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The map label for this gene is ilvC

Identifier: 110633849

GI number: 110633849

Start: 1592721

End: 1593740

Strand: Direct

Name: ilvC

Synonym: Meso_1496

Alternate gene names: 110633849

Gene position: 1592721-1593740 (Clockwise)

Preceding gene: 110633848

Following gene: 110633851

Centisome position: 36.1

GC content: 61.57

Gene sequence:

>1020_bases
ATGCGTGTCTATTACGATCGCGATGCCGATCTGAACCTCATCAAGTCAAAGAAGGTTGCCATTATCGGCTATGGCAGCCA
GGGGCGGGCGCATGCGCTGAACCTCAAGGATTCAGGCGCCAAGGACCTGGCGGTGGCGCTGCGCCCCGGTTCGGCATCGG
CGAAGAAGGCCGAGGCAGACGGCTTGAAAGTCATGAGCGTGGCCGAAGCCGCCGGCTGGGCCGATCTCATGATGATGGCC
ACGCCCGACGAATTGCAGGCCGGGATCTACAATAATGAGATCGCGCCCAATATCCGCGACGGCGCTGCAATCGCCTTCGC
CCACGGCCTCAACGTGCATTTCGGCCTTATCGAACCCAAGAAAACGGTGGACGTGTTGATGATCGCGCCCAAGGGCCCGG
GCCACACGGTGCGCAGCGAATACCAGCGCGGCGGCGGTGTGCCCTGCCTGGTGGCTGTGCATCACGACGCCTCGGGCAAT
GCGCTCGACCTCGCGCTCTCCTATGCCTGTGGCGTCGGCGGCGGCCGTTCGGGCATCATCGAGACCACGTTCCGTGAGGA
ATGCGAGACGGATCTGTTCGGTGAGCAGGTGGTGCTCTGCGGTGGTCTCGTCGAGCTCATCCGCGCCGGATTCGAGACGC
TGGTGGAAGCCGGCTACGCGCCGGAAATGGCGTATTTCGAGTGCCTGCACGAGGTGAAGCTCATCGTAGACCTCATCTAT
GAGGGCGGCATCGCCAACATGAACTATTCGATCTCCAACACGGCCGAGTGGGGCGAGTATGTCTCCGGCCCGCGCATCAT
CACCCCCGAGACGAAGGCCGAGATGAAGCGTGTGCTGAAGGATATTCAGACCGGCAAGTTCACCGCCGAGTGGATGCAGG
AATGGCATTCGGGTGCGGCCCGCTTCAAGGCCACCCGCCGGCTCAACGATTCACATCAGATCGAGGAAGTGGGCGAGAAG
CTGCGCGCCATGATGCCCTGGATTTCCAAGAATAAGCTGGTCGACAAAGCCAAGAACTAG

Upstream 100 bases:

>100_bases
ACGGCCCCTCGCGTAAGGGCTGTCTAAGCAGGTTCCGCAAAAGCGTTCGACGGTTTTGCGAACGGGCCTGCGAGGGAAAT
CCAGCAAGGAAGGAAACGAA

Downstream 100 bases:

>100_bases
GCTTTGGCTTGAACAATAATGAAAGGCGGCGTTGCTGAACGCCGCCTTTCACTTTTTAGCGGAGCGGCGCTCACCCCAAA
TAGGGCGAGACGCAGACCCG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAKDLAVALRPGSASAKKAEADGLKVMSVAEAAGWADLMMMA
TPDELQAGIYNNEIAPNIRDGAAIAFAHGLNVHFGLIEPKKTVDVLMIAPKGPGHTVRSEYQRGGGVPCLVAVHHDASGN
ALDLALSYACGVGGGRSGIIETTFREECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEWGEYVSGPRIITPETKAEMKRVLKDIQTGKFTAEWMQEWHSGAARFKATRRLNDSHQIEEVGEK
LRAMMPWISKNKLVDKAKN

Sequences:

>Translated_339_residues
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAKDLAVALRPGSASAKKAEADGLKVMSVAEAAGWADLMMMA
TPDELQAGIYNNEIAPNIRDGAAIAFAHGLNVHFGLIEPKKTVDVLMIAPKGPGHTVRSEYQRGGGVPCLVAVHHDASGN
ALDLALSYACGVGGGRSGIIETTFREECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEWGEYVSGPRIITPETKAEMKRVLKDIQTGKFTAEWMQEWHSGAARFKATRRLNDSHQIEEVGEK
LRAMMPWISKNKLVDKAKN
>Mature_339_residues
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAKDLAVALRPGSASAKKAEADGLKVMSVAEAAGWADLMMMA
TPDELQAGIYNNEIAPNIRDGAAIAFAHGLNVHFGLIEPKKTVDVLMIAPKGPGHTVRSEYQRGGGVPCLVAVHHDASGN
ALDLALSYACGVGGGRSGIIETTFREECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEWGEYVSGPRIITPETKAEMKRVLKDIQTGKFTAEWMQEWHSGAARFKATRRLNDSHQIEEVGEK
LRAMMPWISKNKLVDKAKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=292, Percent_Identity=36.6438356164384, Blast_Score=162, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323387, Length=335, Percent_Identity=30.1492537313433, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_MESSB (Q11I83)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674057.1
- ProteinModelPortal:   Q11I83
- SMR:   Q11I83
- STRING:   Q11I83
- GeneID:   4179261
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1496
- NMPDR:   fig|266779.1.peg.4341
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q11I83
- ProtClustDB:   PRK05479
- BioCyc:   MSP266779:MESO_1496-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36843; Mature: 36843

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAKDLAVALRPGSASAKKAEAD
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCC
GLKVMSVAEAAGWADLMMMATPDELQAGIYNNEIAPNIRDGAAIAFAHGLNVHFGLIEPK
CEEEEHHHHHCCHHHEEEEECCHHHHCCCCCCCCCCCCCCCCEEEEEECCEEEEEECCCC
KTVDVLMIAPKGPGHTVRSEYQRGGGVPCLVAVHHDASGNALDLALSYACGVGGGRSGII
CCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEHEEEHHHHCCCCCCCCCE
ETTFREECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEWGEYVSGPRIITPETKAEMKRVLKDIQTGKFTAEWMQEWHSGAA
CCCCCCCCCCCCCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RFKATRRLNDSHQIEEVGEKLRAMMPWISKNKLVDKAKN
HHHHHHHCCCCHHHHHHHHHHHHHHCCHHHCHHHHCCCC
>Mature Secondary Structure
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAKDLAVALRPGSASAKKAEAD
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCC
GLKVMSVAEAAGWADLMMMATPDELQAGIYNNEIAPNIRDGAAIAFAHGLNVHFGLIEPK
CEEEEHHHHHCCHHHEEEEECCHHHHCCCCCCCCCCCCCCCCEEEEEECCEEEEEECCCC
KTVDVLMIAPKGPGHTVRSEYQRGGGVPCLVAVHHDASGNALDLALSYACGVGGGRSGII
CCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEHEEEHHHHCCCCCCCCCE
ETTFREECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEWGEYVSGPRIITPETKAEMKRVLKDIQTGKFTAEWMQEWHSGAA
CCCCCCCCCCCCCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RFKATRRLNDSHQIEEVGEKLRAMMPWISKNKLVDKAKN
HHHHHHHCCCCHHHHHHHHHHHHHHCCHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA