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The map label for this gene is xapA [C]

Identifier: 110634745

GI number: 110634745

Start: 2561350

End: 2562180

Strand: Reverse

Name: xapA [C]

Synonym: Meso_2403

Alternate gene names: 110634745

Gene position: 2562180-2561350 (Counterclockwise)

Preceding gene: 110634746

Following gene: 110634744

Centisome position: 58.07

GC content: 62.94

Gene sequence:

>831_bases
ATGACACAAGCGCCTGTCGGCCTCATTACGAGCGCAGCATCCGAAAACCTTCTCCAGGACCGCCGCACGGAGATCGTCTC
GACGCCCTGGGGCGATGCCACCATCCTGATGGGGCAGATCGGCGGACGAGATGCCGCGGTCAACCTGCGCTATGGCGAGA
AGCTGACCACGCCAAGCCACAAGATCAATTATCAGGCCAACCTGTTCGCGCTGCACGAGCTCGGCGTGGAATCCATCATC
TCGCAAAATGCCATCGGCTCGGTGAATCCGGCCATCCGCCCCGGCGACATTGTTATCTCGGACGATTTCCTCGACAAGAC
CAAGTCTCGCGCCCAATCGCTGTTCGATGAGAGCGAGTGCTGGGTGCGCGTGGACTTCACCGATCCGTTCTGCCCGCGCC
TGCGCACCAACTTGATCGAGGCGGCGAACAGGCATTCCAACCGCGTCATCCACCGCGGCACCTTCGTCTGCACGGAAGGA
CCGCGCTTCGAGACGCCGGCGGAGATCCGCGCCTATGCGATGGAAGGAGGCGATATCGTCGGCACGCCGCTGGTCCCGGA
GGTGATCTTCGCCCGCGAGTTGGAAATGTGCTTCGCCTCGATTGCGCCGGTCATCAATTTCGGCGCCGGAATGGCCCCCG
CGGTCGTCCATTTCGGCCCCGGCAGTATGAACGAGATCTACTACAAAGAAGGGCTGCACGACCTGATCGAGAAGACGCTG
ATCGACGCGATCGCCGGTGTATCGGGCGAGCGCACCTGCGCCTGCGCCCGCGCGCTGGAAGGTGGCTTCCACGGCCATCC
GCCCGCATGGCTGAAGCGCAAGATTGCCTGA

Upstream 100 bases:

>100_bases
TCTTCCGAAACGGCAGGCTGCTGCTCGTCGATGAGCCGGCCATTCGCGCGCAAATCCACCAACACTACGCACAACATTGA
CCCAGGGACTGGAAACAAGC

Downstream 100 bases:

>100_bases
CCTTTCCACGGATACGAGTCCGCCATGAGCAACCAAGACTTGCAGACGCCGCCGGCCGGAGACACCACCCAGCCCGTCCT
CTCGGTGCGCGGGCTGACGA

Product: methylthioadenosine phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTQAPVGLITSAASENLLQDRRTEIVSTPWGDATILMGQIGGRDAAVNLRYGEKLTTPSHKINYQANLFALHELGVESII
SQNAIGSVNPAIRPGDIVISDDFLDKTKSRAQSLFDESECWVRVDFTDPFCPRLRTNLIEAANRHSNRVIHRGTFVCTEG
PRFETPAEIRAYAMEGGDIVGTPLVPEVIFARELEMCFASIAPVINFGAGMAPAVVHFGPGSMNEIYYKEGLHDLIEKTL
IDAIAGVSGERTCACARALEGGFHGHPPAWLKRKIA

Sequences:

>Translated_276_residues
MTQAPVGLITSAASENLLQDRRTEIVSTPWGDATILMGQIGGRDAAVNLRYGEKLTTPSHKINYQANLFALHELGVESII
SQNAIGSVNPAIRPGDIVISDDFLDKTKSRAQSLFDESECWVRVDFTDPFCPRLRTNLIEAANRHSNRVIHRGTFVCTEG
PRFETPAEIRAYAMEGGDIVGTPLVPEVIFARELEMCFASIAPVINFGAGMAPAVVHFGPGSMNEIYYKEGLHDLIEKTL
IDAIAGVSGERTCACARALEGGFHGHPPAWLKRKIA
>Mature_275_residues
TQAPVGLITSAASENLLQDRRTEIVSTPWGDATILMGQIGGRDAAVNLRYGEKLTTPSHKINYQANLFALHELGVESIIS
QNAIGSVNPAIRPGDIVISDDFLDKTKSRAQSLFDESECWVRVDFTDPFCPRLRTNLIEAANRHSNRVIHRGTFVCTEGP
RFETPAEIRAYAMEGGDIVGTPLVPEVIFARELEMCFASIAPVINFGAGMAPAVVHFGPGSMNEIYYKEGLHDLIEKTLI
DAIAGVSGERTCACARALEGGFHGHPPAWLKRKIA

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=214, Percent_Identity=37.3831775700935, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI1788746, Length=140, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980569, Length=213, Percent_Identity=34.2723004694836, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323045, Length=198, Percent_Identity=29.7979797979798, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI20130079, Length=198, Percent_Identity=30.3030303030303, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221459247, Length=244, Percent_Identity=30.7377049180328, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 30061; Mature: 29929

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAPVGLITSAASENLLQDRRTEIVSTPWGDATILMGQIGGRDAAVNLRYGEKLTTPSH
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECCCEECCCCC
KINYQANLFALHELGVESIISQNAIGSVNPAIRPGDIVISDDFLDKTKSRAQSLFDESEC
EEEEEEHEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCC
WVRVDFTDPFCPRLRTNLIEAANRHSNRVIHRGTFVCTEGPRFETPAEIRAYAMEGGDIV
EEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCEEEECCCCCCCCCHHHEEEEECCCCEE
GTPLVPEVIFARELEMCFASIAPVINFGAGMAPAVVHFGPGSMNEIYYKEGLHDLIEKTL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
IDAIAGVSGERTCACARALEGGFHGHPPAWLKRKIA
HHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
TQAPVGLITSAASENLLQDRRTEIVSTPWGDATILMGQIGGRDAAVNLRYGEKLTTPSH
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECCCEECCCCC
KINYQANLFALHELGVESIISQNAIGSVNPAIRPGDIVISDDFLDKTKSRAQSLFDESEC
EEEEEEHEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCC
WVRVDFTDPFCPRLRTNLIEAANRHSNRVIHRGTFVCTEGPRFETPAEIRAYAMEGGDIV
EEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCEEEECCCCCCCCCHHHEEEEECCCCEE
GTPLVPEVIFARELEMCFASIAPVINFGAGMAPAVVHFGPGSMNEIYYKEGLHDLIEKTL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
IDAIAGVSGERTCACARALEGGFHGHPPAWLKRKIA
HHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]