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The map label for this gene is pdxJ

Identifier: 110633846

GI number: 110633846

Start: 1589834

End: 1590580

Strand: Direct

Name: pdxJ

Synonym: Meso_1493

Alternate gene names: 110633846

Gene position: 1589834-1590580 (Clockwise)

Preceding gene: 110633844

Following gene: 110633847

Centisome position: 36.03

GC content: 60.91

Gene sequence:

>747_bases
ATGCCAGTAAAGCTCTCGGTCAATCTGAACGCCGTCGCTATGCTGAGGAACCGTCGCGATCTGCCATGGCCGAGTGTTAC
CGCGCTTGGGCGAATCGCGCTTGGCGCAGGCGCGCATGGGCTGACCGTTCACCCGAGGCCCGATCAGCGCCATATCCGCT
TTTCCGATCTCCCGCACATCAGGGCTCTGATAGACGACGAATTCCCCGACCGCGAGTTCAATATCGAAGGATATCCCTCG
GAAGACTTCTTACGGCTGGTGGAAGAAACGCAGCCCGAGCAGGTAACCCTTGTGCCGGATGATCCGTCGCAAGCCACCTC
CGACCATGGCTGGCAATTTCAGGAGCATGAGCGGTTTCTTGCGGCGGCAGTTGGCCGCTTGAAGCGGCGCGGTTTCCGGG
TCTCGCTCTTTGCGGACCCCGATGCGGACGAAGCAGCGCTTGCCGTTGCAAAGGCAGTGGGGGCAGACCGGGTGGAGCTC
TACACGGGACCATATGGCGCTTGCTACGACGACGCCGAAAAGGCCGCTAAAGAGCTAAGAAAGCTGGAAAAGACAGCCAA
GACGGCGCAAGGGCTCGGTCTTGCCGTCAACGCCGGACATGATCTGACCGTTGCGAACCTGCCCGCACTCGTAGAGCATG
TTCCCTCGCTTGCGGAGGTCTCCATCGGCCATGCCCTGACGGCCGATGCTTTGGAATACGGCATGGCGGAGACGGTGCGG
CGCTACCTCAGCGCGTGTGAAGCTTAA

Upstream 100 bases:

>100_bases
GCCCAATGCTGACCACGTCTCACGTCAACATCAATTAGGCCTGTCGGTTCCCTAGGAAACGGTATAGGAGAGAACAAAAT
CCAGTCATAGGGACGTTGGA

Downstream 100 bases:

>100_bases
GCCTGTCCATTGAGCCTGGCCTGAATAGCCGCACGCTGCCATCCCGGCTGGTGTGGTCTGCGTCCTTCTGACGGTCTTCG
GCAACCACTTCGAGCGCTGC

Product: pyridoxine 5'-phosphate synthase

Products: NA

Alternate protein names: PNP synthase

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MPVKLSVNLNAVAMLRNRRDLPWPSVTALGRIALGAGAHGLTVHPRPDQRHIRFSDLPHIRALIDDEFPDREFNIEGYPS
EDFLRLVEETQPEQVTLVPDDPSQATSDHGWQFQEHERFLAAAVGRLKRRGFRVSLFADPDADEAALAVAKAVGADRVEL
YTGPYGACYDDAEKAAKELRKLEKTAKTAQGLGLAVNAGHDLTVANLPALVEHVPSLAEVSIGHALTADALEYGMAETVR
RYLSACEA

Sequences:

>Translated_248_residues
MPVKLSVNLNAVAMLRNRRDLPWPSVTALGRIALGAGAHGLTVHPRPDQRHIRFSDLPHIRALIDDEFPDREFNIEGYPS
EDFLRLVEETQPEQVTLVPDDPSQATSDHGWQFQEHERFLAAAVGRLKRRGFRVSLFADPDADEAALAVAKAVGADRVEL
YTGPYGACYDDAEKAAKELRKLEKTAKTAQGLGLAVNAGHDLTVANLPALVEHVPSLAEVSIGHALTADALEYGMAETVR
RYLSACEA
>Mature_247_residues
PVKLSVNLNAVAMLRNRRDLPWPSVTALGRIALGAGAHGLTVHPRPDQRHIRFSDLPHIRALIDDEFPDREFNIEGYPSE
DFLRLVEETQPEQVTLVPDDPSQATSDHGWQFQEHERFLAAAVGRLKRRGFRVSLFADPDADEAALAVAKAVGADRVELY
TGPYGACYDDAEKAAKELRKLEKTAKTAQGLGLAVNAGHDLTVANLPALVEHVPSLAEVSIGHALTADALEYGMAETVRR
YLSACEA

Specific function: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate

COG id: COG0854

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP synthase family

Homologues:

Organism=Escherichia coli, GI1788917, Length=235, Percent_Identity=37.4468085106383, Blast_Score=135, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXJ_MESSB (Q11I86)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674054.1
- ProteinModelPortal:   Q11I86
- SMR:   Q11I86
- STRING:   Q11I86
- GeneID:   4179258
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1493
- NMPDR:   fig|266779.1.peg.4344
- eggNOG:   COG0854
- HOGENOM:   HBG299314
- OMA:   AGHGLNY
- PhylomeDB:   Q11I86
- ProtClustDB:   PRK05265
- BioCyc:   MSP266779:MESO_1493-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00279
- InterPro:   IPR013785
- InterPro:   IPR004569
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00559

Pfam domain/function: PF03740 PdxJ; SSF63892 PyrdxlP_synth_PdxJ

EC number: =2.6.99.2

Molecular weight: Translated: 27123; Mature: 26992

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: ACT_SITE 44-44 ACT_SITE 76-76 ACT_SITE 200-200 BINDING 8-8 BINDING 19-19 BINDING 46-46 BINDING 51-51 BINDING 106-106 BINDING 201-201

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKLSVNLNAVAMLRNRRDLPWPSVTALGRIALGAGAHGLTVHPRPDQRHIRFSDLPHI
CCEEEEECCHHHEEECCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCEECCCCCHH
RALIDDEFPDREFNIEGYPSEDFLRLVEETQPEQVTLVPDDPSQATSDHGWQFQEHERFL
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
AAAVGRLKRRGFRVSLFADPDADEAALAVAKAVGADRVELYTGPYGACYDDAEKAAKELR
HHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
KLEKTAKTAQGLGLAVNAGHDLTVANLPALVEHVPSLAEVSIGHALTADALEYGMAETVR
HHHHHHHHHHCCCEEEECCCCEEHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHH
RYLSACEA
HHHHHHCC
>Mature Secondary Structure 
PVKLSVNLNAVAMLRNRRDLPWPSVTALGRIALGAGAHGLTVHPRPDQRHIRFSDLPHI
CEEEEECCHHHEEECCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCEECCCCCHH
RALIDDEFPDREFNIEGYPSEDFLRLVEETQPEQVTLVPDDPSQATSDHGWQFQEHERFL
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
AAAVGRLKRRGFRVSLFADPDADEAALAVAKAVGADRVELYTGPYGACYDDAEKAAKELR
HHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
KLEKTAKTAQGLGLAVNAGHDLTVANLPALVEHVPSLAEVSIGHALTADALEYGMAETVR
HHHHHHHHHHCCCEEEECCCCEEHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHH
RYLSACEA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA