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The map label for this gene is clpP2

Identifier: 110633884

GI number: 110633884

Start: 1648366

End: 1648992

Strand: Reverse

Name: clpP2

Synonym: Meso_1531

Alternate gene names: 110633884

Gene position: 1648992-1648366 (Counterclockwise)

Preceding gene: 110633885

Following gene: 110633882

Centisome position: 37.37

GC content: 60.45

Gene sequence:

>627_bases
ATGCGCGACACGATGAATCTCATCCCCATGGTCGTTGAGCAATCGGCGCGCGGAGAACGTTCCTTCGACATCTTCTCCCG
GCTCCTTCGCGAGCGCATCATCTTCCTGAACGGCCAGGTGGACGACAATTCCGCCGCGCTCGTCTGCGCGCAGATGCTGC
ATTTGGAAGCGGAGAACCCGAAAAAGGAAATCGCTTTCTACATCAACTCGCCTGGCGGCGTGGTCTCCAGCGGCTTTGCC
ATCTATGACACGATGCAGTTCATCAAATGCCCCGTCGCCACGCTTTGCCTCGGCACGGCGGCATCCATGGGTTCCTTCCT
GCTCATGGCGGGCGAACGCGGCATGCGTGTCGCCCTGCCCAATGCCAGCATCATCCTGCATCAGCCGCTTGGCGGCTTTC
AGGGACAGGCTTCAGACATTGAACGCCACGCACAAAATGTCATGAGGCATAAGCGCCGCATGATCCGGCTTTACGCGGAA
CATTGCGGACGCGCGGAGGAAGACGTGGAACGCACGCTCGACCGCGATTTCTTCATGACTGCGGAGGACGCCCGCGAATG
GGGCCTGGTCGATCACGTCTATCGCCGGCGCGCAGGAGACTTGCCGCTCATCGCGCCAAGCTCATAG

Upstream 100 bases:

>100_bases
CAAATAGCGAGTAGGGATAGCGGGCGGAGTGCTTCGCCATTCTATTCGCTGCCCCCTATTCGCTTCCCAGTATCCAAACA
AAACTCAAGGAGGTTGCGCC

Downstream 100 bases:

>100_bases
GCCCCTTCGCGCCTCAACGGGGAATCCGCAGGAAGTCGTTGTCATCGTCCCAGGGATCGAGGATGCACCTATAGCCGATG
CGGCAGGATTGCGTATCGCG

Product: ATP-dependent Clp protease proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MRDTMNLIPMVVEQSARGERSFDIFSRLLRERIIFLNGQVDDNSAALVCAQMLHLEAENPKKEIAFYINSPGGVVSSGFA
IYDTMQFIKCPVATLCLGTAASMGSFLLMAGERGMRVALPNASIILHQPLGGFQGQASDIERHAQNVMRHKRRMIRLYAE
HCGRAEEDVERTLDRDFFMTAEDAREWGLVDHVYRRRAGDLPLIAPSS

Sequences:

>Translated_208_residues
MRDTMNLIPMVVEQSARGERSFDIFSRLLRERIIFLNGQVDDNSAALVCAQMLHLEAENPKKEIAFYINSPGGVVSSGFA
IYDTMQFIKCPVATLCLGTAASMGSFLLMAGERGMRVALPNASIILHQPLGGFQGQASDIERHAQNVMRHKRRMIRLYAE
HCGRAEEDVERTLDRDFFMTAEDAREWGLVDHVYRRRAGDLPLIAPSS
>Mature_208_residues
MRDTMNLIPMVVEQSARGERSFDIFSRLLRERIIFLNGQVDDNSAALVCAQMLHLEAENPKKEIAFYINSPGGVVSSGFA
IYDTMQFIKCPVATLCLGTAASMGSFLLMAGERGMRVALPNASIILHQPLGGFQGQASDIERHAQNVMRHKRRMIRLYAE
HCGRAEEDVERTLDRDFFMTAEDAREWGLVDHVYRRRAGDLPLIAPSS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=189, Percent_Identity=52.3809523809524, Blast_Score=217, Evalue=5e-57,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=59.5854922279793, Blast_Score=252, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17538017, Length=195, Percent_Identity=51.2820512820513, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20129427, Length=204, Percent_Identity=52.4509803921569, Blast_Score=231, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_MESSB (Q11I48)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674092.1
- ProteinModelPortal:   Q11I48
- SMR:   Q11I48
- STRING:   Q11I48
- MEROPS:   S14.001
- GeneID:   4180576
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1531
- NMPDR:   fig|266779.1.peg.278
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   CMGTARS
- BioCyc:   MSP266779:MESO_1531-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23331; Mature: 23331

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 102-102 ACT_SITE 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDTMNLIPMVVEQSARGERSFDIFSRLLRERIIFLNGQVDDNSAALVCAQMLHLEAENP
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
KKEIAFYINSPGGVVSSGFAIYDTMQFIKCPVATLCLGTAASMGSFLLMAGERGMRVALP
CEEEEEEECCCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCEEECC
NASIILHQPLGGFQGQASDIERHAQNVMRHKRRMIRLYAEHCGRAEEDVERTLDRDFFMT
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEC
AEDAREWGLVDHVYRRRAGDLPLIAPSS
HHHHHHCCHHHHHHHHCCCCCCEECCCC
>Mature Secondary Structure
MRDTMNLIPMVVEQSARGERSFDIFSRLLRERIIFLNGQVDDNSAALVCAQMLHLEAENP
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
KKEIAFYINSPGGVVSSGFAIYDTMQFIKCPVATLCLGTAASMGSFLLMAGERGMRVALP
CEEEEEEECCCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCEEECC
NASIILHQPLGGFQGQASDIERHAQNVMRHKRRMIRLYAEHCGRAEEDVERTLDRDFFMT
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEC
AEDAREWGLVDHVYRRRAGDLPLIAPSS
HHHHHHCCHHHHHHHHCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA