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The map label for this gene is mraW

Identifier: 110634365

GI number: 110634365

Start: 2163684

End: 2164703

Strand: Reverse

Name: mraW

Synonym: Meso_2015

Alternate gene names: 110634365

Gene position: 2164703-2163684 (Counterclockwise)

Preceding gene: 110634366

Following gene: 110634364

Centisome position: 49.06

GC content: 63.82

Gene sequence:

>1020_bases
ATGACGGGCTCTGGCGGATATGGCGCTGGCGCCGTGCCGGCTCCTCATCTTCCGGTTCTTCTGGCGGAGGTGCTGGAAGC
GCTTGAGCCCGCACGGGGCAAGCTGATCCTCGACGGCACGTTCGGCGCGGGCGGTTACACCCGCGCATTGCTGGAAGCAG
GAGCCGACGTGATCGCGATCGACCAGGATCCCGACGCGATTGCCGGCGGCAAACCACTTGCCCAGGAGTTCGCCCCAAGG
CTGCGGTTGGAGCGCGGGCGTTTTTCCGAGATGGAGGAGATTGCCGGAGAGATGCTCGACGGCATTGTGCTCGATGTCGG
GGTCTCGTCCATGCAGCTCGATCAGGCCGAGCGCGGCTTCTCTTTTCGCAGGGAAGGGCCGCTCGACATGCGTATGGGCC
AGGAGGGAACAAGCGCGGCCGACGTGGTCAATAAATTCAAGGCGGGCGATCTGGCCCGCATCTTCGGCCTTTTGGGCGAG
GAGCGTCACGCAGGCCGCATTGCCCGCGCCATTGAAAAGGGCCGCGCCGAAAAACCGTTTCGGACGACGGGCGATCTGGC
GGAGCTGGTTGAGCGTGTCATCGGCCATAGGCCGACTGACAAAATTCACCCGGCGACGCGCGTCTTTCAGGGATTGCGCA
TCTTCGTCAATGACGAATTGGGCGAACTCGCCCGCGCGCTCTTCGCCGCCGAGCGGCTTTTGAAGCCGGGCGGCATTCTC
GCCGTGGTCACTTTCCACTCTCTTGAAGACAGAATCGTGAAGCGCTTTTTGCAGGCCAGATCGGGACCGCAGGCACAATC
GCGGCATCTGCCGGAAAAAGCCGCGGCGCAGCCGGTATTCGAGAAGCCGATGAAGCCAGTCTCTCCCGGCGAGGCGGAGA
CGGCGGAAAACCCTCGCGCCCGCTCTGCGCACCTGAGGGCGGCGCGGCGCACGGCTCATCCGGCTGGCGTCCAGGATTTC
AAACTGTTCGGTGTTCCTGCGCTGTTCGTCACTGAACAGCTCGGCGAGAAAGCAAGGTAG

Upstream 100 bases:

>100_bases
AGCCGGAGCGGCTCAAGGCTCATGCCGCGGCCGTGCGGTCGAGGCTTCTCAAGCTGCGGCAGCAGGCATCAGAGGCGCGG
GCTGCGGCCCTGCCGGAAAC

Downstream 100 bases:

>100_bases
GCGCATGTTGTTTCGGACCAGCGACGTCGTCCTGATTGCGGTGATGCTCTCGGCAGCCGCGTTCACCTACAAGACCAAGC
ATGACGCGGAAGCCATGATG

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTGSGGYGAGAVPAPHLPVLLAEVLEALEPARGKLILDGTFGAGGYTRALLEAGADVIAIDQDPDAIAGGKPLAQEFAPR
LRLERGRFSEMEEIAGEMLDGIVLDVGVSSMQLDQAERGFSFRREGPLDMRMGQEGTSAADVVNKFKAGDLARIFGLLGE
ERHAGRIARAIEKGRAEKPFRTTGDLAELVERVIGHRPTDKIHPATRVFQGLRIFVNDELGELARALFAAERLLKPGGIL
AVVTFHSLEDRIVKRFLQARSGPQAQSRHLPEKAAAQPVFEKPMKPVSPGEAETAENPRARSAHLRAARRTAHPAGVQDF
KLFGVPALFVTEQLGEKAR

Sequences:

>Translated_339_residues
MTGSGGYGAGAVPAPHLPVLLAEVLEALEPARGKLILDGTFGAGGYTRALLEAGADVIAIDQDPDAIAGGKPLAQEFAPR
LRLERGRFSEMEEIAGEMLDGIVLDVGVSSMQLDQAERGFSFRREGPLDMRMGQEGTSAADVVNKFKAGDLARIFGLLGE
ERHAGRIARAIEKGRAEKPFRTTGDLAELVERVIGHRPTDKIHPATRVFQGLRIFVNDELGELARALFAAERLLKPGGIL
AVVTFHSLEDRIVKRFLQARSGPQAQSRHLPEKAAAQPVFEKPMKPVSPGEAETAENPRARSAHLRAARRTAHPAGVQDF
KLFGVPALFVTEQLGEKAR
>Mature_338_residues
TGSGGYGAGAVPAPHLPVLLAEVLEALEPARGKLILDGTFGAGGYTRALLEAGADVIAIDQDPDAIAGGKPLAQEFAPRL
RLERGRFSEMEEIAGEMLDGIVLDVGVSSMQLDQAERGFSFRREGPLDMRMGQEGTSAADVVNKFKAGDLARIFGLLGEE
RHAGRIARAIEKGRAEKPFRTTGDLAELVERVIGHRPTDKIHPATRVFQGLRIFVNDELGELARALFAAERLLKPGGILA
VVTFHSLEDRIVKRFLQARSGPQAQSRHLPEKAAAQPVFEKPMKPVSPGEAETAENPRARSAHLRAARRTAHPAGVQDFK
LFGVPALFVTEQLGEKAR

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family

Homologues:

Organism=Homo sapiens, GI165377209, Length=336, Percent_Identity=39.5833333333333, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI165377202, Length=187, Percent_Identity=41.7112299465241, Blast_Score=148, Evalue=8e-36,
Organism=Escherichia coli, GI1786270, Length=317, Percent_Identity=44.4794952681388, Blast_Score=217, Evalue=7e-58,
Organism=Drosophila melanogaster, GI62472493, Length=331, Percent_Identity=40.4833836858006, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI28571637, Length=331, Percent_Identity=40.4833836858006, Blast_Score=201, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMH_MESSB (Q11GR7)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674573.1
- ProteinModelPortal:   Q11GR7
- SMR:   Q11GR7
- STRING:   Q11GR7
- GeneID:   4182808
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2015
- NMPDR:   fig|266779.1.peg.610
- eggNOG:   COG0275
- HOGENOM:   HBG302779
- OMA:   PQLDDPE
- PhylomeDB:   Q11GR7
- ProtClustDB:   PRK00050
- BioCyc:   MSP266779:MESO_2015-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01007
- InterPro:   IPR002903
- PANTHER:   PTHR11265
- PIRSF:   PIRSF004486
- TIGRFAMs:   TIGR00006

Pfam domain/function: PF01795 Methyltransf_5

EC number: NA

Molecular weight: Translated: 36538; Mature: 36407

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: NA

Important sites: BINDING 61-61 BINDING 88-88 BINDING 105-105 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSGGYGAGAVPAPHLPVLLAEVLEALEPARGKLILDGTFGAGGYTRALLEAGADVIAI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHCCCCEEEE
DQDPDAIAGGKPLAQEFAPRLRLERGRFSEMEEIAGEMLDGIVLDVGVSSMQLDQAERGF
CCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
SFRREGPLDMRMGQEGTSAADVVNKFKAGDLARIFGLLGEERHAGRIARAIEKGRAEKPF
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
RTTGDLAELVERVIGHRPTDKIHPATRVFQGLRIFVNDELGELARALFAAERLLKPGGIL
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCCCEE
AVVTFHSLEDRIVKRFLQARSGPQAQSRHLPEKAAAQPVFEKPMKPVSPGEAETAENPRA
EEEEHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCHHHCCCCCCCCCCCCCCCCCCH
RSAHLRAARRTAHPAGVQDFKLFGVPALFVTEQLGEKAR
HHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGSGGYGAGAVPAPHLPVLLAEVLEALEPARGKLILDGTFGAGGYTRALLEAGADVIAI
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHCCCCEEEE
DQDPDAIAGGKPLAQEFAPRLRLERGRFSEMEEIAGEMLDGIVLDVGVSSMQLDQAERGF
CCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
SFRREGPLDMRMGQEGTSAADVVNKFKAGDLARIFGLLGEERHAGRIARAIEKGRAEKPF
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
RTTGDLAELVERVIGHRPTDKIHPATRVFQGLRIFVNDELGELARALFAAERLLKPGGIL
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCCCEE
AVVTFHSLEDRIVKRFLQARSGPQAQSRHLPEKAAAQPVFEKPMKPVSPGEAETAENPRA
EEEEHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCHHHCCCCCCCCCCCCCCCCCCH
RSAHLRAARRTAHPAGVQDFKLFGVPALFVTEQLGEKAR
HHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA