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The map label for this gene is tmk

Identifier: 110633933

GI number: 110633933

Start: 1701933

End: 1702610

Strand: Direct

Name: tmk

Synonym: Meso_1581

Alternate gene names: 110633933

Gene position: 1701933-1702610 (Clockwise)

Preceding gene: 110633932

Following gene: 110633934

Centisome position: 38.57

GC content: 60.91

Gene sequence:

>678_bases
ATGGTGCCGCGAGGTTTTTTTATCACGTTCGAGGGAGGGGAGGGCGCAGGGAAGTCCACGCAGATCCACCTGCTGGCGGA
CCGGCTGCGCCGTGAGGGGCGAGATGTTTTGACGACCCGCGAGCCAGGCGGCTCGCCCGGCGCGGAAGCCATCCGCCACG
TGTTGCTTTCAGGCGCTGCCGAACCTTTCGGCGCGACGCTGGAGGCAATCCTCTTCGCCGCGGCGCGATCCGATCATGTG
GAGCAGGTGATTCGCCCTGCGGTCGAGAGCGGCGCAATCGTTCTCTGCGACCGGTTTCTTGATTCCTCCCGGGTTTATCA
GGGAGTCACGGGTGGGCTGGCATCCGATTTCATGGCGGCACTCGAGCGTGTGACCGTCAATGGTTTGATACCCGACCTCA
CCGTCATTCTCGATATTGATCCCGAAGAAGGCCTGCGCCGCGCTTCGGAACGACGCGGAAAGGCAACAGCCGACCGGTTC
GAAAAGGAAAACCTGGAGATTCATAGACGGCGGCGGGAAGCATTTCTGAATATCGCGGCCAGGGAGCCGCAACGCTGCGT
CGTGATCGATGCCTCAAGATCAGCCGACGCGGTTTCGGAGAATGTGACCGAGATTGTCTTGCGAGTCATATTTGATAGAG
CAGGGCTCTCGGAACCAACGGAGGCGGGCAGTGTTTGA

Upstream 100 bases:

>100_bases
CTTAACGCCTCGTCCCATTTTGCCAAACCGGTTCGGCGTTGGACGTCGGCGGCGCGCACGTCTATGTAGGACATGCCGAA
GCAGATGCGTGTACGAGGAA

Downstream 100 bases:

>100_bases
ACGCCGCGCGCCTGAACAGCACGATTCTCTGCCGGATATCCCGGAACCGCCGGAAAACCCGCTCCTTGTCGGCCACGAAA
ACGCACGCTCAATGCTTGCC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MVPRGFFITFEGGEGAGKSTQIHLLADRLRREGRDVLTTREPGGSPGAEAIRHVLLSGAAEPFGATLEAILFAAARSDHV
EQVIRPAVESGAIVLCDRFLDSSRVYQGVTGGLASDFMAALERVTVNGLIPDLTVILDIDPEEGLRRASERRGKATADRF
EKENLEIHRRRREAFLNIAAREPQRCVVIDASRSADAVSENVTEIVLRVIFDRAGLSEPTEAGSV

Sequences:

>Translated_225_residues
MVPRGFFITFEGGEGAGKSTQIHLLADRLRREGRDVLTTREPGGSPGAEAIRHVLLSGAAEPFGATLEAILFAAARSDHV
EQVIRPAVESGAIVLCDRFLDSSRVYQGVTGGLASDFMAALERVTVNGLIPDLTVILDIDPEEGLRRASERRGKATADRF
EKENLEIHRRRREAFLNIAAREPQRCVVIDASRSADAVSENVTEIVLRVIFDRAGLSEPTEAGSV
>Mature_225_residues
MVPRGFFITFEGGEGAGKSTQIHLLADRLRREGRDVLTTREPGGSPGAEAIRHVLLSGAAEPFGATLEAILFAAARSDHV
EQVIRPAVESGAIVLCDRFLDSSRVYQGVTGGLASDFMAALERVTVNGLIPDLTVILDIDPEEGLRRASERRGKATADRF
EKENLEIHRRRREAFLNIAAREPQRCVVIDASRSADAVSENVTEIVLRVIFDRAGLSEPTEAGSV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=203, Percent_Identity=36.9458128078818, Blast_Score=116, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_MESSB (Q11HZ9)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674141.1
- ProteinModelPortal:   Q11HZ9
- SMR:   Q11HZ9
- STRING:   Q11HZ9
- GeneID:   4180274
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1581
- NMPDR:   fig|266779.1.peg.327
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q11HZ9
- ProtClustDB:   PRK13973
- BioCyc:   MSP266779:MESO_1581-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24418; Mature: 24418

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPRGFFITFEGGEGAGKSTQIHLLADRLRREGRDVLTTREPGGSPGAEAIRHVLLSGAA
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCC
EPFGATLEAILFAAARSDHVEQVIRPAVESGAIVLCDRFLDSSRVYQGVTGGLASDFMAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHCHHHHHHHHCCCHHHHHHHH
LERVTVNGLIPDLTVILDIDPEEGLRRASERRGKATADRFEKENLEIHRRRREAFLNIAA
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
REPQRCVVIDASRSADAVSENVTEIVLRVIFDRAGLSEPTEAGSV
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVPRGFFITFEGGEGAGKSTQIHLLADRLRREGRDVLTTREPGGSPGAEAIRHVLLSGAA
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCC
EPFGATLEAILFAAARSDHVEQVIRPAVESGAIVLCDRFLDSSRVYQGVTGGLASDFMAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHCHHHHHHHHCCCHHHHHHHH
LERVTVNGLIPDLTVILDIDPEEGLRRASERRGKATADRFEKENLEIHRRRREAFLNIAA
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
REPQRCVVIDASRSADAVSENVTEIVLRVIFDRAGLSEPTEAGSV
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA