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The map label for this gene is pcaB [H]

Identifier: 110634402

GI number: 110634402

Start: 2203076

End: 2204140

Strand: Direct

Name: pcaB [H]

Synonym: Meso_2052

Alternate gene names: 110634402

Gene position: 2203076-2204140 (Clockwise)

Preceding gene: 110634401

Following gene: 110634408

Centisome position: 49.93

GC content: 64.13

Gene sequence:

>1065_bases
ATGAGCGTCAGCGTCTTCGACCACCCCATTCTTTCCGGACTTGTGGGCGACGAGGCCTTCGCCGCGCTCTTCTCAGTAGC
CGCGGAACTCGCGGCCATCCTTCGCTTCGAGACAGCACTTGCGGAAGCGGAAGCCGAGGAAGACGTCATTTCGCAGGAGG
CGGCAGAAGCCATTGCGGCCGCCGTGCAGCAATTCAAGCCGGATGTGGGCGCCCTCAGCAGAGGTATTGCGCGCGACGGG
GTCGTCATCCCCGCTCTGCTCGACCAATTGCGCCAGAAGCTCTCTGCCGAGCACCGCACCCGACTTCATTTCGGAGCGAC
CAGCCAGGATGCCATCGATACAGGGCTGGCGATGCGTCTTATCGAGGCAACCGCCCTGCTCGCCACCCGGCTGAATGAGG
TGATCGAAAGCCTCGATGCGCTGGAAAGGCGCGACGGCGGCGTAGAGGTCATGGCGCACACGCGCATGCAAGCCGCCATA
CCGGTCACCGCCGCCCGGAAAATCGCCTCCTGGCGCGAGCCTTTGATGCGCCACCGCGCCAGGCTCGAAATCGTTCGTAA
ATCCGTGACGATCCTCACCTTCGGCGGCGCCGCGGGAACGCTCGAAAAGCTCGGCGAAAAGGGCCCCGCGGTGGCAGCGC
GTCTCGCGCGAAAGCTCGGCCTCAACCTCGTCGCCCACGCCCGCCATTCCGAGCGGGACGGGATAGCCGATTTCGCCTCC
TTGCTGTCGCTGGTGACGGGCAGCCTCGGCAAGATGGGACAGGACGTGACGCTGATGGCGCAGAACGAGGTGGGCGAGGT
GAAGCTTGCGGAAGGCGGCGGATCCTCCGCCATGCCTCACAAGCAAAACCCCGTGAAAGCCGAAATTCTTGTTTCGCTTG
CACGCTTCAATGCCACGCTCCTCTCCGGCATGCACCACGCCCTGGTGCATGAAAACGAGCGCTCGGGGTCGGCATGGACG
CTTGAATGGATGCTCCTGCCGCAAATGGTGGTCGCAACAGGTGCCTCGCTCAGAATCGCCGGAGAGCTCGCCGGCGGCAT
TTCCTTCGCCGCCAGCAAGGCTTAG

Upstream 100 bases:

>100_bases
CGTTCCGACTCTGATTGCGCCGCGCACTGGGGACACCTACAATTTCGATATTCATCTGCAGGGCGAGAAGGAAACCGTGT
TCTTTGATGTGTGAGGCGGA

Downstream 100 bases:

>100_bases
CGGGGCCGCGTCTATTCCGCGGCGAGACGTTGTTCCCTGATCGGATGGATGCTCTGGAAGGGCACGCAGAGGCGGTTCCA
AACATTGATCATGCCGATGG

Product: 3-carboxy-cis,cis-muconate cycloisomerase

Products: NA

Alternate protein names: 3-carboxymuconate lactonizing enzyme; CMLE [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSVSVFDHPILSGLVGDEAFAALFSVAAELAAILRFETALAEAEAEEDVISQEAAEAIAAAVQQFKPDVGALSRGIARDG
VVIPALLDQLRQKLSAEHRTRLHFGATSQDAIDTGLAMRLIEATALLATRLNEVIESLDALERRDGGVEVMAHTRMQAAI
PVTAARKIASWREPLMRHRARLEIVRKSVTILTFGGAAGTLEKLGEKGPAVAARLARKLGLNLVAHARHSERDGIADFAS
LLSLVTGSLGKMGQDVTLMAQNEVGEVKLAEGGGSSAMPHKQNPVKAEILVSLARFNATLLSGMHHALVHENERSGSAWT
LEWMLLPQMVVATGASLRIAGELAGGISFAASKA

Sequences:

>Translated_354_residues
MSVSVFDHPILSGLVGDEAFAALFSVAAELAAILRFETALAEAEAEEDVISQEAAEAIAAAVQQFKPDVGALSRGIARDG
VVIPALLDQLRQKLSAEHRTRLHFGATSQDAIDTGLAMRLIEATALLATRLNEVIESLDALERRDGGVEVMAHTRMQAAI
PVTAARKIASWREPLMRHRARLEIVRKSVTILTFGGAAGTLEKLGEKGPAVAARLARKLGLNLVAHARHSERDGIADFAS
LLSLVTGSLGKMGQDVTLMAQNEVGEVKLAEGGGSSAMPHKQNPVKAEILVSLARFNATLLSGMHHALVHENERSGSAWT
LEWMLLPQMVVATGASLRIAGELAGGISFAASKA
>Mature_353_residues
SVSVFDHPILSGLVGDEAFAALFSVAAELAAILRFETALAEAEAEEDVISQEAAEAIAAAVQQFKPDVGALSRGIARDGV
VIPALLDQLRQKLSAEHRTRLHFGATSQDAIDTGLAMRLIEATALLATRLNEVIESLDALERRDGGVEVMAHTRMQAAIP
VTAARKIASWREPLMRHRARLEIVRKSVTILTFGGAAGTLEKLGEKGPAVAARLARKLGLNLVAHARHSERDGIADFASL
LSLVTGSLGKMGQDVTLMAQNEVGEVKLAEGGGSSAMPHKQNPVKAEILVSLARFNATLLSGMHHALVHENERSGSAWTL
EWMLLPQMVVATGASLRIAGELAGGISFAASKA

Specific function: Catalyzes an anti cycloisomerization [H]

COG id: COG0015

COG function: function code F; Adenylosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family [H]

Homologues:

Organism=Homo sapiens, GI68303547, Length=199, Percent_Identity=30.1507537688442, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI31541964, Length=199, Percent_Identity=30.1507537688442, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI68303542, Length=199, Percent_Identity=30.1507537688442, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221473854, Length=217, Percent_Identity=27.6497695852535, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI78706858, Length=217, Percent_Identity=27.6497695852535, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019468
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- InterPro:   IPR012789 [H]

Pfam domain/function: PF10397 ADSL_C; PF00206 Lyase_1 [H]

EC number: =5.5.1.2 [H]

Molecular weight: Translated: 37474; Mature: 37342

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSVFDHPILSGLVGDEAFAALFSVAAELAAILRFETALAEAEAEEDVISQEAAEAIAA
CCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVQQFKPDVGALSRGIARDGVVIPALLDQLRQKLSAEHRTRLHFGATSQDAIDTGLAMRL
HHHHHCCCHHHHHHCHHCCCEEHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHH
IEATALLATRLNEVIESLDALERRDGGVEVMAHTRMQAAIPVTAARKIASWREPLMRHRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RLEIVRKSVTILTFGGAAGTLEKLGEKGPAVAARLARKLGLNLVAHARHSERDGIADFAS
HHHHHHHHEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHH
LLSLVTGSLGKMGQDVTLMAQNEVGEVKLAEGGGSSAMPHKQNPVKAEILVSLARFNATL
HHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LSGMHHALVHENERSGSAWTLEWMLLPQMVVATGASLRIAGELAGGISFAASKA
HHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEHHHHHCCHHHHCCCC
>Mature Secondary Structure 
SVSVFDHPILSGLVGDEAFAALFSVAAELAAILRFETALAEAEAEEDVISQEAAEAIAA
CCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVQQFKPDVGALSRGIARDGVVIPALLDQLRQKLSAEHRTRLHFGATSQDAIDTGLAMRL
HHHHHCCCHHHHHHCHHCCCEEHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHH
IEATALLATRLNEVIESLDALERRDGGVEVMAHTRMQAAIPVTAARKIASWREPLMRHRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RLEIVRKSVTILTFGGAAGTLEKLGEKGPAVAARLARKLGLNLVAHARHSERDGIADFAS
HHHHHHHHEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHH
LLSLVTGSLGKMGQDVTLMAQNEVGEVKLAEGGGSSAMPHKQNPVKAEILVSLARFNATL
HHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LSGMHHALVHENERSGSAWTLEWMLLPQMVVATGASLRIAGELAGGISFAASKA
HHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHCCCCEEEHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1390752 [H]