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The map label for this gene is penA [H]

Identifier: 110634363

GI number: 110634363

Start: 2161572

End: 2163296

Strand: Reverse

Name: penA [H]

Synonym: Meso_2013

Alternate gene names: 110634363

Gene position: 2163296-2161572 (Counterclockwise)

Preceding gene: 110634364

Following gene: 110634362

Centisome position: 49.03

GC content: 61.91

Gene sequence:

>1725_bases
ATGAAGCTTCTTCCCTGGCGTTTCAAGCGCTCCGCGCCGACTGCGGAGCAAGCTTCGATCGTGCTGCAGGGGCGGCGAAA
GGCGACGTCCGGCCGGGCGCAGAGCCGCATTGTCCTGGCGATGGCCATGATCCTCGGCATTTACGGTGCGATCGGCGCCA
GGCTTGTGCATCTGGGGCTGATTGAGGAGGCACCCGTCAACCTGCCGCAAACAAGACCCACTGCCTCGCGGCCCGATCTG
CTCGACCGGAACGGCGAAGTGCTCGCCACCGACATCAAGACATCTTCGCTCTTCGCGGAGCCTCGCCACATCATCGATAT
CGATGAGGTGATCGAGAAGCTGCAAAAGGTGCTGCCGGACCTCGACTATGAGCAGACCTACCGCAGGCTCGACAGCGATG
CCGGCTTCGTCTGGCTGCGCCGGCAGCTTTCGCCGCGTCAGCAGAGCGATATCCTGGCGCTGGGTATCCCCGGCCTCGGT
TTTCGCACCGAGAAGACCCGCTTTTATCCCGGCGGCGCGACCGCTTCGCACATCCTGGGGCTGGTCAACATCGATAACAA
GGGCATCGCCGGCATGGAGCAATATGTCGACGATCAGGGCCTGGCGGATCTTCAGGCCTTGGGCCTCGCCGGACCGGACA
CGCTCGAACCCGTTCGCCTCTCCATTGATCTGAGAGCGCAATACATCCTTCACGACGAGCTCTCCCAGGCCATGGACCGC
TATCACGCGATCGCGGCGGGCGGCGCAATCCTCAATGCGCGCACCGGCGAGGTGGTGGCGATGGTCTCGCTCCCGGACTA
CGATCCCAACAATCCCTATAACGCGCTTGAGAAGGACCGGATCAACCGCATGACGGCGGGCGTGTTCGAAATGGGGTCCA
CGTTCAAGCTCTTCACGACGGCCATGGCGCTCGATTCCGGGCATGTCAAAATGACCGACCGTTTCGACGCGTCGCGTCCG
CTGCGCCTCGGCGGTTTCACCATCAATGACTTTCACGGCAAAGGGCGTGTGCTGTCTGTGCCGGAGGTGTTCATCTATTC
CTCCAATATCGGCACGGCGAAGATGGCCGATGTGGTCGGCATTGAAGGGCACCGCGCATTTCTCAAGAAGGTCGGCCTTC
TCGACAAGATGAAGACCGAGCTGCCCGAGGTTGCTCAGCCGACCGAGCCCAAGGTGTGGAAGAAAATCAATTCCGTGACC
ATTTCCTTCGGCCACGGTGTGGCCACCACGCCGCTTCAGACGGCGGTTTCCGCGGTCGCCATGGTCAATGGCGGCAAGCT
CATTCCGCCCACCTTCCTGCCGCGCACCGAGGAAGAAGCGCAGGCCGTCGCCACCCAGGTGATCTCGCCGGAAACCAGCG
CCCAGATCCGTTACCTCTTCCGCCTCAACGTGCAGAAGGGAACGGGCGGCTCCGGTTCGCGCGCCGATGTGCCCGGCTTT
TATGTGGGCGGCAAGACCGGCACCGCGGAGAAGGTGGTCAACGGCCGTTACTCAAACGACAAGCGCTTCAACGCCTTCCT
CGCGGCCTATCCGATCAACGATCCGGAATATGTCGTTGTGGTCATTTTGGACGAACCGAAGGGCGAAAAACCCGGCATGT
CCGCCACATCCGGCCTCAATGCCGCACCAGTTGTGGGGAATGTTATCCGGCGTACCGCGCCGCTACTTGGCGTGGAGCCG
GATTTCAGCCATGAAAGTGACGCTTTGCTGGTCTCCTACCGGTGA

Upstream 100 bases:

>100_bases
TTCCCTTCCCGGTCGACAAAGTGGGCGATCTGATCGCTGAACTTGGTGTTGCCGATCCCGCGCAAGAAATCGATCCCACC
GCAACCGGCGGAGTACGCCC

Downstream 100 bases:

>100_bases
TTCCGGACACAACGAGCGGAACGGACCGCAGAGAGTACTGGGATGCGATGAAGCTGGGCGAATTTGCCGATATCCTGCCG
CTGAGCGGATCCATAGCGGG

Product: penicillin-binding protein, transpeptidase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MKLLPWRFKRSAPTAEQASIVLQGRRKATSGRAQSRIVLAMAMILGIYGAIGARLVHLGLIEEAPVNLPQTRPTASRPDL
LDRNGEVLATDIKTSSLFAEPRHIIDIDEVIEKLQKVLPDLDYEQTYRRLDSDAGFVWLRRQLSPRQQSDILALGIPGLG
FRTEKTRFYPGGATASHILGLVNIDNKGIAGMEQYVDDQGLADLQALGLAGPDTLEPVRLSIDLRAQYILHDELSQAMDR
YHAIAAGGAILNARTGEVVAMVSLPDYDPNNPYNALEKDRINRMTAGVFEMGSTFKLFTTAMALDSGHVKMTDRFDASRP
LRLGGFTINDFHGKGRVLSVPEVFIYSSNIGTAKMADVVGIEGHRAFLKKVGLLDKMKTELPEVAQPTEPKVWKKINSVT
ISFGHGVATTPLQTAVSAVAMVNGGKLIPPTFLPRTEEEAQAVATQVISPETSAQIRYLFRLNVQKGTGGSGSRADVPGF
YVGGKTGTAEKVVNGRYSNDKRFNAFLAAYPINDPEYVVVVILDEPKGEKPGMSATSGLNAAPVVGNVIRRTAPLLGVEP
DFSHESDALLVSYR

Sequences:

>Translated_574_residues
MKLLPWRFKRSAPTAEQASIVLQGRRKATSGRAQSRIVLAMAMILGIYGAIGARLVHLGLIEEAPVNLPQTRPTASRPDL
LDRNGEVLATDIKTSSLFAEPRHIIDIDEVIEKLQKVLPDLDYEQTYRRLDSDAGFVWLRRQLSPRQQSDILALGIPGLG
FRTEKTRFYPGGATASHILGLVNIDNKGIAGMEQYVDDQGLADLQALGLAGPDTLEPVRLSIDLRAQYILHDELSQAMDR
YHAIAAGGAILNARTGEVVAMVSLPDYDPNNPYNALEKDRINRMTAGVFEMGSTFKLFTTAMALDSGHVKMTDRFDASRP
LRLGGFTINDFHGKGRVLSVPEVFIYSSNIGTAKMADVVGIEGHRAFLKKVGLLDKMKTELPEVAQPTEPKVWKKINSVT
ISFGHGVATTPLQTAVSAVAMVNGGKLIPPTFLPRTEEEAQAVATQVISPETSAQIRYLFRLNVQKGTGGSGSRADVPGF
YVGGKTGTAEKVVNGRYSNDKRFNAFLAAYPINDPEYVVVVILDEPKGEKPGMSATSGLNAAPVVGNVIRRTAPLLGVEP
DFSHESDALLVSYR
>Mature_574_residues
MKLLPWRFKRSAPTAEQASIVLQGRRKATSGRAQSRIVLAMAMILGIYGAIGARLVHLGLIEEAPVNLPQTRPTASRPDL
LDRNGEVLATDIKTSSLFAEPRHIIDIDEVIEKLQKVLPDLDYEQTYRRLDSDAGFVWLRRQLSPRQQSDILALGIPGLG
FRTEKTRFYPGGATASHILGLVNIDNKGIAGMEQYVDDQGLADLQALGLAGPDTLEPVRLSIDLRAQYILHDELSQAMDR
YHAIAAGGAILNARTGEVVAMVSLPDYDPNNPYNALEKDRINRMTAGVFEMGSTFKLFTTAMALDSGHVKMTDRFDASRP
LRLGGFTINDFHGKGRVLSVPEVFIYSSNIGTAKMADVVGIEGHRAFLKKVGLLDKMKTELPEVAQPTEPKVWKKINSVT
ISFGHGVATTPLQTAVSAVAMVNGGKLIPPTFLPRTEEEAQAVATQVISPETSAQIRYLFRLNVQKGTGGSGSRADVPGF
YVGGKTGTAEKVVNGRYSNDKRFNAFLAAYPINDPEYVVVVILDEPKGEKPGMSATSGLNAAPVVGNVIRRTAPLLGVEP
DFSHESDALLVSYR

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=552, Percent_Identity=26.8115942028986, Blast_Score=169, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 62400; Mature: 62400

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLPWRFKRSAPTAEQASIVLQGRRKATSGRAQSRIVLAMAMILGIYGAIGARLVHLGL
CCCCCCCCCCCCCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IEEAPVNLPQTRPTASRPDLLDRNGEVLATDIKTSSLFAEPRHIIDIDEVIEKLQKVLPD
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHCCCCCEECHHHHHHHHHHHCCC
LDYEQTYRRLDSDAGFVWLRRQLSPRQQSDILALGIPGLGFRTEKTRFYPGGATASHILG
CCHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHEEE
LVNIDNKGIAGMEQYVDDQGLADLQALGLAGPDTLEPVRLSIDLRAQYILHDELSQAMDR
EEEECCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEEEEEEEEEEHHHHHHHHHHH
YHAIAAGGAILNARTGEVVAMVSLPDYDPNNPYNALEKDRINRMTAGVFEMGSTFKLFTT
HHHHHCCCEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
AMALDSGHVKMTDRFDASRPLRLGGFTINDFHGKGRVLSVPEVFIYSSNIGTAKMADVVG
HHHCCCCCEEEECCCCCCCCEEECCEEEEEECCCCCEEECCEEEEEECCCCCHHHHHHHC
IEGHRAFLKKVGLLDKMKTELPEVAQPTEPKVWKKINSVTISFGHGVATTPLQTAVSAVA
CCHHHHHHHHHCHHHHHHHHCHHHCCCCCCHHHHHHCCEEEEECCCCCCCHHHHHHHHHH
MVNGGKLIPPTFLPRTEEEAQAVATQVISPETSAQIRYLFRLNVQKGTGGSGSRADVPGF
HCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEE
YVGGKTGTAEKVVNGRYSNDKRFNAFLAAYPINDPEYVVVVILDEPKGEKPGMSATSGLN
EECCCCCCHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCC
AAPVVGNVIRRTAPLLGVEPDFSHESDALLVSYR
CCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MKLLPWRFKRSAPTAEQASIVLQGRRKATSGRAQSRIVLAMAMILGIYGAIGARLVHLGL
CCCCCCCCCCCCCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IEEAPVNLPQTRPTASRPDLLDRNGEVLATDIKTSSLFAEPRHIIDIDEVIEKLQKVLPD
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHCCCCCEECHHHHHHHHHHHCCC
LDYEQTYRRLDSDAGFVWLRRQLSPRQQSDILALGIPGLGFRTEKTRFYPGGATASHILG
CCHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHEEE
LVNIDNKGIAGMEQYVDDQGLADLQALGLAGPDTLEPVRLSIDLRAQYILHDELSQAMDR
EEEECCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEEEEEEEEEEHHHHHHHHHHH
YHAIAAGGAILNARTGEVVAMVSLPDYDPNNPYNALEKDRINRMTAGVFEMGSTFKLFTT
HHHHHCCCEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
AMALDSGHVKMTDRFDASRPLRLGGFTINDFHGKGRVLSVPEVFIYSSNIGTAKMADVVG
HHHCCCCCEEEECCCCCCCCEEECCEEEEEECCCCCEEECCEEEEEECCCCCHHHHHHHC
IEGHRAFLKKVGLLDKMKTELPEVAQPTEPKVWKKINSVTISFGHGVATTPLQTAVSAVA
CCHHHHHHHHHCHHHHHHHHCHHHCCCCCCHHHHHHCCEEEEECCCCCCCHHHHHHHHHH
MVNGGKLIPPTFLPRTEEEAQAVATQVISPETSAQIRYLFRLNVQKGTGGSGSRADVPGF
HCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEE
YVGGKTGTAEKVVNGRYSNDKRFNAFLAAYPINDPEYVVVVILDEPKGEKPGMSATSGLN
EECCCCCCHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCC
AAPVVGNVIRRTAPLLGVEPDFSHESDALLVSYR
CCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]