Click here to switch to the map view.

The map label for this gene is pepA

Identifier: 110634107

GI number: 110634107

Start: 1875704

End: 1877191

Strand: Reverse

Name: pepA

Synonym: Meso_1756

Alternate gene names: 110634107

Gene position: 1877191-1875704 (Counterclockwise)

Preceding gene: 110634114

Following gene: 110634106

Centisome position: 42.54

GC content: 63.17

Gene sequence:

>1488_bases
ATGACCGAGAAACCGACGATCGCCTTCGCCAAATTTGCCGCGCCCAAAAAAGGCAGCGTTATCCTGCTTGTGCCGGAGGG
CGGGAATCTCGGCCAGGCCGCAACGGCAGCGGACCCGGCCGGCGTGATGCCTAAGGTTTTCGCGGCCGCCGAGTTCAAGG
GCAAGCTGGCGGCCACGGTCGAGGCGCTGGCACCACAGGGAACGGCCTATGATCGGGTAGCCGTGATCGGAACAGGCAAT
CCAAGCGCGCTTACGGAACAATCCTGGCTTCAGATCGGCGGCGCGGCGGCCGCCGCGGCAAAGAACGCGGGAGAGGTGAC
CGTGATAGCGGACGTGGCGGGATTGGAGCTCTCCGCGCGCGAGGCGGCCAATATCGGGCTCGGCATTCTCCTTCGCTCCT
ATGTCTTCGACAAATACAAGACCCGCAGGGATGAAAACGGCATCAAGGCAAGGGACAAGAAATTCACCATCCAGTGCGCC
GATCCCAATGCGGCAAAGAAGGCCTTTGCGGAAGCATCTGCCCTGGGGGACGGCGTCTATCTTGCCAGGGACCTCGTCAA
TGAGCCGGCCAATGTGCTGGGTCCGGTGGAGTTCGCCGCTCAGGCCAAGGCATTGGAGTCGCTCGGCGTGAAGGTCGACG
TCCTGACTGAAAGGGAGATGAAGAAGCTCGGCATGGGCGCGCTCCTGGGCGTCGCGCAAGGCTCGGTTCGCCCGCCGCGA
CTCGTCGTCATGCAGTGGAACGGCGGCAAGCCGAAGCAGAAGCCGGTGGCTTTTGTGGGCAAAGGAGTCGTGTTCGATAC
CGGCGGCATTTCCATCAAGCCCGCCGCCAGCATGGAAGACATGAAGGGCGATATGGCGGGGGCGGCGGCCGTCGTTGGCC
TCATGCACGCGCTGGCCGCCCGCAAGGCAAAAACCAACGCGGTGGGAATCATCGGACTCGTCGAGAACATGCCGGACGGC
AATGCCCAGCGGCCGGGCGATATCGTCACCTCCATGTCCGGCCAGACGATCGAGATCATCAATACGGATGCGGAAGGCCG
GCTCGTGCTTGCCGATGCTCTCTGGTACTGCAAGGAGCAGTTCAAGCCGCAGTTTATGGTGAACCTCGCCACGCTGACGG
GAGCCATCATCGTCGCGCTCGGGAACAGCCATGCCGGCCTCTTCTCCAATGACGACACGCTATCAGAAAGGCTCACCGCG
GCCGGACAGGCGACTGGCGAGAAGGTGTGGCGCATGCCTCTGGGCAGCGAGTACGACAAGCTGATCGACACCAAAAACGC
CGACATGAAGAATACCGGCGGACGCCAGGCCGGCTCGATCACCGCCGCACAATTCCTGAAGCGTTTCGTGGACGATACGC
CCTGGGCGCATCTGGACGTGGCAGGCACGGCGATGGGGTCGCCGTCATCGGAGATCAACCAGTCCTGGGCGTCGGGCTTC
GGCGTGCGGCTTCTGGATCGCCTCGTGGCGGATCACTACGAGGGTTAG

Upstream 100 bases:

>100_bases
TTCCTTTACACAGGTTTGGATATTCCTTCCACCCCTTGTCAAACGATTCAAAAGCGCCAAGATCGCGCCACCCTCCGTTT
TTCACGCCACAGGATACCCA

Downstream 100 bases:

>100_bases
GCCCAGTAGGGCAGTAGGGGGCGTATTCATTACCTTGAGATTTGGTCGCCTTGCCTGAACATTACCGTCTTACCAGCGAT
CAAACATATTGAGCTGGTAA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MTEKPTIAFAKFAAPKKGSVILLVPEGGNLGQAATAADPAGVMPKVFAAAEFKGKLAATVEALAPQGTAYDRVAVIGTGN
PSALTEQSWLQIGGAAAAAAKNAGEVTVIADVAGLELSAREAANIGLGILLRSYVFDKYKTRRDENGIKARDKKFTIQCA
DPNAAKKAFAEASALGDGVYLARDLVNEPANVLGPVEFAAQAKALESLGVKVDVLTEREMKKLGMGALLGVAQGSVRPPR
LVVMQWNGGKPKQKPVAFVGKGVVFDTGGISIKPAASMEDMKGDMAGAAAVVGLMHALAARKAKTNAVGIIGLVENMPDG
NAQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYCKEQFKPQFMVNLATLTGAIIVALGNSHAGLFSNDDTLSERLTA
AGQATGEKVWRMPLGSEYDKLIDTKNADMKNTGGRQAGSITAAQFLKRFVDDTPWAHLDVAGTAMGSPSSEINQSWASGF
GVRLLDRLVADHYEG

Sequences:

>Translated_495_residues
MTEKPTIAFAKFAAPKKGSVILLVPEGGNLGQAATAADPAGVMPKVFAAAEFKGKLAATVEALAPQGTAYDRVAVIGTGN
PSALTEQSWLQIGGAAAAAAKNAGEVTVIADVAGLELSAREAANIGLGILLRSYVFDKYKTRRDENGIKARDKKFTIQCA
DPNAAKKAFAEASALGDGVYLARDLVNEPANVLGPVEFAAQAKALESLGVKVDVLTEREMKKLGMGALLGVAQGSVRPPR
LVVMQWNGGKPKQKPVAFVGKGVVFDTGGISIKPAASMEDMKGDMAGAAAVVGLMHALAARKAKTNAVGIIGLVENMPDG
NAQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYCKEQFKPQFMVNLATLTGAIIVALGNSHAGLFSNDDTLSERLTA
AGQATGEKVWRMPLGSEYDKLIDTKNADMKNTGGRQAGSITAAQFLKRFVDDTPWAHLDVAGTAMGSPSSEINQSWASGF
GVRLLDRLVADHYEG
>Mature_494_residues
TEKPTIAFAKFAAPKKGSVILLVPEGGNLGQAATAADPAGVMPKVFAAAEFKGKLAATVEALAPQGTAYDRVAVIGTGNP
SALTEQSWLQIGGAAAAAAKNAGEVTVIADVAGLELSAREAANIGLGILLRSYVFDKYKTRRDENGIKARDKKFTIQCAD
PNAAKKAFAEASALGDGVYLARDLVNEPANVLGPVEFAAQAKALESLGVKVDVLTEREMKKLGMGALLGVAQGSVRPPRL
VVMQWNGGKPKQKPVAFVGKGVVFDTGGISIKPAASMEDMKGDMAGAAAVVGLMHALAARKAKTNAVGIIGLVENMPDGN
AQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYCKEQFKPQFMVNLATLTGAIIVALGNSHAGLFSNDDTLSERLTAA
GQATGEKVWRMPLGSEYDKLIDTKNADMKNTGGRQAGSITAAQFLKRFVDDTPWAHLDVAGTAMGSPSSEINQSWASGFG
VRLLDRLVADHYEG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=406, Percent_Identity=38.9162561576355, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI47155554, Length=316, Percent_Identity=36.0759493670886, Blast_Score=162, Evalue=9e-40,
Organism=Escherichia coli, GI1790710, Length=436, Percent_Identity=37.6146788990826, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=39.3081761006289, Blast_Score=197, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17556903, Length=337, Percent_Identity=32.9376854599407, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=289, Percent_Identity=28.3737024221453, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129969, Length=289, Percent_Identity=36.6782006920415, Blast_Score=204, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24662227, Length=287, Percent_Identity=36.9337979094077, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24661038, Length=408, Percent_Identity=32.5980392156863, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI21355725, Length=402, Percent_Identity=33.5820895522388, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI161077148, Length=287, Percent_Identity=35.5400696864112, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI20130057, Length=287, Percent_Identity=35.5400696864112, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI21355645, Length=289, Percent_Identity=33.2179930795848, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24662223, Length=289, Percent_Identity=33.2179930795848, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI19922386, Length=287, Percent_Identity=36.2369337979094, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI20129963, Length=467, Percent_Identity=30.406852248394, Blast_Score=178, Evalue=9e-45,
Organism=Drosophila melanogaster, GI21357381, Length=317, Percent_Identity=35.6466876971609, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI221379063, Length=317, Percent_Identity=35.6466876971609, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI221379062, Length=317, Percent_Identity=35.6466876971609, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24646701, Length=350, Percent_Identity=30, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24646703, Length=350, Percent_Identity=30, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21358201, Length=350, Percent_Identity=30, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_MESSB (Q11HH5)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674315.1
- ProteinModelPortal:   Q11HH5
- SMR:   Q11HH5
- STRING:   Q11HH5
- MEROPS:   M17.003
- GeneID:   4181192
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1756
- NMPDR:   fig|266779.1.peg.3697
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   SISSDER
- PhylomeDB:   Q11HH5
- ProtClustDB:   PRK00913
- BioCyc:   MSP266779:MESO_1756-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 51694; Mature: 51563

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 273-273 ACT_SITE 347-347

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKPTIAFAKFAAPKKGSVILLVPEGGNLGQAATAADPAGVMPKVFAAAEFKGKLAATV
CCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHH
EALAPQGTAYDRVAVIGTGNPSALTEQSWLQIGGAAAAAAKNAGEVTVIADVAGLELSAR
HHHCCCCCCCCEEEEEECCCCCHHCHHHHHHHCCHHHHHCCCCCCEEEEEEECCCEECHH
EAANIGLGILLRSYVFDKYKTRRDENGIKARDKKFTIQCADPNAAKKAFAEASALGDGVY
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHH
LARDLVNEPANVLGPVEFAAQAKALESLGVKVDVLTEREMKKLGMGALLGVAQGSVRPPR
HHHHHHCCCHHHHCHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCHHHHHHCCCCCCCCE
LVVMQWNGGKPKQKPVAFVGKGVVFDTGGISIKPAASMEDMKGDMAGAAAVVGLMHALAA
EEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCHHHHHHHHHHHHHHHHH
RKAKTNAVGIIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYCKEQ
HHCCCCCEEEEEEEECCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEHHHHHHHHHH
FKPQFMVNLATLTGAIIVALGNSHAGLFSNDDTLSERLTAAGQATGEKVWRMPLGSEYDK
CCCCCEEEHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHEEECCCCCHHHH
LIDTKNADMKNTGGRQAGSITAAQFLKRFVDDTPWAHLDVAGTAMGSPSSEINQSWASGF
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCH
GVRLLDRLVADHYEG
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEKPTIAFAKFAAPKKGSVILLVPEGGNLGQAATAADPAGVMPKVFAAAEFKGKLAATV
CCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHH
EALAPQGTAYDRVAVIGTGNPSALTEQSWLQIGGAAAAAAKNAGEVTVIADVAGLELSAR
HHHCCCCCCCCEEEEEECCCCCHHCHHHHHHHCCHHHHHCCCCCCEEEEEEECCCEECHH
EAANIGLGILLRSYVFDKYKTRRDENGIKARDKKFTIQCADPNAAKKAFAEASALGDGVY
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHH
LARDLVNEPANVLGPVEFAAQAKALESLGVKVDVLTEREMKKLGMGALLGVAQGSVRPPR
HHHHHHCCCHHHHCHHHHHHHHHHHHHCCCEEEEECHHHHHHHCCHHHHHHCCCCCCCCE
LVVMQWNGGKPKQKPVAFVGKGVVFDTGGISIKPAASMEDMKGDMAGAAAVVGLMHALAA
EEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCHHHHHHHHHHHHHHHHH
RKAKTNAVGIIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYCKEQ
HHCCCCCEEEEEEEECCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEHHHHHHHHHH
FKPQFMVNLATLTGAIIVALGNSHAGLFSNDDTLSERLTAAGQATGEKVWRMPLGSEYDK
CCCCCEEEHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHEEECCCCCHHHH
LIDTKNADMKNTGGRQAGSITAAQFLKRFVDDTPWAHLDVAGTAMGSPSSEINQSWASGF
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCH
GVRLLDRLVADHYEG
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA