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The map label for this gene is mltB [H]

Identifier: 110634376

GI number: 110634376

Start: 2177924

End: 2179108

Strand: Direct

Name: mltB [H]

Synonym: Meso_2026

Alternate gene names: 110634376

Gene position: 2177924-2179108 (Clockwise)

Preceding gene: 110634375

Following gene: 110634380

Centisome position: 49.36

GC content: 64.89

Gene sequence:

>1185_bases
ATGCAAGTGAAATATGGCCTGCTTGGAGCGGTTCTTGCGCTTTCGCTGCCTTCCATGGCGGCGGCCCAGCAATGCGGCGG
CGATTTTGCGGCCTGGCGCGCGGGCGTCGAAGCAGAGGCGCAGAGTCAGGGCGTCGGCCCTGCAGGTCTCGACGCGCTTC
AGCGCGCGCGAATCGACCAGCGCGTTCTCGACCGGGATCGCTCCCAGGGGGTTTTCACGCAAACCTTCCGCGAATTCGCG
AACCGGATGATCAGCCGCGACCGGATGCAGCGGGGCGCGGCAAACCTGACAAAATATGCCAGCGTGTTCCAGCGCGCCGA
AAGCGAATATGGCGTGCCGGGGCCGGTGATCGCCGCCTTCTGGGCGCTGGAGACGGATTTCGGCGCTGTTCAGGGCGATT
TCAACACGCTGAACGCGCTGGCGACGCTTTCGCACGACTGCCGCCGGCCGGAGCTGTTCCGTCCCGAGTTTGTGGCTTTC
CTGAAGCTCGTCGACCGGGGTCTCGTCACCACAGATACCACGGGTGCCTGGGCGGGCGAAATCGGCCAGCTCCAGGTGCT
GCCGAGCGACTATCTGGAGAAAGGCGTCGACGGTGACGGGGACGGCCGCGTCGACCTGAAAGGCAGTGCTGCCGACGCGA
TTCTGACGGCGGCCAATAAGCTTGCCAAACTCGGCTGGAAGGCCGGCCAGCCGTGGCTGGACGAAGTGCGCGTGCCAGAA
ACGCTGGACTGGCATGAGACAGGCCGCGTCAACAAGATCCCGCGTTCCGAATGGGCAACGCTCGGCGTGACCGGCCGTGA
CGGCAGCCCCCTTCCCGCGGACGGCCTGATGGCCGGGCTGGTGCTGCCCATGGGCTACAAGGGGCCGGCCTTTCTCGCCT
ACGACAATTTCGACATCTATCTCGAATGGAACCAGTCGCTGATCTACACGCTCACGGCAGCGCATCTGGCCTCGCGCTAT
GCCGGCGCACCGGCCTTCGATGCGCGCAATCCCGAGCAGGGACTGGAGCCGGAAAACATGAAAATCCTGCAGCAGAAGCT
TCAGGCCCTCGGCTATCACGTGGGCGAGGTGGATGGCATCCTAGGCTTCAACACGCGCGAGGCGGTTCGCCAGGAGCAAC
TCCGGCAGGGCCTTCCCGCTGATGGATGGCCAACGCAGACGCTGCTGATCGGGCTAGGACAGTAG

Upstream 100 bases:

>100_bases
ACGCGGACATCAACGTGTTCCACGGAAATGCGGCAGCCTGGAGGGGCTGGCTCAAGGCCCATGCCGGGTGAAGCGGCCCG
ATCGAGTAAGGAGTAGAGGA

Downstream 100 bases:

>100_bases
GGAAAGACAACTCACTAGGGTTGTCCAGGCACCATAAGCATACTGCCTTGCGGCCTTAGTCGGCCATCGTCTCCAGGCTC
GCCATCCCCTCAGGAGCAGC

Product: lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: 35 kDa soluble lytic transglycosylase; Murein hydrolase B; Slt35 [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQVKYGLLGAVLALSLPSMAAAQQCGGDFAAWRAGVEAEAQSQGVGPAGLDALQRARIDQRVLDRDRSQGVFTQTFREFA
NRMISRDRMQRGAANLTKYASVFQRAESEYGVPGPVIAAFWALETDFGAVQGDFNTLNALATLSHDCRRPELFRPEFVAF
LKLVDRGLVTTDTTGAWAGEIGQLQVLPSDYLEKGVDGDGDGRVDLKGSAADAILTAANKLAKLGWKAGQPWLDEVRVPE
TLDWHETGRVNKIPRSEWATLGVTGRDGSPLPADGLMAGLVLPMGYKGPAFLAYDNFDIYLEWNQSLIYTLTAAHLASRY
AGAPAFDARNPEQGLEPENMKILQQKLQALGYHVGEVDGILGFNTREAVRQEQLRQGLPADGWPTQTLLIGLGQ

Sequences:

>Translated_394_residues
MQVKYGLLGAVLALSLPSMAAAQQCGGDFAAWRAGVEAEAQSQGVGPAGLDALQRARIDQRVLDRDRSQGVFTQTFREFA
NRMISRDRMQRGAANLTKYASVFQRAESEYGVPGPVIAAFWALETDFGAVQGDFNTLNALATLSHDCRRPELFRPEFVAF
LKLVDRGLVTTDTTGAWAGEIGQLQVLPSDYLEKGVDGDGDGRVDLKGSAADAILTAANKLAKLGWKAGQPWLDEVRVPE
TLDWHETGRVNKIPRSEWATLGVTGRDGSPLPADGLMAGLVLPMGYKGPAFLAYDNFDIYLEWNQSLIYTLTAAHLASRY
AGAPAFDARNPEQGLEPENMKILQQKLQALGYHVGEVDGILGFNTREAVRQEQLRQGLPADGWPTQTLLIGLGQ
>Mature_394_residues
MQVKYGLLGAVLALSLPSMAAAQQCGGDFAAWRAGVEAEAQSQGVGPAGLDALQRARIDQRVLDRDRSQGVFTQTFREFA
NRMISRDRMQRGAANLTKYASVFQRAESEYGVPGPVIAAFWALETDFGAVQGDFNTLNALATLSHDCRRPELFRPEFVAF
LKLVDRGLVTTDTTGAWAGEIGQLQVLPSDYLEKGVDGDGDGRVDLKGSAADAILTAANKLAKLGWKAGQPWLDEVRVPE
TLDWHETGRVNKIPRSEWATLGVTGRDGSPLPADGLMAGLVLPMGYKGPAFLAYDNFDIYLEWNQSLIYTLTAAHLASRY
AGAPAFDARNPEQGLEPENMKILQQKLQALGYHVGEVDGILGFNTREAVRQEQLRQGLPADGWPTQTLLIGLGQ

Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2951

COG function: function code M; Membrane-bound lytic murein transglycosylase B

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789053, Length=163, Percent_Identity=34.9693251533742, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011757 [H]

Pfam domain/function: NA

EC number: 3.2.1.- [C]

Molecular weight: Translated: 42820; Mature: 42820

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKYGLLGAVLALSLPSMAAAQQCGGDFAAWRAGVEAEAQSQGVGPAGLDALQRARIDQ
CCCCHHHHHHHHHHHCCHHHHHHHCCCCHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHH
RVLDRDRSQGVFTQTFREFANRMISRDRMQRGAANLTKYASVFQRAESEYGVPGPVIAAF
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
WALETDFGAVQGDFNTLNALATLSHDCRRPELFRPEFVAFLKLVDRGLVTTDTTGAWAGE
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCC
IGQLQVLPSDYLEKGVDGDGDGRVDLKGSAADAILTAANKLAKLGWKAGQPWLDEVRVPE
CCEEEECCHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
TLDWHETGRVNKIPRSEWATLGVTGRDGSPLPADGLMAGLVLPMGYKGPAFLAYDNFDIY
CCCHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCEEEE
LEWNQSLIYTLTAAHLASRYAGAPAFDARNPEQGLEPENMKILQQKLQALGYHVGEVDGI
EEECCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCC
LGFNTREAVRQEQLRQGLPADGWPTQTLLIGLGQ
CCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MQVKYGLLGAVLALSLPSMAAAQQCGGDFAAWRAGVEAEAQSQGVGPAGLDALQRARIDQ
CCCCHHHHHHHHHHHCCHHHHHHHCCCCHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHH
RVLDRDRSQGVFTQTFREFANRMISRDRMQRGAANLTKYASVFQRAESEYGVPGPVIAAF
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
WALETDFGAVQGDFNTLNALATLSHDCRRPELFRPEFVAFLKLVDRGLVTTDTTGAWAGE
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCC
IGQLQVLPSDYLEKGVDGDGDGRVDLKGSAADAILTAANKLAKLGWKAGQPWLDEVRVPE
CCEEEECCHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
TLDWHETGRVNKIPRSEWATLGVTGRDGSPLPADGLMAGLVLPMGYKGPAFLAYDNFDIY
CCCHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCEEEE
LEWNQSLIYTLTAAHLASRYAGAPAFDARNPEQGLEPENMKILQQKLQALGYHVGEVDGI
EEECCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCC
LGFNTREAVRQEQLRQGLPADGWPTQTLLIGLGQ
CCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7476170; 7789526; 9205837; 9278503; 3553176; 9761817; 10570954; 10545329; 10684641 [H]