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The map label for this gene is glmU

Identifier: 110634121

GI number: 110634121

Start: 1891643

End: 1893007

Strand: Reverse

Name: glmU

Synonym: Meso_1770

Alternate gene names: 110634121

Gene position: 1893007-1891643 (Counterclockwise)

Preceding gene: 110634122

Following gene: 110634120

Centisome position: 42.9

GC content: 62.93

Gene sequence:

>1365_bases
ATGACCAACCGCACCTGTCTCGCCGTCATTCTCGCCGCTGGCGAGGGAACCCGCATGAAGAGCACGCTTCCTAAGGTGCT
GCACAAGATCGGCGGACTGGAAATGGTGGGCCATGTCATGAACGCCGCATCCTCCGCTGGCGCGGACGCGCTGGCGCTGG
TCGTGGGCAATGGCGCGGAGCAGGTGCGCGCGTTCGCTGAAAAGCAAACCGCCGACCGTCGGGATATATTTGTCCAAGAG
GAGCGGCTTGGCACCGCCCATGCGGTTCTCGCCGCGCGAGAGGCGATGTCCCGTGGCTATGACGACGTGCTCGTCGTCTT
TGGCGATCATCCGCTGCTTGATCCATCGGTTCTCCTCAGCGCGCGTGAAAAGCTCGCCGAAGGCGCGGCGGTGGCCGTGC
TCGGCTTCCGCCCGCCGGTTCCGACCGGCTACGGGCGCCTGATCGAGAAGGAAGGGCGGCTCGTCGCAATCCGCGAGGAG
AAGGACTGCTCCGAAGAGGAGAGGAAGATCACCTTCTGCAACAGCGGTGTGATGGCGATTGCCGGCAAGCACGCGCTCGC
CCTGATCGATCAGGTAAAGAACGAGAATGCCAAGGGCGAATATTATCTCACCGATATCGTTGAGATCGCCAACCGCCAAG
GCCTGCTCGTGGTGGCTAGCGAGGCCGGGAGGGAAAGCGCAGTTGGCATCAACAACCGCGCGGAACTTGCCGAAGCAGAA
GCCGTCTGGCAGCAGAAAAGGCGGCGGGAACTCATGCTTTCAGGTGTAACCCTGATCGCGCCAGAGACGGTCTTCCTTTC
CTACGATACGCAGATCGGCCCGGATACGGTGATCGAGCCGAATGTCTGGTTCGGGCCGGGAGTCCGGATCGCGTCCGGCG
CGCATATCCACGCCTTCTCGCATATCGAGGAGGCCGTGGTGGAAACCGGCGCGACGGTTGGCCCCTTTGCACGGTTGCGG
CCGGGTGCGCAGGTTCAGGAAAAGGCAAAGATCGGCAATTTCTGCGAGATCAAGAACGCGCGTATCGAGCCGGGCGCCAA
GGTGCCGCATCTTTCCTATATCGGCGACGCCACGGTGGGCGCGGGCGCCAATATCGGCGCGGGCACCATCACCTGCAACT
ACGATGGATTTCTGAAACACCATACGGAAATTGGAGCTGGGGCCTTCATCGGCACCAATTCCGCGCTGGTGGCGCCGGTC
ACGATCGGCGCAGGCGCCTATGTTGCCTCCGGCAGCGTGCTGACGGAAGACGTGCCAGCCGATGCGCTTGCCTTCGGGCG
CGCGCGGCAGGCGACCTACGAAGGACGCGGGAAAGTGCTGCGCGATAAGCTAGCCGAAGAGAAGGCGAAAAAGTCGGGCG
GTTGA

Upstream 100 bases:

>100_bases
ACTTTCCCGACGCTCGGAACGCTCGGCTGAAGCCATTTTGCGCCGGGCGCGGTGGAGTGATAGAGATCGTTCCCAATTGC
CGATTCAACGGATATCTCGC

Downstream 100 bases:

>100_bases
GGCAGTTTTTCCTGCCTTGCAAAAGGGGTGCTCGTCTCGCGCTCGTTTCCGACGCGACTGTGGTGGATCACGGCGTTAAC
TGGCAAAAGGCTTGACGTTC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTNRTCLAVILAAGEGTRMKSTLPKVLHKIGGLEMVGHVMNAASSAGADALALVVGNGAEQVRAFAEKQTADRRDIFVQE
ERLGTAHAVLAAREAMSRGYDDVLVVFGDHPLLDPSVLLSAREKLAEGAAVAVLGFRPPVPTGYGRLIEKEGRLVAIREE
KDCSEEERKITFCNSGVMAIAGKHALALIDQVKNENAKGEYYLTDIVEIANRQGLLVVASEAGRESAVGINNRAELAEAE
AVWQQKRRRELMLSGVTLIAPETVFLSYDTQIGPDTVIEPNVWFGPGVRIASGAHIHAFSHIEEAVVETGATVGPFARLR
PGAQVQEKAKIGNFCEIKNARIEPGAKVPHLSYIGDATVGAGANIGAGTITCNYDGFLKHHTEIGAGAFIGTNSALVAPV
TIGAGAYVASGSVLTEDVPADALAFGRARQATYEGRGKVLRDKLAEEKAKKSGG

Sequences:

>Translated_454_residues
MTNRTCLAVILAAGEGTRMKSTLPKVLHKIGGLEMVGHVMNAASSAGADALALVVGNGAEQVRAFAEKQTADRRDIFVQE
ERLGTAHAVLAAREAMSRGYDDVLVVFGDHPLLDPSVLLSAREKLAEGAAVAVLGFRPPVPTGYGRLIEKEGRLVAIREE
KDCSEEERKITFCNSGVMAIAGKHALALIDQVKNENAKGEYYLTDIVEIANRQGLLVVASEAGRESAVGINNRAELAEAE
AVWQQKRRRELMLSGVTLIAPETVFLSYDTQIGPDTVIEPNVWFGPGVRIASGAHIHAFSHIEEAVVETGATVGPFARLR
PGAQVQEKAKIGNFCEIKNARIEPGAKVPHLSYIGDATVGAGANIGAGTITCNYDGFLKHHTEIGAGAFIGTNSALVAPV
TIGAGAYVASGSVLTEDVPADALAFGRARQATYEGRGKVLRDKLAEEKAKKSGG
>Mature_453_residues
TNRTCLAVILAAGEGTRMKSTLPKVLHKIGGLEMVGHVMNAASSAGADALALVVGNGAEQVRAFAEKQTADRRDIFVQEE
RLGTAHAVLAAREAMSRGYDDVLVVFGDHPLLDPSVLLSAREKLAEGAAVAVLGFRPPVPTGYGRLIEKEGRLVAIREEK
DCSEEERKITFCNSGVMAIAGKHALALIDQVKNENAKGEYYLTDIVEIANRQGLLVVASEAGRESAVGINNRAELAEAEA
VWQQKRRRELMLSGVTLIAPETVFLSYDTQIGPDTVIEPNVWFGPGVRIASGAHIHAFSHIEEAVVETGATVGPFARLRP
GAQVQEKAKIGNFCEIKNARIEPGAKVPHLSYIGDATVGAGANIGAGTITCNYDGFLKHHTEIGAGAFIGTNSALVAPVT
IGAGAYVASGSVLTEDVPADALAFGRARQATYEGRGKVLRDKLAEEKAKKSGG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=461, Percent_Identity=39.4793926247288, Blast_Score=318, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_MESSB (Q11HG1)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674329.1
- ProteinModelPortal:   Q11HG1
- SMR:   Q11HG1
- STRING:   Q11HG1
- GeneID:   4181321
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1770
- NMPDR:   fig|266779.1.peg.3711
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   MERTCLA
- PhylomeDB:   Q11HG1
- ProtClustDB:   PRK14353
- BioCyc:   MSP266779:MESO_1770-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 47993; Mature: 47862

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 350-350 BINDING 79-79 BINDING 145-145 BINDING 159-159 BINDING 174-174 BINDING 374-374 BINDING 427-427

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRTCLAVILAAGEGTRMKSTLPKVLHKIGGLEMVGHVMNAASSAGADALALVVGNGAE
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCHH
QVRAFAEKQTADRRDIFVQEERLGTAHAVLAAREAMSRGYDDVLVVFGDHPLLDPSVLLS
HHHHHHHHHCCCHHCEEEEHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHH
AREKLAEGAAVAVLGFRPPVPTGYGRLIEKEGRLVAIREEKDCSEEERKITFCNSGVMAI
HHHHHHCCCEEEEEECCCCCCCCHHHHEECCCCEEEEECCCCCCCHHCEEEEECCCEEEE
AGKHALALIDQVKNENAKGEYYLTDIVEIANRQGLLVVASEAGRESAVGINNRAELAEAE
CCCHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
AVWQQKRRRELMLSGVTLIAPETVFLSYDTQIGPDTVIEPNVWFGPGVRIASGAHIHAFS
HHHHHHHHHHHHHCCEEEEECCEEEEEECCCCCCCCEECCCCEECCCEEEECCCEEHHHH
HIEEAVVETGATVGPFARLRPGAQVQEKAKIGNFCEIKNARIEPGAKVPHLSYIGDATVG
HHHHHHHHCCCCCCCHHHCCCCCCHHHHHHCCCEEEECCCCCCCCCCCCCEEECCCCCCC
AGANIGAGTITCNYDGFLKHHTEIGAGAFIGTNSALVAPVTIGAGAYVASGSVLTEDVPA
CCCCCCCCEEEECCCCHHHHHHHCCCCEEECCCCCEEEEEEECCCCEEECCCEEECCCCH
DALAFGRARQATYEGRGKVLRDKLAEEKAKKSGG
HHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNRTCLAVILAAGEGTRMKSTLPKVLHKIGGLEMVGHVMNAASSAGADALALVVGNGAE
CCCEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCHH
QVRAFAEKQTADRRDIFVQEERLGTAHAVLAAREAMSRGYDDVLVVFGDHPLLDPSVLLS
HHHHHHHHHCCCHHCEEEEHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHH
AREKLAEGAAVAVLGFRPPVPTGYGRLIEKEGRLVAIREEKDCSEEERKITFCNSGVMAI
HHHHHHCCCEEEEEECCCCCCCCHHHHEECCCCEEEEECCCCCCCHHCEEEEECCCEEEE
AGKHALALIDQVKNENAKGEYYLTDIVEIANRQGLLVVASEAGRESAVGINNRAELAEAE
CCCHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
AVWQQKRRRELMLSGVTLIAPETVFLSYDTQIGPDTVIEPNVWFGPGVRIASGAHIHAFS
HHHHHHHHHHHHHCCEEEEECCEEEEEECCCCCCCCEECCCCEECCCEEEECCCEEHHHH
HIEEAVVETGATVGPFARLRPGAQVQEKAKIGNFCEIKNARIEPGAKVPHLSYIGDATVG
HHHHHHHHCCCCCCCHHHCCCCCCHHHHHHCCCEEEECCCCCCCCCCCCCEEECCCCCCC
AGANIGAGTITCNYDGFLKHHTEIGAGAFIGTNSALVAPVTIGAGAYVASGSVLTEDVPA
CCCCCCCCEEEECCCCHHHHHHHCCCCEEECCCCCEEEEEEECCCCEEECCCEEECCCCH
DALAFGRARQATYEGRGKVLRDKLAEEKAKKSGG
HHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA