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The map label for this gene is hemF

Identifier: 110634518

GI number: 110634518

Start: 2317906

End: 2318820

Strand: Reverse

Name: hemF

Synonym: Meso_2169

Alternate gene names: 110634518

Gene position: 2318820-2317906 (Counterclockwise)

Preceding gene: 110634520

Following gene: 110634516

Centisome position: 52.55

GC content: 60.87

Gene sequence:

>915_bases
ATGGAACAACCCCATATCCCGGCGGGACTGCCCGAAGACGTCGAAAACAAGAAGGAAGCGGCGCGGGCGTGGTTCGAAAC
GCTGCGCGACAAAATCTGCGCCGCGCTGGAAGGATTGGAGGACGAGCTTTCCGGCCCTCATTCGTCCTATGCTCCCGGAC
GCTTCGAGCAAACGCCCTGGCTGCGCCAGGAGGGCGCGGGCGGGGGCGGCGTAATGTCCATCATGCATGGCCGCGTGTTT
GAGAAAGTGGGCGTGCACACCTCAACCGTGCATGGGGAGTTTTCGCCCGAATTCCGCCGGCAGATTCCGGGAGCGGAGGA
GGATCCGCGCTTCTGGGCCTCCGGTATTTCCGTTATCGCCCACCCGCAAAATCCTCATGTCCCCACAGTGCATATGAACA
CGCGCATGGTGGTGACAACCCGGCAATGGTTTGGAGGCGGGGCCGACCTCACGCCGATGCTCAACCGCCGGCGCAGCCAG
GAGGACCCGGACGCAATTGCCTTTCACAAGGCAATGCGTTTCGTCTGCGAACGGCACGCAGCGGTGGCCGACTACGAGAA
ATTCAAAAACTGGTGCGAGGAATATTTCTTCCTGCCGCACAGGAACGAGCCACGCGGGATCGGCGGCATTTTTTACGATT
GGCTCAAGAGCCCGGAAGAGAATGGAGGGTGGGATGCGGATTTCGCCTTCACCCAGGATGTCGGGCGCGCCTTTGTGATG
GTCTATCAGCACATCGTGCGGAAGAACTTCAACACCAACTGGACCGAGGCCGACCGGGAAGAACAGCTCATTCGCCGCGG
GCGCTATGTCGAATTCAACCTGCTCTACGACCGCGGCACGATTTTCGGGCTCAAGACCGGCGGGAATGTCAACTCTATCC
TGTCCAGCCTGCCGCCCGTGGTGAAGTGGCCGTAG

Upstream 100 bases:

>100_bases
CCTTGACCCGGCACATAAGGAGATTAGGGATCGCACCGTGAAATTGCGAGTCATTTGTCGCCGCCAGTGGTCGGGGAGGG
CGGCGCATAAGAGGAACGCC

Downstream 100 bases:

>100_bases
GCATCAAGCCTTCAGCATTGCGAGCTTGAGCCCAAAGCCGACGAAAATCGCTCCGGTGATTGCTTTCAGCCAGCGCTGCA
CCCAAGCTCTTCTGCCAACC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MEQPHIPAGLPEDVENKKEAARAWFETLRDKICAALEGLEDELSGPHSSYAPGRFEQTPWLRQEGAGGGGVMSIMHGRVF
EKVGVHTSTVHGEFSPEFRRQIPGAEEDPRFWASGISVIAHPQNPHVPTVHMNTRMVVTTRQWFGGGADLTPMLNRRRSQ
EDPDAIAFHKAMRFVCERHAAVADYEKFKNWCEEYFFLPHRNEPRGIGGIFYDWLKSPEENGGWDADFAFTQDVGRAFVM
VYQHIVRKNFNTNWTEADREEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVNSILSSLPPVVKWP

Sequences:

>Translated_304_residues
MEQPHIPAGLPEDVENKKEAARAWFETLRDKICAALEGLEDELSGPHSSYAPGRFEQTPWLRQEGAGGGGVMSIMHGRVF
EKVGVHTSTVHGEFSPEFRRQIPGAEEDPRFWASGISVIAHPQNPHVPTVHMNTRMVVTTRQWFGGGADLTPMLNRRRSQ
EDPDAIAFHKAMRFVCERHAAVADYEKFKNWCEEYFFLPHRNEPRGIGGIFYDWLKSPEENGGWDADFAFTQDVGRAFVM
VYQHIVRKNFNTNWTEADREEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVNSILSSLPPVVKWP
>Mature_304_residues
MEQPHIPAGLPEDVENKKEAARAWFETLRDKICAALEGLEDELSGPHSSYAPGRFEQTPWLRQEGAGGGGVMSIMHGRVF
EKVGVHTSTVHGEFSPEFRRQIPGAEEDPRFWASGISVIAHPQNPHVPTVHMNTRMVVTTRQWFGGGADLTPMLNRRRSQ
EDPDAIAFHKAMRFVCERHAAVADYEKFKNWCEEYFFLPHRNEPRGIGGIFYDWLKSPEENGGWDADFAFTQDVGRAFVM
VYQHIVRKNFNTNWTEADREEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVNSILSSLPPVVKWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family

Homologues:

Organism=Homo sapiens, GI41393599, Length=265, Percent_Identity=43.7735849056604, Blast_Score=196, Evalue=2e-50,
Organism=Escherichia coli, GI1788777, Length=287, Percent_Identity=41.1149825783972, Blast_Score=201, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6320249, Length=302, Percent_Identity=38.0794701986755, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17864388, Length=308, Percent_Identity=39.9350649350649, Blast_Score=201, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM6_MESSB (Q11GB4)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674726.1
- ProteinModelPortal:   Q11GB4
- SMR:   Q11GB4
- STRING:   Q11GB4
- GeneID:   4182254
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2169
- NMPDR:   fig|266779.1.peg.1753
- eggNOG:   COG0408
- HOGENOM:   HBG631180
- OMA:   HMNTRFV
- PhylomeDB:   Q11GB4
- ProtClustDB:   PRK05330
- BioCyc:   MSP266779:MESO_2169-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00333
- InterPro:   IPR001260
- InterPro:   IPR018375
- Gene3D:   G3DSA:3.40.1500.10
- PANTHER:   PTHR10755
- PIRSF:   PIRSF000166
- PRINTS:   PR00073

Pfam domain/function: PF01218 Coprogen_oxidas; SSF102886 Coprogen_oxidas

EC number: =1.3.3.3

Molecular weight: Translated: 34672; Mature: 34672

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: ACT_SITE 131-131 BINDING 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQPHIPAGLPEDVENKKEAARAWFETLRDKICAALEGLEDELSGPHSSYAPGRFEQTPW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCC
LRQEGAGGGGVMSIMHGRVFEKVGVHTSTVHGEFSPEFRRQIPGAEEDPRFWASGISVIA
HHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCCHHHHCCCEEEE
HPQNPHVPTVHMNTRMVVTTRQWFGGGADLTPMLNRRRSQEDPDAIAFHKAMRFVCERHA
CCCCCCCCEEECCCEEEEEEHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AVADYEKFKNWCEEYFFLPHRNEPRGIGGIFYDWLKSPEENGGWDADFAFTQDVGRAFVM
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
VYQHIVRKNFNTNWTEADREEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVNSILSSLPPV
HHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCEEEEEECCCCHHHHHHHCCCC
VKWP
CCCC
>Mature Secondary Structure
MEQPHIPAGLPEDVENKKEAARAWFETLRDKICAALEGLEDELSGPHSSYAPGRFEQTPW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCC
LRQEGAGGGGVMSIMHGRVFEKVGVHTSTVHGEFSPEFRRQIPGAEEDPRFWASGISVIA
HHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCCHHHHCCCEEEE
HPQNPHVPTVHMNTRMVVTTRQWFGGGADLTPMLNRRRSQEDPDAIAFHKAMRFVCERHA
CCCCCCCCEEECCCEEEEEEHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AVADYEKFKNWCEEYFFLPHRNEPRGIGGIFYDWLKSPEENGGWDADFAFTQDVGRAFVM
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
VYQHIVRKNFNTNWTEADREEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVNSILSSLPPV
HHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCEEEEEECCCCHHHHHHHCCCC
VKWP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA