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The map label for this gene is trxC [H]

Identifier: 110634606

GI number: 110634606

Start: 2413524

End: 2413970

Strand: Direct

Name: trxC [H]

Synonym: Meso_2259

Alternate gene names: 110634606

Gene position: 2413524-2413970 (Clockwise)

Preceding gene: 110634603

Following gene: 110634607

Centisome position: 54.7

GC content: 66.0

Gene sequence:

>447_bases
ATGAACGAGACCCATGTTGTCTGTTCCAAGTGCAGCGGGGTCAATCGCCTGCCGCCCGCCCGTTCCGCCCTCGCTGGCAA
GTGCGGAAAATGCGGAGCCAGGCTCTTTTCAGGACACCCCGAAGACGTCGACGCGGATATTCTGGAGCGTCAGATCGCCC
GCAGCACCGTTCCCGTGCTCGTCGATGTCTGGGCGCCATGGTGCGGACCGTGCCGGATGATGGCGCCCGCATTCGAGGCG
GCTGCGCGTGAACTCGAACCCCGGCTGCGCCTGGTCAAACTCAACTCCGATGTCGAGCAGTCCGCGGCCGCGAGACTTGG
GATTCGGGGAATCCCGACGATGATCCTCTTTCACGGCGGCCGCGAGATAGCGCGCACCTCCGGTGCGATGACCGCCGCCC
AAATCGTCCAGTGGGCGCGCGGGCGTCTGCCGGCCGCCTCCACTTGA

Upstream 100 bases:

>100_bases
AGGCGGTATTCCGCCAAGGCGCGATAGATCTCGAGTGATCGCTCAAGGACGTGGGAGCGCTTTCCCACAAGCTCCCCAAA
CGCCAACGGAAGTGCCAGCA

Downstream 100 bases:

>100_bases
CGTTAGACCAAATGGACCCGCTGATCGCAAGGCTCGGCCTGGCACTCGCCATCGGCCTTCTTGTCGGGCTGGAGCGCGGC
TGGCGGGAGCGGGATGCCCC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MNETHVVCSKCSGVNRLPPARSALAGKCGKCGARLFSGHPEDVDADILERQIARSTVPVLVDVWAPWCGPCRMMAPAFEA
AARELEPRLRLVKLNSDVEQSAAARLGIRGIPTMILFHGGREIARTSGAMTAAQIVQWARGRLPAAST

Sequences:

>Translated_148_residues
MNETHVVCSKCSGVNRLPPARSALAGKCGKCGARLFSGHPEDVDADILERQIARSTVPVLVDVWAPWCGPCRMMAPAFEA
AARELEPRLRLVKLNSDVEQSAAARLGIRGIPTMILFHGGREIARTSGAMTAAQIVQWARGRLPAAST
>Mature_148_residues
MNETHVVCSKCSGVNRLPPARSALAGKCGKCGARLFSGHPEDVDADILERQIARSTVPVLVDVWAPWCGPCRMMAPAFEA
AARELEPRLRLVKLNSDVEQSAAARLGIRGIPTMILFHGGREIARTSGAMTAAQIVQWARGRLPAAST

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=139, Percent_Identity=38.8489208633094, Blast_Score=124, Evalue=2e-30,
Organism=Escherichia coli, GI87082331, Length=98, Percent_Identity=37.7551020408163, Blast_Score=86, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=116, Percent_Identity=33.6206896551724, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=105, Percent_Identity=35.2380952380952, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507915, Length=86, Percent_Identity=36.046511627907, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921434, Length=101, Percent_Identity=35.6435643564356, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647799, Length=83, Percent_Identity=38.5542168674699, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=28.8659793814433, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15874; Mature: 15874

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNETHVVCSKCSGVNRLPPARSALAGKCGKCGARLFSGHPEDVDADILERQIARSTVPVL
CCCCHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
VDVWAPWCGPCRMMAPAFEAAARELEPRLRLVKLNSDVEQSAAARLGIRGIPTMILFHGG
HHHHCCCCCCHHHHHHHHHHHHHHHCHHEEEEECCCCHHHHHHHHCCCCCCCEEEEEECC
REIARTSGAMTAAQIVQWARGRLPAAST
HHHHHHHCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNETHVVCSKCSGVNRLPPARSALAGKCGKCGARLFSGHPEDVDADILERQIARSTVPVL
CCCCHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
VDVWAPWCGPCRMMAPAFEAAARELEPRLRLVKLNSDVEQSAAARLGIRGIPTMILFHGG
HHHHCCCCCCHHHHHHHHHHHHHHHCHHEEEEECCCCHHHHHHHHCCCCCCCEEEEEECC
REIARTSGAMTAAQIVQWARGRLPAAST
HHHHHHHCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]