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The map label for this gene is glmS [H]

Identifier: 110634058

GI number: 110634058

Start: 1826171

End: 1827994

Strand: Reverse

Name: glmS [H]

Synonym: Meso_1706

Alternate gene names: 110634058

Gene position: 1827994-1826171 (Counterclockwise)

Preceding gene: 110634059

Following gene: 110634057

Centisome position: 41.43

GC content: 60.96

Gene sequence:

>1824_bases
ATGTGTGGAATTGTGGGGATCATCGGGCAAACGCCGGTCGCACCACTCATCGTCGATGCGCTGAAGCGGCTCGAATACCG
CGGTTATGACTCCGCGGGCGTAGCCACGGTCGAGCATGGCAGGCTCGCCCGCCGGCGCGCGGAAGGGAAGCTGATCAATC
TGGAAAAGCGTCTCGACGAAGAGCCGCTTGGCGGGCTGATCGGCATCGGTCATACGCGCTGGGCCACCCATGGCGTTCCC
AATGAAACCAATGCGCATCCGCATTTCTCCGGCGACGTGGCCGTGGTCCATAACGGCATCATCGAGAATTTCGCCGAGTT
GCGCGACGAGCTCATCGCCGACGGTTTTACCTTTGCCTCGCAGACGGATACGGAAGTTGTGGCGCATCTGATCGAGCGGG
AATTGCGTCGCGGAAAAAAGCCGAAAGATGCAGCTTTTACGGCGCTCCGGCACCTGCGGGGCGCCTTCGCGCTTGCCGTT
CTGTTCCAGGGCGACGAAGACATGATCGTCGGCGCTCGCAATGGGCCGCCGCTCGCTGTCGGTCATGGCGAGGGCGAGAT
GTTCCTGGGCTCCGATGCGATTGCGCTCGCCCCCTTCACCGATGCCATCACCTATCTGGAGGACGGTGACTGGGTTGTGG
TGCGCCGTTCGGGCATGGAAATCTTCGATATGGAAGGCAACCCCGTGGAGCGGAAGCGGCAGCAGTCGATCGGCACCAGC
TTCCTGGTCGACAAGGGCAACCATCGGCATTTCATGGAGAAGGAAATCCATGAACAGCCGGAGGTGATCTCCCACACGCT
CGCCCATTACCTCGATTTCGTCAGTGGCGGCGTGAAGCCGTTCGAGACTCCTTTCGACCTGGCTCGGGTCGACCGCCTGG
AGGTCTCGGCATGCGGCACGGCCTATCTGGCTGGACTTATCGGCAAATATTGGCTGGAGCGCTATGCAAGGCTGCCGGTC
GATATCGATATCGCATCCGAGTTCCGTTATCGCGAGATGCCGCTTTCCAAAGGAAGCGCGGCGCTCTTCGTTTCACAATC
GGGCGAGACCGCCGATACGCTCGCCTCGCTGCGTTATTGCCGGCGTGAGGGCTTGCCCATCGCCTCGATCGTGAATGTGC
GCGATTCGACCATGGCGCGTGAGAGCGACGGTATTTTCCCGACACTTGCGGGGCCGGAGATCGGGGTGGCCTCTACCAAG
GCGTTCACATGCCAGCTTGCGATCTTTGCTGCCCTGGCCGTGCGGGCGGGGCTCGAGCGTGAAACCATCTCCAGGGAAGA
GGCCGGACGGCTCGTGCGCGCCTTATCGGAAGCGCCACGCTATGCCGCTCAGGCCCTGAAGCTGGAAAACCGGATCGAAC
AGGTCGCGCGCGAGATGTCGCGGGTGCGCCATGTGCTCTATCTCGGCCGTGATACGAGCTATCCGCTGGCTCTTGAAGGT
GCGCTCAAGCTCAAGGAGCTCTCCTATATTCATGCCGAGGGCTATGCCGCGGGTGAGCTCAAGCACGGGCCGATTGCACT
CATTGACGAAAACATGCCCGTGATCGTGATTGCGCCATACGACCGCATTTTTGAAAAGACCGTTTCGAACATGCAGGAGG
TTGCAGCCCGCGGTGGACGCATCATCCTCATAACGGACGAGGAGGGTGCTTCACGTGCTTCGCTCGACGATTTCGAGACG
ATCGTGATGCCAACCGTCCCGGAATTCATAGCCCCCATCATCTATGCGCTGCCGGTCCAGATGCTCGCCTACCATACAGC
CGTCGCGCTGGGCACGGATGTTGACCAGCCGCGCAACCTCGCTAAGTCGGTGACGGTGGAATAG

Upstream 100 bases:

>100_bases
TTGAGGCCTGTAGCTTGTGCGGTAGTGCTGTATAGCTGACCGGAGCCGGCGCCGAGATCGGCTCGATCATTCATTGCGAG
ATGTCCATAGGGGATCGAAA

Downstream 100 bases:

>100_bases
CGGCTAGCGGCTCCTTTGCTCTGGACGCGGGATAGCGCGGTCACGTAAGGTTTCCGCGTGTCACAGCTTTTTCACCTGCC
GAACCAGATACAGGGTGCCG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIVGIIGQTPVAPLIVDALKRLEYRGYDSAGVATVEHGRLARRRAEGKLINLEKRLDEEPLGGLIGIGHTRWATHGVP
NETNAHPHFSGDVAVVHNGIIENFAELRDELIADGFTFASQTDTEVVAHLIERELRRGKKPKDAAFTALRHLRGAFALAV
LFQGDEDMIVGARNGPPLAVGHGEGEMFLGSDAIALAPFTDAITYLEDGDWVVVRRSGMEIFDMEGNPVERKRQQSIGTS
FLVDKGNHRHFMEKEIHEQPEVISHTLAHYLDFVSGGVKPFETPFDLARVDRLEVSACGTAYLAGLIGKYWLERYARLPV
DIDIASEFRYREMPLSKGSAALFVSQSGETADTLASLRYCRREGLPIASIVNVRDSTMARESDGIFPTLAGPEIGVASTK
AFTCQLAIFAALAVRAGLERETISREEAGRLVRALSEAPRYAAQALKLENRIEQVAREMSRVRHVLYLGRDTSYPLALEG
ALKLKELSYIHAEGYAAGELKHGPIALIDENMPVIVIAPYDRIFEKTVSNMQEVAARGGRIILITDEEGASRASLDDFET
IVMPTVPEFIAPIIYALPVQMLAYHTAVALGTDVDQPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIVGIIGQTPVAPLIVDALKRLEYRGYDSAGVATVEHGRLARRRAEGKLINLEKRLDEEPLGGLIGIGHTRWATHGVP
NETNAHPHFSGDVAVVHNGIIENFAELRDELIADGFTFASQTDTEVVAHLIERELRRGKKPKDAAFTALRHLRGAFALAV
LFQGDEDMIVGARNGPPLAVGHGEGEMFLGSDAIALAPFTDAITYLEDGDWVVVRRSGMEIFDMEGNPVERKRQQSIGTS
FLVDKGNHRHFMEKEIHEQPEVISHTLAHYLDFVSGGVKPFETPFDLARVDRLEVSACGTAYLAGLIGKYWLERYARLPV
DIDIASEFRYREMPLSKGSAALFVSQSGETADTLASLRYCRREGLPIASIVNVRDSTMARESDGIFPTLAGPEIGVASTK
AFTCQLAIFAALAVRAGLERETISREEAGRLVRALSEAPRYAAQALKLENRIEQVAREMSRVRHVLYLGRDTSYPLALEG
ALKLKELSYIHAEGYAAGELKHGPIALIDENMPVIVIAPYDRIFEKTVSNMQEVAARGGRIILITDEEGASRASLDDFET
IVMPTVPEFIAPIIYALPVQMLAYHTAVALGTDVDQPRNLAKSVTVE
>Mature_607_residues
MCGIVGIIGQTPVAPLIVDALKRLEYRGYDSAGVATVEHGRLARRRAEGKLINLEKRLDEEPLGGLIGIGHTRWATHGVP
NETNAHPHFSGDVAVVHNGIIENFAELRDELIADGFTFASQTDTEVVAHLIERELRRGKKPKDAAFTALRHLRGAFALAV
LFQGDEDMIVGARNGPPLAVGHGEGEMFLGSDAIALAPFTDAITYLEDGDWVVVRRSGMEIFDMEGNPVERKRQQSIGTS
FLVDKGNHRHFMEKEIHEQPEVISHTLAHYLDFVSGGVKPFETPFDLARVDRLEVSACGTAYLAGLIGKYWLERYARLPV
DIDIASEFRYREMPLSKGSAALFVSQSGETADTLASLRYCRREGLPIASIVNVRDSTMARESDGIFPTLAGPEIGVASTK
AFTCQLAIFAALAVRAGLERETISREEAGRLVRALSEAPRYAAQALKLENRIEQVAREMSRVRHVLYLGRDTSYPLALEG
ALKLKELSYIHAEGYAAGELKHGPIALIDENMPVIVIAPYDRIFEKTVSNMQEVAARGGRIILITDEEGASRASLDDFET
IVMPTVPEFIAPIIYALPVQMLAYHTAVALGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=692, Percent_Identity=35.2601156069364, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=35.9420289855072, Blast_Score=368, Evalue=1e-102,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=49.0196078431373, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1788651, Length=214, Percent_Identity=31.7757009345794, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532899, Length=442, Percent_Identity=36.8778280542986, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17532897, Length=442, Percent_Identity=36.8778280542986, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=36.2586605080831, Blast_Score=271, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6322745, Length=458, Percent_Identity=37.7729257641921, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6323731, Length=440, Percent_Identity=28.1818181818182, Blast_Score=173, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=34.2995169082126, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323958, Length=179, Percent_Identity=30.1675977653631, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=36.2445414847162, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI28573187, Length=142, Percent_Identity=33.0985915492958, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66601; Mature: 66601

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGIIGQTPVAPLIVDALKRLEYRGYDSAGVATVEHGRLARRRAEGKLINLEKRLDE
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCEEEHHHHCCC
EPLGGLIGIGHTRWATHGVPNETNAHPHFSGDVAVVHNGIIENFAELRDELIADGFTFAS
CCCCCEEECCCCHHHCCCCCCCCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHCCCCCCC
QTDTEVVAHLIERELRRGKKPKDAAFTALRHLRGAFALAVLFQGDEDMIVGARNGPPLAV
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEEEECCCCEEEECCCCCCEEE
GHGEGEMFLGSDAIALAPFTDAITYLEDGDWVVVRRSGMEIFDMEGNPVERKRQQSIGTS
ECCCCCEEECCCCEEECCHHHHHHEEECCCEEEEEECCCEEEECCCCCHHHHHHHHCCCE
FLVDKGNHRHFMEKEIHEQPEVISHTLAHYLDFVSGGVKPFETPFDLARVDRLEVSACGT
EEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AYLAGLIGKYWLERYARLPVDIDIASEFRYREMPLSKGSAALFVSQSGETADTLASLRYC
HHHHHHHHHHHHHHHHCCCCEEEHHCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHH
RREGLPIASIVNVRDSTMARESDGIFPTLAGPEIGVASTKAFTCQLAIFAALAVRAGLER
HHCCCCHHHHCCCCHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCH
ETISREEAGRLVRALSEAPRYAAQALKLENRIEQVAREMSRVRHVLYLGRDTSYPLALEG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECC
ALKLKELSYIHAEGYAAGELKHGPIALIDENMPVIVIAPYDRIFEKTVSNMQEVAARGGR
CHHHHHHHEEECCCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCE
IILITDEEGASRASLDDFETIVMPTVPEFIAPIIYALPVQMLAYHTAVALGTDVDQPRNL
EEEEECCCCCCCCCCCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIVGIIGQTPVAPLIVDALKRLEYRGYDSAGVATVEHGRLARRRAEGKLINLEKRLDE
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCEEEHHHHCCC
EPLGGLIGIGHTRWATHGVPNETNAHPHFSGDVAVVHNGIIENFAELRDELIADGFTFAS
CCCCCEEECCCCHHHCCCCCCCCCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHCCCCCCC
QTDTEVVAHLIERELRRGKKPKDAAFTALRHLRGAFALAVLFQGDEDMIVGARNGPPLAV
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEEEECCCCEEEECCCCCCEEE
GHGEGEMFLGSDAIALAPFTDAITYLEDGDWVVVRRSGMEIFDMEGNPVERKRQQSIGTS
ECCCCCEEECCCCEEECCHHHHHHEEECCCEEEEEECCCEEEECCCCCHHHHHHHHCCCE
FLVDKGNHRHFMEKEIHEQPEVISHTLAHYLDFVSGGVKPFETPFDLARVDRLEVSACGT
EEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AYLAGLIGKYWLERYARLPVDIDIASEFRYREMPLSKGSAALFVSQSGETADTLASLRYC
HHHHHHHHHHHHHHHHCCCCEEEHHCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHH
RREGLPIASIVNVRDSTMARESDGIFPTLAGPEIGVASTKAFTCQLAIFAALAVRAGLER
HHCCCCHHHHCCCCHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCH
ETISREEAGRLVRALSEAPRYAAQALKLENRIEQVAREMSRVRHVLYLGRDTSYPLALEG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECC
ALKLKELSYIHAEGYAAGELKHGPIALIDENMPVIVIAPYDRIFEKTVSNMQEVAARGGR
CHHHHHHHEEECCCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCE
IILITDEEGASRASLDDFETIVMPTVPEFIAPIIYALPVQMLAYHTAVALGTDVDQPRNL
EEEEECCCCCCCCCCCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]