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The map label for this gene is pdxA [H]

Identifier: 110634112

GI number: 110634112

Start: 1883185

End: 1884198

Strand: Direct

Name: pdxA [H]

Synonym: Meso_1761

Alternate gene names: 110634112

Gene position: 1883185-1884198 (Clockwise)

Preceding gene: 110634111

Following gene: 110634113

Centisome position: 42.68

GC content: 62.62

Gene sequence:

>1014_bases
ATGTCCTCACTCGCGCTGACCATTGGTGATCCTTCGGGGATCGGCCCGGAAATCCTCCTCCAGGCTTGGCTTAAGCGGAA
CGAGAAAGAGTTGGCGCCCTTTTACGTGCTGGGCGACCCAGCGCTCCTTTCCGCCCGCATCCGCCTGCTGAAGCTTGATA
TTTCCATCGTGGAGGCCGAGCCGGAAACCGCGGCGGCGCATTTTGGTCGTGCCCTCCCCGTCGTGCCGCTTGAAAACAGT
CTCGATGACCTGCCGGGGCATCCCCTCGCCGCCAATGCGGCGGGTGTGATCGAGGCAATCAGCCGCGCGGTCGAAGATAC
GCTATCGGGCCGTGCTGCGGGCGTCGTAACCTGCCCAATCGCCAAGAAGCCCCTCTATGATGCAGGTTTCGGGTTCCCGG
GCCATACGGAGTTCTTGGGCTACCTGGCCGAGAAGATCACGGGCGAAAAATCCAGGCCTGTGATGATGCTCGCAGGACCG
GAACTGCGGACCGTCCCGATAACGGTGCATCAACCCCTCGCAGATGTCCCCGCGAGCCTGACAGCCGATCTGATTGAAAA
AACGGGCGAGATTGTCGCGCGGAACCTGGCGGAGCGTTTTGCCGTTCGCGCCCCGCGCCTGGCCGTTTCCGGACTCAACC
CTCATGCGGGCGAAGGTGGCTCCATGGGGCGGGAAGATGCCGACATCATAGCGCCGGCCATCGAAGCCTTGCGTGCGAAG
GGTATCGATGCATTCGGACCATTGCCGGCAGATACGATGTTCCACGCCGCCGCGCGGCGAACTTACGATGCAGCGCTCTG
CATGTATCATGATCAGGCGCTGATTCCGGTGAAGACCATCGGCTTTGACGAGACCGTGAATGTCACGCTGGGGCTGCCTT
TCATCCGCACCTCGCCGGATCACGGCACCGCCTTCGACATTGCGGGCCGGGGTGTCGCGAAGCCCGATAGCCTGATCGCG
GCAATCCGCCTTGCGCGCCTCCTCGCCGACAACACTGCGAAGCACAACGCATGA

Upstream 100 bases:

>100_bases
AGGAGTATATGGCGGAGCTGCGTAAGAAGGCTCGAATAGTCCGCCGCTGAGACAGGCACGCATCAATCATGCCGCTTAAC
AAGGTCAGCGTGATTTTCCC

Downstream 100 bases:

>100_bases
GCATGGACGGTCTGCCGCCGCTGCGGGATGTCATCGAGCGGCATGGTCTTTTCGCCAGAAAGGCCTTGGGCCAGAATTTT
CTTCTCGACCTCAACCTCAC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSSLALTIGDPSGIGPEILLQAWLKRNEKELAPFYVLGDPALLSARIRLLKLDISIVEAEPETAAAHFGRALPVVPLENS
LDDLPGHPLAANAAGVIEAISRAVEDTLSGRAAGVVTCPIAKKPLYDAGFGFPGHTEFLGYLAEKITGEKSRPVMMLAGP
ELRTVPITVHQPLADVPASLTADLIEKTGEIVARNLAERFAVRAPRLAVSGLNPHAGEGGSMGREDADIIAPAIEALRAK
GIDAFGPLPADTMFHAAARRTYDAALCMYHDQALIPVKTIGFDETVNVTLGLPFIRTSPDHGTAFDIAGRGVAKPDSLIA
AIRLARLLADNTAKHNA

Sequences:

>Translated_337_residues
MSSLALTIGDPSGIGPEILLQAWLKRNEKELAPFYVLGDPALLSARIRLLKLDISIVEAEPETAAAHFGRALPVVPLENS
LDDLPGHPLAANAAGVIEAISRAVEDTLSGRAAGVVTCPIAKKPLYDAGFGFPGHTEFLGYLAEKITGEKSRPVMMLAGP
ELRTVPITVHQPLADVPASLTADLIEKTGEIVARNLAERFAVRAPRLAVSGLNPHAGEGGSMGREDADIIAPAIEALRAK
GIDAFGPLPADTMFHAAARRTYDAALCMYHDQALIPVKTIGFDETVNVTLGLPFIRTSPDHGTAFDIAGRGVAKPDSLIA
AIRLARLLADNTAKHNA
>Mature_336_residues
SSLALTIGDPSGIGPEILLQAWLKRNEKELAPFYVLGDPALLSARIRLLKLDISIVEAEPETAAAHFGRALPVVPLENSL
DDLPGHPLAANAAGVIEAISRAVEDTLSGRAAGVVTCPIAKKPLYDAGFGFPGHTEFLGYLAEKITGEKSRPVMMLAGPE
LRTVPITVHQPLADVPASLTADLIEKTGEIVARNLAERFAVRAPRLAVSGLNPHAGEGGSMGREDADIIAPAIEALRAKG
IDAFGPLPADTMFHAAARRTYDAALCMYHDQALIPVKTIGFDETVNVTLGLPFIRTSPDHGTAFDIAGRGVAKPDSLIAA
IRLARLLADNTAKHNA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=332, Percent_Identity=39.7590361445783, Blast_Score=220, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35538; Mature: 35407

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLALTIGDPSGIGPEILLQAWLKRNEKELAPFYVLGDPALLSARIRLLKLDISIVEAE
CCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHEEEEEEEEEEEECC
PETAAAHFGRALPVVPLENSLDDLPGHPLAANAAGVIEAISRAVEDTLSGRAAGVVTCPI
CHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
AKKPLYDAGFGFPGHTEFLGYLAEKITGEKSRPVMMLAGPELRTVPITVHQPLADVPASL
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEEECCCHHHCCHHH
TADLIEKTGEIVARNLAERFAVRAPRLAVSGLNPHAGEGGSMGREDADIIAPAIEALRAK
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GIDAFGPLPADTMFHAAARRTYDAALCMYHDQALIPVKTIGFDETVNVTLGLPFIRTSPD
CCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCEEEEEEECCEEEECCC
HGTAFDIAGRGVAKPDSLIAAIRLARLLADNTAKHNA
CCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSLALTIGDPSGIGPEILLQAWLKRNEKELAPFYVLGDPALLSARIRLLKLDISIVEAE
CCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHEEEEEEEEEEEECC
PETAAAHFGRALPVVPLENSLDDLPGHPLAANAAGVIEAISRAVEDTLSGRAAGVVTCPI
CHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
AKKPLYDAGFGFPGHTEFLGYLAEKITGEKSRPVMMLAGPELRTVPITVHQPLADVPASL
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEEECCCHHHCCHHH
TADLIEKTGEIVARNLAERFAVRAPRLAVSGLNPHAGEGGSMGREDADIIAPAIEALRAK
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GIDAFGPLPADTMFHAAARRTYDAALCMYHDQALIPVKTIGFDETVNVTLGLPFIRTSPD
CCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCEEEEEEECCEEEECCC
HGTAFDIAGRGVAKPDSLIAAIRLARLLADNTAKHNA
CCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]