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The map label for this gene is lpd [H]

Identifier: 110633978

GI number: 110633978

Start: 1750884

End: 1752347

Strand: Reverse

Name: lpd [H]

Synonym: Meso_1626

Alternate gene names: 110633978

Gene position: 1752347-1750884 (Counterclockwise)

Preceding gene: 110633979

Following gene: 110633977

Centisome position: 39.71

GC content: 59.7

Gene sequence:

>1464_bases
GTGGCTGAAAGCTATGACGTCATCATCATCGGCTCCGGGCCAGGGGGGTATGTGACCGCCGTGCGGTCGGCGCAACTGGG
CTTAAAGACCGCGATCGTTGAACGCGAACATCTGGGGGGCATCTGCCTCAACTGGGGTTGCATTCCCACAAAGGCGTTGC
TGCGATCGGCGGAAATCCTCCACTACGCGCAGCACGCCAAGGATTACGGCCTGAAGCTCGATGGCTCGATCGCGCCCGAT
ACGGCTGCTGTGGTCGACCGTTCCCGTAAGGTCTCGGCACGTCTCAACACCGGCGTTGGCTTTCTGATGAAGAAGAACAA
GGTCGACGTCATCTGGGGCGAGGCAAAGATAAGCAAGGCCGCGAAGGCGAATGAGCCGGGCGAGATCGTGGTTTCCAAAC
CGTCAAAGAAGGCGATGGAGCCGCAGCACCCGGCGCCGAAGAACACCCTGGGCGAGGGGACCTACAAGGCCAAGCACATC
ATCCTGGCCACGGGCGCCCGGCCGCGCGTGCTGCCCGGTATCGAGCCGGACGGCAAGCTCATCTGGACCTATTTCGAGGC
GATGGTGCCGAAGGAAATGCCGAAATCGCTCATCGTCATGGGCTCCGGCGCCATCGGTATCGAGTTCGCCAGCTTCTACC
GCACCATGGGCGCGGACGTGACCGTGATCGAGCTCTTGCCGCAGATCTTGCCGGTTGAAGATGCCGAGGTTTCCAAATTC
GCCCGCCGTCAGCTTGAGAAGCAGGGCATGAAATTCCACGTCGAGGCCAAGGTCACGAAGGTGGAGAAAGGGGCAAACCA
GATTACTGCCCATGTGGAAATGAAGGACGGGAAGGTGGAAAAAATCACTGCCGACCGGCTCATTTCCGCGGTGGGCGTGC
AGGGCAATGTCGAGAATTTGGGCCTGGAAGCGCTTGGCGTGAAGGTCGAACGCGGGACGGTCGCGGTCGATGGCTACGGG
CGAACGAATGTGCCCGGCATTTATGCGATCGGCGATGTGGCGGGGCCGCCGATGCTTGCCCACAAGGCCGAGCATGAAGG
GGTGATCTGCGTTGAGAAGATCGCCGGCGTGCCCGGTGTGCATGCGCTCGACAAGAGCAAGATTCCGGGCTGCACCTATT
GCCAGCCGCAGGTGGCGTCTGTCGGCTTGACGGAAGAAAAGGCGAAGGAGGCGGGTCGCGACATTCGTGTCGGCCGCTTT
CAATTCGGCGCCAATGGCAAAGCAATCGCACTTGGCGAAGATCAAGGTTTCATCAAGACGATTCTCGACAAGAAAACCGG
CGAGCTTCTTGGCGCGCACATGGTTGGCGCCGAAGTAACGGAGCTCATCCAGGGCTTTGTTGTCGCGATGAACCTGGAAA
CCACCGAAGAAGAACTTATGCACACCATCTTCCCTCATCCTACGCTTTCGGAGATGATGAAAGAGAGCGTGCTCGACGCG
TATGGTCGGTCGTTGAACGCTTAA

Upstream 100 bases:

>100_bases
TCGACGGTATTCACCTCGATGCTGAAAACACGCGCGCCATTGGTGCCGGCCTGGAGCCGGTGGTCCGCCAAGCGCTTGGA
TTGTGATTAAGGAGTTTTGC

Downstream 100 bases:

>100_bases
GGGCGGGACCGGGCAGCCGGGCCAGCTTTACTTGGATGATTGATCCGAAACCAAAGCAGGGAGACTTCGTATGGAGGGTC
TTGGTTGGATTTTGACAATT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MAESYDVIIIGSGPGGYVTAVRSAQLGLKTAIVEREHLGGICLNWGCIPTKALLRSAEILHYAQHAKDYGLKLDGSIAPD
TAAVVDRSRKVSARLNTGVGFLMKKNKVDVIWGEAKISKAAKANEPGEIVVSKPSKKAMEPQHPAPKNTLGEGTYKAKHI
ILATGARPRVLPGIEPDGKLIWTYFEAMVPKEMPKSLIVMGSGAIGIEFASFYRTMGADVTVIELLPQILPVEDAEVSKF
ARRQLEKQGMKFHVEAKVTKVEKGANQITAHVEMKDGKVEKITADRLISAVGVQGNVENLGLEALGVKVERGTVAVDGYG
RTNVPGIYAIGDVAGPPMLAHKAEHEGVICVEKIAGVPGVHALDKSKIPGCTYCQPQVASVGLTEEKAKEAGRDIRVGRF
QFGANGKAIALGEDQGFIKTILDKKTGELLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTIFPHPTLSEMMKESVLDA
YGRSLNA

Sequences:

>Translated_487_residues
MAESYDVIIIGSGPGGYVTAVRSAQLGLKTAIVEREHLGGICLNWGCIPTKALLRSAEILHYAQHAKDYGLKLDGSIAPD
TAAVVDRSRKVSARLNTGVGFLMKKNKVDVIWGEAKISKAAKANEPGEIVVSKPSKKAMEPQHPAPKNTLGEGTYKAKHI
ILATGARPRVLPGIEPDGKLIWTYFEAMVPKEMPKSLIVMGSGAIGIEFASFYRTMGADVTVIELLPQILPVEDAEVSKF
ARRQLEKQGMKFHVEAKVTKVEKGANQITAHVEMKDGKVEKITADRLISAVGVQGNVENLGLEALGVKVERGTVAVDGYG
RTNVPGIYAIGDVAGPPMLAHKAEHEGVICVEKIAGVPGVHALDKSKIPGCTYCQPQVASVGLTEEKAKEAGRDIRVGRF
QFGANGKAIALGEDQGFIKTILDKKTGELLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTIFPHPTLSEMMKESVLDA
YGRSLNA
>Mature_486_residues
AESYDVIIIGSGPGGYVTAVRSAQLGLKTAIVEREHLGGICLNWGCIPTKALLRSAEILHYAQHAKDYGLKLDGSIAPDT
AAVVDRSRKVSARLNTGVGFLMKKNKVDVIWGEAKISKAAKANEPGEIVVSKPSKKAMEPQHPAPKNTLGEGTYKAKHII
LATGARPRVLPGIEPDGKLIWTYFEAMVPKEMPKSLIVMGSGAIGIEFASFYRTMGADVTVIELLPQILPVEDAEVSKFA
RRQLEKQGMKFHVEAKVTKVEKGANQITAHVEMKDGKVEKITADRLISAVGVQGNVENLGLEALGVKVERGTVAVDGYGR
TNVPGIYAIGDVAGPPMLAHKAEHEGVICVEKIAGVPGVHALDKSKIPGCTYCQPQVASVGLTEEKAKEAGRDIRVGRFQ
FGANGKAIALGEDQGFIKTILDKKTGELLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTIFPHPTLSEMMKESVLDAY
GRSLNA

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=490, Percent_Identity=38.1632653061225, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI50301238, Length=486, Percent_Identity=27.1604938271605, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=27.4261603375527, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI33519430, Length=477, Percent_Identity=26.4150943396226, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI33519428, Length=477, Percent_Identity=26.4150943396226, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI33519426, Length=477, Percent_Identity=26.4150943396226, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI148277065, Length=477, Percent_Identity=26.4150943396226, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI148277071, Length=477, Percent_Identity=26.4150943396226, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI291045266, Length=450, Percent_Identity=26.2222222222222, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI291045268, Length=493, Percent_Identity=26.1663286004057, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1786307, Length=467, Percent_Identity=36.4025695931477, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87082354, Length=489, Percent_Identity=27.6073619631902, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789915, Length=484, Percent_Identity=30.7851239669421, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87081717, Length=484, Percent_Identity=28.3057851239669, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32565766, Length=490, Percent_Identity=38.3673469387755, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17557007, Length=490, Percent_Identity=24.6938775510204, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983429, Length=464, Percent_Identity=25.4310344827586, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71983419, Length=465, Percent_Identity=25.5913978494624, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=510, Percent_Identity=24.7058823529412, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17559934, Length=145, Percent_Identity=33.7931034482759, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=499, Percent_Identity=36.87374749499, Blast_Score=283, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6325240, Length=493, Percent_Identity=28.8032454361055, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=487, Percent_Identity=28.5420944558522, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21358499, Length=490, Percent_Identity=39.7959183673469, Blast_Score=304, Evalue=8e-83,
Organism=Drosophila melanogaster, GI24640553, Length=492, Percent_Identity=27.0325203252033, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24640551, Length=505, Percent_Identity=27.1287128712871, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24640549, Length=492, Percent_Identity=27.0325203252033, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17737741, Length=509, Percent_Identity=25.147347740668, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 52185; Mature: 52054

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESYDVIIIGSGPGGYVTAVRSAQLGLKTAIVEREHLGGICLNWGCIPTKALLRSAEIL
CCCCEEEEEEECCCCCEEEEEHHHHHCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHH
HYAQHAKDYGLKLDGSIAPDTAAVVDRSRKVSARLNTGVGFLMKKNKVDVIWGEAKISKA
HHHHHHHHCCEEECCCCCCCHHHHHHCCHHEEEEECCCEEEEEECCCEEEEECHHHHHHH
AKANEPGEIVVSKPSKKAMEPQHPAPKNTLGEGTYKAKHIILATGARPRVLPGIEPDGKL
HCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCE
IWTYFEAMVPKEMPKSLIVMGSGAIGIEFASFYRTMGADVTVIELLPQILPVEDAEVSKF
EEEHHHHHCCHHCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
ARRQLEKQGMKFHVEAKVTKVEKGANQITAHVEMKDGKVEKITADRLISAVGVQGNVENL
HHHHHHHCCCEEEEEEEEEHHHCCCCEEEEEEEECCCCEEEEHHHHHHHHHCCCCCHHHC
GLEALGVKVERGTVAVDGYGRTNVPGIYAIGDVAGPPMLAHKAEHEGVICVEKIAGVPGV
CEEEEEEEEECCEEEECCCCCCCCCCEEEECCCCCCCHHHCCCCCCCEEEEHHHCCCCCC
HALDKSKIPGCTYCQPQVASVGLTEEKAKEAGRDIRVGRFQFGANGKAIALGEDQGFIKT
CCCCCCCCCCCCCCCCCHHHCCCCHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHH
ILDKKTGELLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTIFPHPTLSEMMKESVLDA
HHCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHH
YGRSLNA
HHHCCCC
>Mature Secondary Structure 
AESYDVIIIGSGPGGYVTAVRSAQLGLKTAIVEREHLGGICLNWGCIPTKALLRSAEIL
CCCEEEEEEECCCCCEEEEEHHHHHCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHH
HYAQHAKDYGLKLDGSIAPDTAAVVDRSRKVSARLNTGVGFLMKKNKVDVIWGEAKISKA
HHHHHHHHCCEEECCCCCCCHHHHHHCCHHEEEEECCCEEEEEECCCEEEEECHHHHHHH
AKANEPGEIVVSKPSKKAMEPQHPAPKNTLGEGTYKAKHIILATGARPRVLPGIEPDGKL
HCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCE
IWTYFEAMVPKEMPKSLIVMGSGAIGIEFASFYRTMGADVTVIELLPQILPVEDAEVSKF
EEEHHHHHCCHHCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
ARRQLEKQGMKFHVEAKVTKVEKGANQITAHVEMKDGKVEKITADRLISAVGVQGNVENL
HHHHHHHCCCEEEEEEEEEHHHCCCCEEEEEEEECCCCEEEEHHHHHHHHHCCCCCHHHC
GLEALGVKVERGTVAVDGYGRTNVPGIYAIGDVAGPPMLAHKAEHEGVICVEKIAGVPGV
CEEEEEEEEECCEEEECCCCCCCCCCEEEECCCCCCCHHHCCCCCCCEEEEHHHCCCCCC
HALDKSKIPGCTYCQPQVASVGLTEEKAKEAGRDIRVGRFQFGANGKAIALGEDQGFIKT
CCCCCCCCCCCCCCCCCHHHCCCCHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHH
ILDKKTGELLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTIFPHPTLSEMMKESVLDA
HHCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHH
YGRSLNA
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]