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The map label for this gene is pepQ [H]

Identifier: 110634717

GI number: 110634717

Start: 2527509

End: 2528639

Strand: Reverse

Name: pepQ [H]

Synonym: Meso_2374

Alternate gene names: 110634717

Gene position: 2528639-2527509 (Counterclockwise)

Preceding gene: 110634719

Following gene: 110634716

Centisome position: 57.31

GC content: 64.46

Gene sequence:

>1131_bases
ATGCGTCTGGCAAAGTTGCGCGCGGCGCTCGAAAGATCGGAAAACGATGCTCTCCTCTTGTTCAGCCCGGAGAATTTTCT
TTACGCATCGGGCTATGAGAGCATGCCGGCAGCAATAAACCGTCGCTACGTCTACTGCGCGGCGGTGACGCCCGACCGGT
TGCTGCTGGTTGTCCCGGCGGCCGACTTCGCCGCGGCCATCGCGTCGGGCGTGCCGGCCACCGACATCATCACTTTCGGC
ACTTTCTATTTCAGCGGCGAGACGAATTCGGCGCATATCGATCCGCAGAACGCCGATTTCGCCGGCGCGTTGGACAAGGC
TCTGTCCGCGCTGGCCGCCCGCCGGGTGGGAATCGATGTGGACCACGCGCCGGCGGTCGCGTTCGATATTCTGGACAGGC
GGGGGATCATCCATTCTGACGCCGTTTCCTTCATGCTCGCTGTCCGCTCGACAAAGCTGCCCGGCGAGATCGCGCTCATG
CGCTATGCCGCGCGCATCACGGAAGCGGCGATCGAGGCTGGCATGGCGATGGCTCGTGCGGGCATTACCGATAAGGAAGT
GGCAGCCGTCGTCGCCGCCACCATGTCGCGCGGTGGGGGCTATCCCCGCAACGTCACGGTCGTCGGCGGCCTTGACAGCG
CTCTCGCAGATGCTTTCGCCGCGGAGCGGCCTCTTGCGGCCGGCGATCTCCTGCGCTTCGACGTCGGCTGCAGTTATTAC
GGGTACAAGTCCGACCTGGCGCGCACGGCGGTGGTGGGGGAGCCGACAAGGGTGCAGGCGCGGCGCTACGAAGCTCTGCG
TATCGGGCTGCAGGCGGAGATCGACCGAGCCCGGGCGGGCGTTGCGGCGAAGGATATTTACGAAGCGGGAATGGACGCGG
TGGAAGCAGCCGGTTTTGAGGGATTCCGCCGGCACCATCTGGGCCATGCCATCGGCCTGGCTGTCTATGAAGCGCCCGTG
ATCACCGCCACCAGCCAGGCCGTGCTGGAGGCCGGCTCCACCTTCTGTTTCGAGACCCCCTATTATGAGCCGGGCTGGGG
CGGCATGATGTGTGAGGACACCGGTGTCGTGACCGAAGCAGGTTTCGAGCTCATCTCTTCGATGGACCGCAGCCTTCGGG
TCCTGAATTAA

Upstream 100 bases:

>100_bases
CACCATAATCGTCACAGCGTACCGTTATTTGAAACATTGATGCGGAAGGCGACCAATGCAACTTGAACCCTCCCCGACTT
CCCTTGTGGAGCTTGCCGGC

Downstream 100 bases:

>100_bases
ACTGGAGGCCACCAGTGAACCTAGCCGAAGCCCGCAGTGATTTCCCCATCGTCTATCGCCGCGCCTATCTGAATGCCTGT
TCGCTCATGCCGCTGTCCAA

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MRLAKLRAALERSENDALLLFSPENFLYASGYESMPAAINRRYVYCAAVTPDRLLLVVPAADFAAAIASGVPATDIITFG
TFYFSGETNSAHIDPQNADFAGALDKALSALAARRVGIDVDHAPAVAFDILDRRGIIHSDAVSFMLAVRSTKLPGEIALM
RYAARITEAAIEAGMAMARAGITDKEVAAVVAATMSRGGGYPRNVTVVGGLDSALADAFAAERPLAAGDLLRFDVGCSYY
GYKSDLARTAVVGEPTRVQARRYEALRIGLQAEIDRARAGVAAKDIYEAGMDAVEAAGFEGFRRHHLGHAIGLAVYEAPV
ITATSQAVLEAGSTFCFETPYYEPGWGGMMCEDTGVVTEAGFELISSMDRSLRVLN

Sequences:

>Translated_376_residues
MRLAKLRAALERSENDALLLFSPENFLYASGYESMPAAINRRYVYCAAVTPDRLLLVVPAADFAAAIASGVPATDIITFG
TFYFSGETNSAHIDPQNADFAGALDKALSALAARRVGIDVDHAPAVAFDILDRRGIIHSDAVSFMLAVRSTKLPGEIALM
RYAARITEAAIEAGMAMARAGITDKEVAAVVAATMSRGGGYPRNVTVVGGLDSALADAFAAERPLAAGDLLRFDVGCSYY
GYKSDLARTAVVGEPTRVQARRYEALRIGLQAEIDRARAGVAAKDIYEAGMDAVEAAGFEGFRRHHLGHAIGLAVYEAPV
ITATSQAVLEAGSTFCFETPYYEPGWGGMMCEDTGVVTEAGFELISSMDRSLRVLN
>Mature_376_residues
MRLAKLRAALERSENDALLLFSPENFLYASGYESMPAAINRRYVYCAAVTPDRLLLVVPAADFAAAIASGVPATDIITFG
TFYFSGETNSAHIDPQNADFAGALDKALSALAARRVGIDVDHAPAVAFDILDRRGIIHSDAVSFMLAVRSTKLPGEIALM
RYAARITEAAIEAGMAMARAGITDKEVAAVVAATMSRGGGYPRNVTVVGGLDSALADAFAAERPLAAGDLLRFDVGCSYY
GYKSDLARTAVVGEPTRVQARRYEALRIGLQAEIDRARAGVAAKDIYEAGMDAVEAAGFEGFRRHHLGHAIGLAVYEAPV
ITATSQAVLEAGSTFCFETPYYEPGWGGMMCEDTGVVTEAGFELISSMDRSLRVLN

Specific function: Strict dipeptidase active on Xaa-Pro dipeptides, except Gly-Pro and Pro-Pro [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Escherichia coli, GI1788728, Length=232, Percent_Identity=30.1724137931034, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789275, Length=275, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 39997; Mature: 39997

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLAKLRAALERSENDALLLFSPENFLYASGYESMPAAINRRYVYCAAVTPDRLLLVVPA
CCHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCHHHCCCEEEEEEECCCEEEEEEEC
ADFAAAIASGVPATDIITFGTFYFSGETNSAHIDPQNADFAGALDKALSALAARRVGIDV
HHHHHHHHCCCCHHHEEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCC
DHAPAVAFDILDRRGIIHSDAVSFMLAVRSTKLPGEIALMRYAARITEAAIEAGMAMARA
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GITDKEVAAVVAATMSRGGGYPRNVTVVGGLDSALADAFAAERPLAAGDLLRFDVGCSYY
CCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCCC
GYKSDLARTAVVGEPTRVQARRYEALRIGLQAEIDRARAGVAAKDIYEAGMDAVEAAGFE
CCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHCHHHHHHCCHH
GFRRHHLGHAIGLAVYEAPVITATSQAVLEAGSTFCFETPYYEPGWGGMMCEDTGVVTEA
HHHHHHHHHHHHHHHHCCCEEECCHHHHHHCCCEEEEECCCCCCCCCCEEECCCCCHHHH
GFELISSMDRSLRVLN
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLAKLRAALERSENDALLLFSPENFLYASGYESMPAAINRRYVYCAAVTPDRLLLVVPA
CCHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCHHHCCCEEEEEEECCCEEEEEEEC
ADFAAAIASGVPATDIITFGTFYFSGETNSAHIDPQNADFAGALDKALSALAARRVGIDV
HHHHHHHHCCCCHHHEEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCC
DHAPAVAFDILDRRGIIHSDAVSFMLAVRSTKLPGEIALMRYAARITEAAIEAGMAMARA
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GITDKEVAAVVAATMSRGGGYPRNVTVVGGLDSALADAFAAERPLAAGDLLRFDVGCSYY
CCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCCC
GYKSDLARTAVVGEPTRVQARRYEALRIGLQAEIDRARAGVAAKDIYEAGMDAVEAAGFE
CCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHCHHHHHHCCHH
GFRRHHLGHAIGLAVYEAPVITATSQAVLEAGSTFCFETPYYEPGWGGMMCEDTGVVTEA
HHHHHHHHHHHHHHHHCCCEEECCHHHHHHCCCEEEEECCCCCCCCCCEEECCCCCHHHH
GFELISSMDRSLRVLN
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075426 [H]