSPELRKTGRPNW
PLALEETVAAMAKHAGNGLARFYLGGHSPYSCTPELLREVKHEADRLDLPFVIHLAENRRENEMIQERYGLTPTAWLHDL
GALDRRAILAHCVWLDEADMDILARTGAGVAHNPASNAKLASGIAPVPALRRRGVPVGLGTDSTLSNNCLDLFQEMKLSV
LLQRAASLDGFIMNAEDAFTMATIEGARVLNWDNEIGSLEPGKQADLVILDIEHPLGLTAQRVLSDVVYHAGPQHVSGVM
VAGRMIFRNGRLLLVDEPAIRAQIHQHYAQH

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=382, Percent_Identity=24.869109947644, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789249, Length=377, Percent_Identity=27.3209549071618, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI87082177, Length=438, Percent_Identity=25.1141552511416, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17540282, Length=386, Percent_Identity=23.8341968911917, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319963, Length=332, Percent_Identity=24.0963855421687, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24643849, Length=298, Percent_Identity=27.1812080536913, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 47025; Mature: 46894

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLLHNAFICTGRPDGFFQDGAILIRDGRVDWIGDRADLPEQDGSVQREDLGGRVVIPG
CCCEEECEEEECCCCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCHHCCCCEEEECC
LINTHAHGGLSTHRCSCDDGDLFQWAAALAPHTSHLTVEDNRRGCYLAIMDMVRNGITTA
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCH
CDCTRYGAGVFADVASEIGMRSLSGALANSPELRKTGRPNWPLALEETVAAMAKHAGNGL
HHHHHHCCHHHHHHHHHHCHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCE
ARFYLGGHSPYSCTPELLREVKHEADRLDLPFVIHLAENRRENEMIQERYGLTPTAWLHD
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHH
LGALDRRAILAHCVWLDEADMDILARTGAGVAHNPASNAKLASGIAPVPALRRRGVPVGL
HHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCCHHHHHCCCEEEC
GTDSTLSNNCLDLFQEMKLSVLLQRAASLDGFIMNAEDAFTMATIEGARVLNWDNEIGSL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCEEEECCCCCCCC
EPGKQADLVILDIEHPLGLTAQRVLSDVVYHAGPQHVSGVMVAGRMIFRNGRLLLVDEPA
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEECCCEEEEECHH
IRAQIHQHYAQH
HHHHHHHHHHCC
>Mature Secondary Structure 
ATLLHNAFICTGRPDGFFQDGAILIRDGRVDWIGDRADLPEQDGSVQREDLGGRVVIPG
CCEEECEEEECCCCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCHHCCCCEEEECC
LINTHAHGGLSTHRCSCDDGDLFQWAAALAPHTSHLTVEDNRRGCYLAIMDMVRNGITTA
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCH
CDCTRYGAGVFADVASEIGMRSLSGALANSPELRKTGRPNWPLALEETVAAMAKHAGNGL
HHHHHHCCHHHHHHHHHHCHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCE
ARFYLGGHSPYSCTPELLREVKHEADRLDLPFVIHLAENRRENEMIQERYGLTPTAWLHD
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHH
LGALDRRAILAHCVWLDEADMDILARTGAGVAHNPASNAKLASGIAPVPALRRRGVPVGL
HHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCCHHHHHCCCEEEC
GTDSTLSNNCLDLFQEMKLSVLLQRAASLDGFIMNAEDAFTMATIEGARVLNWDNEIGSL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCEEEECCCCCCCC
EPGKQADLVILDIEHPLGLTAQRVLSDVVYHAGPQHVSGVMVAGRMIFRNGRLLLVDEPA
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEECCCEEEEECHH
IRAQIHQHYAQH
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA