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The map label for this gene is pepQ [H]

Identifier: 110634737

GI number: 110634737

Start: 2551684

End: 2552820

Strand: Reverse

Name: pepQ [H]

Synonym: Meso_2395

Alternate gene names: 110634737

Gene position: 2552820-2551684 (Counterclockwise)

Preceding gene: 110634738

Following gene: 110634736

Centisome position: 57.85

GC content: 59.01

Gene sequence:

>1137_bases
ATGCGCAAAGCCATTACCGAGAAACTTATTGGGCTCATGAAGAATGAGGGGTTGGATGCGATCGTGACGTCTTCCCCGGA
AAATTTTGCTTACGTTATGGGCTTTGTCGTGCCCACCCAGCCCCTGCTTCGGCACCGTCATGCCATGACAATCCTGACGG
CCGACGGACGGGCAAGCCTGTTCGGTGTGGACATGGAAGCGAGCACCATCGCCGGCAAGGCACCGGACATGCCGCTGACT
GTCTGGCGGGAATTTCACGACGATCCGATGGTTGTCCTTGCCGGCGCACTAAAGGAGGCAGGCCTTGGTGAGGCAGTGAT
CGGTCTCGAAATGGATTATCTTCCGGCCGGAGATTTCACTCGGCTCGTCGCACAGATGCCTAAGGCGCGGTTCGTTGCTT
GCGAGCGTCAGCTGTCTCGCGCGCGCCAGATCAAGACTCCGGAGGAGGTGACGCTCATTCACCGGCTGTCCCGGATCGCC
GACCAGGCCATCGCCGACAGCTTCGCCGGCGTGCGTGCCGGCGACACTGAACTTGATATCGCCGCCATCCTGACCCGGCG
CATCTATGAAATCGGGGCCGAGAACTTCAAGCTCCTCATCGTGGCGACGGGAGAGCGCAGCCAGCTTCCCAATGTGGGTC
CGACAGACCGTGTGTTGACCAAGGGCGACATCTGCCGGGTGGAGATCTTTTCCGTTATCAACGGATATCAGGCTGGTGTT
TGCCGCACAGCCTATGTGCAGGAGCCTCCAGCAATGGCCGATGAGATCTGGAAGCTCATGATCGAGTGCAAATACGCGAT
CCTGGAAAAGATCCGGCCCGGTGCGAGCTGCCTTGCAATTTATCAGGATTTCATCGCCCGGCTGTCCCGGCTCAATCTTC
CGCCGATCTCCTTTGTCGGCCATGGCATCGGTCTTCATCTGCATGAGGATCCCTATTTGGGCACGACGCCGATACTCGGG
CATCCGGGTCAGGACGCCGTGCTGGAGGAAAACATGGTGCTCGGCTTCGAGCCGCTGTGCTACCGCACGGGCTTCGGCTT
CGGTGTGCAGAACAAGGACGTGTTGCACGTTACCGCGACGGGTTCTCAGCTCCTTTCCGACTATTCCAACACCGACGTTC
TCATCCGGATCGACTAA

Upstream 100 bases:

>100_bases
AGGATGGAGGGATCAGGGTTCCGGACGGGCCGGGCATGGGCTTGCCCATCGATCCGGCCAAGGTGGACAAATATTCGGTC
ACGATCTGAAGAGAAGCACG

Downstream 100 bases:

>100_bases
GTGGAAGGAGCGTTTGCAATGGGCAGCCAGGTCGACATCCTGTTTTCAGGAACGGGCTACTTCACTGAGATCATGCTTGG
CGACATCGCCGCGACTGCGA

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MRKAITEKLIGLMKNEGLDAIVTSSPENFAYVMGFVVPTQPLLRHRHAMTILTADGRASLFGVDMEASTIAGKAPDMPLT
VWREFHDDPMVVLAGALKEAGLGEAVIGLEMDYLPAGDFTRLVAQMPKARFVACERQLSRARQIKTPEEVTLIHRLSRIA
DQAIADSFAGVRAGDTELDIAAILTRRIYEIGAENFKLLIVATGERSQLPNVGPTDRVLTKGDICRVEIFSVINGYQAGV
CRTAYVQEPPAMADEIWKLMIECKYAILEKIRPGASCLAIYQDFIARLSRLNLPPISFVGHGIGLHLHEDPYLGTTPILG
HPGQDAVLEENMVLGFEPLCYRTGFGFGVQNKDVLHVTATGSQLLSDYSNTDVLIRID

Sequences:

>Translated_378_residues
MRKAITEKLIGLMKNEGLDAIVTSSPENFAYVMGFVVPTQPLLRHRHAMTILTADGRASLFGVDMEASTIAGKAPDMPLT
VWREFHDDPMVVLAGALKEAGLGEAVIGLEMDYLPAGDFTRLVAQMPKARFVACERQLSRARQIKTPEEVTLIHRLSRIA
DQAIADSFAGVRAGDTELDIAAILTRRIYEIGAENFKLLIVATGERSQLPNVGPTDRVLTKGDICRVEIFSVINGYQAGV
CRTAYVQEPPAMADEIWKLMIECKYAILEKIRPGASCLAIYQDFIARLSRLNLPPISFVGHGIGLHLHEDPYLGTTPILG
HPGQDAVLEENMVLGFEPLCYRTGFGFGVQNKDVLHVTATGSQLLSDYSNTDVLIRID
>Mature_378_residues
MRKAITEKLIGLMKNEGLDAIVTSSPENFAYVMGFVVPTQPLLRHRHAMTILTADGRASLFGVDMEASTIAGKAPDMPLT
VWREFHDDPMVVLAGALKEAGLGEAVIGLEMDYLPAGDFTRLVAQMPKARFVACERQLSRARQIKTPEEVTLIHRLSRIA
DQAIADSFAGVRAGDTELDIAAILTRRIYEIGAENFKLLIVATGERSQLPNVGPTDRVLTKGDICRVEIFSVINGYQAGV
CRTAYVQEPPAMADEIWKLMIECKYAILEKIRPGASCLAIYQDFIARLSRLNLPPISFVGHGIGLHLHEDPYLGTTPILG
HPGQDAVLEENMVLGFEPLCYRTGFGFGVQNKDVLHVTATGSQLLSDYSNTDVLIRID

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788728, Length=251, Percent_Identity=29.0836653386454, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 41477; Mature: 41477

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAITEKLIGLMKNEGLDAIVTSSPENFAYVMGFVVPTQPLLRHRHAMTILTADGRASL
CCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCHHHHHCCCEEEEEEECCCCEE
FGVDMEASTIAGKAPDMPLTVWREFHDDPMVVLAGALKEAGLGEAVIGLEMDYLPAGDFT
EEECCCHHHCCCCCCCCCHHHHHHHCCCCCEEEEHHHHHCCCCCEEEEEEECCCCCCHHH
RLVAQMPKARFVACERQLSRARQIKTPEEVTLIHRLSRIADQAIADSFAGVRAGDTELDI
HHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
AAILTRRIYEIGAENFKLLIVATGERSQLPNVGPTDRVLTKGDICRVEIFSVINGYQAGV
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEECCCCCHHHHHHHHHCCCCCCC
CRTAYVQEPPAMADEIWKLMIECKYAILEKIRPGASCLAIYQDFIARLSRLNLPPISFVG
EEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHC
HGIGLHLHEDPYLGTTPILGHPGQDAVLEENMVLGFEPLCYRTGFGFGVQNKDVLHVTAT
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCCCCCCCEEEEEEC
GSQLLSDYSNTDVLIRID
HHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MRKAITEKLIGLMKNEGLDAIVTSSPENFAYVMGFVVPTQPLLRHRHAMTILTADGRASL
CCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCHHHHHCCCEEEEEEECCCCEE
FGVDMEASTIAGKAPDMPLTVWREFHDDPMVVLAGALKEAGLGEAVIGLEMDYLPAGDFT
EEECCCHHHCCCCCCCCCHHHHHHHCCCCCEEEEHHHHHCCCCCEEEEEEECCCCCCHHH
RLVAQMPKARFVACERQLSRARQIKTPEEVTLIHRLSRIADQAIADSFAGVRAGDTELDI
HHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
AAILTRRIYEIGAENFKLLIVATGERSQLPNVGPTDRVLTKGDICRVEIFSVINGYQAGV
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEECCCCCHHHHHHHHHCCCCCCC
CRTAYVQEPPAMADEIWKLMIECKYAILEKIRPGASCLAIYQDFIARLSRLNLPPISFVG
EEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHC
HGIGLHLHEDPYLGTTPILGHPGQDAVLEENMVLGFEPLCYRTGFGFGVQNKDVLHVTAT
CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCCCCCCCEEEEEEC
GSQLLSDYSNTDVLIRID
HHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]