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The map label for this gene is argH [H]

Identifier: 110634732

GI number: 110634732

Start: 2545166

End: 2546665

Strand: Reverse

Name: argH [H]

Synonym: Meso_2390

Alternate gene names: 110634732

Gene position: 2546665-2545166 (Counterclockwise)

Preceding gene: 110634734

Following gene: 110634731

Centisome position: 57.72

GC content: 60.73

Gene sequence:

>1500_bases
ATGGCCACACCTTTTACGAAGGCGCGGTTGGGTAAAGATGCTCGCGCAACGCTGATCAACGCCGCCCATCTGCCGGTTCT
CAAACGCGAACTCGACATGTTCGATGCCTATGTTCGCGTCGATCTCGCCCATATCACCATGCTGGCAGAGCAAGGCATCA
TCCCGATCAAGGTTGCCAAGGCTTTGCTTGGGGCACTACAGGACCTGCGGCGCGCCGGTCCCCAGGGGCTGGATGTGAAG
GGCGAGCTTGGCAGCATTCTTTTGCAGGTCGAGCATTATCTGGCCGAAAGGGTAGGGGCAGAGAGCGCAGGCTACCTGCA
GCTCGCGCGAAGCCGCATCGATCAGAATGCCACGATTTCGCGCGTGCATGCACGGGACGAGCTGCTGCACGTCGCAGAGC
GGATCGTCGATTTCCAGAAAGTTATTCTGCAGCGTGCCGAGGAATGGGCCGACGTACTGATGCCCGGCTATACCCATCTG
CAGCACGCGCAGCCCTGGATATTGGGTCACTACATGATCGGCCAGCACGACGTGTTCGCGCGCGACCTGCAGCGGGTTAT
CCAGACCTATGATCGGGTGAACCTCAGTTCGCTCGGCGGACTTGCCCTGGTCGGTACCAGCTGGCCGATCGACCGTGAGC
GGACCGCTTTCCTGCTTGGACACAGCGCTCCCATCCGCCACTCCAAGGACTGCGCCGGCTTTGCCATGGATTATCTGGCT
GAAGTGGGCAGCTCGCTGTCGATCCTGATGTCGGGGCTCGGTCGTCTCGCGTCGGAGTGGTACATCTGGTCCACCTGGGA
GTTCAATCTCATCGAGCTTGACGAAGGGTTGTGCGGCACTTCGAGCATCATGCCCCAGAAGAAAAACCCCTATGTCCTAG
AACGCGTCCGCGCACTGGCGGGCGAGTCCATCGGCTGGACGGCTGCGCAGCTTGGAATGCTGCGCACGCCAACGACGGTG
GATGCCGACCGGTTCTTCTCGACTGGCAATGTGGAGTATTTCCGCGTGGCGAATTGGGCGCTCGACCTGATGCAGGACTG
CGCCGCAACAGTCCGTATCAATCGGGAACGCATGCGCGAACTGGCTGGCGCCAACTGGAATACCGCGAGCAACCTCGCCG
ACGCCATCGTGCGCGAATGCGGTCTTGACTTCCGCAGCGCGCACCAGATTGTCGGCGCCTTGGTCAAGGCTTCGATCGAG
AGCGGCACGCACTCGCGTGATGTCGGATTGGCCGAAGTGAACGCGGCGGCAAGAGCCACGATAGGGCGCGAAATTTCCAT
GACAGACCAGCAGATTCACGACTCCCTCGACCCTGAGCAATTCGTGGCCACCCGCGTGAGCCAGGGGTCTCTCTCCAAGG
CCGAGCTGCAGAAACTGTTTGATATGGCCCGAACGGACATTGCGGCGTCCGAAAAACAATTGGCATCGGAACGGGCGCGG
CTGGCACGCTCGGAAGCCGCACTTAACGAGGCTATAACGGCGATCTCTATGCGAGGGTAG

Upstream 100 bases:

>100_bases
GGCGTTGTGTCACTGCTTTCTCATGTTGATTATATGTATCAATCTTGACGATATCATCAACTGGCCATTTCTTGAACAGG
TAACCAGCCAGGAGAAAGTA

Downstream 100 bases:

>100_bases
AACCCTCCGGGGCGGGCTCGCTGCCGTGGTGCGCCCGTCTTCCATTCGATCTGGAGCGGATACACGCGCCGTCAAACAAG
AGGAGTCTCATCTTGATCAC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MATPFTKARLGKDARATLINAAHLPVLKRELDMFDAYVRVDLAHITMLAEQGIIPIKVAKALLGALQDLRRAGPQGLDVK
GELGSILLQVEHYLAERVGAESAGYLQLARSRIDQNATISRVHARDELLHVAERIVDFQKVILQRAEEWADVLMPGYTHL
QHAQPWILGHYMIGQHDVFARDLQRVIQTYDRVNLSSLGGLALVGTSWPIDRERTAFLLGHSAPIRHSKDCAGFAMDYLA
EVGSSLSILMSGLGRLASEWYIWSTWEFNLIELDEGLCGTSSIMPQKKNPYVLERVRALAGESIGWTAAQLGMLRTPTTV
DADRFFSTGNVEYFRVANWALDLMQDCAATVRINRERMRELAGANWNTASNLADAIVRECGLDFRSAHQIVGALVKASIE
SGTHSRDVGLAEVNAAARATIGREISMTDQQIHDSLDPEQFVATRVSQGSLSKAELQKLFDMARTDIAASEKQLASERAR
LARSEAALNEAITAISMRG

Sequences:

>Translated_499_residues
MATPFTKARLGKDARATLINAAHLPVLKRELDMFDAYVRVDLAHITMLAEQGIIPIKVAKALLGALQDLRRAGPQGLDVK
GELGSILLQVEHYLAERVGAESAGYLQLARSRIDQNATISRVHARDELLHVAERIVDFQKVILQRAEEWADVLMPGYTHL
QHAQPWILGHYMIGQHDVFARDLQRVIQTYDRVNLSSLGGLALVGTSWPIDRERTAFLLGHSAPIRHSKDCAGFAMDYLA
EVGSSLSILMSGLGRLASEWYIWSTWEFNLIELDEGLCGTSSIMPQKKNPYVLERVRALAGESIGWTAAQLGMLRTPTTV
DADRFFSTGNVEYFRVANWALDLMQDCAATVRINRERMRELAGANWNTASNLADAIVRECGLDFRSAHQIVGALVKASIE
SGTHSRDVGLAEVNAAARATIGREISMTDQQIHDSLDPEQFVATRVSQGSLSKAELQKLFDMARTDIAASEKQLASERAR
LARSEAALNEAITAISMRG
>Mature_498_residues
ATPFTKARLGKDARATLINAAHLPVLKRELDMFDAYVRVDLAHITMLAEQGIIPIKVAKALLGALQDLRRAGPQGLDVKG
ELGSILLQVEHYLAERVGAESAGYLQLARSRIDQNATISRVHARDELLHVAERIVDFQKVILQRAEEWADVLMPGYTHLQ
HAQPWILGHYMIGQHDVFARDLQRVIQTYDRVNLSSLGGLALVGTSWPIDRERTAFLLGHSAPIRHSKDCAGFAMDYLAE
VGSSLSILMSGLGRLASEWYIWSTWEFNLIELDEGLCGTSSIMPQKKNPYVLERVRALAGESIGWTAAQLGMLRTPTTVD
ADRFFSTGNVEYFRVANWALDLMQDCAATVRINRERMRELAGANWNTASNLADAIVRECGLDFRSAHQIVGALVKASIES
GTHSRDVGLAEVNAAARATIGREISMTDQQIHDSLDPEQFVATRVSQGSLSKAELQKLFDMARTDIAASEKQLASERARL
ARSEAALNEAITAISMRG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=343, Percent_Identity=31.4868804664723, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI68303542, Length=343, Percent_Identity=31.4868804664723, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI68303547, Length=339, Percent_Identity=30.3834808259587, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI68303549, Length=343, Percent_Identity=29.4460641399417, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI1790398, Length=415, Percent_Identity=30.1204819277108, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321806, Length=389, Percent_Identity=31.1053984575836, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI221473854, Length=328, Percent_Identity=31.0975609756098, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI78706858, Length=328, Percent_Identity=31.0975609756098, Blast_Score=132, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 55066; Mature: 54934

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPFTKARLGKDARATLINAAHLPVLKRELDMFDAYVRVDLAHITMLAEQGIIPIKVAK
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ALLGALQDLRRAGPQGLDVKGELGSILLQVEHYLAERVGAESAGYLQLARSRIDQNATIS
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHH
RVHARDELLHVAERIVDFQKVILQRAEEWADVLMPGYTHLQHAQPWILGHYMIGQHDVFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCHHHHH
RDLQRVIQTYDRVNLSSLGGLALVGTSWPIDRERTAFLLGHSAPIRHSKDCAGFAMDYLA
HHHHHHHHHHHCCCHHHCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
EVGSSLSILMSGLGRLASEWYIWSTWEFNLIELDEGLCGTSSIMPQKKNPYVLERVRALA
HHCCHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
GESIGWTAAQLGMLRTPTTVDADRFFSTGNVEYFRVANWALDLMQDCAATVRINRERMRE
CCCCCHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHHHH
LAGANWNTASNLADAIVRECGLDFRSAHQIVGALVKASIESGTHSRDVGLAEVNAAARAT
HHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IGREISMTDQQIHDSLDPEQFVATRVSQGSLSKAELQKLFDMARTDIAASEKQLASERAR
HCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LARSEAALNEAITAISMRG
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ATPFTKARLGKDARATLINAAHLPVLKRELDMFDAYVRVDLAHITMLAEQGIIPIKVAK
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ALLGALQDLRRAGPQGLDVKGELGSILLQVEHYLAERVGAESAGYLQLARSRIDQNATIS
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHH
RVHARDELLHVAERIVDFQKVILQRAEEWADVLMPGYTHLQHAQPWILGHYMIGQHDVFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCHHHHH
RDLQRVIQTYDRVNLSSLGGLALVGTSWPIDRERTAFLLGHSAPIRHSKDCAGFAMDYLA
HHHHHHHHHHHCCCHHHCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
EVGSSLSILMSGLGRLASEWYIWSTWEFNLIELDEGLCGTSSIMPQKKNPYVLERVRALA
HHCCHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
GESIGWTAAQLGMLRTPTTVDADRFFSTGNVEYFRVANWALDLMQDCAATVRINRERMRE
CCCCCHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHHHH
LAGANWNTASNLADAIVRECGLDFRSAHQIVGALVKASIESGTHSRDVGLAEVNAAARAT
HHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IGREISMTDQQIHDSLDPEQFVATRVSQGSLSKAELQKLFDMARTDIAASEKQLASERAR
HCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LARSEAALNEAITAISMRG
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]