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The map label for this gene is ksdD [H]

Identifier: 110634637

GI number: 110634637

Start: 2443393

End: 2445069

Strand: Reverse

Name: ksdD [H]

Synonym: Meso_2292

Alternate gene names: 110634637

Gene position: 2445069-2443393 (Counterclockwise)

Preceding gene: 110634638

Following gene: 110634635

Centisome position: 55.41

GC content: 58.5

Gene sequence:

>1677_bases
ATGACGGCGGCTCTCGTCGGCGCCATCCAAGGCCTTCGGGTGGTGCTACTCGAAAAATCCCTACAACTTGGCGGCACGTC
AGCGACATCTGCCGGAACCGCCTGGATTCCTGGTACGTCCCGCGCTGCGGAGTGCGGCCATGCAGATTCGATAGAAGCTG
CGTATACCTACCTACAGTCCTTCACGGGTGATAACTCAGCGCAGATCAACACACTCCAGAGGACGTTTCTTGAAACGGGC
GATGAAGCGGTGCGCTATCTGGCATCGCACAGTGAAGTCCAATTGGAACCTGCGGCTCACCATCCCGACTATCGCGGCGA
TGCTCCCGGCGCAGTCGAGAGCGGGCGTGCGCTCGTTACGCCCGACTTTGATGGACGAAAACTGCGCTCCGACGATTTTT
CGCTGGTCAAGCCGCCAAGACCCGAGATGATGATTTTGGGCGGAATGATGATTGCCAAGGAGGATATTCAGCCGCTGCTC
GATGCTTTCCGGAAACCATCAGGCTTTATTTATGCCGCAAAACTGCTGTTCCGGTATCTCAGCGATCGCCTGTTCTATTC
GCGCGGTACGCGGCTCGTCCTGGGCAATGCAATGGTCGCACGCCTGCTCTTCAGTCTGCGGCAGCGAGGCGTCGAAATCC
GCACAGGTGTCGCGGTGAGAGAGTTGTTGACCGAAGGCAGGAAAGTGGTGGGTGTAAGGTGCATCACCGGCGGCAACTTG
ATCGACATTCCGGCTGCTTCGGGTGTGGTACTCGCCACTGGAGGTTTTGCGGGAAGCCCGGCGTGGCGGAGGCGGTTTCT
CGAAGTGGGGGCTCAAGTCCGTGGACTCGTGGACGGAGGCTGTGCGGGGGACGGAATCGAACTCGCTTTGGCGGTTGGAG
GAGCATTGGGCGAGAGTCATGCCGGGGCGGGGTTCTACATGCCCATGTCGACCCTGCGCACGCCAGCCGGGACGACCAAG
ACCTTTCCCCATATCTATCTGGACAGAGCGAAGCCCGGTCTTCTGGCGGTCAACTCCGAGGCGGAACGTTTCGTCAACGA
GGCCGACTCCTACCACGATTTCGTATTGGGCATGCTCAAGGCTAATCGTAGTGTGCCGACCATACCAGCGTATCTCATCT
GTGATTCGGCCTTTCTGAAGGATTATGGTCTTGGCTTAGTCCGGCCGAGATCGTGGTCCGTCGGTTACTACATCCGCAGC
GGCTACCTGAAGTGCGCCGACACGATCGAAGGACTTGCGCACCAGATAGGGGTGCCCGCCGAGAAATTCTCAGACACGGT
GCGAAGATACAACGATTTTGCTGCAATTGGCATCGATGCTGATTTTGGCCGTGGGAGAAGCCCGCTGAATCGGCACAACG
GAGATCCGAGGAATACGCCCAACCCTTGTCTTCGCCCGATATGCCGTCCGCCCTTCTATGCGGTCGCAGTGGAGCCTGCA
GCCCTCGCGACGAGTCTTGGCCTGTCAACGGACCGCGACGCTCGCGTGCTGGACCCAAGTGGGACAGTTGTCGAAGGACT
CTATGCCTGCGGCAACGACATGAATTCGATTATGGCTGGTCACTATCCTGGCCCTGGCGTGACGCTCGGACCGGCTATCG
TTTTCGCTTATCGCGCCGCTCGCCACGCATCCGAAGTTTTTGGTTGCGCTAAGCTAGAATCATTGCACCTGTTATAA

Upstream 100 bases:

>100_bases
TCTCGCGCGCGGACATGAGTTTCACTGTTAATGCTGAGAGGGCTTCCGGGTGACTGGCCAGCGATTTGATCTGGTCGTGG
TCGGTGGAGGTGTGGCCGGA

Downstream 100 bases:

>100_bases
GTCTAATGGGTAGAGGCACCAGTAGAGGAGTGACCTACAAATATTCTCCAGATGTAGGCGACGGAGGTGATCTGGCTTAG
CAGGCTGGTTGGGAGGTTGC

Product: putative succinate dehydrogenase

Products: NA

Alternate protein names: 3-keto-Delta(4)-steroid Delta(1)-dehydrogenase; KSDD; 3-oxo-Delta(4)-steroid 1-dehydrogenase; KSTD [H]

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MTAALVGAIQGLRVVLLEKSLQLGGTSATSAGTAWIPGTSRAAECGHADSIEAAYTYLQSFTGDNSAQINTLQRTFLETG
DEAVRYLASHSEVQLEPAAHHPDYRGDAPGAVESGRALVTPDFDGRKLRSDDFSLVKPPRPEMMILGGMMIAKEDIQPLL
DAFRKPSGFIYAAKLLFRYLSDRLFYSRGTRLVLGNAMVARLLFSLRQRGVEIRTGVAVRELLTEGRKVVGVRCITGGNL
IDIPAASGVVLATGGFAGSPAWRRRFLEVGAQVRGLVDGGCAGDGIELALAVGGALGESHAGAGFYMPMSTLRTPAGTTK
TFPHIYLDRAKPGLLAVNSEAERFVNEADSYHDFVLGMLKANRSVPTIPAYLICDSAFLKDYGLGLVRPRSWSVGYYIRS
GYLKCADTIEGLAHQIGVPAEKFSDTVRRYNDFAAIGIDADFGRGRSPLNRHNGDPRNTPNPCLRPICRPPFYAVAVEPA
ALATSLGLSTDRDARVLDPSGTVVEGLYACGNDMNSIMAGHYPGPGVTLGPAIVFAYRAARHASEVFGCAKLESLHLL

Sequences:

>Translated_558_residues
MTAALVGAIQGLRVVLLEKSLQLGGTSATSAGTAWIPGTSRAAECGHADSIEAAYTYLQSFTGDNSAQINTLQRTFLETG
DEAVRYLASHSEVQLEPAAHHPDYRGDAPGAVESGRALVTPDFDGRKLRSDDFSLVKPPRPEMMILGGMMIAKEDIQPLL
DAFRKPSGFIYAAKLLFRYLSDRLFYSRGTRLVLGNAMVARLLFSLRQRGVEIRTGVAVRELLTEGRKVVGVRCITGGNL
IDIPAASGVVLATGGFAGSPAWRRRFLEVGAQVRGLVDGGCAGDGIELALAVGGALGESHAGAGFYMPMSTLRTPAGTTK
TFPHIYLDRAKPGLLAVNSEAERFVNEADSYHDFVLGMLKANRSVPTIPAYLICDSAFLKDYGLGLVRPRSWSVGYYIRS
GYLKCADTIEGLAHQIGVPAEKFSDTVRRYNDFAAIGIDADFGRGRSPLNRHNGDPRNTPNPCLRPICRPPFYAVAVEPA
ALATSLGLSTDRDARVLDPSGTVVEGLYACGNDMNSIMAGHYPGPGVTLGPAIVFAYRAARHASEVFGCAKLESLHLL
>Mature_557_residues
TAALVGAIQGLRVVLLEKSLQLGGTSATSAGTAWIPGTSRAAECGHADSIEAAYTYLQSFTGDNSAQINTLQRTFLETGD
EAVRYLASHSEVQLEPAAHHPDYRGDAPGAVESGRALVTPDFDGRKLRSDDFSLVKPPRPEMMILGGMMIAKEDIQPLLD
AFRKPSGFIYAAKLLFRYLSDRLFYSRGTRLVLGNAMVARLLFSLRQRGVEIRTGVAVRELLTEGRKVVGVRCITGGNLI
DIPAASGVVLATGGFAGSPAWRRRFLEVGAQVRGLVDGGCAGDGIELALAVGGALGESHAGAGFYMPMSTLRTPAGTTKT
FPHIYLDRAKPGLLAVNSEAERFVNEADSYHDFVLGMLKANRSVPTIPAYLICDSAFLKDYGLGLVRPRSWSVGYYIRSG
YLKCADTIEGLAHQIGVPAEKFSDTVRRYNDFAAIGIDADFGRGRSPLNRHNGDPRNTPNPCLRPICRPPFYAVAVEPAA
LATSLGLSTDRDARVLDPSGTVVEGLYACGNDMNSIMAGHYPGPGVTLGPAIVFAYRAARHASEVFGCAKLESLHLL

Specific function: Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3- ketosteroids. Is also involved in the formation of 1,4- androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. 3-oxosteroid dehydrogenase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =1.3.99.4 [H]

Molecular weight: Translated: 59740; Mature: 59609

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAALVGAIQGLRVVLLEKSLQLGGTSATSAGTAWIPGTSRAAECGHADSIEAAYTYLQS
CCHHHHHHHHHHHEEEEHHHHHCCCCCCCCCCCEECCCCCCHHCCCCCCCHHHHHHHHHH
FTGDNSAQINTLQRTFLETGDEAVRYLASHSEVQLEPAAHHPDYRGDAPGAVESGRALVT
HCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHCCCEEEC
PDFDGRKLRSDDFSLVKPPRPEMMILGGMMIAKEDIQPLLDAFRKPSGFIYAAKLLFRYL
CCCCCCEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SDRLFYSRGTRLVLGNAMVARLLFSLRQRGVEIRTGVAVRELLTEGRKVVGVRCITGGNL
HHHHHHHCCCEEEECHHHHHHHHHHHHHCCCEEECHHHHHHHHHCCCEEEEEEEECCCCE
IDIPAASGVVLATGGFAGSPAWRRRFLEVGAQVRGLVDGGCAGDGIELALAVGGALGESH
EEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCC
AGAGFYMPMSTLRTPAGTTKTFPHIYLDRAKPGLLAVNSEAERFVNEADSYHDFVLGMLK
CCCEEEECHHHHCCCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
ANRSVPTIPAYLICDSAFLKDYGLGLVRPRSWSVGYYIRSGYLKCADTIEGLAHQIGVPA
CCCCCCCCCHHHHCCHHHHHHCCCCEECCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCH
EKFSDTVRRYNDFAAIGIDADFGRGRSPLNRHNGDPRNTPNPCLRPICRPPFYAVAVEPA
HHHHHHHHHHCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCHHHHHCCCCCEEEEEECHH
ALATSLGLSTDRDARVLDPSGTVVEGLYACGNDMNSIMAGHYPGPGVTLGPAIVFAYRAA
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHH
RHASEVFGCAKLESLHLL
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAALVGAIQGLRVVLLEKSLQLGGTSATSAGTAWIPGTSRAAECGHADSIEAAYTYLQS
CHHHHHHHHHHHEEEEHHHHHCCCCCCCCCCCEECCCCCCHHCCCCCCCHHHHHHHHHH
FTGDNSAQINTLQRTFLETGDEAVRYLASHSEVQLEPAAHHPDYRGDAPGAVESGRALVT
HCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHCCCEEEC
PDFDGRKLRSDDFSLVKPPRPEMMILGGMMIAKEDIQPLLDAFRKPSGFIYAAKLLFRYL
CCCCCCEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SDRLFYSRGTRLVLGNAMVARLLFSLRQRGVEIRTGVAVRELLTEGRKVVGVRCITGGNL
HHHHHHHCCCEEEECHHHHHHHHHHHHHCCCEEECHHHHHHHHHCCCEEEEEEEECCCCE
IDIPAASGVVLATGGFAGSPAWRRRFLEVGAQVRGLVDGGCAGDGIELALAVGGALGESH
EEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCC
AGAGFYMPMSTLRTPAGTTKTFPHIYLDRAKPGLLAVNSEAERFVNEADSYHDFVLGMLK
CCCEEEECHHHHCCCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
ANRSVPTIPAYLICDSAFLKDYGLGLVRPRSWSVGYYIRSGYLKCADTIEGLAHQIGVPA
CCCCCCCCCHHHHCCHHHHHHCCCCEECCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCH
EKFSDTVRRYNDFAAIGIDADFGRGRSPLNRHNGDPRNTPNPCLRPICRPPFYAVAVEPA
HHHHHHHHHHCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCHHHHHCCCCCEEEEEECHH
ALATSLGLSTDRDARVLDPSGTVVEGLYACGNDMNSIMAGHYPGPGVTLGPAIVFAYRAA
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHH
RHASEVFGCAKLESLHLL
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA