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The map label for this gene is hisD2 [H]

Identifier: 110634278

GI number: 110634278

Start: 2064253

End: 2065578

Strand: Reverse

Name: hisD2 [H]

Synonym: Meso_1928

Alternate gene names: 110634278

Gene position: 2065578-2064253 (Counterclockwise)

Preceding gene: 110634279

Following gene: 110634274

Centisome position: 46.81

GC content: 54.9

Gene sequence:

>1326_bases
ATGCCTAAATACTTGAAGAGTTCTGGCACGCCCCGAGGGAATGTCAGCAATCTCAAGGTGCGACAGACGGTAGAACGTAT
CATCGAGGATGTCGAACGCGAGAAAGACTTGGCTGTCCGGCGCCTATCAATAGAGTTTGATGGATACGACCGTCAGACCT
ACAGGCTATCTGCACAGGAAATCCAATATTGCATCGATTGGTTGGCCAAAGAAGATCTGGACGATATTCTTTTTGCACAG
GAGCAGGTCCGGAACTTCGCCAGGAAGCAGCGCGATTGCCTGCTTGACCTGGAAGTCGAAACCTATCCTGGCGTTGTGTT
AGGCCACCGCAATATCCCGATCGCCAATGTCGGCTGTTATGTACCGGGTGGCAAGTATCCGCTTCTGGCGTCTGCGCACA
TGTCCGTGGTGACCGCAAAGGTGGCCGGAGTCGAGAGGATTATCACATGTGCTCCGCCGGTGAATGGTCGTCCATCTCCT
GCGATCGTAGCGGCTCAACATCTGGCAGGCGCGGACGAGATATATTGCCTGGGAGGCGTACAAGCGGTTGTCGCTATGGC
CTTGGGAACCGAATCCATTGCCGCCGTTGATATGCTTGTAGGTCCTGGCAATGCGTATGTCGCAGAAGCAAAACGCCAGC
TATATGGGCGTGTCGGAATTGATCTGTTTGCGGGCCCGACGGAAACGCTGATCATTGCCGATGAAACGGCTGATGCCCTT
ACCTGTGCTACCGACATCCTCGGCCAAGCCGAGCACGGACCAGATTCGCCGGCCATATTGCTGACGACGAGTGAGTCCTT
GGCTGTTGAGACACTGCGTCAAATCGAAGAACTACTCTCGGTGCTTCCCACGGCGGAAATCGCTCGGAAAGCATGGGAGG
CTCACGGCGAGATCATCATCTGCAAGGACGACGCCGAACTTGTCGTCGAAGCCGATCGTATCGCGTCGGAGCATGTGCAG
GTTATGACGCGTGATCCGGACTATTTCTTGGAAAATATGCGCAACTACGGCGCTCTTTTTCTTGGCGAACGGACAAATGT
GGCCTATGGCGATAAGGTCATCGGCACCAACCATACGCTGCCGACGTTGGGCGCTGCGCGATATACCGGAGGACTGTGGG
TTGGGAAGTTTCTGAAGACGTGCACCTATCAGCGCGTGCTCACTGACGAAGCTTCCGTGTATTTTGGCGAGTACTGTTCC
CGGTTGAGCATGCTTGAAGGATTTGTCGGTCACACGGAACAGGCCAATATCAGGCTGAGACGTTTTGGTGGACGATCTGT
GCCTTACGGGACTGCTGCAGATCGTGTCATCGGGCCCCATGGCTAG

Upstream 100 bases:

>100_bases
GATCGGCAGCCCTAGCCCGACCAGGGCGCGGGAAGAACCACAATTAGCTAGTCACAAGGAGACGACAGCCGGAGTAGGGC
TTCGTCCCAGGGAGAAAGTC

Downstream 100 bases:

>100_bases
TTTGTATCGTTTCCGCTTTAAGAACCATTATAGAGCTTCGGTGGCGATGCCGTAGCCCTATCTCCGCCGGATCGATGTAT
TAGAATCATCCAAGCGGTTC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 2 [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MPKYLKSSGTPRGNVSNLKVRQTVERIIEDVEREKDLAVRRLSIEFDGYDRQTYRLSAQEIQYCIDWLAKEDLDDILFAQ
EQVRNFARKQRDCLLDLEVETYPGVVLGHRNIPIANVGCYVPGGKYPLLASAHMSVVTAKVAGVERIITCAPPVNGRPSP
AIVAAQHLAGADEIYCLGGVQAVVAMALGTESIAAVDMLVGPGNAYVAEAKRQLYGRVGIDLFAGPTETLIIADETADAL
TCATDILGQAEHGPDSPAILLTTSESLAVETLRQIEELLSVLPTAEIARKAWEAHGEIIICKDDAELVVEADRIASEHVQ
VMTRDPDYFLENMRNYGALFLGERTNVAYGDKVIGTNHTLPTLGAARYTGGLWVGKFLKTCTYQRVLTDEASVYFGEYCS
RLSMLEGFVGHTEQANIRLRRFGGRSVPYGTAADRVIGPHG

Sequences:

>Translated_441_residues
MPKYLKSSGTPRGNVSNLKVRQTVERIIEDVEREKDLAVRRLSIEFDGYDRQTYRLSAQEIQYCIDWLAKEDLDDILFAQ
EQVRNFARKQRDCLLDLEVETYPGVVLGHRNIPIANVGCYVPGGKYPLLASAHMSVVTAKVAGVERIITCAPPVNGRPSP
AIVAAQHLAGADEIYCLGGVQAVVAMALGTESIAAVDMLVGPGNAYVAEAKRQLYGRVGIDLFAGPTETLIIADETADAL
TCATDILGQAEHGPDSPAILLTTSESLAVETLRQIEELLSVLPTAEIARKAWEAHGEIIICKDDAELVVEADRIASEHVQ
VMTRDPDYFLENMRNYGALFLGERTNVAYGDKVIGTNHTLPTLGAARYTGGLWVGKFLKTCTYQRVLTDEASVYFGEYCS
RLSMLEGFVGHTEQANIRLRRFGGRSVPYGTAADRVIGPHG
>Mature_440_residues
PKYLKSSGTPRGNVSNLKVRQTVERIIEDVEREKDLAVRRLSIEFDGYDRQTYRLSAQEIQYCIDWLAKEDLDDILFAQE
QVRNFARKQRDCLLDLEVETYPGVVLGHRNIPIANVGCYVPGGKYPLLASAHMSVVTAKVAGVERIITCAPPVNGRPSPA
IVAAQHLAGADEIYCLGGVQAVVAMALGTESIAAVDMLVGPGNAYVAEAKRQLYGRVGIDLFAGPTETLIIADETADALT
CATDILGQAEHGPDSPAILLTTSESLAVETLRQIEELLSVLPTAEIARKAWEAHGEIIICKDDAELVVEADRIASEHVQV
MTRDPDYFLENMRNYGALFLGERTNVAYGDKVIGTNHTLPTLGAARYTGGLWVGKFLKTCTYQRVLTDEASVYFGEYCSR
LSMLEGFVGHTEQANIRLRRFGGRSVPYGTAADRVIGPHG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=405, Percent_Identity=35.3086419753086, Blast_Score=239, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6319819, Length=415, Percent_Identity=34.9397590361446, Blast_Score=206, Evalue=6e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 48202; Mature: 48071

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYLKSSGTPRGNVSNLKVRQTVERIIEDVEREKDLAVRRLSIEFDGYDRQTYRLSAQE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCEEEEECHHH
IQYCIDWLAKEDLDDILFAQEQVRNFARKQRDCLLDLEVETYPGVVLGHRNIPIANVGCY
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEECCCCCEEEEEEE
VPGGKYPLLASAHMSVVTAKVAGVERIITCAPPVNGRPSPAIVAAQHLAGADEIYCLGGV
CCCCCCCEEEHHHHHHHHHHHHCHHEEEEECCCCCCCCCCHHHHHHHHCCCCCEEEECHH
QAVVAMALGTESIAAVDMLVGPGNAYVAEAKRQLYGRVGIDLFAGPTETLIIADETADAL
HHHHHHHHCCCHHHEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCHH
TCATDILGQAEHGPDSPAILLTTSESLAVETLRQIEELLSVLPTAEIARKAWEAHGEIII
HHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEE
CKDDAELVVEADRIASEHVQVMTRDPDYFLENMRNYGALFLGERTNVAYGDKVIGTNHTL
EECCCCEEEEHHHHHHHHHEEEECCHHHHHHHHHCCCEEEEECCCCCCCCCEEECCCCCC
PTLGAARYTGGLWVGKFLKTCTYQRVLTDEASVYFGEYCSRLSMLEGFVGHTEQANIRLR
CCCCCHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
RFGGRSVPYGTAADRVIGPHG
ECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKYLKSSGTPRGNVSNLKVRQTVERIIEDVEREKDLAVRRLSIEFDGYDRQTYRLSAQE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCEEEEECHHH
IQYCIDWLAKEDLDDILFAQEQVRNFARKQRDCLLDLEVETYPGVVLGHRNIPIANVGCY
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEECCCCCEEEEEEE
VPGGKYPLLASAHMSVVTAKVAGVERIITCAPPVNGRPSPAIVAAQHLAGADEIYCLGGV
CCCCCCCEEEHHHHHHHHHHHHCHHEEEEECCCCCCCCCCHHHHHHHHCCCCCEEEECHH
QAVVAMALGTESIAAVDMLVGPGNAYVAEAKRQLYGRVGIDLFAGPTETLIIADETADAL
HHHHHHHHCCCHHHEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCHH
TCATDILGQAEHGPDSPAILLTTSESLAVETLRQIEELLSVLPTAEIARKAWEAHGEIII
HHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEE
CKDDAELVVEADRIASEHVQVMTRDPDYFLENMRNYGALFLGERTNVAYGDKVIGTNHTL
EECCCCEEEEHHHHHHHHHEEEECCHHHHHHHHHCCCEEEEECCCCCCCCCEEECCCCCC
PTLGAARYTGGLWVGKFLKTCTYQRVLTDEASVYFGEYCSRLSMLEGFVGHTEQANIRLR
CCCCCHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
RFGGRSVPYGTAADRVIGPHG
ECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]