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The map label for this gene is fabD [H]

Identifier: 110634120

GI number: 110634120

Start: 1890543

End: 1891484

Strand: Reverse

Name: fabD [H]

Synonym: Meso_1769

Alternate gene names: 110634120

Gene position: 1891484-1890543 (Counterclockwise)

Preceding gene: 110634121

Following gene: 110634119

Centisome position: 42.87

GC content: 64.12

Gene sequence:

>942_bases
ATGACGATCGCCTTCACCTTCCCGGGGCAGGGAAGTCAGGCCGTCGGGATGGGCCGCGACCTGGCGGAGGCATTTCCCGA
GGCGCGCGACGTCTTTCAGGAAGTGGACGAGGCGCTCGGGCAGTCGCTTTCCAAGCTGATGTGGGAAGGACCGGAGGAGG
AATTGACGCTGACCGCGAATGCGCAGCCGGCGCTGATGGCGGTGTCCCTGGCGGCTATCCGCGTGATGGAAAAGGCCGGG
CTCCCGCTCAAGGACAAAGTGGCGTATGTGGCCGGCCATTCGCTGGGGGAATATTCGGCGCTTGCCGCGGCAGGGACCTT
TTCTCTCCTCGACACGGCGCGGCTCCTGCGCATACGCGGCAATGCCATGCAGGCCGCCGTGCCGGTGGGCGAGGGCGCGA
TGGCCGCCATTATCGGCCTGGAGACGGCCGACGTGGAAGATGTTTGCCTGAAAGCCGCCAATGGGAGCGTATGCCAGATC
GCCAATGACAATGGCGGCGGGCAGCTCATCATTTCCGGCGCGAAAGCGGCGGTGGAGGAGGCCGCACGGCTTGCAGGCGA
GCGGGGCGCCAAGCGCGCAATCATGCTGCCTGTTTCGGCTCCCTTCCACTCCGCGCTGATGGAGCCCGCTGCCGTGCGCA
TGCGCGATGCGCTGGCCGAGGTGGAGAAGCATGCGCCTTCAGTGCCGGTCATCGCCAATGTCACCGTCAGCCCCCTGAGC
GATCCTCAGGAGATCGCGGAGCGGCTGGTTGAACAGGTGACGGGACGTGTACGCTGGCGCGAGACGGTGGAATGGTTCGC
TCAAAACGGCGTGGATACGTTATACGAAATCGGTTCCGGCAAGGTGTTGACGGGCTTGGCACGCCGCATCAACCGTGATC
TCAACGCATTAGCAGTGAATACACCGGCAGACATCGAAGCAACGCTGAAAGCGCTTCTTTGA

Upstream 100 bases:

>100_bases
TGTGGTGGATCACGGCGTTAACTGGCAAAAGGCTTGACGTTCGTCGGCTCTTGCGCCACCACCTGCGCCCCAACAGAGCA
TGGAACAGGGAGAACCGCTG

Downstream 100 bases:

>100_bases
TTCGAGTTCAGAAAGGGACGCCATGTTTGATCTCAATGGCCGCAAGGCTCTCGTCACGGGAGCAACCGGGGGCATCGGCG
AGGCGATCGCCAGGGCGCTT

Product: [Acyl-carrier-protein] S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTIAFTFPGQGSQAVGMGRDLAEAFPEARDVFQEVDEALGQSLSKLMWEGPEEELTLTANAQPALMAVSLAAIRVMEKAG
LPLKDKVAYVAGHSLGEYSALAAAGTFSLLDTARLLRIRGNAMQAAVPVGEGAMAAIIGLETADVEDVCLKAANGSVCQI
ANDNGGGQLIISGAKAAVEEAARLAGERGAKRAIMLPVSAPFHSALMEPAAVRMRDALAEVEKHAPSVPVIANVTVSPLS
DPQEIAERLVEQVTGRVRWRETVEWFAQNGVDTLYEIGSGKVLTGLARRINRDLNALAVNTPADIEATLKALL

Sequences:

>Translated_313_residues
MTIAFTFPGQGSQAVGMGRDLAEAFPEARDVFQEVDEALGQSLSKLMWEGPEEELTLTANAQPALMAVSLAAIRVMEKAG
LPLKDKVAYVAGHSLGEYSALAAAGTFSLLDTARLLRIRGNAMQAAVPVGEGAMAAIIGLETADVEDVCLKAANGSVCQI
ANDNGGGQLIISGAKAAVEEAARLAGERGAKRAIMLPVSAPFHSALMEPAAVRMRDALAEVEKHAPSVPVIANVTVSPLS
DPQEIAERLVEQVTGRVRWRETVEWFAQNGVDTLYEIGSGKVLTGLARRINRDLNALAVNTPADIEATLKALL
>Mature_312_residues
TIAFTFPGQGSQAVGMGRDLAEAFPEARDVFQEVDEALGQSLSKLMWEGPEEELTLTANAQPALMAVSLAAIRVMEKAGL
PLKDKVAYVAGHSLGEYSALAAAGTFSLLDTARLLRIRGNAMQAAVPVGEGAMAAIIGLETADVEDVCLKAANGSVCQIA
NDNGGGQLIISGAKAAVEEAARLAGERGAKRAIMLPVSAPFHSALMEPAAVRMRDALAEVEKHAPSVPVIANVTVSPLSD
PQEIAERLVEQVTGRVRWRETVEWFAQNGVDTLYEIGSGKVLTGLARRINRDLNALAVNTPADIEATLKALL

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=316, Percent_Identity=30.379746835443, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI27477045, Length=103, Percent_Identity=38.8349514563107, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1787334, Length=308, Percent_Identity=47.4025974025974, Blast_Score=249, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71984332, Length=293, Percent_Identity=28.3276450511945, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=292, Percent_Identity=30.1369863013699, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24665753, Length=302, Percent_Identity=33.4437086092715, Blast_Score=137, Evalue=9e-33,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32921; Mature: 32790

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAFTFPGQGSQAVGMGRDLAEAFPEARDVFQEVDEALGQSLSKLMWEGPEEELTLTAN
CEEEEECCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
AQPALMAVSLAAIRVMEKAGLPLKDKVAYVAGHSLGEYSALAAAGTFSLLDTARLLRIRG
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NAMQAAVPVGEGAMAAIIGLETADVEDVCLKAANGSVCQIANDNGGGQLIISGAKAAVEE
CCCEEEEECCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCEEEEECHHHHHHH
AARLAGERGAKRAIMLPVSAPFHSALMEPAAVRMRDALAEVEKHAPSVPVIANVTVSPLS
HHHHHHCCCCCEEEEEECCCCHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
DPQEIAERLVEQVTGRVRWRETVEWFAQNGVDTLYEIGSGKVLTGLARRINRDLNALAVN
CHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCCEEEEC
TPADIEATLKALL
CCCCHHHHHHHHC
>Mature Secondary Structure 
TIAFTFPGQGSQAVGMGRDLAEAFPEARDVFQEVDEALGQSLSKLMWEGPEEELTLTAN
EEEEECCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
AQPALMAVSLAAIRVMEKAGLPLKDKVAYVAGHSLGEYSALAAAGTFSLLDTARLLRIRG
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NAMQAAVPVGEGAMAAIIGLETADVEDVCLKAANGSVCQIANDNGGGQLIISGAKAAVEE
CCCEEEEECCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCEEEEECHHHHHHH
AARLAGERGAKRAIMLPVSAPFHSALMEPAAVRMRDALAEVEKHAPSVPVIANVTVSPLS
HHHHHHCCCCCEEEEEECCCCHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
DPQEIAERLVEQVTGRVRWRETVEWFAQNGVDTLYEIGSGKVLTGLARRINRDLNALAVN
CHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCCEEEEC
TPADIEATLKALL
CCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]