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The map label for this gene is adhA [H]

Identifier: 110634609

GI number: 110634609

Start: 2416843

End: 2417829

Strand: Reverse

Name: adhA [H]

Synonym: Meso_2263

Alternate gene names: 110634609

Gene position: 2417829-2416843 (Counterclockwise)

Preceding gene: 110634610

Following gene: 110634605

Centisome position: 54.8

GC content: 62.01

Gene sequence:

>987_bases
ATGAAGGCGATGGTGCTCAAGGAGGTGCGGAGACCGCTGGTCTTGAGCAAACTTCCGAATCCCACGCCAGGACGCGGCGA
GATCAGGCTTAAGGTGGAGGCCTGCGCGGTCTGTCGCACCGATCTTCACGTGGTCGACGGCGATCTGGAACACCCGAAGC
TTCCGCTTATCCCGGGACACGAGATCGTCGGCATTATCGACATGGTGGGAGAAGGGGTCGACGAGGCGAGGCTCGGTTGC
CGGGCAGGGGTGCCTTGGCTCGGCCATACCTGCGGCGCATGCCCCTATTGTCTTGCGGGTTCCGAGAACCTTTGTGACCA
GCCGCTGTTCACCGGCTACACGCGCGATGGCGGCTTTGCAAGCCATGTGGTCGCCGATGCCGATTTCGCCTTTGATCTCG
ATGCGACGGGAGATCCGATTGCTCTGGCTCCGCTTCTGTGCGCCGGACTCATAGGCTGGCGCTCTCTTAAGATGGCCGGT
GACGGAAGGCGGATCGGCATTTACGGCTTCGGTGCTGCCGCTCATATCATTGCTCAGATCTGTGTCTGGCAGGGCCGGGA
TGTGTTCGCTTTTACCCGGTCAGGCGATACGGACGCGCAGCGTTTTGCGCTGAGCCTCGGTGCGTCCTGGGCTGGCAGTT
CCGACGCCTCGCCGCCTGATCTAATGGATGCTGCGATCATATTTGCTCCTGTCGGGGACCTCGTGCCGGCCGCACTCCAG
GCCGTGCGCAAGGGTGGGCGCGTTGTGTGCGGGGGCATTCACATGAGCGACATCCCCGCGATGCCGTATTCCCTGCTGTG
GGAAGAACGCCAGTTGGTATCTGTGGCCAATCTGACCCGTGCCGACGCGACAGAGTTTTTTCCCGTCGCCAGAAGGGCTG
GAGTGCGTACCCATACAACAGTGTATTCGCTCGAAAGGGCTAATGAAGCGCTCGCAGATTTGCGCGCCGGCCGCCTCAGT
GGTGCAGCGGTGCTCGTCCCGGGTTAG

Upstream 100 bases:

>100_bases
CATTACCATTGGATGAGCTCCACTCATTGCGTCATCATGTGACGGGAGACGGGTGTAGCATCCGCCTCCCGTCGACAACT
TGGTAGTGAGAGAGGCAGCC

Downstream 100 bases:

>100_bases
CCAACCGACCGCATCGGTTGAGCCGGGATGTCGCCAAACAGGGCTGCACCGTAGCCATCGAACGTCTTGGCACCAGAATT
CGTCTATCAGTGCTCGTCCC

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKAMVLKEVRRPLVLSKLPNPTPGRGEIRLKVEACAVCRTDLHVVDGDLEHPKLPLIPGHEIVGIIDMVGEGVDEARLGC
RAGVPWLGHTCGACPYCLAGSENLCDQPLFTGYTRDGGFASHVVADADFAFDLDATGDPIALAPLLCAGLIGWRSLKMAG
DGRRIGIYGFGAAAHIIAQICVWQGRDVFAFTRSGDTDAQRFALSLGASWAGSSDASPPDLMDAAIIFAPVGDLVPAALQ
AVRKGGRVVCGGIHMSDIPAMPYSLLWEERQLVSVANLTRADATEFFPVARRAGVRTHTTVYSLERANEALADLRAGRLS
GAAVLVPG

Sequences:

>Translated_328_residues
MKAMVLKEVRRPLVLSKLPNPTPGRGEIRLKVEACAVCRTDLHVVDGDLEHPKLPLIPGHEIVGIIDMVGEGVDEARLGC
RAGVPWLGHTCGACPYCLAGSENLCDQPLFTGYTRDGGFASHVVADADFAFDLDATGDPIALAPLLCAGLIGWRSLKMAG
DGRRIGIYGFGAAAHIIAQICVWQGRDVFAFTRSGDTDAQRFALSLGASWAGSSDASPPDLMDAAIIFAPVGDLVPAALQ
AVRKGGRVVCGGIHMSDIPAMPYSLLWEERQLVSVANLTRADATEFFPVARRAGVRTHTTVYSLERANEALADLRAGRLS
GAAVLVPG
>Mature_328_residues
MKAMVLKEVRRPLVLSKLPNPTPGRGEIRLKVEACAVCRTDLHVVDGDLEHPKLPLIPGHEIVGIIDMVGEGVDEARLGC
RAGVPWLGHTCGACPYCLAGSENLCDQPLFTGYTRDGGFASHVVADADFAFDLDATGDPIALAPLLCAGLIGWRSLKMAG
DGRRIGIYGFGAAAHIIAQICVWQGRDVFAFTRSGDTDAQRFALSLGASWAGSSDASPPDLMDAAIIFAPVGDLVPAALQ
AVRKGGRVVCGGIHMSDIPAMPYSLLWEERQLVSVANLTRADATEFFPVARRAGVRTHTTVYSLERANEALADLRAGRLS
GAAVLVPG

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=104, Percent_Identity=39.4230769230769, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI34577061, Length=104, Percent_Identity=40.3846153846154, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI71743840, Length=111, Percent_Identity=36.036036036036, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI262073058, Length=111, Percent_Identity=36.036036036036, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4501929, Length=104, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI71565154, Length=106, Percent_Identity=36.7924528301887, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI71565152, Length=106, Percent_Identity=32.0754716981132, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081918, Length=322, Percent_Identity=31.3664596273292, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787863, Length=224, Percent_Identity=30.8035714285714, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082401, Length=309, Percent_Identity=25.2427184466019, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786518, Length=227, Percent_Identity=30.8370044052863, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790045, Length=196, Percent_Identity=31.6326530612245, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788407, Length=206, Percent_Identity=31.5533980582524, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI226510992, Length=114, Percent_Identity=30.7017543859649, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=26.8436578171091, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=157, Percent_Identity=33.7579617834395, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=329, Percent_Identity=24.9240121580547, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=236, Percent_Identity=30.0847457627119, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=160, Percent_Identity=38.75, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324486, Length=160, Percent_Identity=38.125, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=160, Percent_Identity=36.875, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319621, Length=160, Percent_Identity=36.875, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319949, Length=199, Percent_Identity=32.1608040201005, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323980, Length=192, Percent_Identity=30.7291666666667, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=103, Percent_Identity=32.0388349514563, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=110, Percent_Identity=33.6363636363636, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34706; Mature: 34706

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMVLKEVRRPLVLSKLPNPTPGRGEIRLKVEACAVCRTDLHVVDGDLEHPKLPLIPGH
CCCHHHHHHHCCHHHHCCCCCCCCCCEEEEEEEEEHHHHCCCEEECCCCCCCCCCCCCCH
EIVGIIDMVGEGVDEARLGCRAGVPWLGHTCGACPYCLAGSENLCDQPLFTGYTRDGGFA
HHHHHHHHHCCCHHHHHHHHHCCCCHHCHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCH
SHVVADADFAFDLDATGDPIALAPLLCAGLIGWRSLKMAGDGRRIGIYGFGAAAHIIAQI
HHEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCHHHHHHHHH
CVWQGRDVFAFTRSGDTDAQRFALSLGASWAGSSDASPPDLMDAAIIFAPVGDLVPAALQ
HHHCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHH
AVRKGGRVVCGGIHMSDIPAMPYSLLWEERQLVSVANLTRADATEFFPVARRAGVRTHTT
HHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHH
VYSLERANEALADLRAGRLSGAAVLVPG
HHHHHHHHHHHHHHHCCCCCCCEEEECC
>Mature Secondary Structure
MKAMVLKEVRRPLVLSKLPNPTPGRGEIRLKVEACAVCRTDLHVVDGDLEHPKLPLIPGH
CCCHHHHHHHCCHHHHCCCCCCCCCCEEEEEEEEEHHHHCCCEEECCCCCCCCCCCCCCH
EIVGIIDMVGEGVDEARLGCRAGVPWLGHTCGACPYCLAGSENLCDQPLFTGYTRDGGFA
HHHHHHHHHCCCHHHHHHHHHCCCCHHCHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCH
SHVVADADFAFDLDATGDPIALAPLLCAGLIGWRSLKMAGDGRRIGIYGFGAAAHIIAQI
HHEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCHHHHHHHHH
CVWQGRDVFAFTRSGDTDAQRFALSLGASWAGSSDASPPDLMDAAIIFAPVGDLVPAALQ
HHHCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHH
AVRKGGRVVCGGIHMSDIPAMPYSLLWEERQLVSVANLTRADATEFFPVARRAGVRTHTT
HHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHH
VYSLERANEALADLRAGRLSGAAVLVPG
HHHHHHHHHHHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]