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The map label for this gene is tpiA

Identifier: 110633988

GI number: 110633988

Start: 1762728

End: 1763492

Strand: Reverse

Name: tpiA

Synonym: Meso_1636

Alternate gene names: 110633988

Gene position: 1763492-1762728 (Counterclockwise)

Preceding gene: 110633995

Following gene: 110633987

Centisome position: 39.97

GC content: 62.61

Gene sequence:

>765_bases
ATGACACCCACAATCCGCCCCCTCATCGCCGGTAATTGGAAGATGCACGGCACTGAGAGCTCACTGGGTGAGTTGAAAGC
CATCGGCAGCGGTTTTGTGGAGGCCGCGGGAGCGGGAGCGGACGGTGTCATTTGTGTGCCGGCAACGCTGCTGGCGCGCG
CATCCGACATATTGGCGAAAACGCCGGTTGCGACGGGTGGCCAGGACTGCCATCCGGCGACCAGCGGTGCCCATACGGGC
GATATTGCCGCTGAGATGCTGGCCGACTGCGGCGCGAGCTACGTAATCGTCGGGCATTCGGAACGCCGCACCGATCATCA
TGAGGCCGATGAGGATGTCGCAGCCAAGGCGGAAGCCGCCTGGCGCGCCGGCCTCACTGCCATCATCTGCATCGGGGAAA
CCAAGATACAGCGCGAGGCGGGCGAAACGCTGTCGGTGCTTTCCCGGCAGATTGCCGGTTCCGTTCCGCCGGGAGCTACG
GCGAAAAATTCCGTAATCGCCTACGAGCCGGTTTGGGCCATAGGTACCGGCCTCACGCCGACGGTGGAAGATGTGGCCCA
GGCGCACGCCCATCTGCGTGCCGAGCTTGGAATGAAGCTGGGTATTGAAGCCGATGGGATGCGGCTTCTATACGGCGGGT
CGGTGAAGCCGTCGAATGCGGGCGAACTGCTTTCCATACTGAACGTGGATGGGGCGCTGATTGGCGGCGCCAGCCTCAAG
GCTGCCGATTTCCTCGCGATTTCGGCGGCTGTTAAAGGCAAATAA

Upstream 100 bases:

>100_bases
CTAATTGGGAATAGCGCTCTGGAACACAGCTGTCGATTGCTTTGTGGCGTCTTTTTGGTACTGAACCTTCCCGTGCACAA
CCATTGGACACGGAGATGTC

Downstream 100 bases:

>100_bases
GCTTCAAGCGAAGAGTTCTGCTTGCAACGGTGCACAGCTTGCCTATCTGTGCCCGATAGGGCTTGGAAAACGGCCTAAAG
CCGTGTAATGAGCCGCGTCC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTPTIRPLIAGNWKMHGTESSLGELKAIGSGFVEAAGAGADGVICVPATLLARASDILAKTPVATGGQDCHPATSGAHTG
DIAAEMLADCGASYVIVGHSERRTDHHEADEDVAAKAEAAWRAGLTAIICIGETKIQREAGETLSVLSRQIAGSVPPGAT
AKNSVIAYEPVWAIGTGLTPTVEDVAQAHAHLRAELGMKLGIEADGMRLLYGGSVKPSNAGELLSILNVDGALIGGASLK
AADFLAISAAVKGK

Sequences:

>Translated_254_residues
MTPTIRPLIAGNWKMHGTESSLGELKAIGSGFVEAAGAGADGVICVPATLLARASDILAKTPVATGGQDCHPATSGAHTG
DIAAEMLADCGASYVIVGHSERRTDHHEADEDVAAKAEAAWRAGLTAIICIGETKIQREAGETLSVLSRQIAGSVPPGAT
AKNSVIAYEPVWAIGTGLTPTVEDVAQAHAHLRAELGMKLGIEADGMRLLYGGSVKPSNAGELLSILNVDGALIGGASLK
AADFLAISAAVKGK
>Mature_253_residues
TPTIRPLIAGNWKMHGTESSLGELKAIGSGFVEAAGAGADGVICVPATLLARASDILAKTPVATGGQDCHPATSGAHTGD
IAAEMLADCGASYVIVGHSERRTDHHEADEDVAAKAEAAWRAGLTAIICIGETKIQREAGETLSVLSRQIAGSVPPGATA
KNSVIAYEPVWAIGTGLTPTVEDVAQAHAHLRAELGMKLGIEADGMRLLYGGSVKPSNAGELLSILNVDGALIGGASLKA
ADFLAISAAVKGK

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family

Homologues:

Organism=Homo sapiens, GI4507645, Length=252, Percent_Identity=41.6666666666667, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI226529917, Length=252, Percent_Identity=41.6666666666667, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1790353, Length=247, Percent_Identity=42.5101214574899, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17536593, Length=250, Percent_Identity=42.4, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6320255, Length=234, Percent_Identity=41.4529914529915, Blast_Score=174, Evalue=1e-44,
Organism=Drosophila melanogaster, GI28572004, Length=243, Percent_Identity=43.6213991769547, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28572008, Length=234, Percent_Identity=43.5897435897436, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28572006, Length=234, Percent_Identity=43.5897435897436, Blast_Score=169, Evalue=1e-42,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPIS_MESSB (Q11HU4)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674196.1
- ProteinModelPortal:   Q11HU4
- SMR:   Q11HU4
- STRING:   Q11HU4
- GeneID:   4179235
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1636
- NMPDR:   fig|266779.1.peg.382
- eggNOG:   COG0149
- HOGENOM:   HBG708281
- OMA:   RAYHRES
- ProtClustDB:   PRK00042
- BioCyc:   MSP266779:MESO_1636-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00147_B
- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21139
- TIGRFAMs:   TIGR00419

Pfam domain/function: PF00121 TIM; SSF51351 Triophos_ismrse

EC number: =5.3.1.1

Molecular weight: Translated: 25749; Mature: 25617

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00171 TIM_1; PS51440 TIM_2

Important sites: ACT_SITE 99-99 ACT_SITE 169-169 BINDING 12-12 BINDING 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTIRPLIAGNWKMHGTESSLGELKAIGSGFVEAAGAGADGVICVPATLLARASDILAK
CCCCCCCEEECCEEECCCCHHHHHHHHHHCHHHHHCCCCCCCEEEHHHHHHHHHHHHHHC
TPVATGGQDCHPATSGAHTGDIAAEMLADCGASYVIVGHSERRTDHHEADEDVAAKAEAA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
WRAGLTAIICIGETKIQREAGETLSVLSRQIAGSVPPGATAKNSVIAYEPVWAIGTGLTP
HHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHEECCCCCC
TVEDVAQAHAHLRAELGMKLGIEADGMRLLYGGSVKPSNAGELLSILNVDGALIGGASLK
CHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEECCCCCC
AADFLAISAAVKGK
HHHHEEEEEECCCC
>Mature Secondary Structure 
TPTIRPLIAGNWKMHGTESSLGELKAIGSGFVEAAGAGADGVICVPATLLARASDILAK
CCCCCCEEECCEEECCCCHHHHHHHHHHCHHHHHCCCCCCCEEEHHHHHHHHHHHHHHC
TPVATGGQDCHPATSGAHTGDIAAEMLADCGASYVIVGHSERRTDHHEADEDVAAKAEAA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
WRAGLTAIICIGETKIQREAGETLSVLSRQIAGSVPPGATAKNSVIAYEPVWAIGTGLTP
HHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHEECCCCCC
TVEDVAQAHAHLRAELGMKLGIEADGMRLLYGGSVKPSNAGELLSILNVDGALIGGASLK
CHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEECCCCCC
AADFLAISAAVKGK
HHHHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA