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The map label for this gene is cpxA [H]

Identifier: 110634494

GI number: 110634494

Start: 2297318

End: 2298727

Strand: Direct

Name: cpxA [H]

Synonym: Meso_2145

Alternate gene names: 110634494

Gene position: 2297318-2298727 (Clockwise)

Preceding gene: 110634493

Following gene: 110634499

Centisome position: 52.06

GC content: 61.77

Gene sequence:

>1410_bases
ATGGCGAAATTCGATCTATCCTTCACAGAAGGCGGCAGCCCTTCCACACGCGTTCGCCGCGCAATCATAGTGACCCGGCG
CGCATGGCGGCGTTTCTGGCGCACCGTCTCGCATTATATGCCGAAGCGGCTCTACGCCCGTTCTCTCATTATCATGATCG
CCCCGATGATCCTGCTGCAAGCGGTGATCGCCTACTCCTTCATGGAGCGGCATTGGCAGACGGTGACGCAGCGGCTCTCC
GAGGCGGTGACACGCGATATCGCCGCAATCATAGACATCATCGAGACCTACCCGCAGAGCGACAATTACGAGAACATCAT
CCGCATTGCCCAGGAGCGGCTGGAGCTGAGGATCAGCATCGAACCTGCCGGTCCCCTCCCCGCACCCGGGCCGAAGCCCT
TCTTCTCCATTCTCGACCAGACGCTGAGCCAGGAAATCACGCGCCAGATCAACCGGCCCTTCTGGCTCGATACGGTGGGC
AACTCCAACATCATCGAAATCCGCATCCAGCTGAATGACAAGGTGTTGCGAGTTTTTGCCCGGCGCAGCCAGGCCTATGC
ATCCAACACACACATCTTCCTGCTCTGGATGGTGGGAACCTCGCTGGTATTGATTGCCATCGCGGTCGCCTTTCTGCGCA
ACCAGATCCGCCCCGTCCTGCAGCTCGCCGAAGCCGCGGAGAGCTTCGGCAAGGGAAGGCCCACCAGCGATTTCCACCCG
CGGGGTGCGGAGGAGGTACGCCGCGCCGGCACTGCGTTCCTGCAAATGAGGGAGCGTATCGAGCGGCAGATCGAGCAGCG
CACGGCCATGCTGACCGGCGTGAGCCACGACCTGCGGACGATCCTCACCCGCTTCAAGCTTCAACTCGCGCTTGCCCGCA
ACAGAACCGATATCAAGGCGCTCGATCAGGACGTCGAGGAAATGCGCCTCATGCTGGAGGGTTATCTGGCTTTTGCCCGC
GGTGAAGCGCAGGAGGAAGCCGGCCGGTTCGACCTGGCTTCCTGCCTTGCAAAGATGGACGAGGAAGCCAAGATGCGCGG
CTGCTCTTTCAAGGCATCTCTTCTTGGAAGGCCGGAGGTGCATGTGCGGCCCAACGCCTTTTCGAGGCTGCTTTCAAATG
TGGTGGGCAATGCCTTTCGCTACGCATCGAGCGTGGAAGTGAATGCCCGCCACCTTGACGGGACGCTGGTGGTAACCATC
GATGACGATGGCCCCGGCATCCCCGAGAACAAGCGCGAGGAGGTCTTCAAGCCCTTCGTCCGGCTCGACGAGGCGCGCAA
CCAGGACGAAAGCGGCACCGGATTGGGCCTCTCCATCGCTCGGGACATTGCCCGAAGCCACGGTGGCGACATCACGCTGG
AGGACAGCCCGCTGGGTGGCTTGCGCGTCGTGGTGCGCGTACCGGCCTAG

Upstream 100 bases:

>100_bases
GCCACGCACCAAGCCCCATTTCTGCGCCGTGACGCTCTAGGCAAAGGCGGTTAGACTGCCGCGTCCGGGTCGGGTAGATA
GCGGGCAGCGCAGGGTGCAA

Downstream 100 bases:

>100_bases
GCAAGCCACCGCGCCATATCTTAGGATGCGCAAGAACGATTGCCATTGAACTGCGTATACCGCGTTCCTATTCCAGCCAC
GCACATGTGAGGATTTGGAA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MAKFDLSFTEGGSPSTRVRRAIIVTRRAWRRFWRTVSHYMPKRLYARSLIIMIAPMILLQAVIAYSFMERHWQTVTQRLS
EAVTRDIAAIIDIIETYPQSDNYENIIRIAQERLELRISIEPAGPLPAPGPKPFFSILDQTLSQEITRQINRPFWLDTVG
NSNIIEIRIQLNDKVLRVFARRSQAYASNTHIFLLWMVGTSLVLIAIAVAFLRNQIRPVLQLAEAAESFGKGRPTSDFHP
RGAEEVRRAGTAFLQMRERIERQIEQRTAMLTGVSHDLRTILTRFKLQLALARNRTDIKALDQDVEEMRLMLEGYLAFAR
GEAQEEAGRFDLASCLAKMDEEAKMRGCSFKASLLGRPEVHVRPNAFSRLLSNVVGNAFRYASSVEVNARHLDGTLVVTI
DDDGPGIPENKREEVFKPFVRLDEARNQDESGTGLGLSIARDIARSHGGDITLEDSPLGGLRVVVRVPA

Sequences:

>Translated_469_residues
MAKFDLSFTEGGSPSTRVRRAIIVTRRAWRRFWRTVSHYMPKRLYARSLIIMIAPMILLQAVIAYSFMERHWQTVTQRLS
EAVTRDIAAIIDIIETYPQSDNYENIIRIAQERLELRISIEPAGPLPAPGPKPFFSILDQTLSQEITRQINRPFWLDTVG
NSNIIEIRIQLNDKVLRVFARRSQAYASNTHIFLLWMVGTSLVLIAIAVAFLRNQIRPVLQLAEAAESFGKGRPTSDFHP
RGAEEVRRAGTAFLQMRERIERQIEQRTAMLTGVSHDLRTILTRFKLQLALARNRTDIKALDQDVEEMRLMLEGYLAFAR
GEAQEEAGRFDLASCLAKMDEEAKMRGCSFKASLLGRPEVHVRPNAFSRLLSNVVGNAFRYASSVEVNARHLDGTLVVTI
DDDGPGIPENKREEVFKPFVRLDEARNQDESGTGLGLSIARDIARSHGGDITLEDSPLGGLRVVVRVPA
>Mature_468_residues
AKFDLSFTEGGSPSTRVRRAIIVTRRAWRRFWRTVSHYMPKRLYARSLIIMIAPMILLQAVIAYSFMERHWQTVTQRLSE
AVTRDIAAIIDIIETYPQSDNYENIIRIAQERLELRISIEPAGPLPAPGPKPFFSILDQTLSQEITRQINRPFWLDTVGN
SNIIEIRIQLNDKVLRVFARRSQAYASNTHIFLLWMVGTSLVLIAIAVAFLRNQIRPVLQLAEAAESFGKGRPTSDFHPR
GAEEVRRAGTAFLQMRERIERQIEQRTAMLTGVSHDLRTILTRFKLQLALARNRTDIKALDQDVEEMRLMLEGYLAFARG
EAQEEAGRFDLASCLAKMDEEAKMRGCSFKASLLGRPEVHVRPNAFSRLLSNVVGNAFRYASSVEVNARHLDGTLVVTID
DDGPGIPENKREEVFKPFVRLDEARNQDESGTGLGLSIARDIARSHGGDITLEDSPLGGLRVVVRVPA

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=34.2007434944238, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1787894, Length=282, Percent_Identity=30.1418439716312, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789808, Length=274, Percent_Identity=32.8467153284672, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=24.7311827956989, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787374, Length=102, Percent_Identity=41.1764705882353, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=31.8181818181818, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=249, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=27.0833333333333, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082128, Length=313, Percent_Identity=26.1980830670927, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788713, Length=116, Percent_Identity=30.1724137931034, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=27.0042194092827, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=25.8928571428571, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=26.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788279, Length=226, Percent_Identity=24.7787610619469, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53034; Mature: 52903

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFDLSFTEGGSPSTRVRRAIIVTRRAWRRFWRTVSHYMPKRLYARSLIIMIAPMILLQ
CCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVIAYSFMERHWQTVTQRLSEAVTRDIAAIIDIIETYPQSDNYENIIRIAQERLELRISI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEE
EPAGPLPAPGPKPFFSILDQTLSQEITRQINRPFWLDTVGNSNIIEIRIQLNDKVLRVFA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECHHHHHHHH
RRSQAYASNTHIFLLWMVGTSLVLIAIAVAFLRNQIRPVLQLAEAAESFGKGRPTSDFHP
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RGAEEVRRAGTAFLQMRERIERQIEQRTAMLTGVSHDLRTILTRFKLQLALARNRTDIKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHH
LDQDVEEMRLMLEGYLAFARGEAQEEAGRFDLASCLAKMDEEAKMRGCSFKASLLGRPEV
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHCCHHHHHCCCCCHHHHCCCCCE
HVRPNAFSRLLSNVVGNAFRYASSVEVNARHLDGTLVVTIDDDGPGIPENKREEVFKPFV
EECCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHH
RLDEARNQDESGTGLGLSIARDIARSHGGDITLEDSPLGGLRVVVRVPA
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCC
>Mature Secondary Structure 
AKFDLSFTEGGSPSTRVRRAIIVTRRAWRRFWRTVSHYMPKRLYARSLIIMIAPMILLQ
CCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVIAYSFMERHWQTVTQRLSEAVTRDIAAIIDIIETYPQSDNYENIIRIAQERLELRISI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEE
EPAGPLPAPGPKPFFSILDQTLSQEITRQINRPFWLDTVGNSNIIEIRIQLNDKVLRVFA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECHHHHHHHH
RRSQAYASNTHIFLLWMVGTSLVLIAIAVAFLRNQIRPVLQLAEAAESFGKGRPTSDFHP
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RGAEEVRRAGTAFLQMRERIERQIEQRTAMLTGVSHDLRTILTRFKLQLALARNRTDIKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHH
LDQDVEEMRLMLEGYLAFARGEAQEEAGRFDLASCLAKMDEEAKMRGCSFKASLLGRPEV
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHCCHHHHHCCCCCHHHHCCCCCE
HVRPNAFSRLLSNVVGNAFRYASSVEVNARHLDGTLVVTIDDDGPGIPENKREEVFKPFV
EECCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHH
RLDEARNQDESGTGLGLSIARDIARSHGGDITLEDSPLGGLRVVVRVPA
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]