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The map label for this gene is yeiA [H]

Identifier: 110634405

GI number: 110634405

Start: 2205239

End: 2206552

Strand: Reverse

Name: yeiA [H]

Synonym: Meso_2055

Alternate gene names: 110634405

Gene position: 2206552-2205239 (Counterclockwise)

Preceding gene: 110634406

Following gene: 110634404

Centisome position: 50.01

GC content: 63.7

Gene sequence:

>1314_bases
ATGGCTGACATCCGCTCCAACTTCCTCGGCATCAAATCGCCGAACCCGTTCTGGCTCGCTTCTGCCCCGCCCACGGACAA
GGCCTATAATGTCGAGCGTGCCTTCAAGGCCGGCTGGGGCGGCGTGGTGTGGAAGACGCTGGGCGAGGAGGGGCCGCCGG
TCGTCAATGTGAACGGCCCGCGCTACGGCGCCATCTGGGGCGCGGACCGGCGCCTGCTCGGCTTTAACAATATCGAGCTC
ATCACCGACCGCGATCTCTATTTGAACCTTACCGAGATCAAACAGGTGAAGCGGAACTGGCCGGACCGGGCGCTTATCGT
CTCGCTCATGGTGCCCTGCGAGGAGGAGGCCTGGAAGGCCATTTTGCCGCTGGTCGAGGAGACGGAGGCCGACGGCATCG
AGCTCAATTTCGGCTGCCCGCATGGCATGAGCGAGCGCGGTATGGGCTCCGCGGTCGGCCAGGTGCCGGAATATGTCGAG
ATGGTGGTGCGCTGGTGCAAGCAGCACACGCGCATGCCCGTCATTACCAAGCTCACGCCCAACATAACGGACATTCGCAA
GCCCGCGCGCGCCGCCCATGCCGGTGGCACGGACGCGGTCTCGCTCATCAACACCATCAACTCGATCACGGCGGTCGATC
TCGACAGTTTTGCGCCGGAGCCCACCATCGACAGCAAGGGCACACATGGCGGCTATTGCGGGCCGGCGGTGAAGCCCATC
GCGCTCAACATGGTGGCCGAGATCGCGCGCGATCCGGAAACGCGCGGGCTGCCCATCTCTGGCATCGGCGGGATCACCAC
ATGGCGCGACGCCGCGGAGTTCCTGGCGCTGGGCGCCGGAACCGTGCAGGTGTGTACCGCCGCCATGACCTATGGCTTCA
AGATCGTCGAGGAGATGGTCGAGGGGCTGAAGAACTGGATGGACGAGAAGGGGCACGCCACGCTCGACGACATTATCGGC
CGCGCTGTGCCGAACGTGACGGACTGGCAGTACCTCAACCTCAACTACATCACCAAGGCGCGCATCGATCAGGATCTCTG
CATAAAGTGCGGGCGCTGCCATATCGCCTGCGAGGACACATCGCATCAGGCGATTACGTCGGTGGTGAACGGCGTGCGCT
ACTTCGAGGTGAAGGAGGAGGAGTGCGTCGGCTGCAATCTCTGCGTCAATGTCTGCCCCGTGGAGAACTGCATCACCATG
GTGCCGCTGGCAGCCGGCGAGATGGACCGGCGGACCGGGCAGGTCGTTCCCGGCGATTACGCCAACTGGACCACACACCC
GAACAATCCAATGGCGAAGGTGGCGGCGGAATAA

Upstream 100 bases:

>100_bases
GGACGCTTCCTGGGAGCCGGGGGTCGTTTTCGCCGAGTTTCGCGACAGCGAGGGCAACCGCATCGTCGTGTCCTCTTCTT
AAAGGCCAGGGAGAAAACTC

Downstream 100 bases:

>100_bases
CTTCTGTCCAAAATAGCTTTTCGCCCCGGGGATGCGGTTTGCGCCTATTGCGGATCTAAAATATCCAGGATAAGTGATAT
CCATGATGGGTGGCGAGCCA

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MADIRSNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIWGADRRLLGFNNIEL
ITDRDLYLNLTEIKQVKRNWPDRALIVSLMVPCEEEAWKAILPLVEETEADGIELNFGCPHGMSERGMGSAVGQVPEYVE
MVVRWCKQHTRMPVITKLTPNITDIRKPARAAHAGGTDAVSLINTINSITAVDLDSFAPEPTIDSKGTHGGYCGPAVKPI
ALNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGTVQVCTAAMTYGFKIVEEMVEGLKNWMDEKGHATLDDIIG
RAVPNVTDWQYLNLNYITKARIDQDLCIKCGRCHIACEDTSHQAITSVVNGVRYFEVKEEECVGCNLCVNVCPVENCITM
VPLAAGEMDRRTGQVVPGDYANWTTHPNNPMAKVAAE

Sequences:

>Translated_437_residues
MADIRSNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIWGADRRLLGFNNIEL
ITDRDLYLNLTEIKQVKRNWPDRALIVSLMVPCEEEAWKAILPLVEETEADGIELNFGCPHGMSERGMGSAVGQVPEYVE
MVVRWCKQHTRMPVITKLTPNITDIRKPARAAHAGGTDAVSLINTINSITAVDLDSFAPEPTIDSKGTHGGYCGPAVKPI
ALNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGTVQVCTAAMTYGFKIVEEMVEGLKNWMDEKGHATLDDIIG
RAVPNVTDWQYLNLNYITKARIDQDLCIKCGRCHIACEDTSHQAITSVVNGVRYFEVKEEECVGCNLCVNVCPVENCITM
VPLAAGEMDRRTGQVVPGDYANWTTHPNNPMAKVAAE
>Mature_436_residues
ADIRSNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIWGADRRLLGFNNIELI
TDRDLYLNLTEIKQVKRNWPDRALIVSLMVPCEEEAWKAILPLVEETEADGIELNFGCPHGMSERGMGSAVGQVPEYVEM
VVRWCKQHTRMPVITKLTPNITDIRKPARAAHAGGTDAVSLINTINSITAVDLDSFAPEPTIDSKGTHGGYCGPAVKPIA
LNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGTVQVCTAAMTYGFKIVEEMVEGLKNWMDEKGHATLDDIIGR
AVPNVTDWQYLNLNYITKARIDQDLCIKCGRCHIACEDTSHQAITSVVNGVRYFEVKEEECVGCNLCVNVCPVENCITMV
PLAAGEMDRRTGQVVPGDYANWTTHPNNPMAKVAAE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=333, Percent_Identity=36.9369369369369, Blast_Score=212, Evalue=7e-55,
Organism=Escherichia coli, GI87082059, Length=412, Percent_Identity=41.9902912621359, Blast_Score=326, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI71984108, Length=332, Percent_Identity=38.2530120481928, Blast_Score=217, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322633, Length=327, Percent_Identity=27.5229357798165, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640763, Length=320, Percent_Identity=39.6875, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI18858217, Length=320, Percent_Identity=39.6875, Blast_Score=224, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 47767; Mature: 47636

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIRSNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGP
CCCCCCCEECCCCCCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCEEEECCC
RYGAIWGADRRLLGFNNIELITDRDLYLNLTEIKQVKRNWPDRALIVSLMVPCEEEAWKA
CEEEEECCCCEEECCCCEEEEECCCCEEEHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHH
ILPLVEETEADGIELNFGCPHGMSERGMGSAVGQVPEYVEMVVRWCKQHTRMPVITKLTP
HHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
NITDIRKPARAAHAGGTDAVSLINTINSITAVDLDSFAPEPTIDSKGTHGGYCGPAVKPI
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEHHHCCCCCCCCCCCCCCCCCCCCCHHH
ALNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGTVQVCTAAMTYGFKIVEEMV
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EGLKNWMDEKGHATLDDIIGRAVPNVTDWQYLNLNYITKARIDQDLCIKCGRCHIACEDT
HHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEEEEEEHHHCCHHHHHCCCCEEEEECCC
SHQAITSVVNGVRYFEVKEEECVGCNLCVNVCPVENCITMVPLAAGEMDRRTGQVVPGDY
CHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCC
ANWTTHPNNPMAKVAAE
CCCCCCCCCCHHHCCCC
>Mature Secondary Structure 
ADIRSNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGP
CCCCCCEECCCCCCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCEEEECCC
RYGAIWGADRRLLGFNNIELITDRDLYLNLTEIKQVKRNWPDRALIVSLMVPCEEEAWKA
CEEEEECCCCEEECCCCEEEEECCCCEEEHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHH
ILPLVEETEADGIELNFGCPHGMSERGMGSAVGQVPEYVEMVVRWCKQHTRMPVITKLTP
HHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
NITDIRKPARAAHAGGTDAVSLINTINSITAVDLDSFAPEPTIDSKGTHGGYCGPAVKPI
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEHHHCCCCCCCCCCCCCCCCCCCCCHHH
ALNMVAEIARDPETRGLPISGIGGITTWRDAAEFLALGAGTVQVCTAAMTYGFKIVEEMV
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EGLKNWMDEKGHATLDDIIGRAVPNVTDWQYLNLNYITKARIDQDLCIKCGRCHIACEDT
HHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEEEEEEHHHCCHHHHHCCCCEEEEECCC
SHQAITSVVNGVRYFEVKEEECVGCNLCVNVCPVENCITMVPLAAGEMDRRTGQVVPGDY
CHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCC
ANWTTHPNNPMAKVAAE
CCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]